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Data Profile
Data profile: cancer sample cohorts (stomach, breast, colorectal, and liver) in Korea
Daewoo Pak, Suk Yong Jang, Jin-Ha Yoon, Dong Wook Kim, Jin-Won Noh, Dong-Woo Choi, Minyeong Guk, Hyeri Kim, Ju-Won Oh, Heejung Chae, Hyun-Joo Kong, Gi Hyun Kim, Ji Woong Nam, Ga Ram Lee, Dayun Park, Jehoo Jeon, Byungyoon Yun, Ki-Bong Yoo, Kui Son Choi
Epidemiol Health. 2025;47:e2025058.   Published online October 14, 2025
DOI: https://doi.org/10.4178/epih.e2025058
  • 2,611 View
  • 94 Download
AbstractAbstract AbstractSummary PDF
Abstract
Cancer Public Library Database (CPLD) links data from four major population-based public sources: the Korea National Cancer Incidence Database in the Korea Central Cancer Registry, cause-of-death data in Statistics Korea, the National Health Information Database in the National Health Insurance Service, and the National Health Insurance Research Database in the Health Insurance Review & Assessment Service. The National Cancer Data Center has developed a new nationally representative sample cohort dataset from Korean Clinical Data Utilization for Research Excellence project (K-CURE) CPLD: Stomach Cancer Sample Cohort, Breast Cancer Sample Cohort, Colorectal Cancer Sample Cohort, and Liver Cancer Sample Cohort. The sample populations consisted of approximately 21% of all cancer patients from 2012 to 2019. The populations of the Stomach Cancer Sample Cohort, Breast Cancer Sample Cohort, Colorectal Cancer Sample Cohort, and Liver Cancer Sample Cohort were 51,951, 39,586, 53,485, and 27,375 patients, respectively. The dataset included cancer incidence information, demographics, socioeconomic variables, health utilization data (procedures, diagnoses, and medications), general health checkup data, cancer screening data before and after the cancer incidence, as well as death information. These cohorts could help researchers analyze time-to-event data on mortality, treatment outcomes, comorbid conditions following a cancer diagnosis, and cancer incidence risk factors. The data can be accessed through the K-CURE portal (https://k-cure.mohw.go.kr/).
Summary
Korean summary
국립암센터의 국가암데이터센터는 K-CURE 사업의 일환으로 암·공공라이브러리를 구축하고 위암, 유방암, 대장암, 간암 표본을 공개하였다. 암·공공라이브러리는 국립암센터의 암등록자료를 기준으로 건강보험심사평가원 명세서, 국민건강보험공단 자격 및 검진자료, 통계청 사망자료를 결합하여 구축한 것으로 사용하기 쉽게 암종별 표본을 공개하고 있다. 암등록자료는 발생일자, 요약병기, ICD-O-3 코드를 포함해 기존 청구자료보다 정확한 암 예후 등의 연구가 원격으로 가능하다. 이용자는 희망시 맞춤형 자료로도 신청 가능하다. 사용 신청은 https://k-cure.mohw.go.kr/ 에서 가능하다.
Key Message
The National Cancer Data Center (NCDC) of the National Cancer Center(NCC) developed the Cancer Public Library Database (CPLD) under the Korean Clinical Data Utilization for Research Excellence project (K-CURE). CPLD is constructed by linking the NCC’s cancer registry data with claims data from the Health Insurance Review and Assessment Service, eligibility and health screening data from the National Health Insurance Service, and Cause-of-death data from Statistics Korea. The NCDC has opened sample cohorts for stomach, breast, colorectal, and liver cancers to promote cancer research with a remotely accessible environment. The data can be accessed through the K-CURE portal (https://k-cure.mohw.go.kr/).
Original Articles
The delayed cancer treatment and economic inequality in Korea: results of common cancers by the time-to-surgery
Noorhee Son, Woo-Ri Lee, Dong-Woo Choi, Kyu-Tae Han
Epidemiol Health. 2025;47:e2025056.   Published online September 27, 2025
DOI: https://doi.org/10.4178/epih.e2025056
  • 2,938 View
  • 97 Download
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Growing concerns regarding the concentration of cancer treatment in the capital city in Korea have raised questions about equitable access to timely and optimal patient care. In this study, we evaluated the impact of time-to-surgery (TTS) on healthcare utilization and outcomes, with the goal of providing policy recommendations for effective quality assessment of cancer care.
METHODS
This retrospective cohort study analyzed data from 2011 to 2021 obtained from National Health Insurance Service claims. A generalized estimating equation and a Cox proportional hazards model were applied to assess the effects of TTS on length of stay (LOS), medical costs, and 5-year mortality among patients diagnosed with lung, liver, and colorectal cancers. Subgroup analyses were conducted based on patients’ baseline economic status.
