Figure 1Estimated input and output data model of incidence by age and sex in DISMOD II, males (A) and females (B).
Figure 2Input (i) and output (o) variables in DISMOD II modeling. Calculated from prevalence, incidence, case fatality and remission in multiple sclerosis using DISMOD II, males (A) and females (B). Calculation option: piecewise linear interpolation, moving average, cubic spline. (A) males and (B) females.
Figure 3
Years of life lost (YLL), years lived with disability (YLD) and disability-adjusted life year (DALY)s due to multiple sclerosis by age in Korea. (A) Age-specific composition of YLL and YLD of MS by age group. (B) Proportion of YLL and YLD of MS by age group.
DALY=YLL+YLD [14].
Table 1Input and output variables in DISMOD II modeling for multiple sclerosis in Korea
Age |
Input
|
Prevalence* (100,000)
|
Incidence†‡ (100,000)
|
Case fatality†‡ (100,000)
|
Total population§
|
Male |
Female |
Male |
Female |
Male |
Female |
Male |
Female |
0-4 |
0.71 |
0.34 |
0.060 |
0.067 |
0.007 |
0.004 |
938,126 |
870,320 |
5-9 |
0.71 |
0.34 |
0.060 |
0.069 |
0.009 |
0.005 |
1,482,622 |
1,354,937 |
10-14 |
0.95 |
1.59 |
0.060 |
0.069 |
0.009 |
0.005 |
1,776,997 |
1,588,358 |
15-19 |
0.9 |
3.51 |
0.032 |
0.097 |
0.009 |
0.005 |
1,738,188 |
1,538,473 |
20-24 |
2.62 |
4.15 |
0.160 |
0.330 |
91.977 |
62.687 |
1,685,748 |
1,550,575 |
25-29 |
2.62 |
4.15 |
0.149 |
0.747 |
128.768 |
104.478 |
2,033,618 |
1,911,523 |
30-34 |
4.53 |
6.41 |
0.347 |
0.275 |
413.898 |
297.762 |
2,008,237 |
1,889,720 |
35-39 |
4.53 |
6.41 |
0.216 |
0.269 |
643.842 |
574.628 |
2,243,495 |
2,141,558 |
40-44 |
5.84 |
5.33 |
0.083 |
0.123 |
919.774 |
705.225 |
2,104,253 |
2,007,394 |
45-49 |
5.84 |
5.33 |
0.216 |
0.139 |
1,011.751 |
1,097.016 |
2,147,505 |
2,100,878 |
50-54 |
4.74 |
4.77 |
0.041 |
0.056 |
1,241.695 |
1,436.569 |
1,776,842 |
1,744,397 |
55-59 |
4.74 |
4.77 |
0.029 |
0.034 |
1,839.547 |
1,671.644 |
1,242,203 |
1,255,354 |
60-64 |
2.76 |
3.87 |
0.013 |
0.021 |
1,885.536 |
1,880.599 |
974,150 |
1,038,552 |
65-69 |
2.76 |
3.87 |
0.018 |
0.039 |
1,756.768 |
1,530.599 |
829,526 |
987,096 |
70-74 |
1.32 |
1.86 |
0.007 |
0.007 |
1,793.559 |
1,358.210 |
610,634 |
825,685 |
75-79 |
1.32 |
1.86 |
0.000 |
0.026 |
1,747.570 |
1,253.733 |
345,459 |
590,729 |
80-84 |
1.32 |
1.86 |
0.000 |
0.026 |
1,655.593 |
783.583 |
163,459 |
345,906 |
85-89 |
1.32 |
1.86 |
0.000 |
0.026 |
735.819 |
888.061 |
65,151 |
167,598 |
90≤ |
3.96 |
5.58 |
0.000 |
0.078 |
2,207.457 |
2,664.183 |
17,951 |
66,832 |
Total |
3.26 |
3.99 |
NA |
NA |
NA |
NA |
24,187,107 |
23,979,437 |
Table 2Years of life lost (YLL), years lived with disability (YLD) and disability-adjusted life year (DALY)s due to multiple sclerosis in Korea
Age |
Male
|
Female
|
Total
|
YLL |
YLD |
DALY |
YLL |
YLD |
DALY |
YLL |
YLD |
DALY |
0-4 |
0 |
23 |
23 |
0 |
24 |
24 |
0 |
46 |
46 |
5-9 |
0 |
24 |
24 |
0 |
25 |
25 |
0 |
49 |
49 |
10-14 |
0 |
24 |
24 |
0 |
25 |
25 |
0 |
49 |
49 |
15-19 |
0 |
22 |
22 |
0 |
48 |
48 |
0 |
71 |
71 |
20-24 |
0 |
21 |
21 |
0 |
90 |
90 |
0 |
110 |
110 |
25-29 |
31 |
76 |
107 |
0 |
164 |
164 |
31 |
240 |
271 |
30-34 |
28 |
86 |
114 |
0 |
111 |
111 |
28 |
197 |
225 |
35-39 |
25 |
77 |
102 |
26 |
81 |
107 |
50 |
158 |
208 |
40-44 |
22 |
40 |
61 |
23 |
42 |
65 |
44 |
82 |
126 |
45-49 |
18 |
22 |
41 |
39 |
36 |
75 |
58 |
59 |
116 |
50-54 |
15 |
9 |
25 |
33 |
10 |
44 |
49 |
19 |
68 |
55-59 |
13 |
0 |
13 |
28 |
8 |
36 |
41 |
8 |
49 |
60-64 |
10 |
0 |
10 |
11 |
0 |
11 |
21 |
0 |
21 |
65-69 |
8 |
0 |
8 |
9 |
0 |
9 |
17 |
0 |
17 |
70-74 |
6 |
0 |
6 |
7 |
0 |
7 |
13 |
0 |
13 |
75-79 |
0 |
0 |
0 |
5 |
0 |
5 |
5 |
0 |
5 |
80-84 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
85-89 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
≥90 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Total |
176 |
423 |
599 |
181 |
665 |
846 |
356 |
1,088 |
1,444 |