Original Article
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Asymptomatic Middle East Respiratory Syndrome coronavirus infection using a serologic survey in Korea
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Yeong-jun Song, Jeong-Sun Yang, Hee Jung Yoon, Hae-Sung Nam, Soon Young Lee, Hae-Kwan Cheong, Woo-Jung Park, Sung Han Park, Bo Youl Choi, Sung Soon Kim, Moran Ki
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Epidemiol Health. 2018;40:e2018014. Published online April 15, 2018
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DOI: https://doi.org/10.4178/epih.e2018014
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19,109
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Abstract
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PDF
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Abstract
OBJECTIVES
The rates of asymptomatic infection with Middle East Respiratory Syndrome (MERS) coronavirus vary. A serologic study was conducted to determine the asymptomatic MERS infection rate in healthcare workers and non-healthcare workers by exposure status.
METHODS
Study participants were selected from contacts of MERS patients based on a priority system in 4 regions strongly affected by the 2015 MERS outbreak. A sero-epidemiological survey was performed in 1,610 contacts (average duration from exposure to test, 4.8 months), and the collected sera were tested using an enzyme-linked immunespecific assay (ELISA), immunofluorescence assay (IFA), and plaque reduction neutralization antibody test (PRNT). Among the 1,610 contacts, there were 7 ELISA-positive cases, of which 1 exhibited positive IFA and PRNT results.
RESULTS
The asymptomatic infection rate was 0.060% (95% confidence interval, 0.002 to 0.346). The asymptomatic MERS case was a patient who had been hospitalized with patient zero on the same floor of the hospital at the same time. The case was quarantined at home for 2 weeks after discharge, and had underlying diseases, including hypertension, angina, and degenerative arthritis.
CONCLUSIONS
The asymptomatic infection was acquired via healthcare-associated transmission. Thus, it is necessary to extend serologic studies to include inpatient contacts who have no symptoms.
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Summary
Korean summary
2015년 국내 MERS 유행시에 자가격리를 시행하였던 접촉자 약 15,000명 (의료인과 비의료인 포함) 중에서 주요 유행지역, 노출 강도 등을 고려하여 선별된 3,291명을 대상으로 무증상 감염여부를 확인하기 위한 혈청 역학조사를 수행하였다. 최종 검사에 참여한 1,610명 중에서 7명이 ELISA 양성 반응을 보였고, 그 중 1명이 IFA와 PRNT에서도 양성 반응을 보여 무증상 감염률은 0.060%(95% CI: 0.002-0.346)로 기존 연구에 비하여 낮았다. 최종 양성을 보인 1명은 노출 당시 1번환자와 가까운 병실에 입원하였던 환자였다.
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Citations
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Jefree Johari, Robert D. Hontz, Brian L. Pike, Tupur Husain, Norhayati Rusli, Rozainanee Mohd-Zain, Vunjia Tiong, Hai-Yen Lee, Boon-Teong Teoh, Sing-Sin Sam, Chee-Sieng Khor, Shih-Keng Loong, Juraina Abd-Jamil, Siti-Sarah Nor'e, Hasmawati Yahaya, Naim Che
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Le Minh Bui, Huong Thi Thu Phung, Thuy-Tien Ho Thi, Vijai Singh, Rupesh Maurya, Khushal Khambhati, Chia-Ching Wu, Md Jamal Uddin, Do Minh Trung, Dinh Toi Chu
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Afnan A. Degnah, Sawsan S. Al-amri, Ahmed M. Hassan, Abdulrahman S. Almasoud, Manar Mousa, Sarah A. Almahboub, Rowa Y. Alhabbab, Ahmed A. Mirza, Salwa I. Hindawi, Naif Khalaf Alharbi, Esam I. Azhar, Anwar M. Hashem
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Jang-Hoon Choi, Hye-Min Woo, Tae-young Lee, So-young Lee, Sang-Mu Shim, Woo-Jung Park, Jeong-Sun Yang, Joo Ae Kim, Mi-Ran Yun, Dae-Won Kim, Sung Soon Kim, Yi Zhang, Wei Shi, Lingshu Wang, Barney S. Graham, John R. Mascola, Nanshuang Wang, Jason S. McLella
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Dong Zhao, Mengmei Wang, Ming Wang, Yang Zhao, Zhishui Zheng, Xiaochen Li, Yunting Zhang, Tao Wang, Shaolin Zeng, Weihua Hu, Wenzhen Yu, Ke Hu
International Journal of Infectious Diseases.2020; 99: 219. CrossRef - Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Extent and implications for infection control: A systematic review
Jaffar A. Al-Tawfiq, Philippe Gautret
