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Systematic review
Does antiretroviral therapy cause congenital malformations? A systematic review and meta-analysis
Fekadu Mazengia Alemu, Alemayehu Worku Yalew
Epidemiol Health. 2021;43:e2021008.   Published online February 3, 2021
DOI: https://doi.org/10.4178/epih.e2021008
  • 12,831 View
  • 372 Download
  • 2 Web of Science
  • 2 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
This meta-analysis investigated the risk of congenital anomalies among infants of human immunodeficiency virus-infected pregnant women who were exposed to antiretroviral therapy (ART).
METHODS
Cohort studies, case-control studies, randomized controlled trials, and controlled clinical trials were reviewed by searching MEDLINE/PubMed, Embase, Web of Science, Scopus, AIDSLINE, CINAHL, Cochrane Library, and Google/Google Scholar. Methodological quality was assessed using the GRADE evaluation. A DerSimonian and Laird random-effects model was used. Subgroup analyses and meta-regression were used to investigate heterogeneity.
RESULTS
The electronic searches yielded 765 items. After quality assessment and grading, 30 studies were suitable for metaanalysis. In total, 1,461 congenital anomalies were found among 53,186 births. Children born to women receiving combined antiretroviral therapy (cART) had an approximately 10% higher risk of developing congenital anomalies (relative risk [RR], 1.09; 95% confidence interval [CI], 1.04 to 1.14). A subgroup analysis found no significant difference in the risk of congenital anomalies between cART and efavirenz users. However, zidovudine and protease inhibitor (RR, 1.09; 95% CI, 1.00 to 1.19) users were found to have a 10% increased risk of congenital anomalies, and integrase inhibitor users had a 60% increase in risk (RR, 1.61; 95% CI, 1.60 to 2.43). The subgroup results should be interpreted cautiously because of the moderate heterogeneity (I2 =58%).
CONCLUSIONS
The use of protease inhibitors, integrase inhibitors, zidovudine, and newer drugs should be carefully considered in pregnant women. Further studies are needed to address environmental, nutrition, and adherence factors related to ART. Establishing a congenital anomalies surveillance system is recommended.
Summary
Key Message
New drugs are coming to the market and effective ART is available, yet toxicity issues and harmful outcomes during pregnancy, including major congenital anomalies, preterm delivery, anemia, and low birth weight, are of increasing concern among clinicians and program managers. In the development of either WHO or National ARV guidelines, clinical management of patients therefore, careful consideration should be taken in the inclusion of PI-based inhibitors, integrase inhibitors, Zidovudine, and newer drugs. Establishing a congenital anomalies surveillance system is recommended.

