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Chromosome aberration and glutathio -S- transferase activitiy in peripheral lymphocytes of workers exposed to ethylene oxide.
Jin Sook Kim, Sung Eun Lee, Hai Won Chung
This study was undertaken to compare the frequency of chromosome aberrations and Glutathion -S- Transferase activity in peripheral lymphocytes between workers exposed to ethylene oxide and control group. Chromosome aberrations were analyzed in 200cells per sample after culture for 48-51hrs. The results obtained were as follows: 1. The overall frequencies of cells with chromosome aberration were 1.8% in the exposed group and 0.9% in the control group. And the overall level of GST activity was 8.39 I.U in the exposed group and 7.99 I.U in the control group. 2. In the control group, It was found that significant increase in chromosome aberrations was associated with increasing age, but GST activity was not correlated with age. 3. For the exposed group, significant increase in chromosome aberration was observed among the workers working under poor ventilation compared to those under good ventilation. The frequencies of cells with chromosome aberration were 1.3% among the workers under good ventilation, 2.0% under poor ventilation and 2.7% under no ventilation. GST activity was not, however, correlated with the types of ventilation of the working environment. From above results, it is suggested that the exposure to ethylene oxide increased the frequency of chromosome aberration and the level of GST activity, but there was no significant correlation between the frequency of chromosome aberration and level of GST activity.
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