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Health Statistics
A comparison of breast cancer survival across different age groups: a multicentric database study in Penang, Malaysia
King Fang Tan, Farzaana Adam, Hasmah Hussin, Noor Mastura Mohd Mujar
Epidemiol Health. 2021;43:e2021038.   Published online May 25, 2021
DOI: https://doi.org/10.4178/epih.e2021038
  • 13,122 View
  • 378 Download
  • 11 Web of Science
  • 10 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
This study compared breast cancer survival and the prognostic factors across different age groups of women in Penang, Malaysia. Data on 2,166 women with breast cancer who had been diagnosed between 2010 and 2014 were extracted from the Penang Breast Cancer Registry and stratified into 3 age groups: young (< 40 years old), middle-aged (40-59 years old), and elderly (≥ 60 years). The overall and relative survival rates were calculated using the life table method, median survival time was calculated using the Kaplan-Meier method, and comparisons between groups were conducted using the log-rank test. Prognostic factors were analyzed using a Cox proportional hazards model. The 5-year overall and breast cancer-specific survival rates for women with breast cancer in Penang were 72.9% and 75.2%, with a mean survival time of 92.5 months and 95.1 months, respectively. The 5-year breast cancer-specific survival rates for young, middle-aged, and elderly women were 74.9%, 77.8%, and 71.4%, respectively, with a mean survival time of 95.7 months, 97.5 months, and 91.2 months. There was a significant difference in breast cancer survival between age groups, with elderly women showing the lowest survival rate, followed by young and middle-aged women. Disease stage was the most prominent prognostic factor for all age groups. Survival rates and prognostic factors differed according to age group. Treatment planning for breast cancer patients should be age-specific to promote better cancer care and survival.
Summary
Key Message
The relationship between breast cancer survival and age at diagnosis has been explored, but information between survival at different age groups remains unclear, in addition to conflicting study results. This multicentre study was conducted to compare breast cancer survival across different age groups in an Asian setting.

Citations

Citations to this article as recorded by  
  • Illuminating the breast cancer survival rates among Southeast Asian women: A systematic review and meta-analysis spanning four decades
    Duc Tran Quang, Thanh Luong Thi, Khanh Nguyen Di, Chi Vu Thi Quynh, Huyen Nguyen Thi Hoa, Quang Phan Ngoc
    Current Problems in Cancer.2024; 48: 101062.     CrossRef
  • Clinical characteristics and prognostic factors of male breast cancer in China
    Han Lei, Baojie Hua, Yingying Mao, Wei Cui, Caiping Mao, Shaoxue Yang, Jiayu Li
    Frontiers in Oncology.2024;[Epub]     CrossRef
  • Five-year survival prognosis of young, middle-aged, and elderly adult female invasive breast cancer patients by clinical and lifestyle characteristics
    Yu-Tung Teng, Yong Alison Wang, Yaa-Hui Dong, Jason J. Liu
    Breast Cancer Research and Treatment.2024;[Epub]     CrossRef
  • Cancer–related symptoms among young and middle–aged women undergoing chemotherapy for breast cancer: Application of latent class analysis and network analysis
    Tingting Cai, Tingting Zhou, Qingmei Huang, Fulei Wu, Feixia Ni, Changrong Yuan
    European Journal of Oncology Nursing.2023; 63: 102287.     CrossRef
