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Monkeypox: the resurgence of forgotten things
Sun Bean Kim, Jaehun Jung, Kyong Ran Peck
Epidemiol Health. 2022;44:e2022082.   Published online September 26, 2022
DOI: https://doi.org/10.4178/epih.e2022082
  • 4,644 View
  • 145 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
Monkeypox, a rare zoonotic disease, is primarily prevalent in Central and Western Africa. However, monkeypox is emerging as a worldwide concern due to the 2022 monkeypox outbreak, which is the first instance of widespread community transmission outside Africa. Monkeypox is caused by the monkeypox virus, which belongs to the genus <i>Orthopoxvirus</i> and presents as a vesicular-pustular disease that may be preceded by fever, malaise, and other constitutional symptoms. If present, lymphadenopathy may distinguish it from chickenpox or smallpox. However, contrary to previous manifestations, most monkeypox patients presented with atypical features during the 2022 outbreak. Monkeypox is usually a self-limiting disease with symptoms lasting between 2 weeks and 4 weeks and is mainly transmitted when a person comes into contact with an infected animal, person, or fomites contaminated with the virus. Very few treatment options are available for this disease. Tecovirimat has been licensed in some countries for the treatment of smallpox and monkeypox infections. Two other medications, cidofovir and brincidofovir, have been found to be effective against poxviruses in in vitro and animal studies, but data on human cases of monkeypox are limited. Although Imvamune (JYNNEOS), a vaccine against monkeypox, is authorized in the United States, there are currently no established routine vaccination programs. Current preventive strategies focus on the detection of probable cases and containment of the outbreak through the implementation of selected ring vaccination programs. Fundamental principles to prevent the spread of monkeypox, including maintaining personal hygiene and avoiding close contact with symptomatic patients, are of paramount importance.
Summary
Korean summary
원숭이두창은 orthopoxvirus에 속하는 원숭이두창 바이러스에 의해 발생하며, 중앙아프리카와 서아프리카에서 주로 발견되는 희귀한 인수공통감염병이었으나 2022년에 집단 발병했던 원숭이두창 환자들은 이전부터 널리 알려진 증세와 달리 비전형적인 임상 특징을 보이고 있고, 전 세계적으로 아프리카와의 역학적 연관성없이 아프리카 이외의 여러 지역에서 원숭이두창이 집단 발병하면서 보건학적 화두로 대두되었다. 원숭이두창에 대한 치료는 증상 호전을 위한 대증 요법이 주가 되며, 매우 제한적인 항바이러스제가 치료 약제로 이용된다. 2019년 미국에서 Imvamune (Jynneos)가 성인을 대상으로 원숭이두창 백신으로 사용이 승인되었다. 하지만 예방 접종뿐만 아니라 손씻기 등의 개인위생 유지, 의심 혹은 확진 환자와의 긴밀한 접촉을 피하는 것 등이 원숭이두창 확산을 막기 위한 가장 중요한 기본 원칙이다.
Key Message
Monkeypox is caused by the monkeypox virus, which belongs to the genus Orthopoxvirus and presents as a vesicular-pustular disease that may be preceded by fever, malaise, and other constitutional symptoms. Contrary to previous manifestations, most monkeypox patients presented with atypical features during the 2022 outbreak. Very few treatment options are available for this disease and current preventive strategies focus on the detection of probable cases and containment of the outbreak through the implementation of selected ring vaccination programs. Fundamental principles to prevent the spread of monkeypox, including maintaining personal hygiene and avoiding close contact with symptomatic patients, are of paramount importance.

Citations

Citations to this article as recorded by  
  • Breaking Barriers: Current Advances and Future Directions in Mpox Therapy
    Bhumi M. Shah, Palmi Modi
    Current Drug Targets.2024; 25(1): 62.     CrossRef
  • How to cope with suspected mpox patients in the outpatient clinic
    Nam Joong Kim, Sun Huh
    Journal of the Korean Medical Association.2023; 66(5): 325.     CrossRef
  • An International Outburst of New Form of Monkeypox Virus
    Kiran Dobhal, Pallavi Ghildiyal, A.N.M. Ansori, Vikash Jakhmola
    Journal of Pure and Applied Microbiology.2022; 16(suppl 1): 3013.     CrossRef
Epidemiology of myocardial infarction in Korea: hospitalization incidence, prevalence, and mortality
Rock Bum Kim, Jang-Rak Kim, Jin Yong Hwang
Epidemiol Health. 2022;44:e2022057.   Published online July 12, 2022
DOI: https://doi.org/10.4178/epih.e2022057
  • 10,905 View
  • 481 Download
  • 12 Web of Science
  • 14 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
Few studies have comprehensively presented epidemiological indicators of myocardial infarction in Korea. However, multiple published articles and open-source secondary data on the epidemiology of myocardial infarction are now available. This review summarized the hospitalization incidence, prevalence, and mortality rate of myocardial infarction in Korea using articles and open-source data from the Health Insurance Service and the Department of Statistics, surveys of sample populations, registries of patients, and other sources. The epidemiological indicators of myocardial infarction were compared between Korea and other high-income countries. The incidence of hospitalization due to myocardial infarction in Korea was 43.2 cases per 100,000 population in 2016 and has consistently increased since 2011. It was 2.4 times higher among men than among women. The estimated prevalence among adults over 30 years of age ranged from 0.34% to 0.70% in 2020; it was higher among men and increased with age. The mortality in 2020, which was 19.3 per 100,000 population in 2020, remained relatively stable in recent years. Mortality was higher among men than among women. Based on representative inpatient registry data, the proportion of ST-elevated myocardial infarction decreased until recently, and the median time from symptom onset to hospital arrival was approximately 2 hours and 30 minutes. The hospitalization incidence, prevalence, and mortality rate of myocardial infarction were lower in Korea than in other countries, although there was an increasing trend. Comprehensive national-level support and surveillance systems are needed to routinely collect accurate epidemiological indicators.
Summary
Korean summary
○우리나라의 심근경색증 발생률은 2016년 기준 인구 10만명 당 43.2명으로 추정되며 2011년 이후 증가하고 있음. ○ 30세 이상 인구에서 심근경색증 유병률은 0.34% (건강보험청구데이터) 또는 1.0% (국민건강영양조사)로 추정됨. ○ 전체인구에서 심근경색증으로 인한 사망률은 2019년 인구 10만명 당 18.8명으로 최근 큰 변화가 없거나 약간 감소하는 추세임.
Key Message
This review article showed the hospitalized incidence, prevalence, mortality, and features on patient registry of myocardial infarction in Korea from published articles and opened data sources.

