Association between cardiac arrhythmia before pregnancy and gestational diabetes: a nationwide population-based study in Korea

Given the higher prevalence of cardiac arrhythmias in individuals with diabetes, we investigated the relationship between cardiac arrhythmias and the incidence of gestational diabetes (GDM). This retrospective cohort study utilized data from the Korean Health Insurance Service database, encompassing 1,113,729 women who gave birth between January 2007 and December 2015. After excluding those who did not undergo National Health Screening tests within 1 year prior to pregnancy, those with multifetal pregnancies, and those diagnosed with diabetes, we analyzed 365,880 singleton pregnancies without a history of diabetes. Of these, 3,253 (0.9%) had cardiac arrhythmias, including premature extra beats, supraventricular tachyarrhythmias, and/or atrial flutter/fibrillation. GDM occurred in 31,938 (8.7%) subjects during pregnancy, and was more prevalent in women with cardiac arrhythmia than in those without (14.9 vs. 8.7%, p<0.001). In the multivariate analysis, the association between cardiac arrhythmia and GDM remained statistically significant (adjusted odds ratio, 1.78; 95% confidence interval, 1.61 to 1.97; p<0.001). Subgroup analysis revealed that the risk of GDM was consistently statistically significant in subjects with cardiac arrhythmia, regardless of age, body mass index, and the presence or absence of chronic hypertension. Therefore, cardiac arrhythmias before and during pregnancy appear to be associated with an increased risk of developing GDM.

Objective: We aimed to investigate the relationship between cardiac arrhythmias and the incidence of gestational diabetes (GDM).

Design and method:
This retrospective cohort study utilized data from the Korean Health Insurance Service database, encompassing 1,113,729 women who gave birth between January 2007 and December 2015.We excluded subjects who had not undergone the national health screening test within 1 year before pregnancy (n=723,575), those with multifetal pregnancies (n=17,683), and individuals diagnosed with diabetes (ICD-10 codes E08, E09, E10, E11, and E13) and/or those with a fasting blood glucose level of 126 mg/dL or higher at the health screening test conducted within 1 year before pregnancy (n=6,591).Arrhythmias were classified into 5 categories: lethal arrhythmias, premature beats, paroxysmal tachycardia, atrial flutter/fibrillation, and atrioventricular block.The primary outcome was incident GDM, which was defined as having at least 1 claim with ICD-10 codes of O244 or O249 and the use of insulin during pregnancy, or having at least 3 claims with ICD-10 codes of O244 or O294.

Results:
We analyzed 365,880 singleton pregnancies without a history of diabetes.Of these, 3,253 (0.9%) had cardiac arrhythmias, including premature extra beats, supraventricular tachyarrhythmias, and/or atrial flutter/fibrillation. GDM occurred in 31,938 (8.7%) subjects during pregnancy and was more prevalent in women with cardiac arrhythmia than in those without (14.9 vs. 8.7%, p<0.001).In the multivariate analysis, the association between cardiac arrhythmia and GDM remained statistically significant (adjusted odds ratio, 1.78; 95% confidence interval, 1.61 to 1.97; p<0.001).Subgroup analysis revealed that the risk of GDM was consistently statistically significant in subjects with cardiac arrhythmia, regardless of age, body mass index, and the presence or absence of chronic hypertension.
Conclusions: Cardiac arrhythmias before and during pregnancy appear to be associated with an increased risk of developing GDM.

PERINATAL AND POSTNATAL COMPLICATIONS OF CHILDREN OF MOTHERS WITH HYPERGLYCEMIA DURING PREGNANCY. SYSTEMATIC REVIEW 2022
Eulalia Amador Rodero 1 , Leslie Montealegre 1 , Laura Ardila 1 , Roberto Rebolledo 1 , Martha Arteta 1 , Areli Barba 2 , Tania Sanchez 3 , Luis Montaño 4 . 1 Universidad Libre de Colombia, Barranquilla, COLOMBIA, 2 Benemerita Universidad Autonoma de Puebla, Puebla, MEXICO, 3 Centro de estudios Universitarios Vizcaya de las Américas, Uruapan, MEXICO, 4 Universidad de Guadalajara, Guadalajara, MEXICO Objective: To identify, through a systematic review, the prevalence and/or risk of peri-and postnatal complications in children of mothers with gestational diabetes mellitus Design and method: To answer the PICO question: What is the prevalence/risk of peri-and postnatal complications in children of mothers with gestational diabetes mellitus?An exhaustive review of scientific articles was carried out based on the PRISMA methodology, between June 16 and July 26, 2022, in the Pubmed, Scopus, Cochrane, Google Scholar, ScienceDirect and Lilacs databases.The Mesh terms, gestational diabetes, hyperglycemia, infant complications, diabetes mellitus, newborn, observational study, systematic review and overweight.They were combined with Boolean operators AND and OR and entered into the database search engines.The established limits were type of study, type of document, language, date of publication.Articles referring to children of mothers with preexisting diseases were excluded.After passing the established filters, the methodological quality was assessed with Strengthening the Reporting of Observational Studies in Epidemiology STROBE and PRISMA.Those preselected underwent an assessment of the level of evidence with Sackett's proposal; those that obtained a high level and degree of recommendation were included in the present review, a total of 6 studies.

LINKING ULTRASOUND ASSESSMENT OF RENAL ARTERIES TO THE BIOLOGICAL PROFILE OF INFLAMMATION AND COAGULATION AT HYPERTENSIVE PATIENTS WITH OR WITHOUT DIABETES MELLITUS
Gavrila Adrian 1 , Anca Mehedintu 2 . 1 Cardinvest Medical Office, Craiova, ROMA-NIA, 2 University of Craiova, Craiova, ROMANIA Objective: The objective of the study was to estimate how the ultrasound parameters of the renal arteries correlate with the proinflammatory and prothrombotic imbalances at hypertensive patients (pts) with or without diabetes mellitus (DM).

Results:
In group 1, a higher RI was significantly associated with a higher level of CRP (0.81 ± 0.09 vs 0.52 ± 0.12, p = 0.02).In group 2, a higher level of CRP was Copyright © 2024 Wolters Kluwer Health, Inc.All rights reserved.