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Review Paper
Data resource profile: the National Health Insurance Research Database (NHIRD) -
Liang-yu Lin1,2
, Charlotte Warren-Gash1, Liam Smeeth1, Pau-Chung Chen2,3,4,5,6 -
Epidemiol Health 2018;40:e2018062.
DOI: https://doi.org/10.4178/epih.e2018062
Published online: December 27, 2018
1Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
2Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
3Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan
4Innovation and Policy Centre for Population Health and Sustainable Environment, National Taiwan University College of Public Health, Taipei, Taiwan
5Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan
6Office of Occupational Safety and Health, National Taiwan University Hospital, Taipei, Taiwan
- Correspondence: Pau-Chung Chen Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, 17 Xu-Zhou Road, Taipei 10055, Taiwan E-mail: pchen@ntu.edu.tw
• Received: November 15, 2018 • Accepted: December 27, 2018
©2018, Korean Society of Epidemiology
This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
- Electronic health records (EHRs) can provide researchers with extraordinary opportunities for population-based research. The National Health Insurance system of Taiwan was established in 1995 and covers more than 99.6% of the Taiwanese population; this system’s claims data are released as the National Health Insurance Research Database (NHIRD). All data from primary outpatient departments and inpatient hospital care settings after 2000 are included in this database. After a change and update in 2016, the NHIRD is maintained and regulated by the Data Science Centre of the Ministry of Health and Welfare of Taiwan. Datasets for approved research are released in three forms: sampling datasets comprising 2 million subjects, disease-specific databases, and full population datasets. These datasets are de-identified and contain basic demographic information, disease diagnoses, prescriptions, operations, and investigations. Data can be linked to government surveys or other research datasets. While only a small number of validation studies with small sample sizes have been undertaken, they have generally reported positive predictive values of over 70% for various diagnoses. Currently, patients cannot opt out of inclusion in the database, although this requirement is under review. In conclusion, the NHIRD is a large, powerful data source for biomedical research.
- The increasing availability, size, and detail of electronic health records (EHRs) offer unprecedented opportunities for research. The advantages of EHRs include increased statistical power, speed, wide breadth, relatively low cost, representative population coverage, completeness of follow-up, and the ability to assess interventions in routine clinical care [1]. Linking EHRs to disease registries and other resources can further extend their utility. Meanwhile, randomised controlled trials (RCTs) control for known and unknown confounding factors; therefore, they are regarded as the gold standard for measuring the efficacy of interventions [2]. However, the true effectiveness of exposures may be influenced by many factors in a real-world setting, leading to a gap between efficacy and effectiveness. Consequently, real-world data, collected in non-RCT settings, are essential to bridging this gap [3]. As an important source of real-world data, EHRs have become a practical tool in medical research. By utilising EHRs, researchers can measure treatment effects, demonstrate trends in disease incidence and prevalence, and further explore possible disease aetiologies.
- Among national EHR databases all over the world, the National Health Insurance Research Database (NHIRD) of Taiwan is unique. This large database, which contains data from 23 million residents of Taiwan, was previously described by Chen et al. [4]. However, the NHIRD was updated in 2016. This database changed its regulatory administration, was integrated with other datasets for further linkage, and released its full population dataset. The NHIRD now provides greater flexibility for scientific research. In this article, we introduce the latest version of the NHIRD, demonstrate its key features for research, and describe its strengths and weaknesses.
INTRODUCTION
- National Health Insurance programme of Taiwan
- To increase the affordability and accessibility of health care, in 1995, the Taiwanese government initiated a single-payer health insurance system, known as National Health Insurance (NHI). NHI has a contract with most healthcare facilities in Taiwan, and it is mandatory for physicians to upload the claims data from each visit to the National Health Insurance Ministry. Notably, the primary care system in Taiwan is different from that of many other countries. Referrals from general practitioners are not required to receive specialist care; therefore, patients with non-emergency health concerns can either visit local private or public clinics or go directly to specialists at hospital outpatient departments [5]. In 2017, 93% of healthcare facilities in Taiwan contracted with NHI, except some self-pay private clinics [6]. As a programme that provides universal care health coverage, NHI covers all necessary medical expenses including outpatient visits, the inpatient system, prescriptions, treatment with traditional Chinese medicine, dental services, operations, and investigations such as X-rays or magnetic resonance imaging. The coverage of NHI reached 92% as it was established; by the end of 2014, NHI covered 99.9% of the Taiwanese population [7,8].
- History of insurance data usage and governance
- In 2000, the anonymous and encrypted sampling dataset from this national insurance system was first released for use in research, under the regulation and maintenance of the National Health Research Institutes of Taiwan. From 2000 to 2013, the National Health Research Institutes made available to researchers general sampling datasets with 1 million subjects, as well as disease-specific sampling datasets. In 2016, these insurance data were moved to the Data Science Centre of the Ministry of Health and Welfare of Taiwan, where data are regulated and managed by the government [9]. The regulatory structure of the NHIRD is illustrated in Figure 1 [10]. The claims data from the NHI are stored and processed at the Data Science Centre, along with other governmental surveys and datasets. At the Data Science Centre, the NHIRD and other datasets are compared with the Household Registry Record from the Ministry of the Interior for quality control. Variables, such as sex and dates, are examined to ensure accuracy and consistency across different years. All data are de-identified and encrypted to protect participants’ privacy [11].
- Research using the National Health Insurance Research Database data
- The NHIRD is a powerful for observing chronic diseases and assessing the effects of treatments. For instance, hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are relatively prevalent in Taiwan. Previous studies using the NHIRD demonstrated that the use of statins, medicines for decreasing low-density lipoprotein in the blood, was associated with a decreased incidence of hepatocellular carcinoma (HCC) in HBV and HCV patients [8,9]. Another study showed that the use of nucleoside analogues as antiviral treatments for chronic hepatitis B reduced HCC recurrence in HBV patients receiving liver resection [12]. Furthermore, the availability of data linkage makes it possible to conduct population-based studies of rare diseases. By using NHIRD data, Kuo et al. [13] demonstrated an increased heritable risk of systemic lupus erythematosus (SLE) and other autoimmune diseases among families of SLE patients. Since 2014, more than 300 published studies have used NHIRD data each year (Figure 2). To date, over 2,700 peer-reviewed studies have been published using NHIRD data, covering such topics as general medicine, multidisciplinary science, psychiatry, clinical neurology, oncology, and public environmental and occupational health.
BASIC DATA RESOURCES
- Practice and patient data
- The basic structure of the NHIRD data is shown in Figure 3. The de-identified data contain demographic variables, including the insured persons’ registration location, sex, age, investigations, diagnoses, prescriptions, and details of each outpatient visit or their inpatient care. Disease diagnoses are coded using the International Classification of Diseases, Ninth Revision. Each subject in the dataset is coded with an encrypted identifier, which can be used to link future patient data. Detailed laboratory test results and medical notes are not included in this database.
- Data release
- The NHIRD data are released in three forms. The first form is a general dataset containing 2 million patients. Two million subjects are collected using stratified random sampling by age, sex, and the registry of regions from the full database population. They were sampled at three different time points: 2000, 2005, and 2010 (Supplementary Material 1). Each dataset contains claims data including diagnoses, prescriptions, investigation items, and treatments that the subjects received from 2000 to 2016. For the datasets sampled in 2005 and 2010, two additional datasets are available: from 2005 to 2016 and from 2010 to 2016. In addition to the complete claims data, these sampling datasets also contain data from cause of death datasets, cancer registry datasets, major illness datasets, and hospital information datasets. The general 2-million-patient sampling dataset is considered to be nationally representative.
- The second form of NHIRD data are disease-specific databases. These databases contain complete claims data of all patients with a certain health condition. For instance, all patients with a diabetes diagnosis from 2002 to 2015 are included in the diabetes database. As of 2018, there are 13 disease-specific databases available for research (Table 1). These datasets can also be linked to cancer registry data and cause of death data.
- The third form of NHIRD data is the full population dataset, which has been available for research since 2016. The full population dataset covers the entire Taiwanese population from 2000 to 2016, which comprises approximately 23 million people. Researchers can apply for complete claims data, including inpatient and outpatient records, investigations, and treatment, which can be linked with hospital information, birth certificate applications, death records, the cancer registry dataset, and the major illness datasets. Furthermore, the full population data can also be linked with individual datasets, a feature that will be introduced later. These released datasets are a valuable source for epidemiological research.
- Data linkage
- Since 2016, under the authorisation and regulation of the Ministry of Health and Welfare, NHIRD data can be more widely linked with other public surveys at the Data Science Centre. These datasets include governmental surveys, disease registries, health surveys, social reporting system data, and welfare registry data. Detailed descriptions of these databases are given in Table 2. These databases and the NHIRD can be linked through an encrypted personal ID using deterministic record linkage. Due to privacy issues, this data linkage can only be processed by researchers at the Data Science Centre. Accessing some sensitive data, such as the domestic violence database, requires special authorisation from other administrative departments. In addition to linking governmental data, with the informed consent of study subjects, researchers are also allowed to link their own research databases with the NHIRD. For instance, the Taiwan Biobank Database is a national cohort containing biological samples and comprehensive examinations of 200,000 adult volunteers that will be linked to the NHIRD [14]. Such data linkages can help researchers discover possible interactions among genes, environmental factors, and diseases.
- Strengths and weaknesses
- The NHIRD is a nationally representative cohort that contains detailed registry and claims data from all 23 million residents of Taiwan. This huge database provides researchers with powerful and generalisable real-world evidence for biomedical studies. For instance, a molecular epidemiological study has suggested that aristolochic acid (AA), an ingredient in Chinese herbal remedies, was correlated to HCC in Taiwan and other Asian countries [15]. Similar findings were later found using NHIRD data. Chen et al. [16] analysed NHIRD data and discovered that using Chinese herbs containing AA increased the risk of HCC among patients with HBV infections. In addition, after the update in 2016, the NHIRD can be further linked with other datasets to increase the power and potential to research specific population subgroups, rare conditions, and factors that are not usually contained in clinical databases, such as living conditions, violence, or detailed lifestyle data. Payment and reimbursement data are also valuable for health economic analyses.
