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Epidemiology and Health 2021;e2021063.
DOI: https://doi.org/10.4178/epih.e2021063    [Accepted] Published online Sep 8, 2021.
Association between body temperature and leukocyte telomere length in middle-aged and older adults
Carolina García García1  , Chol Shin2  , Inkyung Baik1 
1Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, 02707 Seoul, Republic of Korea
2Department of Internal Medicine, Korea University Ansan Hospital, 15355 Ansan, Republic of Korea
Correspondence  Inkyung Baik ,Tel: 82-2-910-4774 , Fax: 82-2-910-5249 , Email: ibaik@kookmin.ac.kr
Received: Jun 10, 2021  Accepted after revision: Sep 8, 2021
Data on the association between body temperature (BT) and leukocyte telomere length (LTL), which has been widely used as a biomarker of cellular senescence in recent epidemiological studies, are limited. Aims: The present study aimed to explore the association between a normal BT range (35.0 to 37.5℃) and LTL in a 6-year longitudinal observation among 2004 male and female adults aged 50 or older.
BT was obtained by measuring a tympanic temperature and relative LTL was assayed using real-time polymerase chain reaction. Robust regression analysis was used to evaluate the association for baseline and follow-up values of LTL and their differences.
A significant inverse association was found between baseline BT and LTL: regression coefficient estimate was -0.03 [95% confidence interval: -0.07, -0.001] (p<0.05). Such an association was stronger in participants with a body mass index >25 kg/m2 and in males (p<0.01). However, BT was not associated with the follow-up LTL and 6-year longitudinal differences in LTL.
These findings suggest that having a higher BT within a range between 35 and 37.5 ℃ (95 and 99 ℉) may be detrimental for obese persons in terms of biological aging.
Keywords: body temperature; telomere length; obesity; aging; longitudinal study


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