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    Clinical and Experimental Emergency Medicine.2023; 10(S): S1.     CrossRef
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A systematic review of barriers and motivators to physical activity in elderly adults in Iran and worldwide
Soudabeh Yarmohammadi, Hossein Mozafar Saadati, Mohtasham Ghaffari, Ali Ramezankhani
Epidemiol Health. 2019;41:e2019049.   Published online November 29, 2019
DOI: https://doi.org/10.4178/epih.e2019049
  • 18,677 View
  • 443 Download
  • 47 Web of Science
  • 56 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
This study was conducted to identify and characterize the barriers and motivations to physical activity (PA) for elderly adults in Iran and other countries.
METHODS
We searched 6 databases (PubMed, Embase, Scopus, Web of Science, Magiran, and the Scientific Information Database) from 2000 to the November 2017, using “aged 60 and over,” “physical activity” or “exercise,” and “motivator” and “barrier” as keywords. Two reviewers independently performed the search, screening, and quality assessment of the studies.
RESULTS
In total, 34 papers were finally included in the study. The most important barriers, based on the frequency of factors, included physical problems, having no companions, and physical barriers to walking. The motivators included improving one’s physical condition, being social, and suitability of the physical environment.
CONCLUSIONS
Important motivators and barriers to PA were more closely related to intrapersonal factors than to the interpersonal and environmental domains. The barriers and motivators to PA in the elderly were not markedly different between Iran and other countries. Therefore, a general strategy could be designed to improve PA in the elderly.
Summary

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    Jens Ole Rasmussen, Jette Primdahl, Willy Fick, Ann Bremander
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    Nathalie André, Nounagnon Frutueux Agbangla
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    Nejc Šarabon, Žiga Kozinc, Stefan Löfler, Christian Hofer
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    Jiabin Yu, Chen Yang, Shen Zhang, Diankai Zhai, Jianshe Li
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    Yongha Seo, Seungjae Hyun, Sangshin Park
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The global prevalence of dental healthcare needs and unmet dental needs among adolescents: a systematic review and meta-analysis
Mahin Ghafari, Samira Bahadivand-Chegini, Tayebeh Nadi, Amin Doosti-Irani
Epidemiol Health. 2019;41:e2019046.   Published online October 27, 2019
DOI: https://doi.org/10.4178/epih.e2019046
  • 15,040 View
  • 246 Download
  • 9 Web of Science
  • 7 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
Access to dental healthcare services is a major determinant of dental health in communities. This meta-analysis was conducted to estimate the global prevalence of dental needs and of unmet dental needs in adolescents.
METHODS
PubMed, Web of Science, and Scopus were searched in June 2018. The summary measures included the prevalence of met and unmet dental needs. A meta-analysis was performed using the inverse variance method to obtain pooled summary measures. Out of 41,661 retrieved articles, 57 were ultimately included.
RESULTS
The pooled prevalence of orthodontic treatment needs was 46.0% (95% confidence interval [CI], 38.0 to 53.0), that of general treatment needs was 59.0% (95% CI, 42.0 to 75.0), that of periodontal treatment needs was 71.0% (95% CI, 46.0 to 96.0), and that of malocclusion treatment needs was 39.0% (95% CI, 28.0 to 50.0). The pooled prevalence of unmet dental needs was 34.0% (95% CI, 27.0 to 40.0).
CONCLUSIONS
The highest and lowest prevalence of unmet dental needs were found in Southeast Asia and Europe, respectively. The prevalence of dental needs was higher in the countries of the Americas and Europe than in other World Health Organization (WHO) regions. The prevalence of unmet dental needs was higher in Southeast Asia and Africa than in other WHO regions.
Summary

