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- Cohort profile: the KDCA-Tuberculosis-NHIS cohort linking tuberculosis surveillance and health insurance data in Korea
- Dawoon Jeong, Jinsun Kim, Seung Won Lee, Hongjo Choi, Hojoon Sohn, Jieun Kim, Hyewon Lee, Hyeran Jeong, Seung Eun Lee, Young-joon Park, Jaiyong Kim, Eun Mi Kim, Minji Koo, Hoyeon Jang, Young Ae Kang
- Epidemiol Health. 2025;47:e2025071. Published online December 13, 2025
- DOI: https://doi.org/10.4178/epih.e2025071
- 6,198 View
- 111 Download
- 5 Web of Science
- 3 Crossref
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Abstract
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AbstractDespite a steady decline in incidence, tuberculosis (TB) remains a substantial public health burden in Korea, particularly among older adults. Existing national TB surveillance systems lack sufficiently comprehensive data to assess long-term outcomes and health disparities. The K-TB-N cohort integrates data from 3 national sources: the Korean Tuberculosis Surveillance System (2011-2022), the National Health Insurance Database (2010-2022), and mortality data from Statistics Korea (2010-2022). After data cleaning and linkage, the final cohort included 373,812 patients (375,440 episodes) with either drug-susceptible TB or drug- resistant TB. TB notifications declined by approximately 60% over the study period, while the median patient age continued to rise. Treatment success improved over time, accompanied by reductions in lost to follow-up. However, mortality during treatment increased, with more than half of deaths attributed to non-TB causes such as pneumonia, cancer, and cardiovascular disease. Post-treatment mortality also remained high, particularly among patients with drug-resistant TB. The K-TB-N cohort provides a comprehensive, linked dataset for advancing research on TB epidemiology, treatment outcomes, comorbidities, and health disparities. It enables evaluations of public health interventions, long-term prognosis, and strategies for post-TB care. This cohort will remain a valuable resource for shaping data-driven TB control policies in aging and high-burden settings.
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SummaryKorean summary
- K-TB-N 코호트는 결핵 신고자료, 건강보험청구자료, 통계청 사망자료를 연계한 국내 최초의 전국단위 결핵 통합자료 코호트이다. - 이 코호트를 결핵 치료 성과와 치료 종료 이후 사망을 포함한 장기예후 분석이 가능하다. - 코호트에 포함된 2011-2022년 사이, 결핵 발생은 60% 감소하였고, 결핵 환자의 평균 연령은 증가하였다. 결핵 치료 중 사망율은 증가하였는데, 사망원인의 50% 이상은 비결핵성 사망이었다.Key Message
- The K-TB-N cohort is the first national-level integrated TB cohort in South Korea that combines three distinct datasets, overcoming the limitations of single-source TB registries. - The linkage of clinical data (KTB-Surv), health insurance claims (NHID), and mortality records (Statistics Korea) allows long-term tracking of treatment outcomes and post-treatment mortality. - TB notifications declined by ~60% during the study period, while the median patient age increased. - The mortality during TB treatment rose, with over half of deaths attributed to non-TB causes. -
Citations
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- Suicide risk in people with tuberculosis in Republic of Korea: a nationwide cohort, 2012–2021
Chiwook Chung, Seung Won Lee, Dawoon Jeong, Hongjo Choi, Hojoon Sohn, Young Ae Kang
Infectious Diseases of Poverty.2026;[Epub] CrossRef - Clinical outcomes and recurrence after treatment of asymptomatic pulmonary tuberculosis: A nationwide cohort study
Se Hyun Kwak, Hongjo Choi, Seung Won Lee, Dawoon Jeong, Hojoon Sohn, Young Ae Kang
International Journal of Infectious Diseases.2026; 169: 108805. CrossRef - Context-dependent risk stratification using a tuberculin skin test induration threshold of ≥ 15 mm in school tuberculosis screening in Hangzhou, China: a historical cohort study
Xiangjie Meng, Yin Tang, Jun Shou, Nan Jiang, Yu Zhang
Tropical Medicine and Health.2026;[Epub] CrossRef