- There are some issues with the NHIRD. First, the NHIRD lacks comprehensive validation, although some validation studies of the clinical diagnoses in the NHIRD have been done. Some of these validation studies used national disease registries as the reference standard, which is more convincing. Other studies used hospital-based records to validate the diagnoses found in the NHIRD and have reported relatively high positive predictive values (over 70%) (Supplementary Material 2). However, the samples of these studies were small and drawn from a limited number of hospitals. Therefore, the samples may not be regarded as nationally representative. To improve the accuracy of the NHIRD, the Ministry of Health and Welfare of Taiwan recently initiated a national validation project using existing registry data [17]. However, until this new evidence of the database’s validity is reported, researchers should carefully interpret results from the NHIRD. Second, consent from the participants included in the NHIRD is another controversial issue. By law, all residents in Taiwan are required to have NHI, and their data are included in the NHIRD; there is currently no way for participants to opt out of this national cohort. However, in 2017, the Supreme Administrative Court upheld the legitimacy of using the NHIRD data for research [18]. People’s ability to opt out of inclusion in the NHIRD remains under discussion [19]. Finally, records of self-pay healthcare and out-of-pocket payments, such as for cosmetic surgery, are not included in the NHIRD. This may narrow the scope of research using the NHIRD, and researchers must be aware of the effects of these non-included variables.
- Data access
- Researchers can access NHIRD data after ethical and scientific review processes. Prior to applying, researchers must obtain approval from the institutional review board. Notably, the applicant must be Taiwanese or be affiliated with a Taiwanese research institute. Applicants should submit their research proposal to the Data Science Centre. Proposals should include specific methods and variables required for their analyses. The cost of accessing data depends on the number of variables requested and the time period that they require the data for analyses; for example, accessing one variable for 1 year would cost 200 new Taiwanese dollars. After receiving an application, the Ministry of Health and Welfare reviews the legitimacy of the proposal, which is later reviewed by a scientific committee consisting of three experts. If one of the committee members disagrees with the proposed use of the data, then the researchers must submit a revised proposal to a higher advisory committee for a second review.
- After receiving approval, researchers must go to the branches of the Data Science Centre to perform their data analyses. The analyses of NHIRD data are complicated, and there is no structural training course for using the NHIRD. Therefore, a mock dataset containing 100,000 subjects is provided by the Data Science Centre to help researchers in writing statistical analysis syntax. When researchers enter the Data Science Centre, they are allowed to use provided computers and software including SAS, Stata, R, and SPSS to conduct their data analyses [20].
- Ethics and confidentiality
- Ethical review board approval is mandatory when applying to use NHIRD data. There are 27 institutional review boards capable of issuing approvals, and all are supervised and regulated by the Ministry of Health and Welfare [21]. To protect individuals’ confidentiality, all datasets in the Data Science Centre are pseudonymised. Personal ID, birth date, and names are encrypted, and this de-identification process was approved by an independent third party organisation [20]. To further secure the participants’ privacy, NHIRD datasets cannot be accessed outside the Data Science Centre, meaning that researchers must analyse these datasets at the Data Science Centre. When accessing the Data Science Centre, researchers are not allowed to bring any recording devices, including paper and pen. In addition, their statistical analysis syntax needs to be reviewed by the Data Science Centre prior to using the computers and software provided. The analysed results are also examined by the Data Science Centre before exporting. Any results with fewer than 3 subjects are not allowed to be exported to prevent re-identification [22].
MEASUREMENTS
Strengths
Weaknesses
- The NHIRD of Taiwan contains a large quantity of claims data and has the potential for multiple data linkages. Although more validation research is needed, and regulatory work to protect privacy is ongoing, this nationwide cohort is a valuable resource for medical research.
CONCLUSION
ACKNOWLEDGEMENTS
SUPPLEMENTARY MATERIAL
Table 1.Disease-specific databases of the National Health Insurance Research Database
| Database name | Year | No. of new case |
|---|---|---|
| Colorectal Cancer Health | 2002-2015 | 175,405 |
| Breast Cancer Health | 2002-2015 | 136,476 |
| Prostate Cancer Health | 2002-2015 | 53,937 |
| Systemic Lupus Erythematosus Health | 2002-2015 | 29,637 |
| Hypertension Health | 2002-2015 | 3,342,827 |
| Brain Tumour Health | 2002-2015 | 10,267 |
| Chronic Kidney Disease Health | 2002-2015 | 1,066,892 |
| End-Stage Renal Disease Health | 2002-2015 | 134,228 |
| Diabetes Mellitus Health | 2002-2015 | 1,720,602 |
| Injury | 2000-2015 | 25,925,939 |
| Triple-High1 | 2001-2015 | 6,558 |
| Disability Process | 1996, 1999, 2003, 2007, 2011 | 6,935 |
| Maternal and Child Health | 2004-2014 | 2,171,765 |
Table 2.Databases available for linkage
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Journal of Periodontology.2024; 95(5): 483. CrossRef - Sodium-glucose cotransporter-2 inhibitor in risk of sepsis/septic shock among patients with type 2 diabetes mellitus—a retrospective analysis of nationwide medical claims data
Wei-Syun Hu, Cheng-Li Lin
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(3): 1623. CrossRef - Association Between Retirement Age and Incidence of Depressive Disorders: A 19-Year Population-Based Study
Hang-Ju Yang, Yawen Cheng, Teng-Shun Yu, Wan-Ju Cheng
The American Journal of Geriatric Psychiatry.2024; 32(2): 166. CrossRef - Association between severity of dental caries and the risk of stroke
Yukiko Ono, Yu‐Ching Chou, Wu‐Chien Chien, Chien‐An Sun
Oral Diseases.2024; 30(5): 3413. CrossRef - The impact of sleep disturbances on suicide risk among people living HIV: An eleven-year national cohort
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Journal of Affective Disorders.2024; 346: 122. CrossRef - Association Between Use of Fluoroquinolones and Risk of Mitral or Aortic Valve Regurgitation: A Nationwide Cohort Study
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Clinical Pharmacology & Therapeutics.2024; 115(1): 147. CrossRef - Assessing the effectiveness of mitigating pesticide‐related disease risk among pesticide‐spraying drone operators in Taiwan
Wei‐Te Wu, Jyun‐Ming Chen, Yu‐Yin Chang, Shian‐Da Lin, Shih‐Tzong Chen, Yu‐Tang Hung
American Journal of Industrial Medicine.2024; 67(2): 110. CrossRef - A competing risk predictive model for kidney failure in patients with advanced chronic kidney disease
Tai-Shuan Lai, Hsiao-Mei Tsao, Yu-Hsiang Chou, Shu-Ling Liang, Kuo-Liong Chien, Yung-Ming Chen
Journal of the Formosan Medical Association.2024; 123(7): 751. CrossRef - Maternal gestational diabetes mellitus and risk of allergic diseases in offspring
Min-Che Hsu, Chien-Heng Lin, Ming-Chih Lin
Pediatrics & Neonatology.2024; 65(4): 365. CrossRef - Methodological guidance for the use of real-world data to measure exposure and utilization patterns of osteoporosis medications
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Bone Reports.2024; 20: 101730. CrossRef - Risk of placenta accreta spectrum following myomectomy: a nationwide cohort study
Ming-Wei Lin, Heng-Cheng Hsu, Elise Chia Hui Tan, Jin-Chung Shih, Chien-Nan Lee, Jehn-Hsiahn Yang, Yi-Yun Tai, Pao-Ling Torng, Shee-Uan Chen, Hung-Yuan Li, Shin-Yu Lin
American Journal of Obstetrics and Gynecology.2024; 231(2): 255.e1. CrossRef - Mechanical Versus Bioprosthetic Aortic Valve Replacement in Patients Undergoing Bentall Procedure
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Journal of the American Heart Association.2024;[Epub] CrossRef - Investigation of the Therapeutic Potential of Organic Nitrates in Mortality Reduction Following Acute Myocardial Infarction in Hyperlipidemia Patients: A Population-Based Cohort Study
An-Sheng Lee, Chung-Lieh Hung, Thung-Shen Lai, Ching-Hu Chung
Journal of Personalized Medicine.2024; 14(1): 124. CrossRef - The incidences and clinical outcomes of cryptococcosis in Taiwan: A nationwide, population-based study, 2002–2015
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Scientific Reports.2024;[Epub] CrossRef - Prevalence of eye and adnexal disorders among elderly inmates in Taiwan prisons
Ching-Yao Tsai, Zhu Liduzi Jiesisibieke, Ping Tao, Yen-Chun Wang, Dina Jiesisibieke, Ching-Wen Chien, Tao-Hsin Tung
BMC Public Health.2024;[Epub] CrossRef - The incidence of thrombosis with co-occurring thrombocytopenia prior to the SARS-CoV2 pandemic: A population-based study
Yanfang Liu, Choo-Hua Goh, Dereck Shen, Hong Qiu, Kuan-Chih Huang, Man Luo, Zhangjing Chen, Chao-Hsiun Tang, Tulika Chatterjee
PLOS ONE.2024; 19(5): e0301359. CrossRef - Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-weighted cohort study
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Fluids and Barriers of the CNS.2024;[Epub] CrossRef - Stroke and suicide among people with severe mental illnesses
