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Predictors of human immunodeficiency virus and tuberculosis co-infection

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Epidemiol Health. 2015;37.e2015007
Publication date (electronic) : 2015 February 16
doi : https://doi.org/10.4178/epih/e2015007
Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India
Correspondence: Venkataramana Kandi  Department of Microbiology, Prathima Institute of Medical Sciences, Nagunur, Karimnagar 505 417, India  Tel: +91-8728222779, Fax: +91-8728222779 E-mail: ramana_20021@rediffmail.com
Received 2015 January 9; Accepted 2015 February 16.

Dear Editor:

The original paper by Molaeipoor et al. [1] has come at just the right time. While the availability of highly active antiretroviral therapy (HAART) has come as a boon for the human immunodeficiency virus (HIV)-infected population and is instrumental in prolonging life and improving its quality, the co-morbidities associated with HIV remain as a cause for concern. A previous study has noted that HIV-seropositive patients have significantly higher chances of developing other infections like tuberculosis (TB) [2]. The HIV disease course is influenced by the presence of co-morbidities that include infectious diseases like TB, hepatitis B, hepatitis C, and other infectious and non-infectious conditions including malignancies [3,4]. A recent study has also observed that the disease burden in HIV patients is significantly related to illicit drug use [5]. It must be noted that identification of various co-morbidities and their underlying causes prior to initiation of HAART is necessary to minimise related additional complications and resultant morbidity and mortality. The results of Molaeipoor et al. [1] indicating that overcrowding (e.g., in jails), adverse effects of HAART, prior latent TB infection, TCD4+ counts lower than 350 cells/mm3, and prophylactic therapy against other infections were more instrumental in predisposing HIV-seropositive patients to TB than was drug abuse are very significant findings. These results further suggest that future research should concentrate on nutritional issues (e.g., malnutrition) in the HIV-infected population, which may include vitamin and mineral deficiencies.


The author has no conflicts of interest to declare for this study.


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5. Degenhardt L, Whiteford HA, Ferrari AJ, Baxter AJ, Charlson FJ, Hall WD, et al. Global burden of disease attributable to illicit drug use and dependence: findings from the Global Burden of Disease Study 2010. Lancet 2013;382:1564–1574.

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