- Suicide risk in people with tuberculosis in Republic of Korea: a nationwide cohort, 2012–2021
- Cohort profile: understanding health service system needs for people with intellectual disability using linked data in New South Wales, Australia
- Simone Reppermund, Preeyaporn Srasuebkul, Claire M. Vajdic, Sallie-Anne Pearson, Rachael E. Moorin, Julian N. Trollor
- Epidemiol Health. 2024;46:e2024054. Published online June 12, 2024
- DOI: https://doi.org/10.4178/epih.e2024054
- 15,863 View
- 194 Download
- 7 Web of Science
- 7 Crossref
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AbstractThis cohort profile describes one of the largest linked datasets in the world concerning the health of people with intellectual disability. The cohort comprises a retrospective group of 100,089 individuals with intellectual disability who received disability and/or health services in New South Wales, Australia. Of these participants, 34% were female, with a median age at cohort entry of 3 years (interquartile range, 0-19). A separate comparator cohort included 455,677 individuals, matched by 5-year age group, sex, and residential postcode at a 5:1 ratio. Initial results indicate that between 2001 and 2018, people with intellectual disability experienced more than double the rate of hospitalisations (538 vs. 235 per 1,000 person-years), as well as markedly higher rates of emergency department presentations (707 vs. 379 per 1,000 person-years) and use of ambulatory mental health services (1,012 vs. 157 per 1,000 person-years), relative to the comparator cohort. The largest disparities in hospital admissions were for mental disorders, dialysis, and diseases of the nervous system and sense organs. Furthermore, individuals with intellectual disability had more than double the rate of dispensed medications found in the comparator cohort. Of these medications, 46.6% were for the treatment of nervous system conditions, as opposed to 24.7% for the comparator cohort. The mean±standard deviation age at death was 52±19 years for people with intellectual disability and 64±22 years for the comparator participants.
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SummaryKey Message
This cohort study of individuals with intellectual disability is one of the largest internationally looking at health profiles and health service use. The goal is to improve the health and well-being of individuals with intellectual disability by informing the development of services, variations in prescribing practices, and access to preventative health services.Citations
Citations to this article as recorded by- Contraception use in women with intellectual disability: a retrospective cohort study
Yunhe Huang, Peiwen Liao, Preeyaporn Srasuebkul, Pramudie Gunaratne, Julian Trollor
BMJ Sexual & Reproductive Health.2026; 52(3): 176. CrossRef - Addressing the challenges of intellectual disability identification for health policy and research in Australia
Helen Leonard, Kingsley Wong, Peiwen Liao, Manzoor Khan, Zoe Aitken, Jenny Bourke, Julian N. Trollor, Jenny Downs, Mary-Ann O’Donovan, Anne M. Kavanagh, Preeyaporn Srasuebkul
Frontiers in Psychiatry.2026;[Epub] CrossRef - Life expectancy of people with intellectual disability: a retrospective cohort study from New South Wales, Australia
Preeyaporn Srasuebkul, Julian Trofimovs, Julian Trollor
BMJ Open.2026; 16(2): e110184. CrossRef - Improving the health of people with intellectual disability: past progress and future directions
Gloria L. Krahn, Julian N. Trollor
Frontiers in Psychiatry.2026;[Epub] CrossRef - Cancer Incidence in People With Intellectual Disability and Down Syndrome in Australia: A Cohort Study
Julian Trofimovs, Claire M. Vajdic, Preeyaporn Srasuebkul, Sallie‐Anne Pearson, Julian N. Trollor
Cancer Medicine.2026;[Epub] CrossRef - Prevalence of psychiatric conditions in people with intellectual disability: A record linkage study in New South Wales, Australia
