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2 "Single nucleotide polymorphism"
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Interaction between vitamin E intake and a COMT gene variant on colorectal cancer risk among Korean adults: a case-control study
Shinyoung Jun, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim
Epidemiol Health. 2023;45:e2023100.   Published online November 14, 2023
DOI: https://doi.org/10.4178/epih.e2023100
  • 3,454 View
  • 124 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Previous human trials have not supported the anticarcinogenic effect of vitamin E despite biological plausibility and considerable epidemiological evidence. A possible explanation for this inconsistency is the interactive effect of the catechol-O-methyltransferase (COMT) gene and supplemental vitamin E on cancer. We examined whether a COMT gene variant modulates the effect of dietary vitamin E intake on colorectal cancer (CRC) risk.
METHODS
In this case-control study of Korean adults (975 cases and 975 age- and sex-matched controls), dietary vitamin E density (mg/1,000 kcal) was measured using a semiquantitative food frequency questionnaire, COMT single nucleotide polymorphism (SNP) rs740603 (A>G) was genotyped, and CRC was verified histologically. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression models with adjustments for potential confounders.
RESULTS
Higher vitamin E density was associated with a lower risk of CRC (highest vs. lowest quartiles: OR, 0.72; 95% CI, 0.55 to 0.96; p-for-trend=0.002). When stratified by COMT SNP rs740603 genotype, the inverse association between vitamin E density and CRC risk was confined to those with at least 1 A allele (≥median vs. <median: OR, 0.63; 95% CI, 0.51 to 0.78). The interaction between rs740603 and vitamin E density was significant (p-for-interaction=0.020). No direct association was observed between COMT SNP rs740603 and CRC risk (OR, 1.08; 95% CI, 0.83 to 1.41).
CONCLUSIONS
Our findings support a role for a genetic polymorphism in COMT in modifying the association between dietary vitamin E intake and CRC.
Summary
Korean summary
본 연구는 국립암센터에서 수집한 대장암 환자-대조군 자료를 활용하여, catechol-O-methyltransferase (COMT) 유전자의 단일염기다형성(SNP)에 따라 비타민 E 섭취와 대장암 위험 간의 연관성이 달라지는지 파악하고자 하였다. 분석 결과, COMT SNP rs740603의 유전자형에 따라 식이를 통한 비타민 E 섭취 밀도와 대장암 위험 간의 연관성이 다르게 나타나 COMT 유전자와 비타민 E 섭취 간의 상호작용이 대장암 발생 위험에 영향을 미칠 가능성이 있음을 제시하였다.
Key Message
In this case-control study of Korean adults, we examined whether a polymorphism in the catechol-O-methyltransferase (COMT) gene modulates the effect of dietary vitamin E intake on colorectal cancer risk. Our results suggest that the inverse association between vitamin E density and colorectal cancer risk is confined to carriers of the COMT rs740603 A allele. The findings of our study support the interactive effect of the COMT gene and vitamin E intake on colorectal cancer risk.

Citations

Citations to this article as recorded by  
  • The Role of Dietary Vitamins and Antioxidants in Preventing Colorectal Cancer: A Systematic Review
    Mohammed Ajebli, Christopher R Meretsky, Mourad Akdad, Ayoub Amssayef, Morad Hebi
    Cureus.2024;[Epub]     CrossRef
ADIPOQ Gene Variants Associated with Susceptibility to Obesity and Low Serum Adiponectin Levels in Healthy Koreans
Ji Wan Park, Jungyong Park, Sun Ha Jee
Epidemiol Health. 2011;33:e2011003.   Published online April 25, 2011
DOI: https://doi.org/10.4178/epih/e2011003
  • 18,990 View
  • 126 Download
  • 18 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>This study aimed to measure the association between the adiponectin, C1Q and collagen domain-containing (<italic>ADIPOQ</italic>) gene variants and obesity in Koreans.</p></sec><sec><title>METHODS</title><p>Three single nucleotide polymorphisms located in the <italic>ADIPOQ</italic> gene were genotyped in a population-based cross-sectional study of 986 healthy Koreans. Three different case-control groups (i.e. G1, G2, and G3) were defined according to body mass index (BMI) and serum adiponectin levels. Allelic and genotypic associations of this gene with obesity were measured using multivariate logistic regression analyses in each group.</p></sec><sec><title>RESULTS</title><p>The G allele of -11377C>G, a polymorphism located in the promoter region of the <italic>ADIPOQ</italic> gene (odds ratio (OR), 1.48; 95% confidence interval, 1.13-1.94) and most haplotypes including this allele significantly increased the risk for obesity. However, the OR decreased from 3.98 (G1 group) to 2.90 (G2 group) and 2.30 (G3 group) when a less strict definition of obesity was used. Most haplotypes, including this allele, significantly increased the risk of obesity. The statistical evidence from the GG genotype of -11377C>G (OR, 3.98) and the GT/GT diplotype composed of -11377G>C and +45T>G (OR, 5.20) confirmed the contribution of the G allele toward a predisposition for obesity.</p></sec><sec><title>CONCLUSION</title><p>These results suggest the contribution of the <italic>ADIPOQ</italic> gene toward susceptibility to obesity in healthy Koreans. The high-risk genotypes and haplotypes identified here may provide more information for identifying individuals who are at risk of obesity.</p></sec>
Summary

