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Epidemiol Health > Accepted Articles
Epidemiology and Health 2019;e2019024.
DOI: https://doi.org/10.4178/epih.e2019024    [Accepted] Published online June 15, 2019.
A systematic review and meta-analysis for genetic characterization of human echinococcosis in Iran, an endemic country
Abolghasem Siyadatpanah1,2  , Davood Anvari3,4  , Amir Emami Zeydi5  , Seyed Abdollah Hosseini3  , Ahmad Daryani6  , Shahabeddin Sarvi6  , Christine M Budke7  , Reza Esmaeelzadeh Dizaji8  , Mohammad Ali Mohaghegh9  , Mohammad Hasan Kohansal10  , Samira Dodangeh3  , Reza Saberi3  , Shirzad Gholami6 
1Ferdows Paramedical School, Birjand University of Medical Sciences, Birjand, Iran
2Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
3Student Research Committee, Department of Parasitology, Toxoplasmosis Research Center, Mazandaran University of Medical Science, Sari, Iran
4Department of Microbiology and Immunology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran
5Department of Medical-Surgical Nursing, Nasibeh School of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran
6Department of Parasitology, Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran
7Department of Veterinary Integrative Biosciences College of Veterinary Medicine & Biomedical Sciences Texas A&M University
8Department of Poultry Disease, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
9Department of Laboratory Sciences, Health Sciences Research Center, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
10School of Medicine, Bam University of Medical Sciences, Bam, Iran
Correspondence  Shirzad Gholami ,Tel: +981133543087 , Email: sgholami200@gmail.com
Received: April 30, 2019  Accepted after revision: June 15, 2019
Abstract
OBJECTIVES:
Human echinococcosis is an infectious disease caused by tapeworms belonging to the species Echinococcus. This parasite has a worldwide distribution and is considered a neglected tropical disease by the WHO. Due to the diversity of Echinococcus spp. hosts, but also to the contrasted geographical, climatic and socio-ethnic conditions, the question of the strains or genotypes of Echinococcus spp. that are involved in potential human infection is important. The aim of this study was to provide a summary of the available data on genotypes of Echinococcus obtained from the Iranian population.
METHODS:
Four international databases (PubMed, Scopus, Science Direct and Web of Science (ISI)) and four Persian databases (Magiran, Scientific Information Database, Iran Medex, and Iran Doc) were searched for cross-sectional studies that detected genotypes of Echinococcus spp in human echinococcosis cases by molecular method in Iran until July 2018. Also, the Newcastle-Ottawa Scale (NOS) was used to assess the quality assessment of selected studies.
RESULTS:
A total of 559 cases of human cystic echinococcosis were reported in the 22 included articles. The majority of cases belonged to genotype G1 (89.2%, 95% CI: 80.1–95.8), genotype G6 (8.2%, 95% CI: 2.8–15.9) and genotype G3 (2.3%, 95% CI: 1.1 – 3.9), respectively.
CONCLUSION:
Since genotype G1 of Echinococcus appears to be the most prevalent genotype affecting humans in Iran, disease control initiatives aimed at sheep intermediate hosts may be most beneficial. In addition, educational programs and serological screening in individuals, may help reduce the national impact of the disease.
Keywords: cystic echinococcosis; genotype; human; systematic review and meta-analysis; Iran


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