Citations

Citations to this article as recorded by  
  • Understanding clinical outcome measures reported in HIV pregnancy studies involving antiretroviral-naive and antiretroviral-experienced women
    Ahizechukwu C Eke, Rahel D Gebreyohannes, Anna M Powell
    The Lancet Infectious Diseases.2023; 23(4): e151.     CrossRef
  • Fifteen-minute consultation: How to approach the initial discussions of dysmorphism with parents
    Kate Frances Parmenter, Sharon English, Jennifer Campbell
    Archives of disease in childhood - Education & practice edition.2023; : edpract-2023-325658.     CrossRef
Original Articles
Epidemiological characteristics of HIV infected Korean: Korea HIV/AIDS Cohort Study
Yunsu Choi, Bo Youl Choi, Soo Min Kim, Sang Il Kim, June Kim, Jun Young Choi, Shin-Woo Kim, Joon Young Song, Youn Jeong Kim, Dae Won Park, Hyo Youl Kim, Hee-Jung Choi, Mee-Kyung Kee, Young Hyun Shin, Myeongsu Yoo
Epidemiol Health. 2019;41:e2019037.   Published online September 3, 2019
DOI: https://doi.org/10.4178/epih.e2019037
  • 14,954 View
  • 339 Download
  • 20 Web of Science
  • 18 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
To manage evidence-based diseases, it is important to identify the characteristics of patients in each country.
METHODS
The Korea HIV/AIDS Cohort Study seeks to identify the epidemiological characteristics of 1,442 Korean individuals with human immunodeficiency virus (HIV) infection (12% of Korean individuals with HIV infection in 2017) who visited 21 university hospitals nationwide. The descriptive statistics were presented using the Korea HIV/AIDS cohort data (2006-2016).
RESULTS
Men accounted for 93.3% of the total number of respondents, and approximately 55.8% of respondents reported having an acute infection symptom. According to the transmission route, infection caused by sexual contact accounted for 94.4%, of which 60.4% were caused by sexual contact with the same sex or both males and females. Participants repeatedly answered the survey to decrease depression and anxiety scores. Of the total participants, 89.1% received antiretroviral therapy (ART). In the initial ART, 95.3% of patients were treated based on the recommendation. The median CD4 T-cell count at the time of diagnosis was 229.5 and improved to 331 after the initial ART. Of the patients, 16.6% and 9.4% had tuberculosis and syphilis, respectively, and 26.7% had pneumocystis pneumonia. In the medical history, sexually transmitted infectious diseases showed the highest prevalence, followed by endocrine diseases. The main reasons for termination were loss to follow-up (29.9%) and withdrawal of consent (18.7%).
CONCLUSIONS
Early diagnosis and ART should be performed at an appropriate time to prevent the development of new infection.
Summary
Korean summary
국내 감염인은 대부분 성 접촉으로 인해 감염되었고, 감염인의 약 90%가 치료를 경험하였다. 하지만 여전히 결핵, 매독, 주폐포자충 폐렴 등과 같은 HIV 관련 질환의 유병률이 높았고, 치료를 통해 수명이 연장되어 노화 혹은 치료 약제 부작용과 관련된 HIV 비 관련 만성 질환의 유병률도 높았다. 향후 감염인의 HIV/AIDS 비 관련 질환에 대한 연구 및 사망 원인 등에 대한 후속 연구가 필요하겠다.

