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Long-term association of pericardial adipose tissue with incident diabetes and prediabetes: the Coronary Artery Risk Development in Young Adults Study
Minsuk Oh, Wonhee Cho, Dong Hoon Lee, Kara M. Whitaker, Pamela J. Schreiner, James G. Terry, Joon Young Kim
Epidemiol Health. 2023;45:e2023001.   Published online December 3, 2022
DOI: https://doi.org/10.4178/epih.e2023001
  • 4,361 View
  • 113 Download
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
We examined whether pericardial adipose tissue (PAT) is predictive of prediabetes and type 2 diabetes over time.
METHODS
In total, 2,570 adults without prediabetes/diabetes from the Coronary Artery Risk Development in Young Adults Study were followed up over 15 years. PAT volume was measured by computed tomography scans, and the new onset of prediabetes/diabetes was examined 5 years, 10 years, and 15 years after the PAT measurements. Multivariable Cox regression models were used to examine the association between the tertile of PAT and incident prediabetes/diabetes up to 15 years later. The predictive ability of PAT (vs. waist circumference [WC], body mass index [BMI], waist-to-height ratio [WHtR]) for prediabetes/diabetes was examined by comparing the area under the receiver operating characteristic curve (AUC).
RESULTS
The highest tertile of PAT was associated with a 1.56 times (95% confidence interval [CI], 1.03 to 2.34) higher rate of diabetes than the lowest tertile; however, no association was found between the highest tertile of PAT and prediabetes in the fully adjusted models, including additional adjustment for BMI or WC. In the fully adjusted models, the AUCs of WC, BMI, WHtR, and PAT for predicting diabetes were not significantly different, whereas the AUC of WC for predicting prediabetes was higher than that of PAT.
CONCLUSIONS
PAT may be a significant predictor of hyperglycemia, but this association might depend on the effect of BMI or WC. Additional work is warranted to examine whether novel adiposity indicators can suggest advanced and optimal information to supplement the established diagnosis for prediabetes/diabetes.
Summary
Korean summary
본 연구는 심장 내 축적되는 내장지방과 5년에서 15년 뒤의 당뇨병 전조 단계 및 당뇨병의 발생률과 연관성이 있음을 제안한다. 또한, 본 연구는 심장 내 내장지방과 당뇨병 발생률의 관계는 체질량 지수 또는 허리둘레의 영향에 따라 상이할 수 있음을 제안한다.
Key Message
Pericardial adipose tissue may be a significant predictor of future hyperglycemia in adults, but this association might depend on the effect of body mass index or waist circumference.
Lifestyle-related predictors affecting prediabetes and diabetes in 20-30-year-old young Korean adults
Kyong Sil Park, Seon Young Hwang
Epidemiol Health. 2020;42:e2020014.   Published online March 19, 2020
DOI: https://doi.org/10.4178/epih.e2020014
  • 13,993 View
  • 288 Download
  • 5 Web of Science
  • 7 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
To investigate lifestyle-related predictors of prediabetes and diabetes in young adults aged 20–39 years using data from the 2014-2016 Korea National Health and Nutrition Examination Survey (KNHANES).
METHODS
This study is a cross-sectional, secondary analysis using the KNHANES data. Participants were classified into normal group (fasting plasma glucose [FPG] <100 mg/dL and/or hemoglobin A1c [HbA1c] <5.7%), prediabetes group (FPG 100-125 mg/dL and/or HbA1c 5.7-6.4%), and diabetes group (FPG ≥126 mg/dL and/or HbA1c ≥ 6.5%). The data were statistically analyzed using SPSS software.
RESULTS
Out of 4,190 participants, 27.7% of men and 16.3% of women were in the prediabetes group and 1.4% of men and 1.3% of women were in the diabetes group. Logistic regression confirmed that age and obesity are predictors of prediabetes and diabetes in both men and women. Additionally low physical activity and low education level are predictors of prediabetes in men and women, respectively (p<0.05).
CONCLUSIONS
This study has found that age and increased obesity are predictors of elevated blood glucose in young men and women in their 20s and 30s. A strategy to lower obesity by promoting physical activity in men in their 30s is essential to prevent metabolic syndrome and progression to prediabetes.
Summary
Korean summary
20-30대 젊은 성인 남성에서 당뇨전단계 27.7%, 당뇨 1.4%, 여성에서 당뇨전단계 16.4%, 당뇨 1.3%로 확인되었다. 당뇨전단계 및 당뇨의 이환을 예방하기 위해서 비만 관리가 필수적이며, 특히 교육수준이 낮은 젊은 여성과 신체활동이 낮은 30대의 남성에서 신체활동 증진을 통해 효율적으로 비만도를 낮추는 전략 마련이 필요함을 확인하였다.

Citations

Citations to this article as recorded by  
  • Effects of a Remote Physical Activity Improvement Program on Male Office Workers with Metabolic Syndrome in Their 30s and 40s with Sedentary Behavior: A Randomized Controlled Trial
    Kyong Sil Park, Seon Young Hwang
    Asian Nursing Research.2024; 18(2): 81.     CrossRef
  • Relationship between Marriage and Prediabetes among Healthcare Workers: Mediating Effect of Triglycerides
    Yong-Hsin Chen, Jia-June Lin, Hsiu-Mei Tang, Ching-Wen Yang, Gwo-Ping Jong, Yi-Sun Yang
    Medicina.2024; 60(9): 1418.     CrossRef
  • Prediabetes and all-cause mortality in young patients undergoing coronary artery angiography: a multicenter cohort study in China
    Yibo He, Hongyu Lu, Yihang Ling, Jin Liu, Sijia Yu, Ziyou Zhou, Tian Chang, Yong Liu, Shiqun Chen, Jiyan Chen
    Cardiovascular Diabetology.2023;[Epub]     CrossRef
  • A Study Analyzing the Relationship among Impaired Fasting Glucose (IFG), Obesity Index, Physical Activity, and Beverage and Alcohol Consumption Frequency in 20s and 30s:The Korea National Health and Nutrition Examination Survey (KNHANES) 2013-2015
    Yujin Lee, Jung-Hyun Kim
    The Korean Journal of Community Living Science.2022; 33(1): 19.     CrossRef
  • Sex differences in factors associated with prediabetes in Korean adults
    Jin Suk Ra
    Osong Public Health and Research Perspectives.2022; 13(2): 142.     CrossRef
  • Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
    Anshul Sharma, Chen Lulu, Kee-Ho Song, Hae-Jeung Lee
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Mediterranean Diet and Healthy Eating in Subjects with Prediabetes from the Mollerussa Prospective Observational Cohort Study
    Mireia Falguera, Esmeralda Castelblanco, Marina Idalia Rojo-López, Maria Belén Vilanova, Jordi Real, Nuria Alcubierre, Neus Miró, Àngels Molló, Manel Mata-Cases, Josep Franch-Nadal, Minerva Granado-Casas, Didac Mauricio
    Nutrients.2021; 13(1): 252.     CrossRef
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