Citations

Citations to this article as recorded by  
  • Association study between adiponectin gene variants, serum levels and the risk of type 2 diabetes in Tunisian women: Insights from BMI stratification
    Sameh Sarray, Intissar Ezzidi, Saif Moussa, Hassen Ben Abdennebi, Nabil Mtiraoui
    Cytokine.2024; 181: 156695.     CrossRef
  • Risk variants of obesity associated genes demonstrate BMI raising effect in a large cohort
    Muhammad Saqlain, Madiha Khalid, Muhammad Fiaz, Sadia Saeed, Asad Mehmood Raja, Muhammad Mobeen Zafar, Tahzeeb Fatima, João Bosco Pesquero, Cristina Maglio, Hadi Valadi, Muhammad Nawaz, Ghazala Kaukab Raja, Nidaa Ababneh
    PLOS ONE.2022; 17(9): e0274904.     CrossRef
  • Association of the ADIPOQ-AS LncRNA polymorphism rs2241766 with obesity: A Meta-analysis
    M.N. Ammar, L. Lipovich, R.M. Ali, M.A. Amelina, T.P. Shkurat
    Human Gene.2022; 34: 201114.     CrossRef
  • Common Variants in Lipid Metabolism–Related Genes Associate with Fat Mass Changes in Response to Dietary Monounsaturated Fatty Acids in Adults with Abdominal Obesity
    Shatha S Hammad, Peter Eck, Jyoti Sihag, Xiang Chen, Philip W Connelly, Benoît Lamarche, Patrick Couture, Valérie Guay, Julie Maltais-Giguère, Sheila G West, Penny M Kris-Etherton, Kate J Bowen, David J A Jenkins, Carla G Taylor, Danielle Perera, Angela W
    The Journal of Nutrition.2019; 149(10): 1749.     CrossRef
  • Associations between polymorphisms of the ADIPOQ gene and hypertension risk: a systematic and meta-analysis
    Weina Fan, Xiaowei Qu, Jing Li, Xingning Wang, Yanping Bai, Qingmei Cao, Liqun Ma, Xiaoyao Zhou, Wei Zhu, Wei Liu, Qiang Ma
    Scientific Reports.2017;[Epub]     CrossRef
  • An Updated Systematic Review and Meta-analysis of Association Between Adiponectin Gene Polymorphisms and Coronary Artery Disease
    Haifeng Hou, Siqi Ge, Linlin Zhao, Chenglin Wang, Wei Wang, Xuezhen Zhao, Zheng Sun
    OMICS: A Journal of Integrative Biology.2017; 21(6): 340.     CrossRef
  • Change in Weight and Body Mass Index Associated With All-Cause Mortality in Korea: A Nationwide Longitudinal Study
    Yang-Hyun Kim, Seon Mee Kim, Kyung-do Han, Jang-Won Son, Seong-Su Lee, Sang Woo Oh, Won-Young Lee, Soon Jib Yoo
    The Journal of Clinical Endocrinology & Metabolism.2017; 102(11): 4041.     CrossRef
  • A Validation Study of Adiponectin rs266729 Gene Variant with Type 2 Diabetes, Obesity, and Metabolic Phenotypes in a Taiwanese Population
    Tun-Jen Hsiao, Eugene Lin
    Biochemical Genetics.2016; 54(6): 830.     CrossRef
  • ADIPOQ and IL6 variants are associated with a pro-inflammatory status in obeses with cardiometabolic dysfunction
    Raquel de Oliveira, Tamiris Invencioni Moraes, Alvaro Cerda, Mario Hiroyuki Hirata, Cristina Moreno Fajardo, Marcela Correia Sousa, Egidio Lima Dorea, Márcia Martins Silveira Bernik, Rosario Dominguez Crespo Hirata
