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Korean Journal of Epidemiology 1986;8(2): 221-232.
소화성 궤양의 위험요인에 관한 환자-대조군 연구
오희철, 김일순
A case-control study for risk factors of peptic ulcer
Hee Choul Oh, Il Soon Kim
Abstract
A case-control study was conducted to identify risk factors for peptic ulcer with the cases composed of patients who were endoscopically diagnosed from May 1, 1983 to June 30, 1986 in the Kang-wha Community Hospital. A total of 173 duodenal ulcer and a total of 103 benign gastric ulcer cases were studied and the control groups were twice matched by sex and age. Statistically significant variables were screened by X2-test, which were entered to the multiple logistic model to calculate the odds ratios for risk factors. The results were as follows: 1) Odds ratios of three main effects were preference of spicy food 5.6, salty food 5.6, and presence of life event 2.0 for duodenal ulcer respectively. The interaction term between preference of spicy food and salty food was 7.4 whereas odds ratio of drinking alcohol for duodenal ulcer was 0.5. 2) Although preference of spicy food and smoking were statistically significant respectively, their odds ratios could not be determined for benign gastric ulcer because the multiple logistic model was statistically rejected. 3) A multiple logistic analysis showed that the risk factors for duodenal and gastric ulcer were different in composition of risk factors studied here. 4) As in implication for further study, some objective methods to measure preference for spicy and salty food are needed to confirm them to be risk factors of peptic ulcer and new approaches are also needed to understand the effects of stress on peptic ulcer in terms of interactions with stress relieving factors.


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