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2 "Dyslipidemia"
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Original Articles
Non-linear association between serum folate concentrations and dyslipidemia: Korea National Health and Nutrition Examination Survey 2016-2018
Taiyue Jin, Eun Young Park, Byungmi Kim, Jin-Kyoung Oh
Epidemiol Health. 2022;44:e2022046.   Published online May 15, 2022
DOI: https://doi.org/10.4178/epih.e2022046
  • 9,450 View
  • 325 Download
  • 2 Web of Science
  • 3 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
We aimed to evaluate the association between serum folate concentrations and the prevalence of dyslipidemia.
METHODS
A total of 4,477 adults (2,019 male and 2,458 female) enrolled in the Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2018 were included. Serum samples were used to assess folate concentrations and total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol levels. Multivariate logistic regression with sampling weights was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS
Elevated TC, TG, LDL-cholesterol and HDL-cholesterol levels were observed in 506 (11.3%), 646 (14.4%), 434 (9.7%), and 767 (17.1%) participants, respectively. We found non-linear trends between serum folate concentrations and the prevalence of hypercholesterolemia and hyper-LDL cholesterolemia from the restricted cubic smoothing spline. A higher prevalence of hypercholesterolemia was observed among participants in the first tertile of serum folate concentrations (OR,1.38; 95% CI, 1.05 to 1.79) than among those in the second tertile. However, a higher prevalence of hyper-LDL cholesterolemia was identified for both the first and third serum folate concentration tertiles (OR, 1.49; 95% CI, 1.08 to 2.05 and OR, 1.63; 95% CI, 1.20 to 2.20, respectively); furthermore, in these tertiles, the prevalence of hyper-LDL cholesterolemia was more pronounced among obese participants.
CONCLUSIONS
Non-linear associations may exist between serum folate concentrations and the prevalence of hypercholesterolemia and hyper-LDL cholesterolemia in adults. The findings suggest that more accurate recommendations about folate intake and folic acid fortification and supplementation should be provided.
Summary
Korean summary
본 연구는 국민건강영양조사 자료를 활용하여 한국 성인에서 혈청 엽산 농도와 고콜레스테롤혈증 및 저밀도지단백 (LDL) 콜레스테롤혈증 유병률 간의 비선형 연관성을 확인하였다. 이 결과는 적정 혈청 엽산 농도와 정확한 엽산 권장섭취량을 추정하는데 근거로 활용될수 있을 것이다.
Key Message
1. The prevalence of hypercholesterolemia and hyper-LDL cholesterolemia were non-linearly associated with serum concentrations of folate in the Korean population. 2. An inverse association with a significant linear trend between serum folate concentrations and prevalence of hypo-HDL cholesterolemia was observed. 3. In relation to folate intake and folic acid fortification and supplementation, more accurate recommendations should be provided.

Citations

Citations to this article as recorded by  
  • Association between traditional Korean fermented vegetables (kimchi) intake and serum lipid profile: using the Korean Genome and Epidemiology Study (KoGES) cohort
    Seok-Jae Oh, Wooje Lee, Sung Wook Hong, Sangah Shin
    European Journal of Nutrition.2024;[Epub]     CrossRef
  • A Review of Major Secondary Data Resources Used for Research in Traditional Korean Medicine
    Chunhoo Cheon, Bo-Hyoung Jang, Seong-Gyu Ko
    Perspectives on Integrative Medicine.2023; 2(2): 77.     CrossRef
  • The Utilization of Serum Folate and Homocysteine Tests and the Prevalence of Folate Deficiency in Reproductive-Age Korean Women during the COVID-19 Pandemic
    Rihwa Choi, Wonseo Park, Gayoung Chun, Sang Gon Lee, Eun Hee Lee
    Nutrients.2023; 15(14): 3236.     CrossRef
The Dose-response Relationship between Amount of Cigarette Smoking and Blood Lipids and Sugar.
Kang Sook Lee, Hyun Sook Hong, Jin Sook Jeong
Korean J Epidemiol. 1999;21(2):195-204.
  • 5,370 View
  • 12 Download
AbstractAbstract PDF
Abstract
PURPOSE
To explore the dose-response relationship between amount of cigarette smoking and blood lipids and sugar METHODS: In this cross-sectional study, we gathered the smoking history by self-administered questionnaire between 1994 and 1998 among 2888 men who visited the Health Promotion Center at St. Mary's Hospital, Seoul.
RESULTS
Adjusted for age, body mass index, the odds ratio of hypercholesterolemia (> or =240 mg/dl) were 2.06 (95% Confident Interval, 1.44-2.94), 2.03(95% CI 1.31-3.11), higher LDL-cholesterol(> or =160 mg/dl) were 2.06(95% CI 1.43-2.98), 2.25(95% CI 1.45-3.45) among group of men who smoked 21-30, over 30 cigarettes per day respectively compared with nonsmokers group. And adjusted for age, body mass index, the odds ratio of lower HDL-cholesterol(<35 mg/dl) were 1.76(95% CI 1.34-2.33), 1.98(95% CI 1.39-2.81), 2.35(95% CI 1.54-3.54), hypertriglyceridemia(> or =200 mg/dl) were 1.93(95% CI 1.47-2.55), 2.57(95% CI 1.82-3.62), 2.80(95% CI 1.86-4.21) among group of men who smoked 11-20, 21-30, over 30 cigarettes per day respectively compared with nonsmokers group. The adjusted odds ratio of diabetes(FBS> or =126 mg/dl) was 1.86(95% CI 1.10-3.06) only among who smoked more than 30 cigarettes compared with nonsmokers.
CONCLUSION
This study showed that there were dose-response relationships betwen amount of cigarette smoking and total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride and sugar. It suggested that health promotion program including quitting and decrease of cigarette smoking would be necessary to prevent cardiovascular disease in Korean men.
Summary

Epidemiol Health : Epidemiology and Health