Citations

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  • Smoothed quantile residual life regression analysis with application to the Korea HIV/AIDS cohort study
    Soo Min Kim, Yunsu Choi, Sangwook Kang, Korea HIV/AIDS cohort study
    BMC Medical Research Methodology.2024;[Epub]     CrossRef
  • Distribution of Opportunistic Pathogens in People Living with HIV at a University Hospital in Istanbul over a One-Year Treatment Period and Its Association with CD4 T Cell Counts
    Hayriye Kirkoyun Uysal, Muammer Osman Koksal, Kutay Sarsar, Pinar Soguksu, Gonca Erkose Genc, Gizem Yapar, Evrim Ozdemir, Mustafa Onel, Sevim Mese, Mehmet Demirci, Zayre Erturan, Eray Yurtseven, Omer Haluk Eraksoy, Ali Agacfidan
    Pathogens.2023; 12(10): 1226.     CrossRef
  • Effect of characteristics on the clinical course at the initiation of treatment for human immunodeficiency virus infection using dimensionality reduction
    Yunsu Choi, Bo Youl Choi, Sang Il Kim, Jungsoon Choi, Jieun Kim, Bo Young Park, Soo Min Kim, Shin-Woo Kim, Jun Yong Choi, Joon Young Song, Youn Jeong Kim, Hyo Youl Kim, Jin-Soo Lee, Jung Ho Kim, Yoon Hee Jun, Myungsun Lee, Jaehyun Seong
    Scientific Reports.2023;[Epub]     CrossRef
  • Epidemiological Analysis of HIV/AIDS in Kazakhstan During 2018-2020
    Galiya Bilibayeva, Dinara Ospanova, Anarkhan Nurkerimova, Farida Kussainova, Marat Tukeev, Moldir Shokybaeva, Shynar Tanabayeva, Ildar Fakhradiyev, Timur Saliev
    Journal of Research in Health Sciences.2023; 23(2): e580.     CrossRef
  • COPD Risk Factor Profiles in General Population and Referred Patients: Potential Etiotypes
    Jang Ho Lee, Sehee Kim, Ye-Jee Kim, Sei Won Lee, Jae Seung Lee, Yeon-Mok Oh
    International Journal of Chronic Obstructive Pulmonary Disease.2023; Volume 18: 2509.     CrossRef
  • Nationwide population-based incidence of cancer among patients with HIV/AIDS in South Korea
    Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang, Hyunjin Son, Hyungi Lee, Jinmi Kim
    Scientific Reports.2022;[Epub]     CrossRef
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    Wonjeong Chae, Seung Yeon Kang, Sung-In Jang, Yoon Dae Han
    International Journal of Environmental Research and Public Health.2022; 19(12): 7467.     CrossRef
  • Cancer Incidence Among Adults With HIV in a Population-Based Cohort in Korea
    Boyoung Park, Kyoung Hwan Ahn, Yunsu Choi, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Jun Young Choi, Joon Young Song, Eunjung Lee, Yoon Hee Jun, Young Kyung Yoon, Won Suk Choi, Myungsun Lee, Jaehyun Seong, Shin-Woo Kim
    JAMA Network Open.2022; 5(8): e2224897.     CrossRef
  • Comparison of Three Cardiovascular Risk Scores among HIV-Infected Patients in Korea: The Korea HIV/AIDS Cohort Study
    Ji Yun Bae, Soo Min Kim, Yunsu Choi, Jun Yong Choi, Sang Il Kim, Shin-Woo Kim, Bo Young Park, Bo Youl Choi, Hee Jung Choi
    Infection & Chemotherapy.2022; 54(3): 409.     CrossRef
  • Spatiotemporal Clusters and Trends of Pneumocystis Pneumonia in Korea
    Hwa Sun Kim, Ho-Woo Nam, Hye-Jin Ahn, Sang Haak Lee, Yeong Hoon Kim
    The Korean Journal of Parasitology.2022; 60(5): 327.     CrossRef
  • A Korean Post-Marketing Surveillance Study of Dolutegravir Single-Agent Tablets in Patients with HIV-1
    Sungshin Kwon, Jung-Eun Cho, Eun-Bin Lee, Yeon-Sook Kim, Jang-Wook Sohn
    Infection & Chemotherapy.2022; 54(4): 711.     CrossRef
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    Rowena Johnston
    Current Opinion in HIV and AIDS.2021; 16(1): 54.     CrossRef
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    Sangmi Ryou, Myeongsu Yoo, Kisoon Kim, Sangsoo Kim, Sang Il Kim, Youn Jeong Kim, Dae Won Park, Jun Yong Choi, Hyo Youl Kim, Jung Ho Kim, Joon Young Song, Shin-Woo Kim, Hyun-Ha Chang, Bo Youl Choi, Mee-Kyung Kee
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    Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang, Jason T. Blackard
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    Yoon-Min Cho, BumSik Chin
    Infection & Chemotherapy.2021; 53(3): 477.     CrossRef
  • Prevalence of Multidrug-Resistant Tuberculosis in HIV/Tuberculosis Co-Infected Patients
    Chan Mi Lee, Eunyoung Lee, Ji Hwan Bang, Sang-Won Park, Wan Beom Park, Myoung-don Oh, Nam Joong Kim
    Infection & Chemotherapy.2021; 53(4): 792.     CrossRef
  • Trends of Cause of Death among Human Immunodeficiency Virus Patients and the Impact of Low CD4 Counts on Diagnosis to Death: a Retrospective Cohort Study
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Effect of antiretroviral therapy on changes in the fertility intentions of human immunodeficiency virus-positive women in Addis Ababa, Ethiopia: a prospective follow-up study
Hussen Mekonnen, Fikre Enquselassie
Epidemiol Health. 2017;39:e2017028.   Published online July 16, 2017
DOI: https://doi.org/10.4178/epih.e2017028
  • 12,007 View
  • 183 Download
  • 8 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
With access to antiretroviral therapy (ART), people living with human immunodeficiency virus (HIV) are able to consider childbearing to a greater extent than previously. In many cases, ART has transformed their intentions to have children. The present study aimed to assess changes in fertility intentions 12 months after ART initiation among HIV-positive women in Addis Ababa, Ethiopia.
METHODS
An institution-based follow-up study was conducted among 360 HIV-positive women in Addis Ababa. A logistic regression model was used to assess the influence of socio-demographic, reproductive health, and clinical characteristics on changes in the fertility intentions of women.
RESULTS
Overall, 40.8% (147 of 360) of the women reported that they desired to have a child in the future at the baseline visit, while 48.3% (174 of 360) did so at the 12-month follow-up. The proportion of women who reported that they desired to have a child 12 months after ART initiation was higher among ART-initiated women (55.8%, 106 of 190) than ART-naïve women (40.0%, 68 of 170). The adjusted analysis indicated that a change in fertility intentions between baseline and the follow-up visit was significantly associated with ART use (adjusted odds ratio [aOR], 2.47; 95% confidence interval [CI], 1.20 to 5.20) and marital status, with single (aOR, 5.33; 95% CI, 1.10 to 25.92) and married (aOR, 6.35; 95% CI, 1.44 to 27.99) women being more likely to report fertility intentions than divorced/widowed women.
CONCLUSIONS
ART use was a significant predictor of change in fertility intentions between the baseline and follow-up visit, which suggests that additional efforts are necessary to integrate family planning and HIV services to address the safe fertility goals of women in the study area.
Summary

