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- Cohort Profile Cohort profile: the Taiwan Initiative for Geriatric Epidemiological Research - a prospective cohort study on cognition
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Pei-Iun Hsieh1
, Te-Hsuan Huang1
, Jeng-Min Chiou2,3
, Jen-Hau Chen4,5
, Yen-Ching Chen1,6
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Epidemiol Health 2024;46e2024057-0
DOI: https://doi.org/10.4178/epih.e2024057
Published online: June 25, 2024
2Institute of Statistics and Data Science, National Taiwan University, Taipei, Taiwan
3Institute of Statistical Science, Academia Sinica, Taipei, Taiwan
4Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan
5Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
6Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan
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Corresponding author:
Jen-Hau Chen,
Email: jhhchen@ntu.edu.tw
Yen-Ching Chen,
Email: karenchen@ntu.edu.tw
Pei-Iun Hsieh and Te-Hsuan Huang contributed equally to this study as co-first authors.
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Abstract
The Taiwan Initiative for Geriatric Epidemiological Research (TIGER) was founded in 2011 to elucidate the interrelationships among various predictors of global and domain-specific cognitive impairment, with the aim of identifying older adults with an increased risk of dementia in the preclinical phase. TIGER, a population-based prospective cohort, recruited 605 and 629 (total of 1,234) older adults (aged 65 and above) at baseline (2011-2013 and 2019-2022) of phase I and II, respectively. Participants have undergone structured questionnaires, global and domain-specific cognitive assessments, physical exams, and biological specimen collections at baseline and biennial follow-ups to date. By 2022, TIGER I has included 4 biennial follow-ups, with the participants comprising 53.9% female and having a mean age of 73.2 years at baseline. After an 8-year follow-up, the annual attrition rate was 6.1%, reflecting a combination of 9.9% of participants who passed away and 36.2% who dropped out. TIGER has published novel and multidisciplinary research on cognitive-related outcomes in older adults, including environmental exposures (indoor and ambient air pollution), multimorbidity, sarcopenia, frailty, biomarkers (brain and retinal images, renal and inflammatory markers), and diet. TIGER’s meticulous design, multidisciplinary data, and novel findings elucidate the complex etiology of cognitive impairment and frailty, offering valuable insights into factors that can be used to predict and prevent dementia in the preclinical phase.
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