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Scientific Reports.2024;[Epub] CrossRef - Early prediction of chronic kidney disease based on ensemble of deep learning models and optimizers
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Cancer Medicine.2024;[Epub] CrossRef - Clinical Benefit of Fixed‐Dose Combination of Amlodipine and Potent Atorvastatin in Patients With Concomitant Hypertension and Hypercholesterolemia
Chia‐Pin Lin, Tzyy‐Jer Hsu, Ying‐Chang Tung, Fu‐Chih Hsiao, Shing‐Hsien Chou, Yu‐Sheng Lin, Shao‐Wei Chen, Pao‐Hsien Chu
Journal of the American Heart Association.2024;[Epub] CrossRef - Time-dependent risk of atopic dermatitis following nontyphoidal Salmonella infection
Renin Chang, Hui-Yuan Chen, Yao-Min Hung, Jing-Yang Huang, James Cheng-Chung Wei
Postgraduate Medical Journal.2024; 100(1187): 649. CrossRef - Association between vitiligo and risk of retinal detachment: a population-based cohort study in Taiwan
Ching-Li Chen, Chun-Ying Wu, Yen-Ling Chen, Chih-Chiang Chen, Yun-Ting Chang, Chen-Yi Wu
Clinical and Experimental Dermatology.2024; 49(8): 841. CrossRef - Enhancing indicator condition–guided HIV testing in Taiwan: a nationwide case–control study from 2009 to 2015
Chun-Yuan Lee, Yi-Pei Lin, Chun-Yu Lin, Po-Liang Lu, Fu-Wen Liang
BMC Public Health.2024;[Epub] CrossRef - Association of Childhood Attention Deficit/Hyperactivity Disorder With Adolescent Traditional and Cyberbullying Victimization in the Digital Generation: A Population-Based Cohort Study
Chun-Ji Lin, Chao-Ying Tu, Yu-Hsuan Lin, Chih-Yi Wu, Po-Ya Chang, I-Ying Hsiao, Hung-Yi Chiou
Journal of Adolescent Health.2024; 75(1): 51. CrossRef - Genetic predisposition to bone mineral density and their health conditions in East Asians
Ying-Ju Lin, Wen-Miin Liang, Jian-Shiun Chiou, Chen-Hsing Chou, Ting-Yuan Liu, Jai-Sing Yang, Te-Mao Li, Yi-Chin Fong, I-Ching Chou, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Fuu-Jen Tsai
Journal of Bone and Mineral Research.2024; 39(7): 929. CrossRef - Diabetes and further risk of cancer: a nationwide population-based study
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BMC Medicine.2024;[Epub] CrossRef - Association of Asian dust storms and PM2.5 with clinical visits for respiratory diseases in children
Hui-Ju Wen, Shu-Li Wang, Chih-Da Wu, Mao-Chang Liang
Atmospheric Environment.2024; 333: 120631. CrossRef - Long-term safety of total knee arthroplasty in patients with chronic kidney disease in Taiwan: A retrospective cohort study
Chun-Ru Lin, Chune-Chen Lee, Yu-Feng Kuo, Shih-Pei Huang, Yong-Chen Chen, Shu-Hao Chang
Orthopaedics & Traumatology: Surgery & Research.2024; 110(7): 103847. CrossRef - Effects of mitral valve disease etiology on the outcomes of mechanical and biological valve replacement: retrospective cohort study
Chun-Yu Chen, Feng-Cheng Chang, Chia-Pin Lin, Yi-Hsin Chan, Victor Chien-Chia Wu, Yu-Ting Cheng, Pao-Hsien Chu, An-Hsun Chou, Chi-Hsiao Yeh, Shao-Wei Chen
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Yi-Chun Liu, Yin-To Liao, Mei-Hong Wen, Vincent Chin-Hung Chen, Yi-Lung Chen
Journal of Personalized Medicine.2024; 14(6): 632. CrossRef - Risks of anxiety disorders, depressive disorders, and sleep disorders in patients with dengue fever: A nationwide, population-based cohort study
Hsin-I Shih, Yu-Ping Wang, Chia-Yu Chi, Yu-Wen Chien, Alan L Rothman
PLOS Neglected Tropical Diseases.2024; 18(7): e0012239. CrossRef - Age, sex, and pre-arrest comorbidities shape the risk trajectory of sudden cardiac death— Patterns highlighted by population data in Taiwan
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Preventive Medicine.2024; 187: 108102. CrossRef - Risk of severe dengue during secondary infection: A population-based cohort study in Taiwan
Hsin-I Shih, Yu-Ching Wang, Yu-Ping Wang, Chia-Yu Chi, Yu-Wen Chien
Journal of Microbiology, Immunology and Infection.2024; 57(5): 730. CrossRef - Bridging Real-World Data Gaps: Connecting Dots Across 10 Asian Countries
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JMIR Medical Informatics.2024; 12: e58548. CrossRef - Real-World Research on Retinal Diseases Using Health Claims Database: A Narrative Review
Seong Joon Ahn
Diagnostics.2024; 14(14): 1568. CrossRef - Incidence and progression of diabetic retinopathy in patients treated with glucagon‐like peptide‐1 receptor agonists versus sodium‐glucose cotransporter 2 inhibitors: A population‐based cohort study
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Diabetes, Obesity and Metabolism.2024; 26(10): 4386. CrossRef - Impact of linkage level on inferences from big data analyses in health and medical research: an empirical study
Bora Lee, Young-Kyun Lee, Sung Han Kim, HyunJin Oh, Sungho Won, Suk-Yong Jang, Ye Jin Jeon, Bit-Na Yoo, Jean-Kyung Bak
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Scientific Reports.2024;[Epub] CrossRef - The association between acute myocardial infarction and subsequent diagnosis of breast cancer: a nationwide, population-based cohort study
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Scientific Reports.2024;[Epub] CrossRef - Oxaliplatin-associated shock in stage III colorectal cancer patients: real-world evidence in Taiwan
Ling-Yi Wang, Hui-Hsia Hsieh, Sung-Chao Chu, Wei-Chuan Chang, Yi-Ting Kuo, Tien-Yuan Wu
Therapeutic Advances in Drug Safety.2024;[Epub] CrossRef - The Perspectives of Community Pharmacists Toward the Name-Based Rationing System During the COVID-19 Pandemic in Taiwan: Cross-Sectional Survey Study
En-ling Chen, Chyi-Huey Bai, Paul T Kocis, Wenke Hwang
JMIR Formative Research.2024; 8: e60000. CrossRef - Effects of Colchicine on Major Adverse Limb and Cardiovascular Events in Patients With Peripheral Artery Disease
Donna Shu-Han Lin, Kuan-Chih Huang, Ting-Tse Lin, Jen-Kuang Lee, Lian-Yu Lin
Mayo Clinic Proceedings.2024; 99(9): 1374. CrossRef - Anesthesia for cesarean delivery and subsequent depression: A nationwide retrospective cohort study
Yi-Chen Chen, Fu-Wen Liang, Chung-Han Ho, Ying-Jen Chang, Kuo-Chuan Hung, Chin-Chen Chu, Jen-Yin Chen, Chia-Hung Yu
Journal of Affective Disorders.2024; 364: 108. CrossRef - Impact of the Home-Based Medical Integrated Program on Health Outcomes and Medical Resource Utilization in Home Healthcare Patients in Taiwan
Yu-Chieh Ho, Chia-Ti Wang, Tzu-Chieh Weng, Chung-Han Ho, Kang-Ting Tsai, Chien-Chin Hsu, Hung-Jung Lin, Hsiu-Chin Chen, Chien-Cheng Huang
Clinical Interventions in Aging.2024; Volume 19: 1437. CrossRef - Complementary Chinese Herbal Medicine Treatment is Associated with a Reduction of Surgical Rate in Patients with Dysfunctional Uterine Bleeding: A Propensity-Score Matched Cohort Study
Yi-Rong Lin, Wu-Chou Lin, Mei-Yao Wu, Cheng-Li Lin, Su-Tso Yang, Hung-Rong Yen
International Journal of Women's Health.2024; Volume 16: 1361. CrossRef - Real world clinical outcomes when discontinuing denosumab or bisphosphonates in patients with surgically managed osteoporotic vertebral compression fractures: a population-based cohort study
Chuan-Ching Huang, Chih-Chien Hung, Ho-Min Chen, Jou-Wei Lin, Shau-Huai Fu, Chen-Yu Wang
The Spine Journal.2024; 24(12): 2366. CrossRef - Trends of drug expenditure in Taiwan National Health Insurance before and during COVID-19 pandemic
Shu-I Wu, An-Sheng Lee, Ching-Hu Chung
Frontiers in Medicine.2024;[Epub] CrossRef - Long-term exposure to air pollution and the risks of venous thromboembolism: a nationwide population-based retrospective cohort study
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Clinical Research in Cardiology.2024;[Epub] CrossRef - Impact of Ascending HPV Infection on Colorectal Cancer Risk: Evidence from a Nationwide Study
Pin-Ho Pan, Ci-Wen Luo, Wen-Chien Ting, Bei-Hao Shiu, Jing-Yang Huang, Stella Chin-Shaw Tsai, Frank Cheau-Feng Lin
Microorganisms.2024; 12(9): 1746. CrossRef - Potentially Inappropriate Medication Use in Older Adults With Multimorbidity in Taiwan
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Pharmacoepidemiology and Drug Safety.2024;[Epub] CrossRef - Risks of infectious disease hospitalisations in the aftermath of tropical cyclones: a multi-country time-series study
Wenzhong Huang, Thomas Vogt, Jinah Park, Zhengyu Yang, Elizabeth A Ritchie, Rongbin Xu, Yiwen Zhang, Simon Hales, Wenhua Yu, Samuel Hundessa, Christian Otto, Pei Yu, Yanming Liu, Ke Ju, Eric Lavigne, Tingting Ye, Bo Wen, Yao Wu, Wissanupong Kliengchuay, K
The Lancet Planetary Health.2024; 8(9): e629. CrossRef - Acupuncture treatment is associated with a decreased risk of dementia in patients with rheumatoid arthritis in Taiwan: A propensity-score matched cohort study
Hou-Hsun Liao, Ming-Cheng Huang, Yu-Chen Lee, Cheng-Li Lin, Mei-Yao Wu, Peter Karl Mayer, Hung-Rong Yen
Integrative Medicine Research.2024; 13(4): 101086. CrossRef - Risk of Traumatic Intracranial Hemorrhage After Stroke: A Nationwide Population‐Based Cohort Study in Taiwan
Yun‐Ting Fang, Shu‐Fen Liao, Ping‐Ling Chen, Tian‐Shin Yeh, Chin‐I Chen, Krisna Piravej, Chia‐Chieh Wu, Wen‐Ta Chiu, Carlos Lam
Journal of the American Heart Association.2024;[Epub] CrossRef - Influenza Infection During Pregnancy and Risk of Seizures in Offspring
Yi-Feng Lee, Yi-Hsuan Lin, Ching-Heng Lin, Ming-Chih Lin
JAMA Network Open.2024; 7(9): e2434935. CrossRef - ADHD and Risk of Precocious Puberty: Considering the Impact of MPH
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Biomedicines.2024; 12(10): 2304. CrossRef -
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Yi-Chun Chi, Hui-Min Hsieh, Wei-Shan Chang, Ming-Sheng Lee, Chih-Hao Lin, Kun-Der Lin, Fu-Chen Kuo, Deng-Chyang Wu, Shwu-Jiuan Sheu