Citations

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  • Factors associated with pregnancy uptake decisions among seropositive HIV people receiving antiretroviral therapy in sub‐Saharan Africa: A systematic review
    Abdul Razak Doat, Roberta Mensima Amoah, Kennedy Diema Konlan, Kennedy Dodam Konlan, Juliana Asibi Abdulai, Margaret W. Kukeba, Iddrisu Mohammed, Joel Afram Saah
    Nursing Open.2022; 9(5): 2239.     CrossRef
  • Factors Affecting Fertility Intention Among People Living with HIV in Kunming, China
    Yingwu Guo, Yingrong Du, Sanguan Lerkiatbundit, Jun Liu, Jingsong Bai, Yongrui Yang, Yin Yang, Aihui Wu, Virasakdi Chongsuvivatwong
    HIV/AIDS - Research and Palliative Care.2022; Volume 14: 265.     CrossRef
  • Prevalence and factors associated with fertility desire among people living with HIV: A systematic review and meta-analysis
    Xiang Yan, Jie Du, GuoPing Ji, Joseph K.B. Matovu
    PLOS ONE.2021; 16(3): e0248872.     CrossRef
  • Motivations to use hormonal contraceptive methods and condoms among HIV-positive and negative women randomized to a progestin contraceptive in Malawi: a qualitative study
    Agatha K. Bula, Kendra Hatfield-Timajchy, John Chapola, L. Chinula, Stacey A. Hurst, Athena P. Kourtis, J. H. Tang
    BMC Women's Health.2021;[Epub]     CrossRef
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    Fertility and Sterility.2021; 115(4): 860.     CrossRef
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    Penelope Chirambira, Sphiwe Madiba, Busisiwe Ntuli
    AIMS Public Health.2021; 9(1): 173.     CrossRef
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    Leigh F Johnson, Themba Mutemaringa, Alexa Heekes, Andrew Boulle
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    International Journal of Reproductive Medicine.2020; 2020: 1.     CrossRef

  • Risky Sexual Practice and Associated Factors Among Women Living with HIV/AIDS Receiving Antiretroviral Therapy at a PMTCT Clinic in Western Oromia, Ethiopia


