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Original Articles
- Interaction between vitamin E intake and a COMT gene variant on colorectal cancer risk among Korean adults: a case-control study
- Shinyoung Jun, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
- Epidemiol Health. 2023;45:e2023100. Published online November 14, 2023
- DOI: https://doi.org/10.4178/epih.e2023100
- 1,892 View
- 103 Download
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AbstractOBJECTIVES
Previous human trials have not supported the anticarcinogenic effect of vitamin E despite biological plausibility and considerable epidemiological evidence. A possible explanation for this inconsistency is the interactive effect of the catechol-O-methyltransferase (COMT) gene and supplemental vitamin E on cancer. We examined whether a COMT gene variant modulates the effect of dietary vitamin E intake on colorectal cancer (CRC) risk.METHODSIn this case-control study of Korean adults (975 cases and 975 age- and sex-matched controls), dietary vitamin E density (mg/1,000 kcal) was measured using a semiquantitative food frequency questionnaire, COMT single nucleotide polymorphism (SNP) rs740603 (A>G) was genotyped, and CRC was verified histologically. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression models with adjustments for potential confounders.RESULTSHigher vitamin E density was associated with a lower risk of CRC (highest vs. lowest quartiles: OR, 0.72; 95% CI, 0.55 to 0.96; p-for-trend=0.002). When stratified by COMT SNP rs740603 genotype, the inverse association between vitamin E density and CRC risk was confined to those with at least 1 A allele (≥median vs. <median: OR, 0.63; 95% CI, 0.51 to 0.78). The interaction between rs740603 and vitamin E density was significant (p-for-interaction=0.020). No direct association was observed between COMT SNP rs740603 and CRC risk (OR, 1.08; 95% CI, 0.83 to 1.41).CONCLUSIONSOur findings support a role for a genetic polymorphism in COMT in modifying the association between dietary vitamin E intake and CRC. -
SummaryKorean summary
본 연구는 국립암센터에서 수집한 대장암 환자-대조군 자료를 활용하여, catechol-O-methyltransferase (COMT) 유전자의 단일염기다형성(SNP)에 따라 비타민 E 섭취와 대장암 위험 간의 연관성이 달라지는지 파악하고자 하였다. 분석 결과, COMT SNP rs740603의 유전자형에 따라 식이를 통한 비타민 E 섭취 밀도와 대장암 위험 간의 연관성이 다르게 나타나 COMT 유전자와 비타민 E 섭취 간의 상호작용이 대장암 발생 위험에 영향을 미칠 가능성이 있음을 제시하였다.Key Message
In this case-control study of Korean adults, we examined whether a polymorphism in the catechol-O-methyltransferase (COMT) gene modulates the effect of dietary vitamin E intake on colorectal cancer risk. Our results suggest that the inverse association between vitamin E density and colorectal cancer risk is confined to carriers of the COMT rs740603 A allele. The findings of our study support the interactive effect of the COMT gene and vitamin E intake on colorectal cancer risk.
- No Association Between Functional Polymorphisms in COMT and MTHFR and Schizophrenia Risk in Korean Population
- Ho Jin Kang, Byeong Moo Choe, Seong Hwan Kim, Seung-Rak Son, Kyoung-Mu Lee, Byoung Gwon Kim, Young-Seoub Hong
- Epidemiol Health. 2010;32:e2010011. Published online December 24, 2010
- DOI: https://doi.org/10.4178/epih/e2010011
- 18,376 View
- 130 Download
- 13 Crossref
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Abstract<sec><title>OBJECTIVES</title><p>Common genetic SNPs in two genes, encoding catechol-O-methyltransferase (COMT) and methylenetetrahydrofolate reductase (MTHFR), which are interconnected with COMT gene regulation, have been reported to contribute to schizophrenia risk. In this study, we evaluated the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk with a case-control study in a Korean population.</p></sec><sec><title>METHODS</title><p>We performed a case-control study by genotyping analysis using 360 cases and 348 controls in Korean subjects to determine the association between functional polymorphisms in COMT and MTHFR and schizophrenia risk.