Travel Medicine and Infectious Disease.2019; 27: 27. CrossRef - Airflow analysis of Pyeongtaek St Mary's Hospital during hospitalization of the first Middle East respiratory syndrome patient in Korea
Seongmin Jo, Jinkwan Hong, Sang-Eun Lee, Moran Ki, Bo Youl Choi, Minki Sung
Royal Society Open Science.2019; 6(3): 181164. CrossRef - Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017
Sibylle Bernard-Stoecklin, Birgit Nikolay, Abdullah Assiri, Abdul Aziz Bin Saeed, Peter Karim Ben Embarek, Hassan El Bushra, Moran Ki, Mamunur Rahman Malik, Arnaud Fontanet, Simon Cauchemez, Maria D. Van Kerkhove
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International Journal of Environmental Research and Public Health.2018; 15(12): 2757. CrossRef - CD8+ T Cells Responding to the Middle East Respiratory Syndrome Coronavirus Nucleocapsid Protein Delivered by Vaccinia Virus MVA in Mice
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Viruses.2018; 10(12): 718. CrossRef - Considering Revision the Criteria for Patients under Investigations for MERS-CoV Infections: Diarrhea or Not
Mi-Na Kim, Eui-Chong Kim
Journal of Korean Medical Science.2018;[Epub] CrossRef
MERS-Original Articles
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Preventive behaviors by the level of perceived infection sensitivity during the Korea outbreak of Middle East Respiratory Syndrome in 2015
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Soon Young Lee, Hee Jeong Yang, Gawon Kim, Hae-Kwan Cheong, Bo Youl Choi
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Epidemiol Health. 2016;38:e2016051. Published online November 16, 2016
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DOI: https://doi.org/10.4178/epih.e2016051
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17,686
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Abstract
Summary
PDFSupplementary Material
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Abstract
OBJECTIVES
This study was performed to investigate the relationship between community residents’ infection sensitivity and their levels of preventive behaviors during the 2015 Middle East Respiratory Syndrome (MERS) outbreak in Korea.
METHODS
Seven thousands two hundreds eighty one participants from nine areas in Gyeonggi-do including Pyeongtaek, the origin of the outbreak in 2015 agreed to participate in the survey and the data from 6,739 participants were included in the final analysis. The data on the perceived infection sensitivity were subjected to cluster analysis. The levels of stress, reliability/practice of preventive behaviors, hand washing practice and policy credibility during the outbreak period were analyzed for each cluster.
RESULTS
Cluster analysis of infection sensitivity due to the MERS outbreak resulted in classification of participants into four groups: the non-sensitive group (14.5%), social concern group (17.4%), neutral group (29.1%), and overall sensitive group (39.0%). A logistic regression analysis found that the overall sensitive group with high sensitivity had higher stress levels (17.80; 95% confidence interval [CI], 13.77 to 23.00), higher reliability on preventive behaviors (5.81; 95% CI, 4.84 to 6.98), higher practice of preventive behaviors (4.53; 95% CI, 3.83 to 5.37) and higher practice of hand washing (2.71; 95% CI, 2.13 to 3.43) during the outbreak period, compared to the non-sensitive group.
CONCLUSIONS
Infection sensitivity of community residents during the MERS outbreak correlated with gender, age, occupation, and health behaviors. When there is an outbreak in the community, there is need to maintain a certain level of sensitivity while reducing excessive stress, as well as promote the practice of preventive behaviors among local residents. In particular, target groups need to be notified and policies need to be established with a consideration of the socio-demographic characteristics of the community.
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Summary
Korean summary
2015년 한국에서 발생한 메르스 유행 시 지역 주민이 인식하는 민감도와 예방행위 수준을 파악하고 연관성을 밝히고자 2015년 경기도 9개 시의 지역사회건강조사 대상자 6,739명을 대상으로 감염 민감도와 예방행위 등을 조사 분석하였다. 감염 민감도는 성별, 연령, 직업, 건강행위와 연관성이 있었으며, 감염에 대한 민감도가 높을수록 스트레스를 많이 받는 한편, 예방행위 실천에 긍정적인 영향을 미침을 알 수 있었다. 따라서 감염병 유행 시 지나친 스트레스는 줄이되 공중보건 위기에 대한 적정 수준의 민감도를 유지하고, 인구사회학적 특성을 고려한 관리정책이 요구된다.