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    Sonja M. Kalf‐Scholte, Renate van Zoonen, Dina Sijperda‐Abdul, Henk Algra, Cees Valkenburg
    Journal of Applied Research in Intellectual Disabilities.2024;[Epub]     CrossRef
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    Ana Carla Souza COSTA, Djessyca Miranda e PAULO, Maria Tereza Campos VIDIGAL, Walbert de Andrade VIEIRA, Andres Felipe Millan CARDENAS, Luiz Renato PARANHOS
    Brazilian Oral Research.2023;[Epub]     CrossRef
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    Wan Nurazreena Wan Hassan, Mohd Zambri Mohamed Makhbul, Zamros Yuzadi Mohd Yusof
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    Maria Tereza Campos Vidigal, Caio Melo Mesquita, Murilo Navarro de Oliveira, Walbert de Andrade Vieira, Cauane Blumenberg, Gustavo G Nascimento, Matheus Melo Pithon, Luiz Renato Paranhos
    European Journal of Orthodontics.2022; 44(4): 359.     CrossRef
  • Minimal Important Difference of the Psychosocial Impact of Dental Aesthetics Questionnaire Following Orthodontic Treatment: A Cohort Study
    Wan Nurazreena Wan Hassan, Mohd Zambri Mohamed Makhbul, Zamros Yuzadi Mohd Yusof, Siti Adibah Othman
    Children.2022; 9(4): 506.     CrossRef
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    Glauber S. Belitz, Lara J. N. Furlan, Jessica K. Knorst, Luana C. Berwig, Thiago M. Ardenghi, Vilmar A. Ferrazzo, Mariana Marquezan
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Meta-analysis of the prevalence of depression among breast cancer survivors in Iran: an urgent need for community supportive care programs
Hassan Ahmadi Gharaei, Mostafa Dianatinasab, Seyyed Mostafa Kouhestani, Mohammad Fararouei, Hossein Moameri, Reza Pakzad, Reza Ghaiasvand
Epidemiol Health. 2019;41:e2019030.   Published online July 4, 2019
DOI: https://doi.org/10.4178/epih.e2019030
  • 14,151 View
  • 299 Download
  • 15 Web of Science
  • 18 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
Depression, which is the most common comorbidity in breast cancer (BC) patients, has adverse effects on patients’ quality of life, disease progress, and survival.
METHODS
The protocol of this study was registered in PROSPERO (registration No. CRD42019121494). We electronically searched published studies through January 2019 with the aim of finding articles that investigated the prevalence of depression among BC survivors. Web of Science, Scopus, PubMed/MEDLINE, Science Direct, and Google Scholar were searched to obtain relevant published studies. This review included 14 cross-sectional and 4 cohort studies published from 2000 to 2018. We used a random-effects model to conduct the meta-analysis and generated a summary estimate for the pooled prevalence with 95% confidence intervals (CIs). A subgroup analysis was also conducted based on the depression assessment tool used and the study design.
RESULTS
The total sample size of the studies contained 2,799 women with BC, including 1,228 women who were diagnosed with depression. The pooled prevalence of depression among Iranian women with BC was 46.83% (95% CI, 33.77 to 59.88) with significant heterogeneity (I2 =98.5%; p<0.001). The prevalence of depression ranged from 14.00% (95% CI, 4.91 to 23.09) to 95.90% (95% CI, 91.97 to 99.83). The results of the subgroup analyses suggested that the depression assessment tool, year of publication, and study design were sources of heterogeneity.
CONCLUSIONS
Our findings indicate a high prevalence of depression among BC patients, underscoring the urgent need for clinicians and health authorities to provide well-defined social and psychological supportive care programs for these patients.
Summary