  • myBeST—A Web-Based Survival Prognostic Tool for Women with Breast Cancer in Malaysia: Development Process and Preliminary Validation Study
    Mohd Nasrullah Nik Ab Kadir, Suhaily Mohd Hairon, Najib Majdi Yaacob, Siti Norbayah Yusof, Kamarul Imran Musa, Maya Mazuwin Yahya, Seoparjoo Azmel Mohd Isa, Muhammad Hafizuddin Mamat Azlan, Imi Sairi Ab Hadi
    International Journal of Environmental Research and Public Health.2023; 20(4): 2985.     CrossRef
  • Clinical Features and Outcomes of Triple-Negative Breast Cancer Among Latin American Adolescents and Young Adults Compared to Middle-Aged and Elder Females: A Cohort Analysis Over 15 Years
    Bryan Valcarcel, J. Smith Torres-Roman, Daniel Enriquez-Vera, Gabriel De-la-Cruz-Ku
    Journal of Adolescent and Young Adult Oncology.2023; 12(5): 625.     CrossRef
  • Metastasis pattern and prognosis of large cell neuroendocrine carcinoma: a population-based study
    Tongchao Jiang, Haishuang Sun, Na Li, Tongcui Jiang
    Journal of Cancer Research and Clinical Oncology.2023; 149(15): 13511.     CrossRef
  • The prognostic impact of body mass index on female breast cancer patients in underdeveloped regions of northern China differs by menopause status and tumor molecular subtype
    Lijun Ma, Ailan Liu, Jinnan Gao, Haoliang Zhao
    Open Life Sciences.2023;[Epub]     CrossRef
  • A Metabolic Gene Signature to Predict Breast Cancer Prognosis
    Jun Lu, Pinbo Liu, Ran Zhang
    Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
  • Development of Predictive Models for Survival among Women with Breast Cancer in Malaysia
    Mohd Nasrullah Nik Ab Kadir, Najib Majdi Yaacob, Siti Norbayah Yusof, Imi Sairi Ab Hadi, Kamarul Imran Musa, Seoparjoo Azmel Mohd Isa, Balqis Bahtiar, Farzaana Adam, Maya Mazuwin Yahya, Suhaily Mohd Hairon
    International Journal of Environmental Research and Public Health.2022; 19(22): 15335.     CrossRef
Original Articles
A comparison of breast cancer survival among young, middle-aged, and elderly patients in southern Iran using Cox and empirical Bayesian additive hazard models
Samane Nematolahi, Seyyed Mohammad Taghi Ayatollahi
Epidemiol Health. 2017;39:e2017043.   Published online October 16, 2017
DOI: https://doi.org/10.4178/epih.e2017043
  • 11,151 View
  • 208 Download
  • 6 Web of Science
  • 5 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
A survival analysis of breast cancer patients in southern Iran according to age has yet to be conducted. This study aimed to quantify the factors contributing to a poor prognosis, using Cox and empirical Bayesian additive hazard (EBAH) models, among young (20-39 years), middle-aged (40-64 years), and elderly (≥ 65 years) women.
METHODS
Data from 1,574 breast cancer patients diagnosed from 2002 to 2012 in the cancer registry of Fars Province (southern Iran) were stratified into 3 age groups. The Kaplan-Meier method was used to estimate the overall survival rates. Cox and EBAH models were applied to each age category, and the Akaike information criterion was used to assess the goodness-of-fit of the 2 hazard models.
RESULTS
As of December 2012, 212 women (13.5%) in our study population had died, of whom 43 were young (15.3%), 134 middle-aged (11.8%), and 35 elderly (22.3%). The 5-year survival probability by age category was 0.83 (standard error [SE], 0.03), 0.88 (SE, 0.01), and 0.75 (SE, 0.04), respectively.
CONCLUSIONS
The Nottingham Prognostic Index was the most effective prognostic factor. The model based on Bayesian methodology performed better with various sample sizes than the Cox model, which is the most widely used method of survival analysis.