    Bikila Balis
    HIV/AIDS - Research and Palliative Care.2020; Volume 12: 739.     CrossRef
  • Health workers’ knowledge of safer conception and attitudes toward reproductive rights of HIV-infected couples in Kano, Nigeria
    Zubairu Iliyasu, Hadiza S Galadanci, Ahmad A Zubairu, Taiwo G Amole, Nadia A Sam-Agudu, Muktar H Aliyu
    International Health.2019; 11(6): 536.     CrossRef
Survival and predictors of mortality among human immunodeficiency virus patients on anti-retroviral treatment at Jinka Hospital, South Omo, Ethiopia: a six years retrospective cohort study
Erdaw Tachbele, Gobena Ameni
Epidemiol Health. 2016;38:e2016049.   Published online November 6, 2016
DOI: https://doi.org/10.4178/epih.e2016049
  • 15,801 View
  • 366 Download
  • 23 Web of Science
  • 10 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
The survival rate of human immunodeficiency virus (HIV)-infected patients receiving treatment in Ethiopia is poorly understood. This study aimed to determine the survival rate and predictors of mortality among HIV-infected adults on antiretroviral therapy (ART) at Jinka Hospital, South Omo, Ethiopia.
METHODS
A 6-year retrospective cohort study was conducted using 350 patient records drawn from 1,899 patients on ART at Jinka Hospital from September 2010 to August 2015. The data were analyzed using Kaplan-Meier statistics and Cox regression models.
RESULTS
Of the 350 study participants, 315 (90.0%) were censored and 35 (10.0%) died. Twenty-two (62.9%) of the deaths occurred during the first year of treatment. The total follow-up encompassed 1,995 person-years, with an incidence rate of 1.75 deaths per 100 person-years. The mean survival time of patients on highly active antiretroviral therapy (HAART) was 30.84±19.57 months. The overall survival of patients on HAART was 64.00% (95% confidence interval [CI], 61.85 to 66.21%) at 72 months of follow-up. The significant predictors of mortality included non-disclosure of HIV status (adjusted hazard ratio [aHR], 5.82; 95% CI, 1.91 to 17.72), a history of tuberculosis (aHR, 1.82; 95% CI, 1.41 to 3.51), and ambulatory (aHR, 2.97; 95% CI, 1.20 to 8.86) or bedridden (aHR, 4.67; 95% CI, 1.30 to 17.27) functional status, World Health Organization (WHO) clinical stage IV illness (aHR, 24.97; 95% CI, 2.75 to 26.45), and substance abusers (aHR, 3.72; 95% CI, 1.39 to 9.97).
CONCLUSIONS
Patients with a history of tuberculosis treatment, ambulatory or bedridden functional status, or advanced WHO clinical stage disease, as well substance abusers, should be carefully monitored, particularly in the first few months after initiating antiretroviral therapy. Patients should also be encouraged to disclose their status to their relatives.
Summary

Citations

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  • Predictors of Survival Time Among HIV-Infected Adults After Initiating Anti-Retroviral Therapy in Kombolcha Town: A 5-Year Retrospective Cohort Study
    Muhammed Siraj, Sisay Gedamu, Belachew Tegegne
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    Balta Bargude, Fanta Amanuel
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    Achamyeleh Birhanu Teshale, Adino Tesfahun Tsegaye, Haileab Fekadu Wolde
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    Firew Tiruneh, Lalisa Chewaka, Dinaol Abdissa
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    Haddis Birhanu, Atsede Alle, Molla Yigzaw Birhanu
    HIV/AIDS - Research and Palliative Care.2021; Volume 13: 251.     CrossRef
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    Abdi Birhanu, Tariku Dingeta, Moti Tolera
    HIV/AIDS - Research and Palliative Care.2021; Volume 13: 727.     CrossRef
  • Epidemiology of survival pattern and its predictors among HIV positive patients on highly active antiretroviral therapy in Southern Ethiopia public health facilities: a retrospective cohort study
    Abewa Kebede, Fasil Tessema, Gadisa Bekele, Zerihun Kura, Hailu Merga
    AIDS Research and Therapy.2020;[Epub]     CrossRef
  • Prognostic Factors of Mortality among Adult Patients on Antiretroviral Therapy in India: A Hospital Based Retrospective Cohort Study
    Nitin Joseph, Ushasti Sinha, Nishtha Tiwari, Pritha Ghosh, Patneedi Sindhu
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    Eticha Endalkachew Mekonnen
    Journal of HIV for Clinical and Scientific Research.2018; : 007.     CrossRef
  • Prevalence and Risk Factors of Mortality among Adult HIV Patients Initiating ART in Rural Setting of HIV Care and Treatment Services in North Western Tanzania: A Retrospective Cohort Study
    Daniel Wilfred Gunda, Igembe Nkandala, Semvua Bukheti Kilonzo, Boniface Bartholomew Kilangi, Bonaventura Cornel Mpondo
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