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  • The prevalence of anxiety and depression in cancer around the world: An overview of systematic reviews evaluating 128 meta-analyses
    Javier Martinez-Calderon, Cristina García-Muñoz, Alberto Marcos Heredia-Rizo, Francisco Javier Cano-García
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    Celest Su Yi Leo, Ling Jie Cheng, Xin Rong Lam, Honggu He
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    Rahimeh Khajoei, Mahnaz Ilkhani, Payam Azadeh, Sima Zohari Anboohi, Fatemah Heshmati Nabavi
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    Yi Wang, Sheng Bao, Yubing Chen
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    Fuying Tao, Mengnan Xu, Qi Zou, Lin Tang, Jianping Feng, Zhenyu Li
    Frontiers in Psychiatry.2023;[Epub]     CrossRef
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    Reza Pakzad, Saharnaz Nedjat, Hamid Salehiniya, Nasrin Mansournia, Mahyar Etminan, Maryam Nazemipour, Iraj Pakzad, Mohammad Ali Mansournia
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    Hussein Amer Hussein Al-Saffar, Nibras Alaa Hussain
    Medical Journal of Babylon.2023; 20(4): 852.     CrossRef
  • Global and regional geographical prevalence of depression in gastric cancer: a systematic review and meta-analysis
    Mostafa Kouhestani, Hasan Ahmadi Gharaei, Mohammad Fararouei, Hasan Hosienpour Ghahremanloo, Reza Ghaiasvand, Mostafa Dianatinasab
    BMJ Supportive & Palliative Care.2022; 12(e4): e526.     CrossRef
  • The prevalence of anxiety and depression and its association with coping strategies, supportive care needs, and social support among women with breast cancer
    Hassan Okati-Aliabad, Alireza Ansari-Moghadam, Mahdi Mohammadi, Shiva Kargar, Fariba Shahraki-Sanavi
    Supportive Care in Cancer.2022; 30(1): 703.     CrossRef
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    Shu-Yi Yang, Hanoch Livneh, Jing-Siang Jhang, Shu-Wen Yen, Hua-Lung Huang, Michael W. Y. Chan, Ming-Chi Lu, Chia-Chou Yeh, Chang-Kuo Wei, Tzung-Yi Tsai
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    Homayoun Farhad, Shahnam Abolghasemi, Tahereh Hamzehpoor
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    Jiaqi Liu, Heshan Yu, Yuxiao He, Ting Yan, Yu Ding, Jun Chu, Ning Gao, Xiaona Lin, Yanbin Xu, Guijin He
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    Abdallah Y. Naser, Anas Nawfal Hameed, Nour Mustafa, Hassan Alwafi, Eman Zmaily Dahmash, Hamad S. Alyami, Haya Khalil
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    Mohammadali Amini‐Tehrani, Hadi Zamanian, Mona Daryaafzoon, Seyedehroja Andikolaei, Mahshid Mohebbi, Arefeh Imani, Bita Tahmasbi, Sahar Foroozanfar, Zahra Jalali
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    Penelope Aggeli, Georgia Fasoi, Afroditi Zartaloudi, Konstantinos Kontzoglou, Michael Kontos, Theocharis Konstantinidis, Ioannis Kalemikerakis, Ourania Govina
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    Parvaneh Isfahani, Marziye Arefy, Monire Shamsaii
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    Karimollah Hajian-Tilaki, Erfaneh Hajian-Tilaki
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A systematic review and meta-analysis of the genetic characterization of human echinococcosis in Iran, an endemic country
Abolghasem Siyadatpanah, Davood Anvari, Amir Emami Zeydi, Seyed Abdollah Hosseini, Ahmad Daryani, Shahabeddin Sarvi, Christine M. Budke, Reza Esmaeelzadeh Dizaji, Mohammad Ali Mohaghegh, Mohammad Hasan Kohansal, Samira Dodangeh, Reza Saberi, Shirzad Gholami
Epidemiol Health. 2019;41:e2019024.   Published online June 15, 2019
DOI: https://doi.org/10.4178/epih.e2019024
  • 14,476 View
  • 331 Download
  • 12 Web of Science
  • 14 Crossref
AbstractAbstract PDF
Abstract
Human echinococcosis is an infectious disease caused by tapeworms belonging to the species Echinococcus. This parasite has a worldwide distribution and is considered a neglected tropical disease by the World Health Organization. Due to the diversity of Echinococcus spp. hosts, as well as variation in geographical, climatic, and socio-ethnic conditions, the question of the strains or genotypes of Echinococcus spp. that are involved in human infections is important. The aim of this study was to provide a summary of the available data on genotypes of Echinococcus obtained from the Iranian population. Four international databases (PubMed, Scopus, Science Direct, and Web of Science) and 4 Persian databases (Magiran, Scientific Information Database, Iran Medex, and IranDoc) were searched for cross-sectional studies that reported the genotypes of Echinococcus spp. in human echinococcosis cases using molecular methods in Iran through July 2018. The Newcastle-Ottawa Scale was used to assess the quality of the selected studies. A total of 559 cases of human cystic echinococcosis were reported in the 21 included articles. The majority of cases belonged to genotype G1 (89.2%; 95% confidence interval [CI], 80.1 to 95.8), genotype G6 (8.2%; 95% CI, 2.8 to 15.9), and genotype G3 (2.3%; 95% CI, 1.1 to 3.9). Since genotype G1 of Echinococcus appears to be the most prevalent genotype affecting humans in Iran, disease control initiatives aimed at sheep intermediate hosts may be the most beneficial. In addition, educational programs and serological screening in individuals may help reduce the national impact of the disease.
Summary

