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- Original Article A study on the genetic effect of cadmium on mouse
- Hai Won Chung, Jong Kyu Kim, Joung Soon Kim
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Epidemiol Health 1986;8(2):260-268
DOI: https://doi.org/
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Abstract
This study was carried out in order to evaluate the genetic effect of cadmium on mouse by measuring rates of chromosome aberration and sperm abnormality. The study was done to explore the possibility of utilizing the measurements as an indicator or for the degree of exposure to environmental toxic pollutants. The results of the study summarized are as follows: 1) The frequency of chromosome aberration was increased as the dose of cadmium was increased 2) The frequency of sperm with abnormal head shape also was increased as the dose of cadmium was increased and the frequency of sperm abnormalities was higher in the group autopsized after 4 weeks from the cadmium I.P. injection than the group after 6 weeks 3) The sperm head count in cauda epididymides was decreased as the dose of cadmium was increased. And the density of sperm after 4 weeks from cadmium injection was lower than that after 6 weeks. Different susceptibility in different age of mice to cadmium was not observed for all doses of cadmium except 1mg / kg administered group. The sperm density for the mice given 1mg / kg cadmium injection was lower in 10-week-old mice than that in 32-week old mice. 4) The weight loss of tests was observed as the doses of cadmium was increased 5) Seminiferous necrosis and calcification were observed in the mice to which 3mg / kg and 5mg / kg cadmium were administered. 6) Therefore it was considered that the measurement of chromosome aberration and sperm abnormalities could be useful indicator in measuring genetic effect of environmental toxic pollutants.
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