RESULTS
Among patients who underwent surgical treatment for lung, liver, or colorectal cancer, 20.4%, 11.4%, and 11.4% experienced treatment delays, respectively. Regardless of cancer type, longer TTS was associated with prolonged LOS and higher medical costs. Moreover, patients with extended TTS demonstrated an increased risk of 5-year mortality. Disparities by income level were evident, with greater differences observed in the lower-income group.
CONCLUSIONS
This study highlights the importance of timely surgical treatment for patients with cancer, particularly in relation to income-based disparities. These findings emphasize the need to improve Korea’s concentrated cancer care delivery system to enhance healthcare efficiency and address health literacy gaps affecting treatment by income level.
Summary
Korean summary
- 수술 환자의 약 10%~20%에서 치료 지연이 발생했다. - 수술까지 대기시간이 길수록 재원일수가 늘고, 의료비용이 증가하며, 5년 사망위험이 높았다. - 소득수준에 따른 격차가 확인되었고, 저소득층에서 불리한 영향이 더 크게 나타났다.
Key Message
- Among surgical patients, approximately 10–20% experienced treatment delays. - Longer time-to-surgery (TTS) was linked to prolonged length of stay (LOS), higher medical costs, and an increased 5-year mortality risk. - Income-level disparities were evident, with more pronounced adverse differences in lower-income groups.
A comprehensive study of deaths due to exposure to humidifier disinfectant in Korea: focusing on medical records, assessment of exposure to humidifier disinfectants, and causes of death
Yeong Jun Ju, Seungho Lee, Seungsoo Sheen, Dong-Woo Choi, Jong-Han Leem, Soon Young Lee
Epidemiol Health. 2021;43:e2021091.   Published online November 1, 2021
DOI: https://doi.org/10.4178/epih.e2021091
  • 22,489 View
  • 321 Download
  • 9 Web of Science
  • 12 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
We aimed to determine the characteristics of the deceased victims of deaths caused by exposure to humidifier disinfectants, and present the distribution of the victims’ data submitted for damage application, demographic characteristics, imaging findings, characteristics of humidifier disinfectant exposure, and distribution of the causes of death.
METHODS
An integrated database of victims was established using the medical records data of 1,413 victims submitted during the application for death damage caused by exposure to humidifier disinfectants, and the demographic characteristics, medical records, imaging findings, exposure characteristics, and cause of death were examined.
RESULTS
The average numbers of data submissions of each applicant for death damage were 3.0 medical use records. A total of 608 (43.0%) victims had more than one finding of acute, subacute, or chronic interstitial lung diseases. The average daily and cumulative use times of the victims were 14.40 and 24,645.81 hours, respectively, indicating greater exposure in this group than in the survivors. The humidifier disinfectants’ components comprised polyhexamethylene guanidine (72.8%), chloromethylisothiazolinone/methylisothiazolinone (10.5%), other components (15.0%), and oligo-[2-(2-ethoxy)-ethoxyethyl] guanidine chloride (1.5%). The components’ distribution was 67.8% for single-component use, which was higher than that in the survivors (59.8%). The distribution of the causes of death were: respiratory diseases (54.4%), neoplasms (16.8%), and circulatory diseases (6.3%). Other interstitial lung diseases (65.5%) were the most common cause of death among those who died due to respiratory diseases.
CONCLUSIONS
Careful discussions of appropriate remedies should be conducted based on a comprehensive understanding of the characteristics of the deceased victims, considering their specificities and limitations.
Summary
Korean summary
가습기 살균제 사망 피해 신청자 들 중 건강피해를 인정받지 못한 신청자들이 여전히 많이 남아있으며 (약 40%), 피해판정의 복잡성과 다양한 이슈들이 산적해 있어 사망 피해 신청자들의 적정 구제를 위해 종합적인 특성파악을 바탕으로 세심한 관점에서의 검토가 필요하다. 특히, 가습기 살균제 사망 피해 신청자의 특수성과 피해구제의 제한점을 고려하여야 하며, 기계적인 건강피해 판정을 지양하고 사망 피해 신청자 중심의 세밀한 특성 파악을 바탕으로 다양한 전문가집단이 참여하는 종합적인 논의를 통해 적정구제를 이루어 나가야 함을 제안한다.
Key Message
Careful discussions of appropriate remedies should be conducted based on a comprehensive understanding of the characteristics of the deceased victims, considering their specificities and limitations.