    Diabetology & Metabolic Syndrome.2015;[Epub]     CrossRef
  • Metabolic abnormalities in young Egyptian women with polycystic ovary syndrome and their relation to ADIPOQ gene variants and body fat phenotype
    Moushira Zaki, Shams Kholoussi, Somaia Ismail, Haiam Abdel Raouf, Iman Helwa, Naglaa Hassan, Eman Youness, Nadia A. Mohamed, Sanaa Kamal, Walaa Yousef, Mohamed Shaker, Wafaa Ezzat, Yasser A. Elhosary, Omnia M. Saleh, Mona El Gammal, HalaT. El-Bassyouni, S
    Egyptian Journal of Medical Human Genetics.2015; 16(4): 367.     CrossRef
  • Gender-specific associations between ADIPOQ gene polymorphisms and adiponectin levels and obesity in the Jackson Heart Study cohort
    Pia Riestra, Samson Y. Gebreab, Ruihua Xu, Rumana J. Khan, Aurelian Bidulescu, Adolfo Correa, Fasil Tekola-Ayele, Sharon K. Davis
    BMC Medical Genetics.2015;[Epub]     CrossRef
  • Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis
    Jie-fu Lu, You Zhou, Gui-hua Huang, Hai-xing Jiang, Bang-li Hu, Shan-yu Qin
    Human Immunology.2014; 75(10): 1062.     CrossRef
  • Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia
    J S R Machado, A C T Palei, L M Amaral, A C Bueno, S R Antonini, G Duarte, J E Tanus-Santos, V C Sandrim, R C Cavalli
    Journal of Human Hypertension.2014; 28(2): 128.     CrossRef
  • Effect of the ADIPOQ Gene -11391G/A Polymorphism Is Modulated by Lifestyle Factors in Mexican Subjects
    Maritza Roxana Garcia-Garcia, María Antonieta Morales-Lanuza, Wendy Yareny Campos-Perez, Bertha Ruiz-Madrigal, Monserrat Maldonado-Gonzalez, Barbara Vizmanos, Ivan Hernandez-Cañaveral, Irinea Yañez-Sanchez, Sonia Roman, Arturo Panduro, Erika Martinez-Lope
    Lifestyle Genomics.2014; 7(4-6): 212.     CrossRef
  • Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure
    Yuqin Ye, Danhua Pu, Jiayin Liu, Fanghong Li, Yugui Cui, Jie Wu
    Gene.2013; 518(2): 262.     CrossRef
  • Adiponectin Level and Gene Variability Are Obesity and Metabolic Syndrome Markers in a Young Population
    Ivana Karmelić, Jasna Lovrić, Tamara Božina, Hana Ljubić, Željka Vogrinc, Nada Božina, Jadranka Sertić
    Archives of Medical Research.2012; 43(2): 145.     CrossRef
  • Single-nucleotide polymorphisms and haplotypes in the adiponectin gene contribute to the genetic risk for type 2 diabetes in Tunisian Arabs
    Nabil Mtiraoui, Intissar Ezzidi, Amira Turki, Arbi Chaieb, Touhami Mahjoub, Wassim Y. Almawi
    Diabetes Research and Clinical Practice.2012; 97(2): 290.     CrossRef
  • Associations of adiponectin gene polymorphisms with polycystic ovary syndrome: a meta-analysis
    Hongxia Jia, Lili Yu, Xuxiao Guo, Wei Gao, Zhaoshun Jiang
    Endocrine.2012; 42(2): 299.     CrossRef

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