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Korean Journal of Epidemiology 2000;22(1): 32-41.
The Effect of Vitamin Supplementation on Cognitive Function in the Elderly.
Sam Soon Lee, Byung Yeol Chun, Sang Soon Kim
1Department of Nursing, Koje College.
2Department of Preventive Medicine and Public Health,Kyungpook National University School of Medicine.
3Department of Nursing, Kyungpook National University Schoolof Medicine.
To estimate the effects of an oral vitamin supplementation on cognitive function in the elderly, 254 elderly people(experiment group) who were received an oral vitamin supplement for one-year was compared with 292 elderly who were treated as the control group in Koje city during the study period(from February 1997 to March 1998).
The cognitive function was tested by mini-mental state examination Korea(MMSE-K). Multiple regression analysis was done to control other confounding variables such as gender, age, educational level, smoking, alcohol, a past 15-day medical history, satisfaction for living cost, family number, cognitive function of the baseline survey.
In the baseline survey, the prevalence of cognitive impairment was 31%(mild impairment 12.5% and severe impairment 18.5%). There was a significant difference(0.76) in cognitive change in the elderly between two groups, 0.68 improved in the experiment group and 0.08 worsen in the control group(p<0.01). In multiple regression analysis, the significant variables were an oral vitamin supplementation, a past 15-day medical history, family number, cognitive function of baseline survey(p<0.05). The improvement of cognitive function was observed in those who do not have a past 15-day medical history, have a large family number, and have a low cognitive function of the baseline survey.
It appears that an oral vitamin supplementation was effective in improving the cognitive function in the elderly and more effective in the cases with abnormal cognitive function.
Keywords: Vitamin supplementation; Cognitive function; Elderly; Field trial
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