Samuel RC Arnold, Yunhe Huang, Preeyaporn Srasuebkul, Rachael C Cvejic, Stefan C Michalski, Julian N Trollor
Australian & New Zealand Journal of Psychiatry.2025; 59(5): 433. CrossRef - Predictors of mental illness onset in adolescents and adults with intellectual disability: A retrospective cohort study in New South Wales, Australia
Stefan C Michalski, Yunhe Huang, Preeyaporn Srasuebkul, Rachael C Cvejic, Samuel RC Arnold, Julian N Trollor
Australian & New Zealand Journal of Psychiatry.2025; 59(12): 1095. CrossRef
Data Profile- The Korea National Health and Nutrition Examination Survey data linked Cause of Death data
- Sungha Yun, Kyungwon Oh
- Epidemiol Health. 2022;44:e2022021. Published online February 9, 2022
- DOI: https://doi.org/10.4178/epih.e2022021
- 43,827 View
- 838 Download
- 39 Web of Science
- 40 Crossref
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Abstract
Summary
PDFSupplementary Material
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AbstractThe Korea National Health and Nutrition Examination Survey (KNHANES) is a national health survey that is conducted annually to assess the health and and health-related behaviors of Korean population. To utilize KNHANES data to studies of mortality risk factors, the Korea Disease Control and Prevention Agency (KDCA) constructed a database linking KNHANES data to cause-of-death statistics in Statistics Korea, made available to researchers since 2020. The KNHANES data were linked to the Cause of Death Statistics based on resident registration numbers for subjects aged 19 years or older who agreed to link the data. The linkage rate between 2007-2015 National Health and Nutrition Examination Survey and 2007-2019 Cause of Death Statistics was 97.1%. In the linked dataset, the total death rate was 6.6%, of which neoplasms accounted for the highest death rate (32.1%), followed by circulatory system disease (22.7%) and respiratory system disease (11.5%). The linked dataset was made available through the Research Data Center of the KDCA after a review of the research proposal, and will be made available after periodical updates.
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SummaryKorean summary
1. 국민건강영양조사 자료가 사망 위험요인 규명 연구에 활용되도록 통계청의 사망원인통계와 연계자료 구축함 2. 2007~2015년 국민건강영양조사와 2007~2019년 사망원인통계의 연계율은 97.1%이었음 3. 국민건강영양조사-사망원인통계 연계자료는 2020년부터 연구자에게 질병관리청 내 학술연구자료처리실를 통해 제공되고 있음Key Message
1. To utilize the Korea National Health and Nutrition Examination Survey (KNHANES) data to studies of mortality risk factors, the data were linked to the Cause of Death Statistics in the Statistics Korea. 2. The linkage rate between the 2007-2015 KNHANES and the 2007-2019 Cause of Death Statistics was 97.1%. 3. The Korea National Health and Nutrition Examination Survey data linked Cause of Death data have been provided to researchers through the Research Data Center in the Korea Disease Control and Prevention Agency (KDCA) since 2020. -
Citations
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Sergej M. Ostojic, Sonja Baltic, Dragana Zanini
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Epidemiology and Health.2026; 48: e2026001. CrossRef - Associations between Live Dietary Microbe Intake and Cardiometabolic Health in Korean Adults
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The Journal of Nutrition.2026; 156(5): 101459. CrossRef - Interaction Between Vitamin D Status and Aerobic Physical Activity in Relation to Cardiometabolic Risk Clustering Among Rural Older Adults
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Kyeongmin Jang
Geriatric Nursing.2026; 70: 103989. CrossRef - Sex differences in the association between hazardous alcohol consumption and suicide mortality: A population-based cohort study in South Korea
Seong-Uk Baek, Jin-Ha Yoon
Journal of Affective Disorders.2026; 411: 122031. CrossRef - Development and validation of an explainable machine learning model using routine laboratory biomarkers for identifying prevalent MASLD: Evidence from two observational studies