</p></sec><sec><title>RESULTS</title><p>Four functional SNPs in COMT (Val158Met and rs165599) and MTHFR (C677T and A1298C) were genotyped by primer extension assay. None of the genotype distributions for the four SNPs was significantly different between cases and controls. Stratified analysis did not show any significant gender difference for any polymorphism. In addition, we found no evidence of a gene-gene interaction in the analysis of combined genotypes.</p></sec><sec><title>CONCLUSION</title><p>Our results suggest no significant association between the selected functional polymorphisms of COMT or MTHFR in Korean schizophrenia subjects. However, further studies are required to confirm our findings in a larger number of subjects.</p></sec>
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Citations
Citations to this article as recorded by
- Molecular Mechanisms Provide a Landscape for Biomarker Selection for Schizophrenia and Schizoaffective Psychosis
Stephanie Fryar-Williams, Jörg Strobel, Peter Clements
International Journal of Molecular Sciences.2023; 24(20): 15296. CrossRef - Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis
Xinyao Meng, Ji-long Zheng, Mao-ling Sun, Hai-yun Lai, Bao-jie Wang, Jun Yao, Hongbo Wang, Zezhi Li
PLOS ONE.2022; 17(7): e0271170. CrossRef - Association between variants of MTHFR genes and psychiatric disorders: A meta-analysis
Yu-Xin Zhang, Lu-Ping Yang, Cong Gai, Cui-Cui Cheng, Zhen-yu Guo, Hong-Mei Sun, Die Hu
Frontiers in Psychiatry.2022;[Epub] CrossRef - MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia
Jia Hong Liu, Cheng Zhu, Ke Zheng, Wei Tang, Li Li Gao, Tammy H. Trihn, Hanjing Emily Wu, Da Chun Chen, Mei Hong Xiu, Xiang Yang Zhang
Scientific Reports.2020;[Epub] CrossRef - Effort-related decision making in humanized COMT mice: Effects of Val158Met polymorphisms and possible implications for negative symptoms in humans
Jen-Hau Yang, Rose E. Presby, Suzanne Cayer, Renee A. Rotolo, Peter A. Perrino, R. Holly Fitch, Merce Correa, Elissa J. Chesler, John D. Salamone
Pharmacology Biochemistry and Behavior.2020; 196: 172975. CrossRef - Association of functional polymorphisms in 3′-untranslated regions of COMT, DISC1, and DTNBP1 with schizophrenia
Zahra I. Mohamed, Shiau F. Tee, Pek Y. Tang
Psychiatric Genetics.2018; 28(6): 110. CrossRef - Role of MTHFR C677T gene polymorphism in the susceptibility of schizophrenia: An updated meta-analysis
Upendra Yadav, Pradeep Kumar, Sanjay Gupta, Vandana Rai
Asian Journal of Psychiatry.2016; 20: 41. CrossRef - The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects
Thelma Beatriz González-Castro, Yazmin Hernández-Díaz, Isela Esther Juárez-Rojop, María Lilia López-Narváez, Carlos Alfonso Tovilla-Zárate, Ana Fresan
NeuroMolecular Medicine.2016; 18(2): 216. CrossRef - Evaluation of an association between plasma total homocysteine and schizophrenia by a Mendelian randomization analysis
Shusuke Numata, Makoto Kinoshita, Atsushi Tajima, Akira Nishi, Issei Imoto, Tetsuro Ohmori
BMC Medical Genetics.2015;[Epub] CrossRef - Catechol-O-methyltransferase gene polymorphisms in Saudi cases with schizophrenia
Ashraf Tantawy, Abduhamid Al-Yahia, Yasser Raya, Abdurrahman Al-Mohaimeed, Ahmad Settin
Egyptian Journal of Psychiatry.2015; 36(3): 118. CrossRef - Association of MTHFR C677T polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients
Yanling Zhang, Hao Yan, Lin Tian, Fang Wang, Tianlan Lu, Lifang Wang, Jun Yan, Qi Liu, Lan Kang, Yanyan Ruan, Dai Zhang, Weihua Yue
Behavioural Brain Research.2013; 243: 146. CrossRef - Genetic Variation Throughout the Folate Metabolic Pathway Influences Negative Symptom Severity in Schizophrenia
J. L. Roffman, D. G. Brohawn, A. Z. Nitenson, E. A. Macklin, J. W. Smoller, D. C. Goff
Schizophrenia Bulletin.2013; 39(2): 330. CrossRef - No Association of Functional Polymorphisms in Methlylenetetrahydrofolate Reductase and the Risk and Minor Physical Anomalies of Schizophrenia in Korean Population
Su-Gyeong Kim, Joo Yun Song, Eun-Jeong Joo, Seong Hoon Jeong, Se Hyun Kim, Kyu Young Lee, Nam Young Lee, Yong Min Ahn, Yong Sik Kim, Myoung-Sun Roh
Journal of Korean Medical Science.2011; 26(10): 1356. CrossRef
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