Summary

Citations

Citations to this article as recorded by  
  • The health literacy level and its related factors in Iranian women with breast cancer undergoing chemotherapy
    Reyhaneh Sadeghian, Mahsa Asadollahi Hamedani, Sajad Salehipour, Anahita Sarabandi, Fatemeh Kiani, Hassan Babamohamadi
    Frontiers in Public Health.2023;[Epub]     CrossRef
  • sHLA-G as a biomarker for colorectal cancer pathogenesis
    Sabrine Dhouioui, Nadia Boujelbene, Hanen Chelbi, Ines Zemni, Ines Ben Safta, Hadda-Imene Ouzari, Amel Mezlini, Abdel Halim Harrath, Vera Rebmann, Inès Zidi
    Journal of King Saud University - Science.2022; 34(1): 101708.     CrossRef
  • Geo-epidemiological reporting and spatial clustering of the 10 most prevalent cancers in Iran
    Ebrahim Babaee, Gholamreza Roshandel, Meysam Olfatifar, Arash Tehrani-Banihashemi, Arezou Ashaari, Marzieh Nojomi
    Geospatial Health.2021;[Epub]     CrossRef
  • BREAST CANCER IN WESTERN KAZAKHSTAN: INCIDENCE, MORTALITY AND FACTORS ASSOCIATED WITH SURVIVAL
    Marzhan A. Aitmagambetova, Yerbol Zh. Bekmukhambetov, Gaziza A. Smagulova, Anar B. Tulyayeva, Arip K. Koyshybaev, Andrey M. Grjibovski
    Ekologiya cheloveka (Human Ecology).2021; 28(7): 51.     CrossRef
  • Validation of the 8th edition of the American Joint Committee on Cancer Pathological Prognostic Staging for young breast cancer patients
    Juan Zhou, Jian Lei, Jun Wang, Chen-Lu Lian, Li Hua, Li-Chao Yang, San-Gang Wu
    Aging.2020; 12(8): 7549.     CrossRef
Intestinal obstruction: predictor of poor prognosis in colorectal carcinoma?
Mohd Azri Mohd Suan, Wei Leong Tan, Shahrul Aiman Soelar, Ibtisam Ismail, Muhammad Radzi Abu Hassan
Epidemiol Health. 2015;37:e2015017.   Published online March 30, 2015
DOI: https://doi.org/10.4178/epih/e2015017
  • 59,433 View
  • 184 Download
  • 10 Web of Science
  • 13 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
The goal of this study was to assess the relationship between intestinal obstruction and the prognosis of colorectal carcinoma.
METHODS
Data pertaining to 4,501 colorectal carcinoma patients were extracted from the national colorectal registry and analysed. Survival analysis was performed using the Kaplan-Meier method. The log-rank test was used to compare the survival rate between patients with intestinal obstruction and those without intestinal obstruction. The p-values<0.05 were considered to indicate statistical significance. Simple Cox proportional hazards regression analysis was used to estimate the crude hazard ratio of mortality from colorectal cancer.
RESULTS
Intestinal obstruction was reported in more than 13% of patients. The 3-year survival rate after treatment was 48.3% (95% confidence interval [CI], 43.9 to 52.8) for patients with intestinal obstruction (n=593) and 54.9% (95% CI, 53.1 to 56.6) for patients without intestinal obstruction (n=3,908). The 5-year survival rate for patients with intestinal obstruction was 37.3% (95% CI, 31.9 to 42.8), which was lower than that of patients without intestinal obstruction (45.6%; 95% CI, 43.5 to 47.7). After adjusting the hazard ratio for other prognostic variables, intestinal obstruction had a statistically significant negative correlation with the survival rate of colorectal cancer patients, with an adjusted hazard ratio of 1.22 (p=0.008).
CONCLUSIONS
The presence of intestinal obstruction is associated with a lower survival rate among colorectal cancer patients.
