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Korean Journal of Epidemiology 1986;8(2): 211-220.
원발성 간염의 위험요인에 관한 환자-대조군 연구
최수영, 이경희, 윤택구
A case-control study for risk factors on primary liver cancer
Soo Yong Choi, Kyung Hee Lee, Taik Koo Yun
Abstract
This study is to investigate risk factors in primary liver cancer due to hepatitis B virus(HBV), smoking, drinking and other risk factors by a case-control study. Two hundred and three patients with primary liver cancer and 609 hospital controls were analyzed. The summary of the results are as followings: 1) There were 172(84.7) male cases with a mean age of 50.0 years and the 31(15.3%) female cases had a mean age of 50.7 years. 2) The positive rates of HBsAg for PLC patients, and controls without cancer and with cancer were 70.4%, and 7.1% and 7.9% respectively. 3) Active HBV infection, indicated by positive tests for HBsAg or anti-HBc without anti-HBs was 80.2% in PLC patients and 23.4% in controls(p < 0.001). An estimated relative risk of PLC was 8.9 times of the risk in subject without evidence of active infection. 4) Patients with markers, anti-HBs or anti-HBs and anti-HBc had approximately the same low risk for PLC.(Estimated relative risk:0.8 and 0.7) 5) Three viral markers without HBsAg, anti-HBs and anti-HBc were detected 3.0% of PLC patients and in 20.9% of controls. 6) There was a dose-response relationship between PLC and alcohol. 7) There was no significant association between cigarette smoking and PLC negative for HBsAg. 8) There was no significant positive association between PLC, and history of blood transfusion and history of acupuncture.


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