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  • Echinococcus granulosus sheep strain (G1) as the predominant genotype in definitive host (dogs) isolates in northeastern Iran
    Seyed-Hossein Hejazi, Seyed-Reza Mirbadie, Rasool Jafari, Mohammad-Reza Rezaiemanesh, Omid Azizi, Farzad Badmasti, Hamed Kalani, Kourosh Cheraghipour, Peyman Heydarian, Nooshin Hashemi, Shahrokh Izadi, Zahra Jabalameli, Mohammad-Ali Mohaghegh
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    Carlos Manterola, Armando Totomoch-Serra, Claudio Rojas, Ángela L. Riffo-Campos, Nayely García-Méndez
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    Nayely García-Méndez, Carlos Manterola, Armando Totomoch-Serra, Angela L. Riffo-Campos, César A. Brito-Carreón
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    Davood Anvari, Nima Pourmalek, Saeed Rezaei, Amir Fotovati, Seyed Abdollah Hosseini, Ahmad Daryani, Adel Spotin, Shahabeddin Sarvi, Mona Hosseini, Mohammad Reza Narouei, Mohammad Kalkali, Faezeh Pendar, Shirzad Gholami
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    Salar ZARRABİ AHRABİ, Rasoul MADANİ, Majid MONTAZER BAVİLİ, Ahmad BABAZADEH BEDOUSTANİ
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    Davood Anvari, Reza Saberi, Mehdi Sharif, Shahabbedin Sarvi, Seyed Abdollah Hosseini, Mahmood Moosazadeh, Zahra Hosseininejad, Tooran Nayeri Chegeni, Ahmad Daryani
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    Davood Anvari, Elahe Narouei, Ahmad Daryani, Shahabeddin Sarvi, Mahmood Moosazadeh, Hajar Ziaei Hezarjaribi, Mohammad Reza Narouei, Shirzad Gholami
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    Davood Anvari, Elahe Narouei, Mona Hosseini, Mohammad Reza Narouei, Ahmad Daryani, Seyyed Ali Shariatzadeh, Abdol Sattar Pagheh, Shirzad Gholami, Shahabeddin Sarvi, Dariush Sargazi, Reza Saberi, Seyed Abdollah Hosseini, Abolghasem Siyadatpanah
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Protective factors of marital stability in long-term marriage globally: a systematic review
Reza Karimi, Maryam Bakhtiyari, Abbas Masjedi Arani
Epidemiol Health. 2019;41:e2019023.   Published online June 15, 2019
DOI: https://doi.org/10.4178/epih.e2019023
  • 45,431 View
  • 719 Download
  • 25 Web of Science
  • 23 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
In recent decades, due to the high prevalence of divorce in numerous countries and the detrimental aftermath thereof, it has become increasingly important to study the components of marital stability. The current study explored fundamental protective factors in long-term marriage through a systematic review.
METHODS
Searches for relevant publications were conducted in Embase, Web of Science, PubMed, Scopus, Science Direct, Magiran, and Scientific Information Database from their inception through January 30, 2019. Through the keyword search, 1,706 articles were found, of which 25 articles remained after screening based on the eligibility criteria.
RESULTS
The extracted protective factors associated with marital stability in long-term marriage were classified as interpersonal and intrapersonal. Notable extracted factors included spirituality and religion, commitment, sexual relationship, communication, children, love and attachment, intimacy, and conflict resolution approach. These findings show that some aspects of relationships, such as commitment, act to preserve the pillars of marriage in critical situations, while other aspects, such as intimacy, help to construct marital identity and satisfaction.
CONCLUSIONS
The identified components of marital stability are structures that enhance a couple’s identity and sense of togetherness. Identifying the specific aspects of marital relationships that contribute to marital stability may help specialists and researchers to target specific types of marital interaction that may enhance the happiness and longevity of relationships, thereby preventing avoidable divorces.
Summary

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Congenital toxoplasmosis among Iranian neonates: a systematic review and meta-analysis
Shahabeddin Sarvi, Tooran Nayeri Chegeni, Mehdi Sharif, Mahbobeh Montazeri, Seyed Abdollah Hosseini, Afsaneh Amouei, Zahra Hosseininejad, Davood Anvari, Reza Saberi, Shaban Gohardehi, Ahmad Daryani
Epidemiol Health. 2019;41:e2019021.   Published online May 17, 2019
DOI: https://doi.org/10.4178/epih.e2019021
  • 15,436 View
  • 240 Download
  • 10 Web of Science
  • 9 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
Toxoplasmosis is a serious zoonotic disease that can lead to abortion and congenital disorders and has a widespread global distribution in humans and animals. The objective of this review was to investigate the incidence of toxoplasmosis in Iranian neonates in order to obtain a comprehensive assessment of the overall situation of the disease for use in developing future interventions. Original studies investigating the incidence of Toxoplasma gondii infections in Iranian neonates were systematically searched in a number of English-language and Persian-language electronic databases. The search process resulted in the inclusion of a total of 11 studies in the systematic review, 10 of which were entered into the meta-analysis. The reviewed articles included 2,230 Iranian neonates investigated through January 1, 2018. Based on the retrieved studies, the overall weighted incidence rates of toxoplasmosis in the Iranian neonatal population and neonates with suspected congenital toxoplasmosis were estimated to be 0.64% (95% confidence interval [CI], 0.31 to 1.09) and 4.10% (95% CI, 2.68 to 5.77), respectively, using a fixed-effects model. The findings of the reviewed studies demonstrate that the incidence of toxoplasmosis is high in Iranian neonates. Accordingly, it can be concluded that toxoplasmosis is a serious public health concern that has been ignored by the Ministry of Health. Therefore, it is essential to perform further studies, in addition to implementing screening and detection programs, using standardized methods to estimate the incidence of toxoplasmosis in Iran and to determine its associated risk factors.
Summary