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Mental health status of people isolated due to Middle East Respiratory Syndrome
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Hyunsuk Jeong, Hyeon Woo Yim, Yeong-Jun Song, Moran Ki, Jung-Ah Min, Juhee Cho, Jeong-Ho Chae
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Epidemiol Health. 2016;38:e2016048. Published online November 5, 2016
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DOI: https://doi.org/10.4178/epih.e2016048
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48,400
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1,178
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Abstract
Summary
PDFSupplementary Material
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Abstract
OBJECTIVES
Isolation due to the management of infectious diseases is thought to affect mental health, but the effects are still unknown. We examined the prevalence of anxiety symptoms and anger in persons isolated during the Middle East Respiratory Syndrome (MERS) epidemic both at isolation period and at four to six months after release from isolation. We also determined risk factors associated with these symptoms at four to six months.
METHODS
Of 14,992 individuals isolated for 2-week due to having contact with MERS patients in 2015, when MERS was introduced to Korea, 1,692 individuals were included in this study. Anxiety symptoms were evaluated with the Generalized Anxiety Disorder 7-item scale and anger was assessed with the State-Trait Anger Expression Inventory at four to six months after release from isolation for MERS.
RESULTS
Of 1,692 who came in contact with MERS patients, 1,656 were not diagnosed with MERS. Among 1,656, anxiety symptoms showed 7.6% (95% confidence interval [CI], 6.3 to 8.9%) and feelings of anger were present in 16.6% (95% CI, 14.8 to 18.4%) during the isolation period. At four to six months after release from isolation, anxiety symptoms were observed in 3.0% (95%CI, 2.2 to 3.9%). Feelings of anger were present in 6.4% (95% CI, 5.2 to 7.6%). Risk factors for experiencing anxiety symptoms and anger at four to six months after release included symptoms related to MERS during isolation, inadequate supplies (food, clothes, accommodation), social networking activities (email, text, Internet), history of psychiatric illnesses, and financial loss.
CONCLUSIONS
Mental health problems at four to six month after release from isolation might be prevented by providing mental health support to individuals with vulnerable mental health, and providing accurate information as well as appropriate supplies, including food, clothes, and accommodation.
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Summary
Korean summary
메르스 환자와의 밀착접촉으로 격리되었던 1,692명을 대상으로 격리 당시와 격리해제 후 4-6개월 시점의 불안증상과 분노감 유병율을 파악하고 격리 해제 후 4-6개월 시점에 불안증상과 분노감 유병과 연관된 격리기간 동안의 위험요인을 알아보고자 하였다.
메르스 격리자에서 격리시점의 불안증상 유병율은 7.6% (95%CI: 6.3-8.9%), 분노감 유병율은 16.6% (95%CI: 14.8-18.4%) 였고, 4-6개월 시점이 불안증상 유병율은 3.0% (95%CI: 2.2-3.9%), 분노감 유병율은 6.4% (95%CI: 5.2-7.6%) 이였다.
성별과 연령을 보정한 후 격리해제 4-6개월 지난 시점에서 불안증상 및 분노감 유병의 위험요인은 격리 당시 메르스 증상이 있었거나 구호품 보급이 충분하지 않았거나, 정신과 질환의 과거력이 있었던 경우, 재정 손실이 있었던 사람이었다.
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MERS-Epidemiologic Investigation
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Epidemiological investigation of the 119th confirmed Middle East Respiratory Syndrome coronavirus case with an indefinite mode of transmission during the Pyeongtaek outbreak in Korea
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Jong Hyuk Choi, Byoungin Yoo, Soon Young Lee, Eun Gyu Lee, Moran Ki, Woncheol Lee, Jong Rak Jung, Kyujin Chang
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Epidemiol Health. 2015;37:e2015054. Published online December 10, 2015
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DOI: https://doi.org/10.4178/epih/e2015054
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Abstract
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Abstract
Since the first case was diagnosed on May 20, 2015, there were 186 confirmed cases of Middle East Respiratory Syndrome (MERS) until the end of outbreak in South Korea. Although medical institutions were the most identifiable sources of MERS transmission in South Korea, similar to other countries, in-depth epidemiological investigation was required for some confirmed cases with indefinite contact history or hospital visit records. The subject of epidemiological investigation in the present study was a 35 year-old male patient diagnosed with MERS (#119) who lived in Asan-city and worked in Pyeongtaek-city. Various potential sources of transmission were carefully investigated. While he could have been exposed to MERS through a friend from Saudi Arabia or confirmed MERS cases in his workplace, neighboring areas, and medical institutions, as well as contacts in his home, the chances of transmission were low; however, the potential for transmission through his local community could not be excluded. Practically, it was difficult to determine the modes of transmission for all outbreak cases in communicable disease that occurred in this short period of time. The investigation to identify the mode of transmission in this case was ultimately unsuccessful. However, the various data collected and analyzed to reveal modes of transmission provided detailed information that could not be collected using only interview surveys.