Jialin Wu, Wenting Wei, Terry Cheuk-Fung Yip, Xinyi Deng, Bonan Chen, Yang Lyu, Peiyao Yu, Tiejun Feng, Fuda Xie, Ge Zhang, Kangmin Zhuang, Aimin Li, Wei Kang
Clinical and Experimental Medicine.2026;[Epub] CrossRef - Association of Comorbidity Duration with the Occurrence and Prognosis of Steatotic Liver Disease
Hyunji Sang, Jihye Lim, Ha Il Kim
Digestive Diseases and Sciences.2025; 70(1): 386. CrossRef - Association between physical activity and mortality across levels of psychological stress and distress among Korean adults
Suyeon Kim, Younghwan Choi, Yeon Soo Kim
Mental Health and Physical Activity.2025; 28: 100662. CrossRef - Metabolic outcomes in non-alcoholic and alcoholic steatotic liver disease among Korean and American adults
Yeongmin Kim, Tae Sic Lee, Chang-Myung Oh
BMC Gastroenterology.2025;[Epub] CrossRef - Preventable Cancers Caused by Infection in Korea From 2015 to 2030
Sungji Moon, Jeoungbin Choi, Soseul Sung, Youjin Hong, Kwang-Pil Ko, Jung Eun Lee, Inah Kim, Seungho Ryu, Sun Ha Jee, Guen Hui Kim, Sun Young Yang, Aesun Shin, Sun-Seog Kweon, Jeongseon Kim, Jieun Jang, Sangjun Lee, Kyungsik Kim, Woojin Lim, Yoon-Jung Cho
Journal of Korean Medical Science.2025;[Epub] CrossRef - Socioeconomic Inequalities in Intention to Quit Smoking Plan Among Korean Adults, 2016–2021
Sunhee Park, Jeoung A Kwon, Byungmi Kim, Naeun Kim, Yejin Ha, Mark Parascandola, YoonJoo Choi
Tobacco Use Insights.2025;[Epub] CrossRef - Life’s Essential 8 and All-Cause and Cardiovascular Disease Mortality Among Korean Adults
Yunmin Han, Soomin Lee, Suyeon Kim, Younghwan Choi, Yeon Soo Kim
Circulation Journal.2025; 89(8): 1238. CrossRef - Socioeconomic gradients and inequalities in all-cause mortality and cardiovascular diseases: A retrospective cohort study using Korean NHANES-mortality linkage data
Chaiho Jeong, Kyu-Na Lee, Jin-Hyung Jung, Tae-Seo Sohn, Hyuk-Sang Kwon, Kyungdo Han, Seung-Hwan Lee
Public Health.2025; 244: 105767. CrossRef - Data Resource Profile: The Statistics of the Korea National Health and Nutrition Examination Survey (KNHANES) Biobank Project
Hye Ah Lee, Hye Ryun Kim, Hyunjin Park, So-Young Jung, Jae-Pil Jeon, Bomi Park, Keum Ji Jung, Sun Ha Jee, Sung-Mi Shim, Hyesook Park
Journal of Korean Medical Science.2025;[Epub] CrossRef - Impact of comorbidities on health-related quality of life in diabetic patients: Evidence from a South Korean population-based panel study
Djoko Priyono, Sanghee Kim
Science Progress.2025;[Epub] CrossRef - Dietary Intakes of Soy and Isoflavones and Risk of Mortality in a Population with High Soy Consumption
Sihan Song, Shinyoung Jun, Hyojee Joung, Jung Eun Lee
The Journal of Nutrition.2025; 155(10): 3517. CrossRef - Preventable cancer cases and deaths attributable to tobacco smoking in Korea from 2015 to 2030
Soseul Sung, Jihye An, Jeehi Jung, Hyeon Sook Lee, Sungji Moon, Inah Kim, Jung Eun Lee, Aesun Shin, Sun Ha Jee, Sun-Seog Kweon, Min-Ho Shin, Sangmin Park, Seungho Ryu, Sun Young Yang, Seung Ho Choi, Jeongseon Kim, Sang-Wook Yi, Yoon-Jung Choi, Youjin Hong
Epidemiology and Health.2025; 47: e2025008. CrossRef - Preventable cancer cases and deaths attributable to deficit of physical activity in Korea from 2015 to 2030
Soseul Sung, Sungji Moon, Jihye An, Jeehi Jung, Hyeon Sook Lee, Youjin Hong, Sangjun Lee, Woojin Lim, Kyungsik Kim, Inah Kim, Jung Eun Lee, Sun Ha Jee, Aesun Shin, Ji-Yeob Choi, Sun-Seog Kweon, Min-Ho Shin, Sangmin Park, Seungho Ryu, Sun Young Yang, Seung
Epidemiology and Health.2025; 47: e2025010. CrossRef - Medication-Related Osteonecrosis of the Jaw: An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force
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Endocrinology and Metabolism.2025; 40(6): 787. CrossRef - Iodine Intake and Risk of Mortality: Evidence from a Nationally Representative Korean Cohort