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Impact of pharmacist-led home medicines review services on drug-related problems among the elderly population: a systematic review
Sai Krishna Gudi, Ananth Kashyap, Manik Chhabra, Muhammed Rashid, Komal Krishna Tiwari
Epidemiol Health. 2019;41:e2019020.   Published online May 17, 2019
DOI: https://doi.org/10.4178/epih.e2019020
  • 14,893 View
  • 344 Download
  • 25 Web of Science
  • 28 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
To address and elucidate the impact of pharmacist-led home medicines review (HMR) services on identifying drug-related problems (DRPs) among the elderly population in home care settings.
METHODS
A comprehensive systematic search was performed using electronic scientific databases such as PubMed, Scopus, Embase, and Web of Science for studies published between January 1, 2008 and December 31, 2018, pertaining to HMR services by pharmacists for identifying DRPs.
RESULTS
In total, 4,292 studies were retrieved from the searches, of which 24 were excluded as duplicates. Titles and abstracts were screened for the remaining 4,268 studies, of which 4,239 were excluded due to the extraneous nature of the titles and/or abstracts. Subsequently, 29 full-text articles were assessed, and 19 were removed for lacking the outcome of interest and/or not satisfying the study’s inclusion criteria. Finally, 10 studies were included in the review; however, publication bias was not assessed, which is a limitation of this study. In all studies, pharmacists identified a highly significant amount of DRPs through HMR services. The most common types of DRPs were potential drug-drug interactions, serious adverse drug reactions, need for an additional drug, inappropriate medication use, non-adherence, untreated indications, excessive doses, and usage of expired medications.
CONCLUSIONS
HMR is a novel extended role played by pharmacists. The efficiency of such programs in identifying and resolving DRPs could minimize patients’ health-related costs and burden, thereby enhancing the quality of life and well-being among the elderly.
Summary

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    Ahlam Sundus, Renukha Sellappans, Tan Maw Pin
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    Sha Zhang, Deqiu Zhu, Zhan Qi, Lulu Tian, Shijing Qian, Danfei Song, Beilei Chen, Shanshan Tong, Jing Wang, Juan Wu
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Review
Efficacy of miltefosine compared with glucantime for the treatment of cutaneous leishmaniasis: a systematic review and meta-analysis
Sohrab Iranpour, Ali Hosseinzadeh, Abbas Alipour
Epidemiol Health. 2019;41:e2019011.   Published online March 31, 2019
DOI: https://doi.org/10.4178/epih.e2019011
  • 13,591 View
  • 345 Download
  • 11 Web of Science
  • 11 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
Cutaneous leishmaniasis (CL) is most common form of leishmaniasis and is characterized by ulcerative skin lesions. The objective of this study was to conduct a systematic review and meta-analysis of clinical trials that compared the efficacy of miltefosine and glucantime for the treatment of CL. We searched the following databases: Cochrane, PubMed, Embase, Scopus, Web of Science, ProQuest, Cochrane Central Register of Controlled Trials, International Clinical Trials Registry Platform search portal of World Health Organization, Sid, Irandoc, Magiran, and clinicaltrials.gov. We used keywords including “miltefosine,” “glucantime,” and “Leishmania.” The quality of studies was assessed using the Cochrane risk of bias tool. A random-effects model was employed for the analysis. We assessed heterogeneity by the chi-square test and the I2 index statistic. When heterogeneity was present, meta-regression analyses were performed. The Egger method was used to assess publication bias; when it was significant, the trim-and-fill method was used to test and adjust for publication bias. A total of 1,570 reports were identified, of which 10 studies were included in the meta-analysis. In the meta-analysis, there was no significant difference between the efficacy of miltefosine and glucantime; however, subgroup analysis showed that, regarding parasite species other than Leishmania braziliensis, miltefosine was significantly superior to glucantime (intention to treat; relative risk, 1.15; 95% confidence interval, 1.01 to 1.32). In the meta-regression, only the glucantime injection type was significant at the p=0.1 level. The Egger test found statistically significant publication bias; however, including the 3 missing studies in the trim-and-fill analysis did not change the results. This meta-analysis found that miltefosine seems to be more effective than glucantime, at least in species other than L. braziliensis, for treating CL.
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    P.J. Barba, D. Morgado-Carrasco, A. Quera
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    P.J. Barba, D. Morgado-Carrasco, A. Quera
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    I. Abadías-Granado, A. Diago, P.A. Cerro, A.M. Palma-Ruiz, Y. Gilaberte
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    Ginés M. Esteban‐Parra, Inmaculada Moscoso, Javier Cepeda, Jose A. García, Manuel Sánchez‐Moreno, Antonio Rodríguez‐Diéguez, Miguel Quirós
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Reviews
Freshwater snails as the intermediate host of trematodes in Iran: a systematic review
Samira Dodangeh, Ahmad Daryani, Mehdi Sharif, Shirzad Gholami, Elham Kialashaki, Mahmood Moosazadeh, Shahabeddin Sarvi
Epidemiol Health. 2019;41:e2019001.   Published online January 7, 2019
DOI: https://doi.org/10.4178/epih.e2019001
  • 19,638 View
  • 426 Download
  • 18 Web of Science
  • 17 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
Freshwater snails, as the first intermediate hosts of trematodes, can cause health hazards in animals and humans. Recently, the World Health Organization has included Iran in a list of 6 countries known to have serious problems with fascioliasis. In addition, cercarial dermatitis is a job-related disease that is seen often in paddy workers, agricultural labourers, and fishermen in Iran, particularly in Mazandaran Province. Many studies have been conducted in Iran to survey larval trematodes in freshwater snails. However, to the best of our knowledge, no comprehensive data exist regarding infections in gastropods. Therefore, the aim of the present study was to estimate the types and prevalence of cercarial infections in snails in Iran. Electronic English-language and Persian-language databases were searched to identify 24 published articles reporting the prevalence of trematode infections in snails (9 species from 6 families) in various provinces of Iran. In total, 4.4% of gastropods were infected with the larval stages of trematodes. According to the studies reviewed in this meta-analysis‚ the highest infection prevalence was found in Radix auricularia (9.9%). Twelve larval species of trematodes were identified, and the highest prevalence of cercariae was found for Echinostomatidae cercariae (4.3%). Among the provinces explored, West Azerbaijan had the highest prevalence of infected snails (16.9%). The presence of trematodes in snails could pose a serious health problem in Iran. Thus, further studies are necessary to characterize these infections in other provinces.
Summary

