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Epidemiol Health > Volume 43; 2021 > Article
Epidemiology and Health 2021;43: e2021051-0.
DOI: https://doi.org/10.4178/epih.e2021051    Published online Aug 3, 2021.
Hydrogen peroxide as an auxiliary treatment for COVID-19 in Brazil: a randomized double-blind clinical trial
Marielle Bazzo Di Domênico  , Kauê Collares  , Renan Brandenburg dos Santos  , Ulysses Lenz  , Vinícius Picoli Antunes  , Vinicius Webber Godinho  , Henrique Cesca  , Thales Henrique Jincziwski Ponciano  , Pedro Henrique Corazza 
Graduate Program in Dentistry, Dental School, University of Passo Fundo, Passo Fundo, Brazil
Correspondence  Pedro Henrique Corazza ,Email: pedrocorazza@upf.br
Received: Jun 7, 2021  Accepted after revision: Aug 3, 2021
This study evaluated the effectiveness of hydrogen peroxide (H2O2) as mouthwash and nasal spray on symptom relief in coronavirus disease 2019 (COVID-19) patients.
Patients positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), who were treated in a hospital or at home, and patients’ family members (not positive for SARS-CoV-2), were randomized into 2 groups: experimental (1% H2O2 for gargling, 0.5% H2O2 for nasal wash), and control. Patients gargled the solution 3 times a day, and applied the nasal spray twice a day, for a 7-day period. Family members received the same treatment as the treated COVID-19 patient. The researchers contacted patients every 2 days over an 8-day period. An average post-treatment interval of 8 days passed before testing family members.
The most frequent symptoms on day 0 were cough, loss of taste, and hyposmia; there were no significant differences between groups, independent of the period. The symptom of dyspnea presented a significant difference between days 2 and 4 (p<0.05). Among family members, 86.0% had no antibodies, 2.3% had antibodies, and 11.6% had active infections (4 in the experimental group and 6 in the control group). The most frequent adverse effects in the H2O2 group were a burning throat and nose.
H2O2 was not effective for the relief of COVID-19 symptoms and was associated with reports of transient adverse effects.
Keywords: Hydrogen peroxide, COVID-19, SARS-CoV-2, Brazil


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