Citations

Citations to this article as recorded by  
  • Association of respiratory diseases with humidifier disinfectants exposure and its latency: A study of health damage reporter cohort in South Korea
    Jaiyong Kim, Kyoung Sook Jeong, Seungyeon Heo, Youngmee Lee, Taksoo Kim, Hye-Jin Kim, Suejin Kim, Hae-Kwan Cheong, Mina Ha
    Ecotoxicology and Environmental Safety.2026; 309: 119552.     CrossRef
  • Humidifier disinfectant exposure and lung cancer development: A propensity score matching analysis
    Su Hwan Kim, Sungchan Kang, Sanghee Shin, Jeong-In Hwang, Hyungryul Lim, Dong-Wook Lee, Woojoo Lee, Kang Hee Ha, Youngmee Lee, Taksoo Kim, Hye-Jin Kim, Kyoung-Nam Kim
    Cancer Epidemiology.2026; 100: 102982.     CrossRef
  • Effects of chloromethylisothiazolinone/methylisothiazolinone on cytotoxicity and mitochondrial dysfunction in bronchial epithelial cells
    Eunah Lee, Haeun Lee, Yong Joo Park, Kyu Hyuck Chung, Hyung Sik Kim
    Chemosphere.2026; 395: 144831.     CrossRef
  • Chronic fatigue syndrome induced by environmental toxic exposure: Effects of polyhexamethyleneguanidine phosphate exposure on mitochondrial function and neural health
    Hyo-Seon Yang, Jin-Seok Lee, Mi-hyun Kang, Mi-kyung Song, Ji-Yun Kang, Hyung Doo Kim, Hwan-Cheol Kim, Jong-Han Leem, Chang-Gue Son, Kyuhong Lee
    Environmental Research.2026; 295: 123874.     CrossRef
  • Polyhexamethylene guanidine-phosphate enhances pro-coagulant activity of human erythrocytes and venous thrombosis in rats through phosphatidylserine externalization
    Sungbin Choi, Eun-Hye Kim, Donghyun Kim, Han Jin Park, Junkyung Gil, Yiying Bian, Ok-Nam Bae
    Journal of Hazardous Materials.2025; 492: 138303.     CrossRef
  • A Review of Domestic and International Health Monitoring Questionnaires for Physical and Mental Health after Social Disasters: Implications for the Humidifier Disinfectant Case Survey in Korea
    Eun Seong Song, Boluwatife Olamide Dareowolabi, Tak-soo Kim, Seung Chul Ahn, Seungho Lee, Young-Seoub Hong, Jin Hee Kim
    Journal of Environmental Health Sciences.2025; 51(6): 395.     CrossRef
  • Polyhexamethylene Guanidine Phosphate Enhanced Procoagulant Activity through Oxidative-Stress-Mediated Phosphatidylserine Exposure in Platelets
    Ju Hee Choi, Keunyoung Kim
    Toxics.2024; 12(1): 50.     CrossRef
  • Next generation risk assessment of biocides (PHMG-p and CMIT/MIT)-induced pulmonary fibrosis using adverse outcome pathway-based transcriptome analysis
    Jun Woo Kim, Hyung Sik Kim, Ha Ryong Kim, Kyu Hyuck Chung
    Journal of Hazardous Materials.2024; 476: 134986.     CrossRef
  • Metabolite analysis of 14C-labeled chloromethylisothiazolinone/methylisothiazolinone for toxicological consideration of inhaled isothiazolinone biocides in lungs
    Jung Eun Park, Seung-Hun Ryu, Satoshi Ito, Hyunil Shin, Young-Hee Kim, Jongho Jeon
    Chemosphere.2024; 362: 142666.     CrossRef
  • Toxicity and Safety Analysis of Polyhexamethylene Guanidine: A Comprehensive Systematic Review
    Ivan Ivanov, Daria Kirillova, Kenes Erimbetov, Denis Shatalov
    Sciences of Pharmacy.2024; 3(3): 153.     CrossRef
  • Gene expression related to lung cancer altered by PHMG-p treatment in PBTE cells
    Yoon Hee Park, Sang Hoon Jeong, Hyejin Lee, Cherry Kim, Yoon Jeong Nam, Ja Young Kang, Jin Young Choi, Yu-Seon Lee, Su A. Park, Jaeyoung Kim, Eun-Kee Park, Yong-Wook Baek, Hong Lee, Ju-Han Lee
    Molecular & Cellular Toxicology.2023; 19(1): 205.     CrossRef
  • Health Effects Associated With Humidifier Disinfectant Use: A Systematic Review for Exploration
    Ji-Hun Song, Joonho Ahn, Min Young Park, Jaeyoung Park, Yu Min Lee, Jun-Pyo Myong, Jung-Wan Koo, Jongin Lee
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
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