Ocular Immunology and Inflammation.2024; 32(10): 2467. CrossRef - Traditional Chinese Medicine Herbs for Breast Cancer Prevention and Survival: A Narrative Review of Epidemiological Studies from Taiwan
Yen-Nien Hou, Susan Chimonas, Prusha Patel, Elizabeth D. Kantor, Tiffany A. Traina, Hung-Rong Yen, Jun J. Mao
Current Oncology Reports.2024; 26(11): 1321. CrossRef - Trend of Pediatric Tracheostomy in Taiwan: A Population-Based Survey from 2000 to 2019
Kun-Tai Kang, Chia-Hsuan Lee, Che-Yi Lin, Wei-Chung Hsu
Journal of Otolaryngology - Head & Neck Surgery.2024;[Epub] CrossRef - Prevalence and risk factors for chronic postamputation pain requiring analgesia or nerve interventions: a population-based study in East Asia
Wen-Chih Liu, Fu-Wei Su, Sheng-You Su, Chen-Hao Chiang, Shu-Hsin Yao, Chia-Lung Shih, Kyle R Eberlin
Regional Anesthesia & Pain Medicine.2024; : rapm-2024-105982. CrossRef - Seasonal variations in peptic ulcer disease incidence in Taiwan, a country spanning both tropical and subtropical regions: a real-world database analysis
Yi-Chen Lai, Yu-Han Chen, Chien-An Chen, Chung-Han Ho, Yu-Cih Wu, Jhi-Joung Wang, Shih-Feng Weng, Yuan Kao
BMJ Open Gastroenterology.2024; 11(1): e001522. CrossRef - Use of fluoroquinolones and risk of rhegmatogenous retinal detachment: a retrospective cohort study using two nationwide representative claims databases
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Frontiers in Pharmacology.2024;[Epub] CrossRef - Incidence and Risk of Cardiovascular Outcomes in Patients With Anorexia Nervosa
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JAMA Network Open.2024; 7(12): e2451094. CrossRef - Bioprosthetic versus mechanical mitral valve replacements in patients with rheumatic heart disease
Cheng-Yu Chen, Yi-Hsin Chan, Victor Chien-Chia Wu, Kuo-Sheng Liu, Yu-Ting Cheng, Pao-Hsien Chu, Shao-Wei Chen
The Journal of Thoracic and Cardiovascular Surgery.2023; 165(3): 1050. CrossRef - Associations between domestic violence and poor pregnancy outcomes in taiwanese women: a nested case–control study
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BMC Women's Health.2023;[Epub] CrossRef - Infective endocarditis after surgical aortic or mitral valve replacement: A nationwide population-based study
Hsiu-An Lee, Victor Chien-Chia Wu, Yi-Shin Chan, Yu-Ting Cheng, Jen-Kuang Lee, Pao-Hsien Chu, Shao-Wei Chen
The Journal of Thoracic and Cardiovascular Surgery.2023; 166(4): 1056. CrossRef - Urban–Rural Disparity in the Incidence of Diagnosed Autism Spectrum Disorder in Taiwan: A 10-Year National Birth Cohort Follow-up Study
Yuu-Hueih Hsu, Chi-Wen Chen, Yuh-Jyh Lin, Chung-Yi Li
Journal of Autism and Developmental Disorders.2023; 53(5): 2127. CrossRef - Revision of endoscopic sinus surgery in adults: A population‐based study in Taiwan
Kun‐Tai Kang, Chia‐Hsuan Lee, Wei‐Chung Hsu, Jenq‐Yuh Ko, Te‐Huei Yeh
Clinical Otolaryngology.2023; 48(2): 321. CrossRef - Antenatal Corticosteroid Exposure is Associated with Childhood Mental Disorders in Late Preterm and Term Infants
Yi-Hsuan Lin, Ching-Heng Lin, Ming-Chih Lin, Ya-Chi Hsu, Chung-Ting Hsu
The Journal of Pediatrics.2023; 253: 245. CrossRef - Occupational health surveillance and detection of emerging occupational diseases among Taiwan farmers, through analysis of national‐based farmers' and medico‐administrative databases
Chung‐Ching Wang, Gwan‐Ling Lin, Yu‐Jen Lin, Wei‐Liang Chen, Wei‐Te Wu
American Journal of Industrial Medicine.2023; 66(1): 85. CrossRef - Effectiveness of statins for the primary prevention of cardiovascular disease in the Asian elderly population
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International Journal of Cardiology.2023; 373: 25. CrossRef - The effects of mineralocorticoid receptor antagonists on cardiovascular outcomes in patients with end‐stage renal disease and heart failure
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European Journal of Heart Failure.2023; 25(1): 98. CrossRef - Trends in pharmaceutical expenditure in the Taiwan National Health Insurance database at different hospital levels
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Journal of Comparative Effectiveness Research.2023;[Epub] CrossRef - The methodology to estimate the demand and supply of national psychiatric services in Taiwan from 2005 to 2030
Yu-Hsuan Lin, Yu-Tung Lan, Yen-Cheng Ho, Yu-Hung Chang, Chao A. Hsiung, Hung-Yi Chiou
Asian Journal of Psychiatry.2023; 79: 103393. CrossRef - The association of trastuzumab with atrial fibrillation and heart failure in breast cancer patients in routine clinical practice: a population-based propensity score matching and competing risk model analysis
Wen-Chi Wu, Chi-Cheng Huang, Yi-Fang Tsai, Yen-Shu Lin, Chin-Jung Feng, Yen-Jen Chen, Jiun-I. Lai, Ta-Chung Chao, Chun-Yu Liu, Ling-Ming Tseng
Breast Cancer Research and Treatment.2023; 198(1): 113. CrossRef - Health big data in Taiwan: A national health insurance research database
Tsung-Hsi Wang, Yuan-Ting Tsai, Po-Chang Lee
Journal of the Formosan Medical Association.2023; 122(4): 296. CrossRef - Impact of medications on outcomes in patients with acute myocardial infarction and chronic obstructive pulmonary disease: A nationwide cohort study
Cheng-Hung Chiang, You-Cheng Jiang, Wan-Ting Hung, Shu-Hung Kuo, Kai Hsia, Chia-Lin Wang, Yun-Ju Fu, Kun-Chang Lin, Su-Chiang Lin, Chin-Chang Cheng, Wei-Chun Huang
Journal of the Chinese Medical Association.2023; 86(2): 183. CrossRef - Disparities in the medical expenditures of patients with cancer and concomitant mental disorder: analyzing the effects of diagnosis sequence order
Kai-Jie Ma, Shu-Yuan Su, Daniel Nie, Wei-Sheng Chung, Chi-Yu Yao, Jong-Yi Wang
BMC Health Services Research.2023;[Epub] CrossRef - The Impact of Psychological Distress on Cervical Cancer
Chen-Ta Wu, Lu-Ting Chiu
Cancers.2023; 15(4): 1100. CrossRef - Risk factor identification and prediction models for prolonged length of stay in hospital after acute ischemic stroke using artificial neural networks
Cheng-Chang Yang, Oluwaseun Adebayo Bamodu, Lung Chan, Jia-Hung Chen, Chien-Tai Hong, Yi-Ting Huang, Chen-Chih Chung
Frontiers in Neurology.2023;[Epub] CrossRef - Association between statin use and the risk of gout in patients with hyperlipidemia: A population-based cohort study
Guan-Ling Lin, Hsiu-Chen Lin, Hsiu-Li Lin, Joseph Jordan Keller, Li-Hsuan Wang
Frontiers in Pharmacology.2023;[Epub] CrossRef - Fluoroquinolones and Risk of Aortic Aneurysm or Dissection in Patients With Congenital Aortic Disease and Marfan Syndrome
Shao-Wei Chen, Chia-Pin Lin, Yi-Hsin Chan, Victor Chien-Chia Wu, Yu-Ting Cheng, Ying-Chang Tung, Fu-Chih Hsiao, Dong-Yi Chen, Kuo-Chun Hung, An-Hsun Chou, Pao-Hsien Chu
Circulation Journal.2023; 87(9): 1164. CrossRef - Synthetic data generation: State of the art in health care domain
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Computer Science Review.2023; 48: 100546. CrossRef - Evaluating Prescription Pattern and Effectiveness of Antihypertensive Drugs in Non-Operated Aortic Dissection Patients
Yun-Hui Huang, Kai-Lin Chiu, Chuan-Wei Shen, Ming-Jong Bair, Chung-Yu Chen
Journal of Clinical Medicine.2023; 12(5): 1962. CrossRef - Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study
Hsin-I Shih, Chia-Yu Chi, Pei-Fang Tsai, Yu-Ping Wang, Yu-Wen Chien, William B. Messer
PLOS Neglected Tropical Diseases.2023; 17(3): e0011127. CrossRef - Association between tooth extraction during radiotherapy and the risk of osteoradionecrosis in patients with head and neck cancers
Pei-Hsun Liao, Che Lin, Jing-Yang Huang, Hsin-Mei Lin, Tsu-Jen Kuo
European Archives of Oto-Rhino-Laryngology.2023; 280(6): 2945. CrossRef - Pharmacotherapy May Attenuate the Risk of Child Abuse in Attention-Deficit/Hyperactivity Disorder from the Real-World Evidence
Cian-Cian Lin, Chi-Hsiang Chung, Wu-Chien Chien, Nian-Sheng Tzeng
Journal of Child and Adolescent Psychopharmacology.2023; 33(2): 59. CrossRef - Association of periodontal disease with migraine: A large‐scale community‐based cross‐sectional study
Yen‐Ju Chen, Kai‐Fang Hu, Chi Chan, Claire Huang, Yu‐Han Huang, Yen‐Feng Wang, Shuu‐Jiun Wang, Shih‐Pin Chen, Mei‐Hsuan Lee
Headache: The Journal of Head and Face Pain.2023; 63(4): 539. CrossRef - Prescription Patterns of New Use of Fixed-Dose Combination Inhalers in Patients with Chronic Obstructive Pulmonary Disease: Long-Acting β2 Agonists Plus Long-Acting Muscarinic Antagonists versus Long-Acting β2 Agonists Plus Inhaled Corticosteroids
Pei-An Liao, Sheng-Wei Pan, Chun-Yu Chen, Chung-Yeh Deng, Yaa-Hui Dong
International Journal of Chronic Obstructive Pulmonary Disease.2023; Volume 18: 553. CrossRef - Data source profile reporting by studies that use routinely collected health data to explore the effects of drug treatment
Wen Wang, Mei Liu, Qiao He, Mingqi Wang, Jiayue Xu, Ling Li, Guowei Li, Lin He, Kang Zou, Xin Sun
BMC Medical Research Methodology.2023;[Epub] CrossRef - Absence of an association between gastrointestinal tract surgery and newly diagnosed psoriasis: A nationwide, population‐based, nested, case‐control study
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International Journal of Rheumatic Diseases.2023; 26(7): 1350. CrossRef - Survival and Its Correlates in Multiple Sclerosis Patients under a Universal Health Insurance Program in Taiwan: An 18-Year Nationwide Cohort Study
Chun-Ming Liao, Chia-Yu Chen, Pei-Tseng Kung, Wei-Yin Kuo, Hui-Chuan Chuang, Wen-Chen Tsai
Healthcare.2023; 11(11): 1551. CrossRef - Air quality health index (AQHI) based on multiple air pollutants and mortality risks in Taiwan: Construction and validation