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A systematic review and meta-analysis of the prevalence of toxoplasmosis in hemodialysis patients in Iran
Masoud Foroutan, Ali Rostami, Hamidreza Majidiani, Seyed Mohammad Riahi, Sasan Khazaei, Milad Badri, Elham Yousefi
Epidemiol Health. 2018;40:e2018016.   Published online April 23, 2018
DOI: https://doi.org/10.4178/epih.e2018016
  • 18,589 View
  • 347 Download
  • 35 Web of Science
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AbstractAbstract PDFSupplementary Material
Abstract
OBJECTIVES
Toxoplasmosis is a parasitic disease that occurs worldwide, with a wide range of complications in immunocompromised patients. This systematic review and meta-analysis was performed to evaluate the seroprevalence of Toxoplasma gondii among patients undergoing hemodialysis in Iran.
METHODS
We searched English and Persian databases for studies reporting T. gondii seroprevalence in Iranian hemodialysis patients through December 31, 2017. Inclusion and exclusion criteria were applied.
RESULTS
A total of 10 studies containing 1,865 participants (1,048 patients and 817 controls) met the eligibility criteria. Immunoglobulin G (IgG) antibodies against T. gondii were found in 58% (95% confidence interval [CI], 46 to 70) of hemodialysis patients and 40% (95% CI, 31 to 50) of healthy controls, while immunoglobulin M (IgM) antibodies were found in 2% (95% CI, 0 to 6) of hemodialysis patients and 0% (95% CI, 0 to 1) of healthy controls. The meta-analysis showed that hemodialysis patients were significantly more likely to be seropositive for IgG (odds ratio [OR], 2.04; 95% CI, 1.54 to 2.70; p<0.001) and IgM (OR, 2.53; 95% CI, 1.23 to 5.22; p<0.001) antibodies against T. gondii infection than healthy individuals.
CONCLUSIONS
The current study revealed a high prevalence of T. gondii infection in hemodialysis patients. Since hemodialysis patients are immunocompromised and T. gondii can cause serious clinical complications, we recommend that periodic screenings for T. gondii infection should be incorporated into the routine clinical care of these patients.
Summary

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Road dust and its effect on human health: a literature review
Raihan K. Khan, Mark A. Strand
Epidemiol Health. 2018;40:e2018013.   Published online April 10, 2018
DOI: https://doi.org/10.4178/epih.e2018013
  • 25,809 View
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AbstractAbstract PDF
Abstract
The purpose of this study was to determine the effects of road dust on human health. A PubMed search was used to extract references that included the words “road dust” and “health” or “fugitive dust” and “health” in the title or abstract. A total of 46 references were extracted and selected for review after the primary screening of 949 articles. The respiratory system was found to be the most affected system in the human body. Lead, platinum-group elements (platinum, rhodium, and bohrium), aluminum, zinc, vanadium, and polycyclic aromatic hydrocarbons were the components of road dust that were most frequently referenced in the articles reviewed. Road dust was found to have harmful effects on the human body, especially on the respiratory system. To determine the complex mechanism of action of various components of road dust on the human body and the results thereof, the authors recommend a further meta-analysis and extensive risk-assessment research into the health impacts of dust exposure.
Summary