Jung-Hwan Cho, Jun Young Kim, Nak Gyeong Ko, Hanaro Park, Byung Soo Kwan, Ji Min Han, Sunghwan Suh, Ji Cheol Bae, Tae Hyuk Kim, Sun Wook Kim, Jae Hoon Chung, Hye Rang Bak, Hye In Kim
Nutrients.2025; 17(24): 3859. CrossRef - Fraction of cancer incidence and mortality attributable to dietary factors in Korea from 2015 to 2030
Hyun Jeong Cho, Jin Young Yoo, Ga-Eun Yie, An Na Kim, Soseul Sung, Sungji Moon, Youjin Hong, Sangjun Lee, Inah Kim, Kwang-Pil Ko, Sun-Seog Kweon, Jung Eun Lee, Sue K. Park
Epidemiology and Health.2025; 47: e2025065. CrossRef - Chronic Disease Patterns and Their Relationship With Health-Related Quality of Life in South Korean Older Adults With the 2021 Korean National Health and Nutrition Examination Survey: Latent Class Analysis
Mi-Sun Lee, Hooyeon Lee
JMIR Public Health and Surveillance.2024; 10: e49433. CrossRef - Toloese Generates Nitric Oxide through Natural Radiation of Far Infrared Rays, Reducing Serum Glucose, Cholesterol, and Triglycerides
Min-Ho Yeo, Young-Hyeon Lee, Mi-Jin Ryu, Yong-Hak Choi, Hye-Sook Kim, Kyung-Soo Chang
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Nutrition Research and Practice.2024; 18(4): 554. CrossRef - Association of resting heart rate and physical activity with cardiovascular mortality: A population-based cohort study of Korean adults
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Journal of Sports Sciences.2024; 42(16): 1529. CrossRef - Association between physical activity levels and mortality across adiposity: A longitudinal study of age‐specific Asian populations
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Journal of the Korean Neurological Association.2024; 42(4): 361. CrossRef - Socioeconomic inequalities in the prevalence, non-awareness, non-treatment, and non-control of diabetes among South Korean adults in 2021
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- Dietary creatine intake and mental health among the Korean population
Review Paper- Population data science: advancing the safe use of population data for public benefit
- Kerina Helen Jones, David Vincent Ford
- Epidemiol Health. 2018;40:e2018061. Published online December 25, 2018
- DOI: https://doi.org/10.4178/epih.e2018061
- 27,154 View
- 169 Download
- 10 Web of Science
- 10 Crossref
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Abstract
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AbstractThe value of using population data to answer important questions for individual and societal benefit has never been greater. Governments and research funders world-wide are recognizing this potential and making major investments in data-intensive initiatives. However, there are challenges to overcome so that safe, socially-acceptable data sharing can be achieved. This paper outlines the field of population data science, the International Population Data Linkage Network (IPDLN), and their roles in advancing data-intensive research. We provide an overview of core concepts and major challenges for data-intensive research, with a particular focus on ethical, legal, and societal implications (ELSI). Using international case studies, we show how challenges can be addressed and lessons learned in advancing the safe, socially-acceptable use of population data for public benefit. Based on the case studies, we discuss the common ELSI principles in operation, we illustrate examples of a data scrutiny panel and a consumer panel, and we propose a set of ELSI-based recommendations to inform new and developing data-intensive initiatives.We conclude that although there are many ELSI issues to be overcome, there has never been a better time or more potential to leverage the benefits of population data for public benefit. A variety of initiatives, with different operating models, have pioneered the way in addressing many challenges. However, the work is not static, as the ELSI environment is constantly evolving, thus requiring continual mutual learning and improvement via the IPDLN and beyond.