Mu-Jean Chen, Yue Leon Guo, Pinpin Lin, Hung-Che Chiang, Pau-Chung Chen, Yu-Cheng Chen
Environmental Research.2023; 231: 116214. CrossRef - Real-World Dispensing Patterns of Inhalation Medication in Young Adult Asthma: An Inception Cohort Study
Irene Mommers, Job FM van Boven, Catharina CM Schuiling-Veninga, Jens HJ Bos, Marten Koetsier, Eelko Hak, Maarten J Bijlsma
Clinical Epidemiology.2023; Volume 15: 721. CrossRef - Risks of Acute Cholecystitis, Acute Pancreatitis, and Acute Appendicitis in Patients with Dengue Fever: A Population-Based Cohort Study in Taiwan
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Infectious Diseases and Therapy.2023; 12(6): 1677. CrossRef - Cardiovascular risk in rheumatoid arthritis patients treated with targeted synthetic and biological disease‐modifying antirheumatic drugs: A multi‐centre cohort study
Xinning Tong, Chin‐Yao Shen, Ha‐Lim Jeon, Yihua Li, Ju‐Young Shin, Shirley CW Chan, Kai Hang Yiu, Nicole L. Pratt, Michael Ward, Chak Sing Lau, Ian CK Wong, Xue Li, Edward Chia‐Cheng Lai
Journal of Internal Medicine.2023; 294(3): 314. CrossRef - Treatment patterns of targeted and nontargeted therapies and survival effects in patients with locally advanced head and neck cancer in Taiwan
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BMC Cancer.2023;[Epub] CrossRef - Association of Influenza Vaccination With Risk of Bell Palsy Among Older Adults in Taiwan
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JAMA Otolaryngology–Head & Neck Surgery.2023; 149(8): 726. CrossRef - The growing burden of generalized myasthenia gravis: a population-based retrospective cohort study in Taiwan
Keira Joann Herr, Shih-Pei Shen, Yanfang Liu, Chih-Chao Yang, Chao-Hsiun Tang
Frontiers in Neurology.2023;[Epub] CrossRef - Changes in employment status and income before and after newly diagnosed depressive disorders in Taiwan: a matched cohort study using controlled interrupted time series analysis
Yu-Ling Chen, Wei-Hsiang Liao, Shih-Heng Wang, Yin-Ju Lien, Chia-Ming Chang, Shih-Cheng Liao, Wei-Lieh Huang, Chi-Shin Wu
Epidemiology and Psychiatric Sciences.2023;[Epub] CrossRef - Editorial: Pharmacovigilance and drug repositioning research using pharmacoepidemiology
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Frontiers in Pharmacology.2023;[Epub] CrossRef - The intention of utilization and experience toward traditional Chinese medicine among breast cancer patients in the early and late stages: a qualitative study
Kai-wei Chen, Kuo-piao Chung, Chung-hua Hsu
BMC Complementary Medicine and Therapies.2023;[Epub] CrossRef - Association between ambient BTEX mixture and neurological hospitalizations: A multicity time-series study in Taiwan
Hong Qiu, Kai-Jen Chuang, Yen-Chun Fan, Ta-Pang Chang, Hsiao-Chi Chuang, Eliza Lai-Yi Wong, Chyi-Huey Bai, Kin-Fai Ho
Ecotoxicology and Environmental Safety.2023; 263: 115239. CrossRef - Clinical outcomes of generic versus brand‐name clopidogrel for secondary prevention in patients with acute myocardial infarction: A nationwide cohort study
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Clinical and Translational Science.2023; 16(9): 1594. CrossRef - The association between SGLT2 inhibitors and new-onset acute coronary syndrome in the elderly: a population-based longitudinal cohort study
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Diabetology & Metabolic Syndrome.2023;[Epub] CrossRef - Progression to myocardial infarction short-term death based on interval sequential pattern mining
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BMC Cardiovascular Disorders.2023;[Epub] CrossRef - The association between non-alcoholic fatty liver disease and atopic dermatitis: a population-based cohort study
Shuo-Yan Gau, Ching-Hua Huang, Yih Yang, Tung-Han Tsai, Kuang-Hua Huang, Chien-Ying Lee
Frontiers in Immunology.2023;[Epub] CrossRef - Multi-Criterial Model for Weighting Biological Risk Factors in Multiple Sclerosis: Clinical and Health Insurance Implications
Roberto De Masi, Stefania Orlando, Chiara Leo, Matteo Pasca, Luca Anzilli, Maria Carmela Costa
Healthcare.2023; 11(17): 2420. CrossRef - Real‐world epidemiology, treatment patterns and disease burden of patients diagnosed with chronic hepatitis B in Taiwan
Hsiu‐Ting Chien, Tung‐Hung Su, Hazel Huang, Chih‐Lin Chiang, Fang‐Ju Lin
Liver International.2023; 43(11): 2404. CrossRef - Beyond the Surface: Investigating the Relationship Between Autoimmune Blistering Disorders and Venous Thromboembolism
Chih‐Hsin Hsu, Chao‐Kai Hsu
Journal of the American Heart Association.2023;[Epub] CrossRef - Comparative cardiovascular safety of LABA/LAMA FDC versus LABA/ICS FDC in patients with chronic obstructive pulmonary disease: a population-based cohort study with a target trial emulation framework
Chun-Yu Chen, Sheng-Wei Pan, Chia-Chen Hsu, Jason J. Liu, Hiraku Kumamaru, Yaa-Hui Dong
Respiratory Research.2023;[Epub] CrossRef - Herpes zoster associated with stroke incidence in people living with human immunodeficiency virus: a nested case–control study
Han-Chang Ku, Yi-Lin Wu, Hei-Tung Yip, Cheng-Yang Hsieh, Chung-Yi Li, Huang-Tz Ou, Yen-Chin Chen, Nai-Ying Ko
BMC Infectious Diseases.2023;[Epub] CrossRef - Differential Effects of Metformin on Immune-Mediated and Androgen-Mediated Non-Cancer Skin Diseases in Diabetes Patients: A Retrospective Cohort Study
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Dermatology.2023; 239(4): 542. CrossRef - Detection of Amyotrophic Lateral Sclerosis (ALS) Comorbidity Trajectories Based on Principal Tree Model Analytics
Yang-Sheng Wu, David Taniar, Kiki Adhinugraha, Li-Kai Tsai, Tun-Wen Pai
Biomedicines.2023; 11(10): 2629. CrossRef - Long-Term Use of Immunosuppressive Agents Increased the Risk of Fractures in Patients with Autoimmune Diseases: An 18-Year Population-Based Cohort Study
Feng-Chen Kao, Yao-Chun Hsu, Yuan-Kun Tu, Tzu-Shan Chen, Hsi-Hao Wang, Jeff (Chien-Fu) Lin
Biomedicines.2023; 11(10): 2764. CrossRef - Real-world data analysis on effectiveness of integrative therapies: A practical guide to study design and data analysis using healthcare databases
Ye-Seul Lee, Yoon Jae Lee, In-Hyuk Ha
Integrative Medicine Research.2023; 12(4): 101000. CrossRef - Cost-effectiveness analysis of atezolizumab plus bevacizumab versus sorafenib in first line treatment for Chinese subpopulation with unresectable hepatocellular carcinoma
Chien-Yu Tseng, Yi-Wen Tsai, Ming-Neng Shiu
Frontiers in Oncology.2023;[Epub] CrossRef - Estimation of life expectancy and healthcare cost in rheumatoid arthritis patients with and without depression: a population-based retrospective cohort study
Ying-Ming Chiu, Joung-Liang Lan, Wei-Lieh Huang, Chi-Shin Wu
Frontiers in Medicine.2023;[Epub] CrossRef - Comparative effectiveness of two intravenous immunoglobulin products in children with Kawasaki disease, a nationwide cohort study
Ni-Chun Kuo, Ching-Heng Lin, Ming-Chih Lin
Scientific Reports.2023;[Epub] CrossRef - 23-valent pneumococcal polysaccharide vaccine and the risk of renal progression in older patients with chronic kidney disease
Po-Ya Chang, Chun-Ji Lin, Hao-Cheng Chen, Hueng-Chuen Fan, Hsuchung Kuo
Preventive Medicine.2023; 177: 107753. CrossRef - Deep-kidney: an effective deep learning framework for chronic kidney disease prediction
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Health Information Science and Systems.2023;[Epub] CrossRef - Association Between Endometriosis and Mental Disorders Including Psychiatric Disorders, Suicide, and All-Cause Mortality -A Nationwide Population-Based Cohort Study in Taiwan
Tsan-Min Wang, Yi-Liang Lee, Chi-Hsiang Chung, Chien-An Sun, Chieh-Yi Kang, Gwo-Jang Wu, Wu-Chien Chien
International Journal of Women's Health.2023; Volume 15: 1865. CrossRef - Re-examination of the risk of dementia after dengue virus infection: A population-based cohort study
Yu-Wen Chien, Hsin-I Shih, Yu-Ping Wang, Chia-Yu Chi, Mabel Carabali
PLOS Neglected Tropical Diseases.2023; 17(12): e0011788. CrossRef - Long-term outcomes of mitral valve replacement in dialysis patients: evidence from a nationwide database
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Indonesian Journal of Law and Justice.2023; 1(2): 10. CrossRef - Trends in Coprescription Among Taiwanese Children from 2002 to 2012
Sio-Ian Tou, Cheng-Li Lin, Chia-Yu Huang, Hung-Rong Yen
Journal of Multidisciplinary Healthcare.2023; Volume 16: 4307. CrossRef - SISPRO: La base de datos administrativa del sistema de salud colombiano
Diego Rosselli, Camila Pantoja-Ruiz
Acta Neurológica Colombiana.2023; 38(4): 187. CrossRef - Mitral valve repair versus replacement in patients with rheumatic heart disease
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The Journal of Thoracic and Cardiovascular Surgery.2022; 164(1): 57. CrossRef - Data Resource Profile of Shizuoka Kokuho Database (SKDB) Using Integrated Health- and Care-insurance Claims and Health Checkups: The Shizuoka Study
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Journal of Epidemiology.2022; 32(8): 391. CrossRef - Venous Thromboembolism and Critical Limb Events in Patients with Atrial Fibrillation: A Nationwide Population-Based Cohort Study
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Angiology.2022; 73(5): 413. CrossRef - Tuberculosis treatment delay and nosocomial exposure remain important risks for patients undergoing regular hemodialysis
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Ya-Hsin Li, Shih-Chang Hung, Hung-Chang Hung, Kuei-Chuan Chan, Ya-Chin Li, Ling-Ling Liu, Wen Yi Chao, Jong-Wen Huang, Huan-Wen Hsu
