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2 "Beta-thalassemia"
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Original Articles
The survival rate of patients with beta-thalassemia major and intermedia and its trends in recent years in Iran
Alireza Ansari-Moghaddam, Hossein Ali Adineh, Iraj Zareban, Mehdi Mohammadi, Mahtab Maghsoodlu
Epidemiol Health. 2018;40:e2018048.   Published online October 3, 2018
DOI: https://doi.org/10.4178/epih.e2018048
  • 13,696 View
  • 285 Download
  • 21 Web of Science
  • 20 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
Thalassemia is a common genetic disease in Iran, especially in the north and south of Iran. The present study sought to determine the survival rate of patients with thalassemia in highly endemic regions of Iran and its variation in patients born before and after 1971.
METHODS
The present historical cohort study extracted data from the health records of patients with beta-thalassemia major, beta-thalassemia intermedia, and sickle beta-thalassemia who had presented to thalassemia treatment centers in the past years. The collected data were analyzed using the Kaplan-Meier test, the log-rank test, and the chi-square test.
RESULTS
Of the total of 5,491 medical records (2,647 men and 2,634 women; mean age, 23.81±11.32 years), 3,936 belonged to patients with beta-thalassemia major, and 999 and 89 to patients with beta-thalassemia intermedia and sickle beta-thalassemia, respectively. In 467 cases, the type of thalassemia was not clear. The cumulative survival rate was calculated as 0.92, 0.83, 0.74, and 0.51 by ages 25, 35, 45, and 55, respectively. The hazard ratio of death was 4.22 (p<0.05) for beta-thalassemia major and 0.77 for beta-thalassemia intermedia (p=0.70). It was calculated as 1.45 for men patients and as 3.82 for single patients.
CONCLUSIONS
The present study showed relatively high survival rates in patients with thalassemia. The survival of patients was unfavorable in poorer regions (Zahedan and Iranshahr). Factors including women gender, a higher level of education, being married, and living in metropolises decreased the risk of death at younger ages and improved survival.
Summary

Citations

Citations to this article as recorded by  
  • Beta thalassemia: Looking to the future, addressing unmet needs and challenges
    Michael Angastiniotis
    Annals of the New York Academy of Sciences.2024; 1532(1): 63.     CrossRef
  • Predicting factors of survival rates among alpha- and beta-thalassemia patients: a retrospective 10-year data analysis
    Kunapa Iam-arunthai, Tawatchai Suwanban, Pravinwan Thungthong, Supat Chamnanchanunt, Suthat Fucharoen
    Frontiers in Hematology.2024;[Epub]     CrossRef
  • Investigating the effectiveness of Case‐Based Technology‐Enhanced workshops (e‐Flipped vs. Online) among health worker nurses during the COVID‐19 pandemic
    Nahid Zarifsanaiey, Roghaye Sajjadian, Zahra Karimian, Laleh Khojasteh, Hadi Raeisi Shahraki
    Nursing Open.2023; 10(4): 2329.     CrossRef
  • The Need for Translational Epidemiology in Beta Thalassemia Syndromes
    Soteris Soteriades, Michael Angastiniotis, Dimitrios Farmakis, Androulla Eleftheriou, Aurelio Maggio
    Hematology/Oncology Clinics of North America.2023; 37(2): 261.     CrossRef
  • Desire for biological parenthood and patient counseling on the risk of infertility among adolescents and adults with hemoglobinopathies
    Anne‐Catherine Radauer‐Plank, Tamara Diesch‐Furlanetto, Monika Schneider, Greta Sommerhäuser, Lucía Alácan Friedrich, Vivienne Salow, Jill Dülberg, Miriam Diepold, Alicia Rovó, Linet Muthoni Njue, Beatrice Drexler, Laura Infanti, Sabine Kroiss, Ramona Mer
    Pediatric Blood & Cancer.2023;[Epub]     CrossRef
  • Systematic Literature Review Shows Gaps in Data on Global Prevalence and Birth Prevalence of Sickle Cell Disease and Sickle Cell Trait: Call for Action to Scale Up and Harmonize Data Collection