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Summary
Citations
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Hasina Samji, Jorge A. Delgado-Ron, Kimberly A. Schonert-Reichl, Martin Guhn, David Long, Jenna Whitehead, Lauren Gorfinkle, Giulia De Arruda Maluf, Judy Wu, Julia Kaufmann, Jose M. del Casal, Jacqueline Maloney
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International Journal of Pediatric Otorhinolaryngology.2020; 130: 109836. CrossRef - Age-Dependent and Seasonal Changes in Menstrual Cycle Length and Body Temperature Based on Big Data
Takayuki Tatsumi, Makiko Sampei, Kazuki Saito, Yuka Honda, Yuka Okazaki, Naoko Arata, Kanako Narumi, Naho Morisaki, Tomonori Ishikawa, Satoshi Narumi
Obstetrics & Gynecology.2020; 136(4): 666. CrossRef - Public Views on Models for Accessing Genomic and Health Data for Research: Mixed Methods Study
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Review- Registry-based stroke research in Taiwan: past and future
- Cheng-Yang Hsieh, Darren Philbert Wu, Sheng-Feng Sung
- Epidemiol Health. 2018;40:e2018004. Published online February 4, 2018
- DOI: https://doi.org/10.4178/epih.e2018004
- 40,194 View
- 401 Download
- 23 Web of Science
- 20 Crossref
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Abstract
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AbstractStroke registries are observational databases focusing on the clinical information and outcomes of stroke patients. They play an important role in the cycle of quality improvement. Registry data are collected from real-world experiences of stroke care and are suitable for measuring quality of care. By exposing inadequacies in performance measures of stroke care, research from stroke registries has changed how we manage stroke patients in Taiwan. With the success of various quality improvement campaigns, mortality from stroke and recurrence of stroke have decreased in the past decade. After the implementation of a nationwide stroke registry, researchers have been creatively expanding how they use and collect registry data for research. Through the use of the nationwide stroke registry as a common data model, researchers from many hospitals have built their own stroke registries with extended data elements to meet the needs of research. In collaboration with information technology professionals, stroke registry systems have changed from web-based, manual submission systems to automated fill-in systems in some hospitals. Furthermore, record linkage between stroke registries and administrative claims databases or other existing databases has widened the utility of registry data in research. Using stroke registry data as the reference standard, researchers have validated several algorithms for ascertaining the diagnosis of stroke and its risk factors from claims data, and have also developed a claims-based index to estimate stroke severity. By making better use of registry data, we believe that we will provide better care to patients with stroke.
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Original ArticlesTOP- Is the Tuberculosis Case Reporting Rate of Medical Care Institutions in Private Sector low?
- Jong Seon Han, Won Gi Jhang, Young Hwangbo, Sung Soo Lee, Moran Ki
- Korean J Epidemiol. 2008;30(2):230-238. Published online December 31, 2008
- DOI: https://doi.org/10.4178/kje.2008.30.2.230
- 12,344 View
- 27 Download
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AbstractPURPOSE
To estimate the reporting rate of tuberculosis in one medium-sized city in Korea.METHODSData claimed by national health insurance corporationand notification data of KTBS (Korea Tuberculosis Surveillance System) were compared through medical record-linkage method. Regarding the cases that were claimed medical care fee as tuberculosis but not notified to KTBS, we reviewed medical charts of the patients and investigated the reasons of failure to notify.RESULTSNumber of cases claimed health insurance fee as tuberculosis occurrences in Cheonan was 2,331 in 2007, while 956 cases were matched as notified cases to KTBS after electronic record-linkage by personal identifier. Among remaining 1,375 cases that were not matched, real missed cases through medical record review survey were found to be 104. The reasons of failure to notify were because of 'not tuberculosis patients' (500, 36.4%), 'notified in 2006' (421, 30.6%), 'diseases coding error' (341, 24.8%) and 'notified as other diseases' (9, 0.7%). Therefore, the corrected reporting rate was calculated at 93% (95% CI: 91.6% - 94.2%). Notably, reporting rate of clinics (58.1%) was significantly lower than those of hospitals (93.4%) or general hospitals (96.6%).CONCLUSIONSAll cases of tuberculosis diagnosis, which were claimed and not notified, were verified, the reporting rate was not as low as that of the data known through media. However, to reach the goal of tuberculosis elimination (reporting rate over 95%), more effort into improvement of the reporting system is necessary. -
Summary
- Examples and outlook of family-based cohort study.