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Summary
Korean summary
2015년 한국에서 유행한 메르스 환자들 중, 감염 경로가 불분명한 119번째 환자에 대한 심층 역학조사를 통해 다양한 감염경로의 가능성을 검토하였다. 감염경로를 명확하게 밝혀내지 못한 한계점이 있지만, 지역사회 전파에 대한 가능성을 제시하였다. 감염병 대유행시 효율적인 감염경로 파악을 위해서는 다방면의 자료에 대한 확보체계와 이를 신속히 분석하고 판단할 수 있는 전문 인력 확충이 필요하다.
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Citations to this article as recorded by
- A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences
Rebecca E. Ramshaw, Ian D. Letourneau, Amy Y. Hong, Julia Hon, Julia D. Morgan, Joshua C. P. Osborne, Shreya Shirude, Maria D. Van Kerkhove, Simon I. Hay, David M. Pigott
Scientific Data.2019;[Epub] CrossRef
MERS-Original Article
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Epidemiologic features of the first MERS outbreak in Korea: focus on Pyeongtaek St. Mary’s Hospital
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Kyung Min Kim, Moran Ki, Sung-il Cho, Minki Sung, Jin Kwan Hong, Hae-Kwan Cheong, Jong-Hun Kim, Sang-Eun Lee, Changhwan Lee, Keon-Joo Lee, Yong-Shik Park, Seung Woo Kim, Bo Youl Choi
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Epidemiol Health. 2015;37:e2015041. Published online September 17, 2015
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DOI: https://doi.org/10.4178/epih/e2015041
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Abstract
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Abstract
OBJECTIVES
This study investigated the epidemiologic features of the confirmed cases of Middle East Respiratory Syndrome (MERS) in Pyeongtaek St. Mary’s Hospital, where the outbreak first began, in order to identify lessons relevant for the prevention and control of future outbreaks.
METHODS
The patients’ clinical symptoms and test results were collected from their medical records. The caregivers of patients were identified by phone calls.
RESULTS
After patient zero (case #1) was admitted to Pyeongtaek St. Mary’s Hospital (May 15-May 17), an outbreak occurred, with 36 cases between May 18 and June 4, 2015. Six patients died (fatality rate, 16.7%). Twenty-six cases occurred in the first-generation, and 10 in the second-generation. The median incubation period was five days, while the median period from symptom onset to death was 12.5 days. While the total attack rate was 3.9%, the attack rate among inpatients was 7.6%, and the inpatients on the eighth floor, where patient zero was hospitalized, had an 18.6% attack rate. In contrast, caregivers and medical staff showed attack rates of 3.3% and 1.1%, respectively.
CONCLUSIONS
The attack rates were higher than those of the previous outbreaks in other countries. The outbreak spread beyond Pyeongtaek St. Mary’s Hospital when four of the patients were moved to other hospitals without appropriate quarantine. The best method of preventing future outbreaks is to overcome the vulnerabilities observed in this outbreak, such as ward crowding, patient migration without appropriate data sharing, and the lack of an initial broad quarantine.
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Summary
Korean summary
평택성모병원에서는 총 36명의 메르스 환자가 발생하여 이중 6명이 사망하였다. 또한 평택성모병원 유행의 발병률은 기존에 알려진 것보다 높았다. 한국의 메르스 유행이 시작된 평택성모병원에서 나타난 초기 방역 부족, 적절한 정보공유 없이 환자들이 병원간에 이동하는 것, 혼잡한 병동 문제 등의 감염병 전파 취약점을 극복하는 것이 향후 새로운 감염병 유행을 막을 수 있는 최선의 방법이 될 것이다.
