In the middle of March 2009, an increase in nonspecific ILI was observed by Mexico's Ministry of Health. Two H1N1 cases were reported in California by the United States Centers for Disease Control and Prevention (US CDC) in the middle of April 2009. By the end of the third week in April, it was confirmed that patients who had influenza or pneumonia symptoms were infected by the same H1N1 virus in Texas and Mexico [
12]. The World Health Organization (WHO) announced that this virus was a different type than the previous ones found in pigs and humans [
13]. According to this announcement, influenza A prevention systems were activated all over the world. In Korea, the containment (quarantine and isolation) level of the quarantine masure (border control) was taken to prevent the inflow of H1N1. During this period, fever tests and health questionnaire collection were performed by 13 National Quarantine Stations on every entrant from all countries. Beginning July 27, 2009, the range of travelers subject to quarantine was reduced to travelers from 11 high risk countries. After September 15, border measeure was converted gain to the level of raising public awareness about how to prevent H1N1. As confirmed H1N1 cases had been reported in most countries, and the number of patients had increased, the WHO no longer collected the number of confirmed patients beginning July 17, 2009 [
14]. However, local cities had reported daily data in accordance with government policy about mandatory reporting for suspected imported and community-acquired H1N1 patients beginning May 1 and continued to do so through August 19, 2009. Reviewing the daily trend of H1N1 cases in Korea, the first imported case was confirmed on May 2, 2009. On June 25, the first putative community-acquired case was reported. The gap between the official date, July 11, and the date reported by local cities and provinces of the first putative community-acquired case was about 2 weeks because the data from local cities and provinces was reported daily; however, the official data was reported after additional epidemiological investigation. The number of putative community-acquired H1N1 cases exceeded that of imported cases, and community-acquired H1N1 had spread all over the country since August. In China, which has the same seasonal conditions as Korea, the number of putative community-acquired H1N1 cases exceeded that of imported cases on July 28, 2009 [
15], with a trend similar to that of Korea. Meanwhile, in Japan, public health actions taken included the closing of schools and the delay of public assemblies because the epidemic had already spread, with 321 H1N1 patients reported by May 23, 2009 [
6]. Japan reduced its quarantine measure from the isolation level to the mitigation level on May 21 which was five days later after confirming the first community-acquired H1N1 case on May 16, 2009 [
16]. However, Korea and China maintained the isolation level by the end of July and July 10, respectively. The ratio of H1N1 cases per 100,000 people in Japan was three times higher, at 0.29 patients, than the ratio in Korea, with 0.09 patients at the end of May 2009. However, by August 9, 2009, the ratio of H1N1 cases per 100,000 people was lower in Japan (3.89 cases) than Korea (4.02 cases). It should be noted that unlike Japan's focus on treatment instead of diagnosis of H1N1 early in the epidemic, the use of active PCR tests could have increased the official H1N1 ratio in Korea. The next part of the investigation concerned the trend of 372 imported H1N1 patients who were confirmed by 13 National Quarantine Stations from the 22nd week, 2009, to the 53rd week. The average number of imported H1N1 cases per week identified by quarantine was 11.6 for those 32 weeks in 2009. The average number of weekly imported H1N1 cases during the period of the containment (quarantine and isolation) level was 15.6 for 9 weeks, and during the period of the mitigation level, it was 13 cases for 7 weeks. The average number for imported H1N1 cases per week during the period at the level of raising public awareness was 8.7 for 16 weeks. The decrease in the countries visited that triggered quarantine and the change of quarantine measure could have played a role in the decrease in the number of H1N1 cases per month. In other words, the total number of entrants coming from foreign countries had been subject to quarantine during the period with the containment (Quarantine and Isolation) level, but the number of subject to quarantine was reduced to only entrants from countries classified as high risk countries during the period at the mitigation level. In addition, during the period of the level of raising public awareness, a prompt visit to the doctor's office was recommended to those with symptoms rather than tests for entrants. In the assessment of the epidemiological characteristics of imported H1N1 cases, it was found that the distribution by sex was similar, 50.7% of the cases were male and 49.3% were female. The adults aged 20 to 59 years old comprised 61.5%, and the ones 60 years old and above comprised 0.8%. The US CDC reported that the cross-reaction antibody for H1N1 did not exist in children; however, among adults 18 to 64 years old, 6-9% had the antibody for H1N1, and 33% of those 65 years old and above had it [
17]. Of all of the H1N1 patients, 75.6% were younger than 30 years old. This is similar to the European data, in which the percentage of H1N1 patients younger than 30 years old was 80% [
18]. Among 367 patients, that is, all except 8 who did not report their nationality, 328 (89.4%)were Korean citizens and 31 (8.4%) were non-Koreans. Thus, the vast majority of the cases were from Korean travelers returning from overseas. Of the total cases, the groups including the primary, middle school, high school, undergraduate, and graduate students comprised 52.3% (
Table 1). Notably, during summer vacation, which was from the middle of July to the end of August, cases from these groups were 32% of the total cases. Travelers from foreign countries are the main carriers for pandemics [
4]. In addition, the ratio of student travelers is high. This implies that thorough control and the education of student travelers is necessary. When the data on countries visited are considered, it can be seen that 67.3% of the total cases were travelers from elsewhere in Asia. However, the highest ratio of H1N1 patients per 1,000 people by region was 0.199 in travelers from Oceania, followed by South America with 0.118, Southeast Asia with 0.071, North America with 0.049, Europe with 0.035, and Northeast Asia with 0.016, in that order. The areas which patients had visited were classified into three parts, which were the Northern Hemisphere, the Tropics, and the Southern Hemisphere, because the trends of seasonal epidemic influenza were different by the area [
19]. The number of cases from the Northern Hemisphere including China and Japan was 93 out of 372, from tropical regions including Hong Kong, Malaysia, the Philippine, Singapore, and Vietnam was 104, and from the Southern Hemisphere including Australia and New Zealand was 29. By these data, the comparisons of the ILI ratio for the Northern Hemisphere, the Tropics, and the Southern Hemisphere in the Western Pacific Region were performed [
20]. Comparing the graphs of these data, the monthly data for H1N1 were similar, and the order of peaking was the Southern Hemisphere, Tropics, and the Northern Hemisphere (
Figure 4). Reviewing the H1N1 data in the 30th weeks, which had the highest number of cases, there were 7 cases from the Philippines, 13 cases from Singapore, 5 cases from Vietnam, and no cases from Hong Kong or Malaysia. The comparison between seasonal influenza by region and the trends of the H1N1 outbreak is useful in developing effective control strategies for future pandemics [
21]. In case of the Southern Hemisphere, although there are geographical and demographical differences, the H1N1 pandemic showed highly consistent patterns in 2009 [
22]. This geographical and epidemiological information suggests countries that should be priorities for strict border control measure when new pandemics occur. In other words, this data would suggest effective selected and focused quarantine measure given limited manpower. This study has the limitation of uncertainty about the nature of the overlap of imported H1N1 cases between local citis data and 13 National Quarantine Stations data from May 24 to August 19, 2009. Thus, the number of imported H1N1 cases was expressed as a range with a minimum and maximum during that period. Nevertheless, this study is meaningful in that it provides the basic data for developing more effective quarantine measure because it is the initial attempt to analyze descriptive epidemiological characteristics of H1N1 cases imported to Korea who were confirmed by quarantine and daily report data from local cities for a certain period.