- Jae Woong Sull, Sue Kyung Park, Heechoul Ohrr, Sun Ha Jee
- Korean J Epidemiol. 2008;30(1):49-59. Published online June 30, 2008
- DOI: https://doi.org/10.4178/kje.2008.30.1.49
- 65,535 View
- 61 Download
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AbstractFamily-based designs are commonly used in genetic association studies to identify and to locate genes that underlie complex diseases. In this paper, we review two examples of genome-wide association studies using family-based cohort studies, including the Framingham Heart Study and International Multi-Center ADHD Genetics Project. We also review statistical methods of family-based designs, including the transmission disequilibrium test (TDT), linkage analysis, and imprinting effect analysis. In addition, we evaluate the strengths and limitations of the family-based cohort design. Despite the costs and difficulties in carrying out this type of study, a family-based cohort study can play avery important role in genome wide studies. First, the design will be free from biases due to population heterogeneity or stratification. Moreover, family-based designs provide the opportunity to conduct joint tests of linkage and association. Finally, family-based designs also allow access to epigenetic phenomena like imprinting. The family-based cohort design should be given careful consideration in planning new studies for genome-wide strategies.
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- Occupational Cancer Surveillance System Using Data Linkage Analysis in Korea.
- Sang Yun Lee, Jaiyong Kim, Seongwoo Choi, Hyungjun Im, Kijung Yoon, Ho Jang Kwon, Soo Hun Cho, Daehee Kang
- Korean J Epidemiol. 1999;21(2):276-282.
- 10,675 View
- 15 Download
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AbstractTo develop the occupational cancer surveillance system in Korea, data linkage analysis was performed on the subjects of Health-monitoring-pocketbook (the list of subjects who were exposed to selected occupational carcinogens) and the retired workers of a cokes manufacturing factory using the Korean medical insurance data, Korean death certificate data and Korean cancer registry data. Study subjects comprised the 822 retired subjects and the 3101 present-post subjects of Health-monitoring-pocketbook and the 182 retired workers of a cokes manufacturing factory. The incidence of cancer of these study subjects was ascertained by linkage of Korean medical insurance data of year 1995-6, Korean death certificate data of year 1992-8 and Korean cancer registry data of year 1993-5. In the study subjects, Eighty seven percent were males and mean age was 39.3+/-8.9 year-old, Average work duration was 8.0+/-5.5 years. Chrome, asbestos and cokes were the most frequent exposed agents. In the study subjects, total 13 cancer cases were ascertained by data linkage analysis. In the ascertained cancer cases, 8 cases were male and 5 cases were female, and 7 cases were aged 40-49 yr, 5 cases were aged 50-59 yr and 1 cases were aged 30-39 yr. The commonest exposure agent in the ascertained cancer cases was asbestos and cokes. By the site of cancer, 3 stomach cancer cases, 2 hematopoietic cancer cases and 2 biliary tract cancer cases were ascertained. The occupational cancer surveillance system using data linkage analysis on the workers exposed to hazardous agents was the most feasible and efficient method in Korea. And to do this, establishment of occupational history information in several disease registry database is needed with the effort of estimating the proper size of workers exposed hazardous agents.
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