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Citations to this article as recorded by
- Super-spreaders of novel coronaviruses that cause SARS, MERS and COVID-19: a systematic review
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Epidemiology and Health.2015; 37: e2015049. CrossRef
MERS-Epidemiologic Investigation
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Surveillance operation for the 141st confirmed case of Middle East Respiratory Syndrome coronavirus in response to the patient’s prior travel to Jeju Island
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Jong-Myon Bae
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Epidemiol Health. 2015;37:e2015035. Published online August 7, 2015
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DOI: https://doi.org/10.4178/epih/e2015035
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Abstract
Summary
PDFSupplementary Material
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Abstract
The provincial government of Jeju, South Korea, was notified that a 42-year-old man infected with the Middle East Respiratory Syndrome (MERS) coronavirus had gone sightseeing in Jeju Island. Although the visiting period might be interpreted as the incubation period of MERS, the province decided to conduct active surveillance to prevent a worst-case scenario. Based on the channel of movement of the patient, healthy isolation and active monitoring were conducted for persons who came in contact with the patient. During the active surveillance, none of the 56 persons in self-isolation and 123 persons under active monitoring became infected. This fact supports that MERS is not contagious during the incubation period.
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Summary
Korean summary
141번 MERS 양성확진자에 대한 역학조사를 통해 잠복기간에 제주도를 여행한 것이 확인되었다. 이에 제주도 MERS 방역본부는 최악의 경우를 염두에 두고, 밀접접촉자 56명과 일상접촉자 123명을 각각 자택격리와 능동모니터링 대상자로 조치하였다. 잠복기 14일을 기준으로 감시체계를 운영하였지만, 양성감염자는 전무하였다. 이는 MERS의 잠복기 동안에는 감염력이 없다는 근거가 된다.
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Citations
Citations to this article as recorded by
- Sources of Infection Among Confirmed Cases of COVID-19 in Jeju Province, Korea
Moonkyong Hwang, Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2021; 54(4): 245. CrossRef - A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences
Rebecca E. Ramshaw, Ian D. Letourneau, Amy Y. Hong, Julia Hon, Julia D. Morgan, Joshua C. P. Osborne, Shreya Shirude, Maria D. Van Kerkhove, Simon I. Hay, David M. Pigott
Scientific Data.2019;[Epub] CrossRef
MERS-Editorial
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2015 MERS outbreak in Korea: hospital-to-hospital transmission
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Moran Ki
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Epidemiol Health. 2015;37:e2015033. Published online July 21, 2015
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DOI: https://doi.org/10.4178/epih/e2015033
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43,438
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417
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47
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161
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Abstract
Summary
PDFSupplementary Material
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Abstract
The distinct characteristic of the Middle East Respiratory Syndrome (MERS) outbreak in South Korea is that it not only involves intra-hospital transmission, but it also involves hospital-to-hospital transmission. It has been the largest MERS outbreak outside the Middle East, with 186 confirmed cases and, among them, 36 fatal cases as of July 26, 2015. All confirmed cases are suspected to be hospital-acquired infections except one case of household transmission and two cases still undergoing examination. The Korean health care system has been the major factor shaping the unique characteristics of the outbreak. Taking this as an opportunity, the Korean government should carefully assess the fundamental problems of the vulnerability to hospital infection and make short- as well as long-term plans for countermeasures. In addition, it is hoped that this journal, <i>Epidemiology and Health</i>, becomes a place where various topics regarding MERS can be discussed and shared.
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Summary
Korean summary
한국의 메르스 유행은 병원내 감염뿐 아니라 병원에서 병원으로 전파되는 양상을 보인 것이 특징이다. 사우디아라비아 다음으로 가장 많은 환자가 발생하였는데 전체 확진자는 186명이고, 이중에 사망자는 36명이다. 확진자 대부분이 병원에서 감염된 것으로 추정된다. 가족간 감염이 의심되는 경우는 1명정도이며, 2명은 경로를 조사중인데 이중에 한명은 지역사회 감염이 의심된다. 한국의 의료체계 특성이 이번 유행에 중요한 요인이 되었다. 이 기회에 한국은 병원감염관리에 취약한 우리의 근본적인 문제점을 살펴서 장단기적인 대책을 마련하여야 할 것이다. 또한 역학회지가 메르스와 관련된 다양한 주제가 논의되는 장이 되기를 바란다.
