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The relationship between smoking and female lung cancer was examined according to the morphological subtypes. Two data sets were analyzed. One is the data comprising 235 pathologically confirmed female primary lung cancer patients and 940 community control frequency matched at a ratio of 1 : 4 within ten-year-sized birth cohorts from Kangwha county female residents. The other is the data with 125 female lung cancer patients and 125 controls who are either patients’ sisters or friends where telephone surveys were used as the data collecting methods.
The telephone interview survey limited the number of the latter data which need information of the patients' sisters or friends who made the controls.
The morphology of the lung cancers were categorized in three types i. e. adenocarcinoma, squamous cell carcinoma and small cell carcinoma. Odds ratios were estimated by unconditional logistic regression analysis controlling age at first diagnosis as a confounder.
Results
are as follows:
1. The odds ratios of smoking were estimated to be 1.6(p>0.05) for adencoarcinama, 3.2 (p<0.01) for squamous cell carcinomas, and 7.1 (p<0.01) for small cell carcinomas in the logistic model with 235 cases and 940 controls The odds ration estimated in the model with 125 cases and 125 controls showed almost the same values as the former.
2. Females with less than 20 pack-year were estimated to have 1.8 times (p<0.05)higher risk of lung cancer than non-smokers and those with 20 or more pack-year were estimated to have 5.0 times (p<0.01) higher risk. The estimate for small cell carcinoma was 13.5(p<0.01) for females with 20 or more pack-year.
3. The odds ratio estimates of lung cancer were 1.8 (p<0.05) for those who began to smoke after their forties and 2.7(p<0.05) for those who began to smoke before forty-year old. This tendency was observed in every subtype of lung cancer.
This report reconfirms that there are different associations between smoking and morphological types of lung cancers, the absolute values of odds ratio being smaller than those of other countries, however. This finding implicates that further researches are needed to confirm the size of contribution of smoking to Korean female lung cancers. And the second step shall be the reason of low association between smoking and lung cancer, conditioned to this finding is true.