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Systematic review of the published data on the worldwide prevalence of John Cunningham virus in patients with multiple sclerosis and neuromyelitis optica
Sonia Patricia Castedo Paz, Luciana Branco, Marina Alves de Camargo Pereira, Caroline Spessotto, Yara Dadalti Fragoso
Epidemiol Health. 2018;40:e2018001.   Published online January 5, 2018
DOI: https://doi.org/10.4178/epih.e2018001
  • 21,671 View
  • 555 Download
  • 29 Web of Science
  • 22 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
John Cunningham virus (JCV) is a polyoma virus that infects humans, mainly in childhood or adolescence, and presents no symptomatic manifestations. JCV can cause progressive multifocal leukoencephalopathy (PML) in immunosuppressed individuals, including those undergoing treatment for multiple sclerosis (MS) and neuromyelitis optica (NMO). PML is a severe and potentially fatal disease of the brain. The prevalence of JCV antibodies in human serum has been reported to be between 50.0 and 90.0%. The aim of the present study was to review worldwide data on populations of patients with MS and NMO in order to establish the rates of JCV seropositivity in these individuals.
METHODS
The present review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and used the following search terms: “JCV” OR “JC virus” AND “multiple sclerosis” OR “MS” OR “NMO” OR “neuromyelitis optica” AND “prevalence.” These terms were searched for both in smaller and in larger clusters of words. The databases searched included PubMed, MEDLINE, SciELO, LILACS, Google Scholar, and Embase.
RESULTS
After the initial selection, 18 papers were included in the review. These articles reported the prevalence of JCV antibodies in the serum of patients with MS or NMO living in 26 countries. The systematic review identified data on 29,319 patients with MS/NMO and found that 57.1% of them (16,730 individuals) were seropositive for the anti-JCV antibody (range, 40.0 to 69.0%).
CONCLUSIONS
The median worldwide prevalence of JCV among adults with MS or NMO was found to be 57.1%.
Summary

Citations

Citations to this article as recorded by  
  • Potential adverse events associated with sphingosine-1-phosphate (S1P) receptor modulators in patients with multiple sclerosis: an analysis of the FDA adverse event reporting system (FAERS) database
    Xiping Yang, Yan Yan, Suyao Liu, Zhiqing Wang, Xia Feng
    Frontiers in Pharmacology.2024;[Epub]     CrossRef
  • B-cell Depletion Therapy in Pediatric Neuroinflammatory Disease
    Helen C Wu, Grace Y Gombolay, Jennifer H Yang, Jennifer S Graves, Alison Christy, Xinran M Xiang
    Current Neurology and Neuroscience Reports.2024; 24(10): 479.     CrossRef
  • Analysis of Immunological Memory for John Cunningham Virus in a Mexican Population of Patients with Multiple Sclerosis Under Treatment
    Silvia García, Adriana García-Martell, Sandra Quiñones-Aguilar, Sergio Sauri-Suárez, Mario Antonio Téllez González, Guillermo García-Castillo, Juan Antonio Suárez-Cuenca, Christian Gabriel Toledo-Lozano, Paul Mondragón Terán, Sofia Lizeth Alcaraz-Estrada
    Biomedicines.2024; 12(12): 2737.     CrossRef
  • Revisiting JC virus and progressive multifocal leukoencephalopathy
    Angela Rocchi, Ilker K. Sariyer, Joseph R. Berger
    Journal of NeuroVirology.2023; 29(5): 524.     CrossRef
  • Progressive multifocal leukoencephalopathy in the context of newer therapies in hematology and review of new treatment strategies
    Panagiotis T. Diamantopoulos, Konstantinos Kalopisis, Aikaterini Tsatsou, Athina Efthymiou, Nefeli Giannakopoulou, Sevastianos Hatzidavid, Nora‐Athina Viniou
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The impact of disease characteristics on multiple sclerosis patients’ quality of life
Aziz Rezapour, Abdollah Almasian Kia, Sahar Goodarzi, Mojtaba Hasoumi, Soraya Nouraei Motlagh, Sajad Vahedi
Epidemiol Health. 2017;39:e2017008.   Published online February 19, 2017
DOI: https://doi.org/10.4178/epih.e2017008
  • 19,721 View
  • 401 Download
  • 50 Web of Science
  • 47 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
The aim of this study was to assess the quality of life (QoL) of patients with multiple sclerosis (MS), and to investigate the effects of characteristics of MS such as disease course, severity, and relapses on patients’ QoL.
METHODS
This was a cross-sectional study, in which 171 patients were enrolled. Health-related QoL was assessed using the Persian version of the Multiple Sclerosis Quality of Life-54 questionnaire. To measure patients’ disability status, we used the Expanded Disability Status Scale. Other variables included in the study were disease course and relapses of the disease.
RESULTS
The average scores for patients’ physical and mental QoL were 60.9±22.3 and 59.5±21.4, respectively. In a bivariate analysis, disease course, severity of the disease, and relapses were significantly associated with the physical and mental health composite scores. In a hierarchal regression analysis, disease course, severity of the disease, and relapses were responsible for 38 and 16% of the variance in physical and mental QoL, respectively. It was also observed that relapses were a strong predictor of both physical and mental QoL.
CONCLUSIONS
Our results showed that disease characteristics significantly affected both dimensions of QoL. It is therefore suggested that health care providers should be aware of these characteristics of MS to more successfully improve MS patients’ QoL.
Summary

Citations

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Burden of Disease of Multiple Sclerosis in Korea
Soo-Eun Chung, Hae-Kwan Cheong, Jae-Hyun Park, Ho Jin Kim
Epidemiol Health. 2012;34:e2012008.   Published online November 30, 2012
DOI: https://doi.org/10.4178/epih/e2012008
  • 23,225 View
  • 157 Download
  • 20 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. There are few reports on the burden of disease of MS, worldwide. The authors aim to estimate burden of disease and estimate the epidemiologic indexes of MS in Korea using available epidemiologic data.</p></sec><sec><title>METHODS</title><p>Epidemiologic indexes were computed using DISMOD II software based on prevalence from nationwide survey, incidence estimated from extrapolation, mortality from National Statistics Office, and duration of disease from literature as input indexes. We calculated disability-adjusted life year (DALY) as a measure of premature mortality and disability, equivalent to years of healthy life lost due to a given condition.</p></sec><sec><title>RESULTS</title><p>The incidence of MS in Korea was 0.1 per 100,000, higher in female than in male. The highest incidence was estimated in the age group between 35 and 44 years in male and age group between 25 and 29 years in female. Total burden of disease of MS was 1,394 DALY, comprised of 292 (21%) years of life lost and 1,101 (79%) years lived with disability. The mean age at onset of MS was 33 years old in men and 32 years old in female. Estimated duration of disease was 35 years in men and 40 years in female. Most of the DALY of MS occurred in the adult population between 25 and 54 years of age.</p></sec><sec><title>CONCLUSION</title><p>Although MS is a rare disease in Korea, most of the DALY arises from young people, which results in a major financial burden on the patient, family, health system and society.</p></sec>
Summary

Citations

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