Australasian Emergency Care.2022; 25(3): 224. CrossRef - The nationwide Finnish anticoagulation in atrial fibrillation (FinACAF): study rationale, design, and patient characteristics
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European Journal of Epidemiology.2022; 37(1): 95. CrossRef - Venous Thromboembolism and Atherosclerotic Events in Patients With Non-Valvular Atrial Fibrillation
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Angiology.2022; 73(5): 393. CrossRef - ‘What about the dads?’ Linking fathers and children in administrative data: A systematic scoping review
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Big Data & Society.2022;[Epub] CrossRef - Association Between Nonselective Beta-Blocker Use and Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Without Cirrhosis and Decompensation
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Frontiers in Pharmacology.2022;[Epub] CrossRef - Magnesium exposure increases hip fracture risks in patients with chronic kidney disease: a population-based nested case–control study
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Seminars in Dialysis.2022; 35(3): 278. CrossRef - H1-Antihistamines Reduce the Risk of Hepatocellular Carcinoma in Patients With Hepatitis B Virus, Hepatitis C Virus, or Dual Hepatitis B Virus-Hepatitis C Virus Infection
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Frontiers in Oncology.2022;[Epub] CrossRef - The Association Between Acupuncture Therapies and Reduced Fracture Risk in Patients with Osteoarthritis: A Nationwide Retrospective Matched Cohort Study
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Journal of Integrative and Complementary Medicine.2022; 28(5): 418. CrossRef - Prenatal and early life exposure to air pollution and the incidence of Kawasaki disease
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BioDrugs.2022; 36(2): 205. CrossRef - Acute effects of ambient non-methane hydrocarbons on cardiorespiratory hospitalizations: A multicity time-series study in Taiwan
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Statistical Analysis and Data Mining: The ASA Data Science Journal.2022; 15(2): 179. CrossRef - Association of Glucagon-Like Peptide-1 Receptor Agonist vs Dipeptidyl Peptidase-4 Inhibitor Use With Mortality Among Patients With Type 2 Diabetes and Advanced Chronic Kidney Disease
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Journal of Healthcare Engineering.2022; 2022: 1. CrossRef - Hydralazine Associated With Reduced Therapeutic Phlebotomy Frequency in a Nationwide Cohort Study: Real-World Effectiveness for Drug Repurposing
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Frontiers in Pharmacology.2022;[Epub] CrossRef - Comparison of risks of arterial thromboembolic events and glaucoma with ranibizumab and aflibercept intravitreous injection: A nationwide population‐based cohort study
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PLOS ONE.2022; 17(4): e0267088. CrossRef - Long-term exposure to ambient fine particulate matter (PM2.5) and associations with cardiopulmonary diseases and lung cancer in Taiwan: a nationwide longitudinal cohort study
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International Journal of Epidemiology.2022; 51(4): 1230. CrossRef - Sex differences following percutaneous coronary intervention or coronary artery bypass surgery for acute myocardial infarction
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Biology of Sex Differences.2022;[Epub] CrossRef - Association between bullous pemphigoid and risk of venous thromboembolism: A nationwide population‐based cohort study
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The Journal of Dermatology.2022; 49(8): 753. CrossRef - Comorbidities of systemic lupus erythematosus prior to and following diagnosis in different age-at-onset groups
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Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy.2022; 42(6): 483. CrossRef - A Roadmap for Investigating Preclinical Autoimmunity Using Patient-Oriented and Epidemiologic Study Designs: Example of Rheumatoid Arthritis
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Frontiers in Immunology.2022;[Epub] CrossRef - Bisphosphonate Use Is Not Associated With Tuberculosis Risk Among Patients With Osteoporosis: A Nationwide Cohort Study
Jin‐Hua Chen, Chih‐Hsin Lee, Meng‐Rui Lee, Pei‐Yu Huang, Tzu‐Hsin Yen, Ming‐Chia Lee, Ching‐Wen Tsai, Jann‐Yuan Wang, Jen‐Ai Lee
The Journal of Clinical Pharmacology.2022; 62(11): 1412. CrossRef - Prevalence of exposure to benzodiazepines among pregnant women in Taiwan: A nationwide longitudinal study
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Journal of Sleep Research.2022;[Epub] CrossRef - Time Trends in Psoriasis and Psoriatic Arthritis Incidence from 2002 to 2016 in Taiwan: An Age–Period–Cohort Analysis
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Archives of Dermatological Research.2022; 315(3): 419. CrossRef - Timing of symptomatic subsequent vertebral compression fracture associated with different demographic factors
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European Spine Journal.2022; 31(9): 2439. CrossRef - The Combination of Sleep Disorders and Depression Significantly Increases Cancer Risk: A Nationwide Large-Scale Population-Based Study
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International Journal of Environmental Research and Public Health.2022; 19(15): 9266. CrossRef - Oral anticoagulant decreases stroke recurrence in patients with atrial fibrillation detected after stroke
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Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Analyses and identification of ICD codes for dementias in the research based on the NHIRD: a scoping review protocol
Ying-Jyun Shih, Jiun-Yi Wang, Ya-Hui Wang, Rong-Rong Shih, Yung-Jen Yang
BMJ Open.2022; 12(8): e062654. CrossRef - Major adverse cardiovascular and limb events in people with diabetes treated with GLP-1 receptor agonists vs SGLT2 inhibitors
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Diabetologia.2022; 65(12): 2032. CrossRef - Health Inequality among Fishery Workers during Climate Change: A National Population-Based and Retrospective Longitudinal Cohort Study
Ming-Shyan Lin, Yu-Chih Lin, Tung-Jung Huang, Mei-Yen Chen
International Journal of Environmental Research and Public Health.2022; 19(16): 10281. CrossRef - Elevated risk of acute epiglottitis in patients with chronic obstructive pulmonary disease: A nationwide cohort study
Shu-Yi Huang, Cheng-Ming Hsu, Yao-Hsu Yang, Yuan-Hsiung Tsai, Ming-Shao Tsai, Geng-He Chang, Chia-Yen Liu, Yi-Chan Lee, Ethan I. Huang, Yao-Te Tsai, Marie Jetté
PLOS ONE.2022; 17(8): e0273437. CrossRef - Association between osteoarthritis and urinary tract infection in older adults: A nationwide population-based cohort study
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Medicine.2022; 101(33): e30007. CrossRef - Clinical Characteristics of Hyperandrogenism Include Hirsutism, Polycystic Ovary Syndrome, and Acne: Association with Psychiatric Disease in Women -A Nationwide Population-Based Cohort Study in Taiwan
Tsan-Min Wang, Cheng-Hao Chou, Yi-Liang Lee, Chi-Hsiang Chung, Yao-Ching Huang, Xiao-Cheng Lai, Chien-An Sun, Chieh-Yi Kang, Gwo-Jang Wu, Wu-Chien Chien
International Journal of Women's Health.2022; Volume 14: 1173. CrossRef - Association of Statin Therapy With Major Adverse Cardiovascular and Limb Outcomes in Patients With End-stage Kidney Disease and Peripheral Artery Disease Receiving Maintenance Dialysis
Hao-Yun Lo, Yu-Sheng Lin, Donna Shu-Han Lin, Jen-Kuang Lee, Wen-Jone Chen
JAMA Network Open.2022; 5(9): e2229706. CrossRef - Patterns of Outpatient Phecodes Predating the Diagnosis of Systemic Lupus Erythematosus in Taiwanese Women
Ming-Chi Lu, Chia-Wen Hsu, Malcolm Koo
Journal of Clinical Medicine.2022; 11(18): 5406. CrossRef - Recurrent thromboembolism, bleeding, and mortality in Asian patients with venous thromboembolism receiving different oral anticoagulants: A nationwide analysis
Mei-Chuan Lee, Chia-Te Liao, I-Jung Feng, Tsung Yu, Wei-Ting Chang, Mei-Fen Shih, Hui-Chen Su, Han Siong Toh
Medicine.2022; 101(37): e30412. CrossRef - Prognostic Factors for Clinical Outcomes in Patients with Newly Diagnosed Advanced-stage Hodgkin Lymphoma: A Nationwide Retrospective Study
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Cancer Control.2022;[Epub] CrossRef - Mortality Prediction Model before Surgery for Acute Mesenteric Infarction: A Population-Based Study
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Journal of Clinical Medicine.2022; 11(19): 5784. CrossRef - Long‐Term Risks of Stroke in Patients With Type A Aortic Dissection: A Nationwide Cohort Study
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Journal of the American Heart Association.2022;[Epub] CrossRef - Use of fibrates is not associated with reduced risks of mortality or cardiovascular events among ESRD patients: A national cohort study
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Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef - Association between metabolic syndrome and colorectal cancer incidence and all-cause mortality: a hospital-based observational study
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BMC Gastroenterology.2022;[Epub] CrossRef - Fetal–neonatal and maternal pregnancy outcomes in women with rheumatoid arthritis: a population-based cohort study
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BMJ Open.2022; 12(10): e059203. CrossRef - Human Papillomavirus and Risk of Colorectal Cancer: An Analysis of Nationwide Claims Data