Summary

Citations

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  • A Novel Clinical Nomogram for Predicting Overall Survival in Patients with Emergency Surgery for Colorectal Cancer
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    Journal of Personalized Medicine.2023; 13(4): 575.     CrossRef
  • Colorectal Liver Metastases: A Literature Review of Viable Surgical Options with a Special Focus on Microwave Liver Thermal Ablation and Mini-Invasive Approach
    Michele Finotti, Francesco Enrico D’Amico, Maurizio Romano, Marco Brizzolari, Michele Scopelliti, Giacomo Zanus
    Journal of Personalized Medicine.2022; 13(1): 33.     CrossRef
  • A nomogram model for predicting prognosis of obstructive colorectal cancer
    Jian Lv, Yuan yuan Liu, Yi tao Jia, Jing li He, Guang yao Dai, Peng Guo, Zhao long Zhao, Yan ni Zhang, Zhong xin Li
    World Journal of Surgical Oncology.2021;[Epub]     CrossRef
  • A Comparison of Emergency First Presentations of Colorectal Cancer in Under–50 and Over–50 Year-Old Patients
    Prateush Singh, Krashna Patel, Pallavi Arya, Esha Singh, Amitabh Mishra
    Journal of Investigative Surgery.2020; 33(6): 514.     CrossRef
  • Survival Status and Predictors of Mortality Among Colorectal Cancer Patients in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A Retrospective Follow-up Study
    Bantalem Tilaye Atinafu, Fekadu Aga Bulti, Tefera Mulugeta Demelew
    Journal of Cancer Prevention.2020; 25(1): 38.     CrossRef
  • CR-Possum—Can It Be Used to Predict Morbidity? A Single-Centre Retrospective Study
    Viswakumar Prabakaran, Thamizhmathi Thangaraju, Anil C. Mathew, Vimalkumar Govindan, Vignesh Kannan, Tracy Rosalin Poulose
    Indian Journal of Surgical Oncology.2019; 10(1): 174.     CrossRef
  • Clinical Implications of Lymph Node Metastasis in Colorectal Cancer: Current Status and Future Perspectives
    Hye Jin Kim, Gyu–Seog Choi
    Annals of Coloproctology.2019; 35(3): 109.     CrossRef
  • Efficacy of 18-fluoro deoxy glucose-positron emission tomography computed tomography for the detection of colonic neoplasia proximal to obstructing colorectal cancer
    Daisuke Hojo, Toshiaki Tanaka, Miwako Takahashi, Koji Murono, Shigenobu Emoto, Manabu Kaneko, Kazuhito Sasaki, Kensuke Otani, Takeshi Nishikawa, Keisuke Hata, Kazushige Kawai, Toshimitsu Momose, Hiroaki Nozawa
    Medicine.2018; 97(31): e11655.     CrossRef
  • Kolorektal Kanserde Endoskopik Özelliklerler Tümör Patolojisini ve Tümör Evresini Predikte Edebilir mi?
    Muhammet Yener AKPINAR, Metin UZMAN, Zeynep GÖKTAŞ, Gülçin Güler ŞİMŞEK, Evrim KAHRAMANOĞLU AKSOY, Ferdane SAPMAZ, Yaşar NAZLIGÜL
    Endoskopi Gastrointestinal.2018; 26(3): 84.     CrossRef
  • The possibilities to improve the outcomes in patients with colon cancer complicated by acute obstruction
    Z. V. Totikov, V. Z. Totikov
    Khirurgiya. Zhurnal im. N.I. Pirogova.2017; (3): 17.     CrossRef
  • Colectomie par laparoscopie ou par laparotomie pour tumeur colique droite en occlusion : revue systématique de la littérature et méta-analyse
    R. Cirocchi, F.C. Campanile, S. Di Saverio, G. Popivanov, L. Carlini, D. Pironi, R. Tabola, N. Vettoretto
    Journal de Chirurgie Viscérale.2017; 154(6): 399.     CrossRef
  • Laparoscopic versus open colectomy for obstructing right colon cancer: A systematic review and meta-analysis
    R. Cirocchi, F. Cesare Campanile, S. Di Saverio, G. Popivanov, L. Carlini, D. Pironi, R. Tabola, N. Vettoretto
    Journal of Visceral Surgery.2017; 154(6): 387.     CrossRef
  • Advances in adjuvant therapy of colon cancer
    Santosh Kumar, Marcus S. Noel, Alok A. Khorana
    Seminars in Colon and Rectal Surgery.2016; 27(4): 204.     CrossRef
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