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Registry-based stroke research in Taiwan: past and future
Cheng-Yang Hsieh, Darren Philbert Wu, Sheng-Feng Sung
Epidemiol Health. 2018;40:e2018004.   Published online February 4, 2018
DOI: https://doi.org/10.4178/epih.e2018004
  • 22,588 View
  • 377 Download
  • 18 Web of Science
  • 17 Crossref
AbstractAbstract PDF
Abstract
Stroke registries are observational databases focusing on the clinical information and outcomes of stroke patients. They play an important role in the cycle of quality improvement. Registry data are collected from real-world experiences of stroke care and are suitable for measuring quality of care. By exposing inadequacies in performance measures of stroke care, research from stroke registries has changed how we manage stroke patients in Taiwan. With the success of various quality improvement campaigns, mortality from stroke and recurrence of stroke have decreased in the past decade. After the implementation of a nationwide stroke registry, researchers have been creatively expanding how they use and collect registry data for research. Through the use of the nationwide stroke registry as a common data model, researchers from many hospitals have built their own stroke registries with extended data elements to meet the needs of research. In collaboration with information technology professionals, stroke registry systems have changed from web-based, manual submission systems to automated fill-in systems in some hospitals. Furthermore, record linkage between stroke registries and administrative claims databases or other existing databases has widened the utility of registry data in research. Using stroke registry data as the reference standard, researchers have validated several algorithms for ascertaining the diagnosis of stroke and its risk factors from claims data, and have also developed a claims-based index to estimate stroke severity. By making better use of registry data, we believe that we will provide better care to patients with stroke.
Summary

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  • Predicting ischemic stroke patients’ prognosis changes using machine learning in a nationwide stroke registry
    Ching-Heng Lin, Yi-An Chen, Jiann-Shing Jeng, Yu Sun, Cheng-Yu Wei, Po-Yen Yeh, Wei-Lun Chang, Yang C. Fann, Kai-Cheng Hsu, Jiunn-Tay Lee
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    Sung‐Chun Tang, Yi‐Chen Hsieh, Chun‐Jen Lin, Yu‐Wei Chen, Kuan‐Hung Lin, Pi‐Shan Sung, Meng‐Tsang Hsieh, Chih‐Wei Tang, Hai‐Jui Chu, Kun‐Chang Tsai, Chao‐Liang Chou, Cheng‐Yu Wei, Shang‐Yih Yen, Po‐Lin Chen, Hsu‐Ling Yeh, Lung Chan, Sheng‐Feng Sung, Hon‐M
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    Kay-Sin Tan, Byung-Woo Yoon, Ruey-Tay Lin, Man Mohan Mehndiratta, Nijasri C. Suwanwela, Narayanaswamy Venketasubramanian
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    Sheng-Feng Sung, Chien-Chou Su, Cheng-Yang Hsieh, Ching-Lan Cheng, Chih-Hung Chen, Huey-Juan Lin, Yu-Wei Chen, Yea-Huei Kao Yang
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    David Ung, Joosup Kim, Amanda G. Thrift, Dominique A. Cadilhac, Nadine E. Andrew, Vijaya Sundararajan, Moira K. Kapral, Mathew Reeves, Monique F. Kilkenny
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  • STAIR X
    David S. Liebeskind, Colin P. Derdeyn, Lawrence R. Wechsler, Greg Albers, Eric P. Ankerud, Johannes Boltze, Joseph Broderick, Bruce C.V. Campbell, Mitchell S.V. Elkind, Derick En’Wezoh, Anthony J. Furlan, Philip B. Gorelick, James Grotta, David Hess, Anee
    Stroke.2018; 49(9): 2241.     CrossRef
Rapid qualitative review of ethical issues surrounding healthcare for pregnant women or women of reproductive age in epidemic outbreaks
Patrik Hummel, Abha Saxena, Corinna Klingler
Epidemiol Health. 2018;40:e2018003.   Published online January 23, 2018
DOI: https://doi.org/10.4178/epih.e2018003
  • 16,466 View
  • 244 Download
  • 2 Web of Science
  • 1 Crossref
AbstractAbstract PDFSupplementary Material
Abstract
This article describes, categorizes, and discusses the results of a rapid literature review aiming to provide an overview of the ethical issues and corresponding solutions surrounding pregnancies in epidemic outbreaks. The review was commissioned by the World Health Organization to inform responses to the Zika outbreak that began in 2015. Due to the urgency of the response efforts that needed to be informed by the literature search, a rapid qualitative review of the literature published in PubMed was conducted. The search and analysis were based on the operationalization of 3 key concepts: ethics, pregnancy, and epidemic outbreak. Ethical issues and solutions were interpreted within a principlist framework. The data were analyzed using qualitative content analysis. The search identified 259 publications, of which the full text of 23 papers was read. Of those, 20 papers contained a substantive part devoted to the topic of interest and were therefore analyzed further. We clustered the ethical issues and solutions around 4 themes: uncertainty, harms, autonomy/liberty, and effectiveness. Recognition of the identified ethical issues and corresponding solutions can inform and improve response efforts, public health planning, policies, and decision-making, as well as the activities of medical staff and counselors who practice before, during, or after an epidemic outbreak that affects pregnant women or those of reproductive age. The rapid review format proved to be useful despite its limited data basis and expedited review process.
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  • How often is the placenta included in human pregnancy research? A rapid systematic review of the literature
    Leigh A. Taylor, Kelly Gallagher, Katherine A. Ott, Alison D. Gernand
    Gates Open Research.2021; 5: 38.     CrossRef

Epidemiol Health : Epidemiology and Health