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Epidemiology and Health 2017;e2017050.
DOI: https://doi.org/10.4178/epih.e2017050    [Accepted] Published online November 8, 2017.
Epidemiologic incidence of rhabdomyolysis in opioid overdose in ICU of poisoning center in Iran, 2014
Babak Khoshideh1  , Mohammad Arefi1  , Mazaher Ghorbani1  , Samaneh Akbarpour2  , Fatemeh Taghizadeh1 
1Baharloo Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Correspondence  Mohammad Arefi ,Tel: +989112138691, Fax: +989123359004, Email: armaniair@yahoo.com
Submitted: September 7, 2017  Accepted after revision: November 8, 2017
The aim of this study is to investigate the clinical, demographical characteristics and some laboratory findings of hospitalized patients with acute opioid toxicity and rhabdomyolysis.
In this cross-sectional study, 354 hospitalized patients were investigated at Baharloo Educational Hospital in Tehran, with acute illicit drug toxicity in 2014. Data was collected by an investigator-made check lists. The collected data and variations (such as mortality rate, demographic data, and renal function tests as well as serum biochemical elements) were analyzed by descriptive statistics and x-square test.
The total number of patients admitted to hospital in 2014 was 354 patients, containing, 291 males and 63 females. The total number of patients with rhabdomyolysis was reported 76 patients (21.46% of total) in which 69 patients (90.7%) were male and 7 (9.3%) were female. Most cases of rhabdomyolysis were associated with methadone and then Opium abuse. Based on the reports the highest age range was 30 to 39 years old with methadone and opium as the most common illicit drug abused. Mean blood urea was 3.8 ± 1 mmol /dl, Mean serum potassium and sodium was measured, 3.8 ± 0.3 mmol /dL and 140.4 ± 4 mmol /dL respectively. Five patients passed away due to severe renal failure (6.5%), all the 5 cases were male.
Toxicity caused by opioid is associated with clinical complications and laboratory disorders such as electrolyte disorders which can lead to lethal and life threatening results in some cases. Laboratory test error/disorders should be identified in opioid toxicity in order to initiate efficient treatment.
Keywords: laboratory findings; Toxicity; Rhabdomyolysis; Opioid


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