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Asia-Pacific Journal of Ophthalmology.2022; 11(6): 505. CrossRef - A Machine Learning Model to Predict Length of Stay and Mortality among Diabetes and Hypertension Inpatients
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Environmental Pollution.2021; 283: 115864. CrossRef - Changes in Pramipexole Utilization after Introduction of the Extended-Release Formulation: A Nationwide Study in Taiwan
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Drugs - Real World Outcomes.2021; 8(1): 63. CrossRef - Income level and outcomes in patients with heart failure with universal health coverage
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Heart.2021; 107(3): 208. CrossRef - Nationwide cohort study of tricuspid valve repair versus replacement for infective endocarditis
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European Journal of Cardio-Thoracic Surgery.2021; 59(4): 878. CrossRef - Increased risk of dementia in patients with nasopharyngeal cancer treated with radiation therapy: A nationwide population-based cohort study
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Archives of Gerontology and Geriatrics.2021; 93: 104303. CrossRef - Le risque d’hospitalisation évitable avant et après le diagnostic chez des patients atteints de polyarthrite rhumatoïde comparativement à des témoins sans polyarthrite rhumatoïde
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Revue du Rhumatisme.2021; 88(1): 40. CrossRef - Machine-learning model to predict the cause of death using a stacking ensemble method for observational data
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Journal of the American Medical Informatics Association.2021; 28(6): 1098. CrossRef - Chronic obstructive pulmonary disease research by using big data
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The Clinical Respiratory Journal.2021; 15(3): 257. CrossRef - Recurrence rate and risk factors for recurrence after thoracoscopic surgery for primary spontaneous pneumothorax: A nationwide population-based study
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Journal of the Formosan Medical Association.2021; 120(10): 1890. CrossRef - Selective serotonin reuptake inhibitors use and hepatocellular carcinoma in patients with alcohol use disorder
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Drug and Alcohol Dependence.2021; 219: 108495. CrossRef - Association of Obstructive Sleep Apnea With the Risk of Male Infertility in Taiwan
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Advances in Therapy.2021; 38(6): 2908. CrossRef - Use of bladder antimuscarinics is associated with an increased risk of dementia: a retrospective population-based case–control study
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Clinical Epidemiology.2021; Volume 13: 175. CrossRef - Effect of Permanent Pacemaker Implantation After Valve Surgery on Long-Term Outcomes
Mu-Chieh Chi, Kuo-Chun Hung, Shang-Hung Chang, Victor Chien-Chia Wu, An-Hsun Chou, Yi-Hsin Chan, Chia-Pin Lin, Chih-Hsiang Chang, Pao-Hsien Chu, Shao-Wei Chen
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The Journal of Clinical Pharmacology.2021; 61(8): 1131. CrossRef - Midterm Prognosis of Patients With Pulmonary Embolism Receiving Catheter‐Directed Thrombolysis or Systemic Thrombolysis: A Nationwide Population‐Based Study
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Journal of the American Heart Association.2021;[Epub] CrossRef - Association Between Preeclampsia Risk and Fine Air Pollutants and Acidic Gases: A Cohort Analysis in Taiwan
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Frontiers in Public Health.2021;[Epub] CrossRef - Fenofibrate Delays the Need for Dialysis and Reduces Cardiovascular Risk Among Patients With Advanced CKD
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The Journal of Clinical Endocrinology & Metabolism.2021; 106(6): 1594. CrossRef - Association between gastroesophageal reflux disease and colorectal cancer risk: a population-based cohort study
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Therapeutic Advances in Musculoskeletal Disease.2021;[Epub] CrossRef - Chinese Herbal Medicine Decreases Incidence of Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease in Taiwan: A Propensity Score-Matched Cohort Study
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The Journal of Alternative and Complementary Medicine.2021; 27(7): 596. CrossRef - Uracil-tegafur vs fluorouracil as postoperative adjuvant chemotherapy in Stage II and III colon cancer
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Journal of Clinical Medicine.2021; 10(10): 2097. CrossRef - Increased Risk of Kawasaki Disease in Infants Born of Mothers With Immune Disorders
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Frontiers in Pediatrics.2021;[Epub] CrossRef - Gout as a Risk Factor for Acute Myocardial Infarction: Evidence from Competing Risk Model Analysis
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International Journal of Clinical Practice.2021;[Epub] CrossRef - Major adverse cardiovascular and limb events in patients with diabetes treated with GLP-1 receptor agonists vs DPP-4 inhibitors
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Diabetologia.2021; 64(9): 1949. CrossRef - Clinical Study Using Healthcare Claims Database
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Journal of Rheumatic Diseases.2021; 28(3): 119. CrossRef - Acupuncture Treatment Reduced the Risk of Coronary Heart Disease in Patients with Depression: A Propensity-Score Matched Cohort Study
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Neuropsychiatric Disease and Treatment.2021; Volume 17: 2315. CrossRef - Switching and Discontinuation Pattern of Biologic Disease-Modifying Antirheumatic Drugs and Tofacitinib for Patients With Rheumatoid Arthritis in Taiwan
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Pharmacoepidemiology and Drug Safety.2021; 30(12): 1653. CrossRef - Data Analysis of the Risks of Type 2 Diabetes Mellitus Complications before Death Using a Data-Driven Modelling Approach: Methodologies and Challenges in Prolonged Diseases
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Nutrients.2021; 13(9): 3002. CrossRef - Inpatient Outcomes Following a Return Visit to the Emergency Department: A Nationwide Cohort Study
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Frontiers in Medicine.2021;[Epub] CrossRef - Children with appendectomy have increased risk of future sepsis: Real‐world data in Taiwan
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International Journal of Clinical Practice.2021;[Epub] CrossRef - Risk of COPD Exacerbations Associated with Statins versus Fibrates: A New User, Active Comparison, and High-Dimensional Propensity Score Matched Cohort Study
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International Journal of Chronic Obstructive Pulmonary Disease.2021; Volume 16: 2721. CrossRef - Effect of chronic kidney disease on outcomes following proximal humerus fragility fracture surgery in diabetic patients: A nationwide population-based cohort study
Chien-Tien Chen, Su-Ju Lin, Liang-Tseng Kuo, Tien-Hsing Chen, Wei-Hsiu Hsu, Chi-Lung Chen, Pei-An Yu, Kuo-Ti Peng, Yao-Hung Tsai, Robert Daniel Blank
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Journal of Personalized Medicine.2021; 11(10): 1038. CrossRef - The dialysis facility levels and sizes are associated with outcomes of incident hemodialysis patients
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Scientific Reports.2021;[Epub] CrossRef - Association of Acute Upper Respiratory Tract Infections with Sudden Sensorineural Hearing Loss: A Case-Crossover, Nationwide, Population-Based Cohort Study
Chuan-Yi Lin, Po-Hsiu Kuo, Szu-Yuan Wu
International Journal of Environmental Research and Public Health.2021; 18(20): 10745. CrossRef - Effect of Nephrology Care on Mortality in Incident Dialysis Patients: A Population-Based Cohort Study
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Journal of Personalized Medicine.2021; 11(11): 1071. CrossRef - Coprescription Trends in Western Medicine, Chinese Herbal Medicine and Dental Medicine among Older Adults in Taiwan from 1997 to 2013
Chia-Yu Huang, Mei-Yao Wu, Chia-Ling Chang, Yuan-Ching Liao, Ying-Yu Chen, Wu-Chou Lin, Hung-Rong Yen
Complementary Therapies in Medicine.2021; 63: 102782. CrossRef - High Risk for Attention-Deficit Hyperactive Disorder in Children with Strabismus: A Nationwide Cohort Study from the National Health Insurance Research Database
Chia-Ying Tsai, Chien-Chia Su, Yao-Lin Liu, I-Ju Tsai, Tzu-Hsun Tsai
Life.2021; 11(11): 1139. CrossRef - Comparison of Medical Comorbidity between Patients with Normal-Tension Glaucoma and Primary Open-Angle Glaucoma: A Population-Based Study in Taiwan
Wei-Yang Lu, Ci-Wen Luo, Shyan-Tarng Chen, Yu-Hsiang Kuan, Shun-Fa Yang, Han-Yin Sun
Healthcare.2021; 9(11): 1509. CrossRef - Is Colectomy Associated with the Risk of Type 2 Diabetes in Patients without Colorectal Cancer? A Population-Based Cohort Study
Chin-Chia Wu, Cheng-Hung Lee, Ta-Wen Hsu, Chia-Chou Yeh, Mei-Chen Lin, Chun-Ming Chang, Jui-Hsiu Tsai
Journal of Clinical Medicine.2021; 10(22): 5313. CrossRef - Association between different systemic therapies and the risk of tuberculosis in psoriasis patients: A population‐based study
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International Journal of Clinical Practice.2021;[Epub] CrossRef - Differential Presentations of Arterial Thromboembolic Events Between Venous Thromboembolism and Atrial Fibrillation Patients
