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- Original article Adherence to the American Cancer Society Guidelines on Nutrition and Physical Activity for Cancer Survivors and Biomarkers of Inflammation among Breast Cancer Survivors
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Minji Kang2
, Sihan Song3
, Hyun Jeong Cho4
, Zisun Kim6
, Hyun Jo Youn7
, Jihyoung Cho8
, Jun Won Min9
, Yoo Seok Kim10
, Sang-Woon Choi11
, Jung Eun Lee1
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Epidemiol Health 2024;e2024026
DOI: https://doi.org/10.4178/epih.e2024026 [Accepted]
Published online: January 25, 2024
2Department of Food and Nutrition, Duksung Women’s University, Seoul, Korea
3Department of Food and Nutrition, Seoul National University, Seoul, Korea
4Department of Food and Nutrition, Seoul National University, Seoul, Korea
5K-BIO KIURI Center, Seoul National University, Seoul, Korea
6Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea
7Department of Surgery, Jeonbuk National University Medical School, Jeonju, Korea
8Department of Surgery, Keimyung University School of Medicine, Daegu, Korea
9Department of Surgery, Dankook University College of Medicine, Cheonan, Korea
10Department of Surgery, Chosun University College of Medicine, Gwangju, Korea
11Chaum Life Center, CHA University, Seoul, Korea
12Department of Nutrition, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, United States
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Corresponding author:
Jung Eun Lee,
Email: jungelee@snu.ac.kr
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Abstract
OBJECTIVES
This study investigated whether adherence to the overall lifestyle recommendations in the American Cancer Society (ACS) guidelines on nutrition and physical activity for cancer survivors was associated with inflammation in breast cancer survivors.
METHODS
The study included 409 women who had undergone breast cancer surgery at least 1 year before enrollment. A generalized linear model was used to estimate the least square mean and 95% confidence interval of plasma levels of inflammatory markers according to lifestyle factors defined in terms of adherence to the ACS guidelines.
RESULTS
Higher overall adherence scores were associated with lower levels of high-sensitivity C-reactive protein (hs-CRP) (p for trend=0.0153) and higher levels of adiponectin (p for trend=0.0095). Similar significant associations of hs-CRP (p for trend=0.0040) and adiponectin (p for trend=0.0097) levels were observed with the score for the body mass index (BMI) component of the adherence score. A higher diet component score was associated with a higher adiponectin level (p for trend=0.0198), but there was no significant association for the physical activity component score.
CONCLUSIONS
The present study's findings suggest that maintaining a healthy lifestyle according to the ACS guidelines was associated with beneficial effects on inflammatory marker levels, especially hs-CRP and adiponectin, among breast cancer survivors. Among the 3 components of lifestyle guidelines, the BMI component exhibited the most similar tendency to the overall adherence score in relation to inflammatory indicators. Further prospective and intervention studies are needed to investigate longitudinal associations between lifestyle factors and inflammatory markers among breast cancer survivors.
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