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1 "sensitivity;specificity;Pap;liquid-based cytology;human papillomavirus;meta-analysis"
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Original Article
Diagnostic accuracy of conventional Pap test, liquid-based cytology and human papillomavirus DNA testing in cervical cancer screening in Korea: a meta-analysis.
Jin Kyoung Oh, Hai Rim Shin, Gyungyub Gong, Jin Hee Sohn, Shin Kwang Khang
Korean J Epidemiol. 2008;30(2):178-187.   Published online December 31, 2008
DOI: https://doi.org/10.4178/kje.2008.30.2.178
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AbstractAbstract PDF
Abstract
Objective: The aim of this study was to compare the diagnostic accuracy of the Pap test, liquid-based cytology (LBC), and human papillomavirus (HPV) testing used as screening methods for the early detection of cervical cancer in Korea. Materials and Methods: Articles reporting the sensitivity and specificity of each screening method that were published between 1995 and March 2008 were retrieved from MEDLINE and KoreaMed. A meta-analysis was conducted to calculate pooled estimates for the sensitivity and specificity of each method. Only cases with histological confirmation were included, and cervical cancer was defined as samples exhibiting cervical intraepithelial neoplasia 2 or worse. In cytological tests, findings of atypical squamous cells of undetermined significance or worse were considered positive.
Results
Of the 24 studies, 15 studies of the Pap test, 3 studies of LBC, and 4 studies of HPV met the inclusion criteria and were included in the meta-analysis. The meta-analysis showed that the sensitivity was highest for LBC (92%), followed by HPV testing (83%) and the Pap test (76%), and the specificity of LBC was the highest (79%), followed by the Pap test (76%) and HPV testing (59%). However, except for the sensitivity of LBC (heterogeneity p-value = 0.682), significant heterogeneity was found among the results of the studies (heterogeneity p-value < 0.0001).
Discussion
Due to the significant heterogeneity among the studies, the results of this meta-analysis are limited in representing the accuracy of each test method. The accuracy and cost-effectiveness of cervical cancer screening methods should be further evaluated.
Summary

Citations

Citations to this article as recorded by  
  • A prospective pilot evaluation of vaginal and urine self-sampling for the Roche cobas 4800 HPV test for cervical cancer screening
    Sang-Hyun Hwang, Hye Young Shin, Dong Ock Lee, Na Young Sung, Bomyee Lee, Do-Hoon Lee, Jae Kwan Jun
    Scientific Reports.2018;[Epub]     CrossRef
  • Comparison of Unsatisfactory Samples from Conventional Smear versus Liquid-Based Cytology in Uterine Cervical Cancer Screening Test
    Hoiseon Jeong, Sung Ran Hong, Seoung-Wan Chae, So-Young Jin, Hye Kyoung Yoon, Juhie Lee, Eun Kyung Kim, Sook Tai Ha, Sung Nam Kim, Eun-Jung Park, Jong Jae Jung, Sun Hee Sung, Sung-chul Lim
    Journal of Pathology and Translational Medicine.2017; 51(3): 314.     CrossRef
  • The performance of multimodal hyperspectral spectroscopy in the detection of precancerous cervical lesions
    Trahmono, N Lusiana, J Indarti
    Journal of Physics: Conference Series.2017; 884: 012152.     CrossRef
  • Usefulness of anti‐phosphohistone H3 immunoreactivity to determine mitotic rate in gastrointestinal stromal tumors
    Ahrong Kim, Dong Han Im, Kyungbin Kim, Jee Yeon Kim, Mee Young Sol, Jeong Hee Lee, Kyung Un Choi
    Basic and Applied Pathology.2012; 5(4): 91.     CrossRef
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