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Original Article
Dietary mercury intake, the IL23R rs10889677 polymorphism, and the risk of gastric cancer in a Korean population: a hospital-based case-control study
Ji Hyun Kim, Madhawa Gunathilake, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
Epidemiol Health. 2024;46:e2024051.   Published online May 21, 2024
DOI: https://doi.org/10.4178/epih.e2024051
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  • 1 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
Mercury can stimulate immune responses through T helper 17 (Th17). The gene <i>IL23R</i> is a key factor in Th17 function, which may also contribute to digestive tract diseases. The aim of this study was to identify the associations between dietary mercury and gastric cancer (GC) and to investigate whether the <i>IL23R</i> rs10889677 polymorphism modifies those associations.
METHODS
This case-control study included 377 patients with GC and 756 healthy controls. Dietary mercury intake (total mercury and methylmercury) was assessed using a dietary heavy metal database incorporated into the food frequency questionnaire. <i>IL23R</i> genetic polymorphism rs10889677 (A>C) was genotyped. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression models with adjustments for potential confounders.
RESULTS
A higher dietary methylmercury intake was associated with an elevated risk of GC (OR for the highest vs. lowest tertile [T<sub>3</sub> vs. T<sub>1</sub>], 2.02; 95% CI, 1.41 to 2.91; p for trend <0.001). The <i>IL23R</i> rs10889677 reduced the risk of GC in individuals who carried at least 1 minor allele (OR, 0.62; 95% CI, 0.46 to 0.83; p=0.001; AC/CC vs. AA). Individuals with a C allele exhibited a lower susceptibility to GC through methylmercury intake than those with the AA genotype (OR for the T<sub>3</sub> of methylmercury and AA carriers, 2.93; 95% CI, 1.77 to 4.87; and OR for the T<sub>3</sub> of methylmercury and AC/CC genotype, 1.30; 95% CI, 0.76 to 2.21; p-interaction=0.013).
CONCLUSIONS
Our findings suggest that a genetic polymorphism, rs10889677 in <i>IL23R</i>, plays a role in modifying the association between dietary methylmercury intake and the risk of GC.
Summary
Korean summary
본 연구는 식이 수은과 위암 간의 연관성을 탐색하고, microRNA-lethal-7의 예측된 결합 부위 내에 위치한 IL23R rs10889677 다형성이 이러한 연관성에 영향을 미칠 수 있는지 규명하고자 합니다. 식이 메틸수은 섭취량에 비례하여 위암 발생 위험이 증가하는 경향이 확인되었고, IL23R rs10889677 다형성은 식이 메틸수은으로 의한 위암 발생 위험을 조절하는 인자로 작용할 수 있음을 시사합니다.
Key Message
This study aimed to investigate the associations between dietary mercury and gastric cancer (GC) and to determine whether the IL23R rs10889677 polymorphism, located within a predicted binding site for microRNA-lethal-7, may modify these associations. A higher dietary methylmercury intake was associated with an increased risk of GC, while the IL23R rs10889677 polymorphism may modify the detrimental effect of dietary methylmercury on gastric carcinogenesis.

Citations

Citations to this article as recorded by  
  • Replication Study and Meta‐Analysis of the Contribution of Seven Genetic Polymorphisms in Immune‐Related Genes to the Risk of Gastric and Colorectal Cancers
    Weiguang Zhou, Siqi Yuan, Wenqiang Kang, Xiangyuan Deng, Hang Zhou, Jiangyi Ruan, Xianhong Feng, Meifang Qi, Bifeng Chen
    International Journal of Immunogenetics.2025; 52(1): 39.     CrossRef
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