Yu-Sheng Lin, Ming-Shyan Lin, Victor Chien-Chia Wu, Yung-Lung Chen, Jung-Jung Chang, Pao-Hsien Chu, Gregory Y. H. Lip, Mien-Cheng Chen
Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef - Developing the New National Patient Sample and Evaluating Representations
Chul Young Yoon, Jae Joon Ahn, Gyeongmin Lee, Yongseok Choi, Lihyun Kim, Dae Yoo Ha, Ki-Bong Yoo
Health Insurance Review & Assessment Service Research.2021; 1(2): 166. CrossRef - Economic evaluation of transferring first-stroke survivors to rehabilitation wards: A 10-year longitudinal, population-based study
Chien-Min Chen, Yao-Hsu Yang, Meng Lee, Kai-Hua Chen, Shih-Shin Huang
Topics in Stroke Rehabilitation.2020; 27(1): 8. CrossRef - Risk of preventable hospitalization before and after diagnosis among rheumatoid arthritis patients compared to non-rheumatoid arthritis controls
Chang-Fu Kuo, Patricia B. Burns, Jung-Sheng Chen, Lu Wang, Kevin C. Chung
Joint Bone Spine.2020; 87(2): 149. CrossRef - Examining the Potential of Blockchain Technology to Meet the Needs of 21st-Century Japanese Health Care: Viewpoint on Use Cases and Policy
Tim Mackey, Hirofumi Bekki, Tokio Matsuzaki, Hiroshi Mizushima
Journal of Medical Internet Research.2020; 22(1): e13649. CrossRef - Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
Nen-Chung Chang, Patrick Hu, Tien-Hsing Chen, Chun-Tai Mao, Ming-Jui Hung, Chi-Tai Yeh, Ming-Yow Hung, Giuseppe Coppola
PLOS ONE.2020; 15(1): e0227571. CrossRef - Biologic Agents Reduce Cardiovascular Events in Rheumatoid Arthritis Not Responsive to Tumour Necrosis Factor Inhibitors: A National Cohort Study
Ming-Jer Hsieh, Cheng-Hung Lee, Ming-Lung Tsai, Chang-Fu Kao, Wen-Ching Lan, Yu-Tung Huang, Wen-Yi Tseng, Ming-Shien Wen, Shang-Hung Chang
Canadian Journal of Cardiology.2020; 36(11): 1739. CrossRef - Increased Risk of Systemic Lupus Erythematosus in Patients With Helicobacter pylori Infection: A Nationwide Population-Based Cohort Study
Meng-Che Wu, Pui-Ying Leong, Jeng-Yuan Chiou, Huang-Hsi Chen, Jing-Yang Huang, James Cheng-Chung Wei
Frontiers in Medicine.2020;[Epub] CrossRef - The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan
Pei-Han Yu, Chih-Fen Hu, Jen-Wei Liu, Chi-Hsiang Chung, Yong-Chen Chen, Chien-An Sun, Wu-Chien Chien
BMC Pediatrics.2020;[Epub] CrossRef - Are Anticholinergic Medications Associated With Increased Risk of Dementia and Behavioral and Psychological Symptoms of Dementia? A Nationwide 15-Year Follow-Up Cohort Study in Taiwan
Yia-Ping Liu, Wu-Chien Chien, Chi-Hsiang Chung, Hsin-An Chang, Yu-Chen Kao, Nian-Sheng Tzeng
Frontiers in Pharmacology.2020;[Epub] CrossRef - The impact of colectomy on the risk of cardiovascular disease among patients without colorectal cancer
Chin-Chia Wu, Ta-Wen Hsu, Chia-Chou Yeh, Cheng-Hung Lee, Mei-Chen Lin, Chun-Ming Chang
Scientific Reports.2020;[Epub] CrossRef - Associations Between Periodontal Health/Treatment and Cognitive Impairment: Latest Evidence From Epidemiological Studies
Misuzu Sato, Masanori Iwasaki, Kumiko Minagawa, Akane Miyamoto
Current Oral Health Reports.2020; 7(2): 119. CrossRef Validity of ICD-10-CM Codes Used to Identify Patients with Chronic Hepatitis B and C Virus Infection in Administrative Claims Data from the Taiwan National Health Insurance Outpatient Claims Dataset
Ming-Jen Sheu, Fu-Weng Liang, Sheng-Tung Li, Chung-Yi Li, Tsung-Hsueh Lu
Clinical Epidemiology.2020; Volume 12: 185. CrossRef- Preadmission Antihypertensive Drug Use and Sepsis Outcome: Impact of Angiotensin-Converting Enzyme Inhibitors (ACEIs) and Angiotensin Receptor Blockers (ARBs)
Ming-Shun Hsieh, Chorng-Kuang How, Vivian Chia-Rong Hsieh, Pau-Chung Chen
Shock.2020; 53(4): 407. CrossRef - Continuity of Care Is Associated with Medical Costs and Inpatient Days in Children with Cerebral Palsy
Kuang-Tsu Yang, Chun-Hao Yin, Yao-Min Hung, Shih-Ju Huang, Ching-Chih Lee, Tsu-Jen Kuo
International Journal of Environmental Research and Public Health.2020; 17(8): 2913. CrossRef - Effect of early eradication therapy on systemic lupus erythematosus risk in patients with Helicobacter pylori infection: a nationwide population-based cohort study
Meng-Che Wu, Jing-Yang Huang, Huang-Hsi Chen, James Cheng-Chung Wei
Lupus.2020; 29(7): 751. CrossRef Association Between Attention Deficit Hyperactivity Disorder and Risk of Burn Injury: A Propensity-Matched Cohort Study
Jia-Yin Yeh, Tsai-Yu Hou, Wei-Ting Tseng, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Jun-Cheng Weng, Charles Tzu-Chi Lee, Yi-Lung Chen, Min-Jing Lee
Neuropsychiatric Disease and Treatment.2020; Volume 16: 1249. CrossRef- Risk of ankylosing spondylitis following human papillomavirus infection: A nationwide, population-based, cohort study
Chen-Yu Wei, Jia-Ying Lin, Yi-Ting Wang, Jing-Yang Huang, James Cheng-Chung Wei, Jeng-Yuan Chiou
Journal of Autoimmunity.2020; 113: 102482. CrossRef Decreased Risk of Influenza in Child and Adolescent Patients with Attention-Deficit Hyperactivity Disorder Following Methylphenidate Treatment: A Nationwide Cohort Study in Taiwan
Hsuan Lee, Vincent Chin-Hung Chen, Yao-Hsu Yang, Ting-Yu Kuo, Tzu-Chin Lin, Shu-I Wu, Kai-Liang Kao, Jun-Cheng Weng, Brent Allan Kelsen, Sophie Hsin-Yi Liang
Neuropsychiatric Disease and Treatment.2020; Volume 16: 1309. CrossRef- Creating the BELgian COngenital heart disease database combining administrative and clinical data (BELCODAC): Rationale, design and methodology
Fouke Ombelet, Eva Goossens, Ruben Willems, Lieven Annemans, Werner Budts, Julie De Backer, Katya De Groote, Stéphane Moniotte, Liesbet Van Bulck, Ariane Marelli, Philip Moons
International Journal of Cardiology.2020; 316: 72. CrossRef - The Trend of Aggressive Treatments in End-of-Life Care for Older People With Dementia After a Policy Change in Taiwan
Ying Hsin Hsu, Ming Yueh Chou, Hsiu-Min Chen, Wei-Cheng Chang, Che Sheng Chu, Yu-Chun Wang, Chiao-Lin Hsu, Chih-Kuang Liang, Ching-Chih Lee, Yu Te Lin
Journal of the American Medical Directors Association.2020; 21(6): 858. CrossRef - Relationship between Helicobacter pylori infection and psoriasis: a nationwide population-based longitudinal cohort study
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- Data profile: the Korean Workers’ Compensation-National Health Insurance Service (KoWorC-NHIS) cohort
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Data resource profile: the National Health Insurance Research Database (NHIRD)
Figure 1. Administrative structure of the National Health Insurance Research Database [10].
Figure 2. Publications using the National Health Insurance Research Database from 2000 to 2018.
Figure 3. Data structure of the National Health Insurance Research Database.
Figure 1.
Figure 2.
Figure 3.
Data resource profile: the National Health Insurance Research Database (NHIRD)
| Database name | Year | No. of new case |
|---|---|---|
| Colorectal Cancer Health | 2002-2015 | 175,405 |
| Breast Cancer Health | 2002-2015 | 136,476 |
| Prostate Cancer Health | 2002-2015 | 53,937 |
| Systemic Lupus Erythematosus Health | 2002-2015 | 29,637 |
| Hypertension Health | 2002-2015 | 3,342,827 |
| Brain Tumour Health | 2002-2015 | 10,267 |
| Chronic Kidney Disease Health | 2002-2015 | 1,066,892 |
| End-Stage Renal Disease Health | 2002-2015 | 134,228 |
| Diabetes Mellitus Health | 2002-2015 | 1,720,602 |
| Injury | 2000-2015 | 25,925,939 |
| Triple-High |
2001-2015 | 6,558 |
| Disability Process | 1996, 1999, 2003, 2007, 2011 | 6,935 |
| Maternal and Child Health | 2004-2014 | 2,171,765 |
| Name of database | Year |
|---|---|
| Health data | |
| Taiwan Cancer Registry | 2007-2012 |
| Cause of death data | 1971-2014 |
| Birth certificate applications | 2001-2013 |
| Traffic accident data | 2003-2014 |
| “Triple-high Status” Survey | 2006-2007 |
| Taiwan Birth Cohort Study | 2005 |
| “Knowledge, Attitude, and Practice of Contraception” Survey | 1965-2008 |
| Taiwan Youth Health Survey File | 2006-2010 |
| Rare disease data | 2012 |
| Artificial reproductive data | 1998-2012 |
| Cancer screening – Pap smear data | 2004-2013 |
| Colorectal cancer screening | 2010-2013 |
| Breast cancer screening | 2004-2013 |
| Oral mucosal screening | 2010-2013 |
| Taiwan Healthy Behaviour Risk Factor Surveillance Survey File | 2007-2012 |
| Social surveys | |
| National Aboriginal Population Profile | 2006-2012 |
| Personal data for the sampled NHI claims cohorts | 2000, 2005 |
| National Health Interview Survey | 2001-2009 |
| Taiwan Longitudinal Study on Aging | 1998-2011 |
| Taiwan Smoking Behaviour Survey | 2004-2009 |
| Welfare databases | |
| The Juvenile Condition Survey in Taiwan-Fuchien Area | 2003 |
| Report of the Home Care Subsidy User Condition Survey | 2007 |
| The Satisfaction with Home Care Services Survey | 2011 |
| The Low-Income and Middle-Income Family Living Condition Survey | 2013 |
| Taiwan Longitudinal Study on Aging | 2009-2013 |
| Physically and Mentally Disabled Citizens Living and Demand Assessment Survey | 2011 |
| Single Parent Family Condition Survey | 2010 |
| Women’s Living Conditions Survey | 1998-2011 |
| Disabled Population Profile | 2014 |
| Low-income and middle-low-income household data | 2014 |
| Family violence data | 2011-2014 |
| Reported data of protection of children and youths | 2011-2014 |
| Reported data of sexual assault | 2011-2014 |
Table 1. Disease-specific databases of the National Health Insurance Research Database
Triple-High: hypertension, hyperglycaemia, hyperlipidaemia.
Table 2. Databases available for linkage
NHI, National Health Insurance.