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International Journal of Nursing Studies.2019; 91: 70. CrossRef - Airflow analysis of Pyeongtaek St Mary's Hospital during hospitalization of the first Middle East respiratory syndrome patient in Korea
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Royal Society Open Science.2019; 6(3): 181164. CrossRef - Comparative Analysis of Eleven Healthcare-Associated Outbreaks of Middle East Respiratory Syndrome Coronavirus (Mers-Cov) from 2015 to 2017
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Frontiers in Microbiology.2019;[Epub] CrossRef - Worldwide Reduction in MERS Cases and Deaths since 2016
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BMB Reports.2019; 52(6): 397. CrossRef - Risk Factors for Fatal Middle East Respiratory Syndrome Coronavirus Infections in Saudi Arabia: Analysis of the WHO Line List, 2013–2018
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Canadian Journal of Infectious Diseases and Medical Microbiology.2018; 2018: 1. CrossRef - Chaperna-Mediated Assembly of Ferritin-Based Middle East Respiratory Syndrome-Coronavirus Nanoparticles
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Yonsei Medical Journal.2017; 58(1): 174. CrossRef - MERS-CoV spike protein: a key target for antivirals
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New England Journal of Medicine.2017; 376(6): 584. CrossRef - Outcome of strict implementation of infection prevention control measures during an outbreak of Middle East respiratory syndrome
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American Journal of Infection Control.2017; 45(5): 502. CrossRef - DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice
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International Journal of Infectious Diseases.2017; 58: 37. CrossRef - Effects of operational decisions on the diffusion of epidemic disease: A system dynamics modeling of the MERS-CoV outbreak in South Korea
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Jung Wan Park, Keon Joo Lee, Kang Hyoung Lee, Sang Hyup Lee, Jung Rae Cho, Jin Won Mo, Soo Young Choi, Geun Yong Kwon, Ji-Yeon Shin, Jee Young Hong, Jin Kim, Mi-Yeon Yeon, Jong Seok Oh, Hae-Sung Nam
Emerging Infectious Diseases.2017; 23(6): 898. CrossRef - Zero Transmission of Middle East Respiratory Syndrome: Lessons Learned From Thailand
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Clinical Infectious Diseases.2017; 64(suppl_2): S167. CrossRef - A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein
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BMC Infectious Diseases.2017;[Epub] CrossRef - Impact of Middle East respiratory syndrome outbreak on the use of emergency medical resources in febrile patients
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Clinical and Experimental Emergency Medicine.2017; 4(2): 94. CrossRef - Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
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Journal of Korean Medical Science.2017; 32(10): 1717. CrossRef - The Impact of Middle East Respiratory Syndrome Outbreak on Trends in Emergency Department Utilization Patterns
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Asian Nursing Research.2017; 11(3): 230. CrossRef - Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study
Yaseen M. Arabi, Awad Al-Omari, Yasser Mandourah, Fahad Al-Hameed, Anees A. Sindi, Basem Alraddadi, Sarah Shalhoub, Abdullah Almotairi, Kasim Al Khatib, Ahmed Abdulmomen, Ismael Qushmaq, Ahmed Mady, Othman Solaiman, Abdulsalam M. Al-Aithan, Rajaa Al-Radda
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Epidemiology and Health.2017; 39: e2017052. CrossRef - Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants
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Emerging Microbes & Infections.2017; 6(1): 1. CrossRef - Risk Factors for Transmission of Middle East Respiratory Syndrome Coronavirus Infection During the 2015 Outbreak in South Korea
Seung Woo Kim, Jung Wan Park, Hee-Dong Jung, Jeong-Sun Yang, Yong-Shik Park, Changhwan Lee, Kyung Min Kim, Keon-Joo Lee, Donghyok Kwon, Young Joo Hur, BoYoul Choi, Moran Ki
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Clinical Microbiology and Infection.2016; 22(2): e11. CrossRef - Drivers of MERS-CoV transmission: what do we know?
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Expert Review of Respiratory Medicine.2016; 10(3): 331. CrossRef - Vaccines for the prevention against the threat of MERS-CoV
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Expert Review of Vaccines.2016; 15(9): 1123. CrossRef - JSIPC in The Future, Based on Its History of 30 Years
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Japanese Journal of Infection Prevention and Control.2016; 31(1): 1. CrossRef - Emerging infectious diseases: Focus on infection control issues for novel coronaviruses (Severe Acute Respiratory Syndrome-CoV and Middle East Respiratory Syndrome-CoV), hemorrhagic fever viruses (Lassa and Ebola), and highly pathogenic avian influenza vi
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American Journal of Infection Control.2016; 44(5): e91. CrossRef - Diagnosis for Imported Cases of Emerging and Reemerging Infectious Diseases in Korea
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Clinical Infectious Diseases.2016; 63(3): 363. CrossRef - Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015
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