    Raffaella Colombatti, Inga Hegemann, Morten Medici, Camilla Birkegård
    Journal of Clinical Medicine.2023; 12(17): 5538.     CrossRef
  • Economic burden of adult patients with β-thalassaemia major in mainland China
    Xuemei Zhen, Jing Ming, Runqi Zhang, Shuo Zhang, Jing Xie, Baoguo Liu, Zijing Wang, Xiaojie Sun, Lizheng Shi
    Orphanet Journal of Rare Diseases.2023;[Epub]     CrossRef
  • Accelerated atherosclerosis in beta-thalassemia
    Julian Hurtado, Hassan Sellak, Giji Joseph, Caitlin V. Lewis, Crystal R. Naudin, Sergio Garcia, James Robert Wodicka, David R. Archer, W. Robert Taylor
    American Journal of Physiology-Heart and Circulatory Physiology.2023; 325(5): H1133.     CrossRef
  • Prevalence and risk factors of fractures in transfusion dependent thalassemia – A Hong Kong Chinese population cohort
    Samantha Lai Ka Lee, Raymond Siu Ming Wong, Chi Kong Li, Wing Kwan Leung
    Endocrinology, Diabetes & Metabolism.2022;[Epub]     CrossRef
  • Estimation of the prevalence of Hemoglobinopathies in Erbil governorate, Kurdistan region of Iraq
    SarkarS Aziz, BahraK Hamad, HeroO Hamad, MuzhdaI Qader, EmanN Ali, RayanH Muhammed, MudhirSabir Shekha
    Iraqi Journal of Hematology.2022; 11(1): 19.     CrossRef
  • Thalassaemia
    Antonis Kattamis, Janet L Kwiatkowski, Yesim Aydinok
    The Lancet.2022; 399(10343): 2310.     CrossRef
  • Bone Mineral Density, Serum Calcium, and Vitamin D Levels in Adult Thalassemia Major Patients: Experience From a Single Center in Eastern India
    Soumya Santra, Kunal Sharma, Ipsita Dash, Shaikat Mondal, Himel Mondal
    Cureus.2022;[Epub]     CrossRef
  • Thalassemia Intermedia: Chelator or Not?
    Yen-Chien Lee, Chi-Tai Yen, Yen-Ling Lee, Rong-Jane Chen
    International Journal of Molecular Sciences.2022; 23(17): 10189.     CrossRef
  • The Outcomes of Patients with Haemoglobin Disorders in Cyprus: A Joined Report of the Thalassaemia International Federation and the Nicosia and Paphos Thalassaemia Centres (State Health Services Organisation)
    Michael Angastiniotis, Soteroula Christou, Annita Kolnakou, Evangelia Pangalou, Irene Savvidou, Dimitrios Farmakis, Androulla Eleftheriou
    Thalassemia Reports.2022; 12(4): 143.     CrossRef
  • Abnormal diastolic function and Global longitudinal strain in patients with Thalassemia Major on long term chelation therapy
    Sunil K. Nadar, Shahina Daar, Wael A. Abdelmottaleb, Muhammad M. Shaikh, Hafsa Al Mahrouqi, Majida Al-Raiisi, Moez Hassan, Badar Al Rawahi, Sarah Al Rahbi
    The International Journal of Cardiovascular Imaging.2021; 37(2): 643.     CrossRef
  • The effect of curcumin on serum copper, zinc, and zinc/copper ratio in patients with β-thalassemia intermedia: a randomized double-blind clinical trial
    Mohammadreza Saeidnia, Peyman Nowrouzi-Sohrabi, Mehran Erfani, Pooria Fazeli, Gholamhossein Tamaddon, Mehran Karimi
    Annals of Hematology.2021; 100(3): 627.     CrossRef
  • The Prevention of Thalassemia Revisited: A Historical and Ethical Perspective by the Thalassemia International Federation
    Michael Angastiniotis, Mary Petrou, Dimitrios Loukopoulos, Bernadette Modell, Dimitrios Farmakis, Panos Englezos, Androulla Eleftheriou
    Hemoglobin.2021; 45(1): 5.     CrossRef
  • Developing a databank for multiple transfusion patients: Rh antigen and phenotype distribution among 3000 regular blood donors in Iran
    Zahra Bakhshandeh, Naser Amirizadeh, Mahtab Maghsoodlu, Arezoo Oodi, Amirali Naghi, Ali Arab Khazaeli, Azita Azarkeivan
    Transfusion and Apheresis Science.2021; 60(3): 103124.     CrossRef
  • Thalassemia-Beta major-Case report
    Ambarkova Vesna, Krmzova Tina, Nonkulovski Zoran
    Archives of Hematology Case Reports and Reviews.2021; : 021.     CrossRef
  • An insight into Indonesian current thalassaemia care and challenges
    Pustika Amalia Wahidiyat, Teny Tjitra Sari, Ludi Dhyani Rahmartani, Iswari Setianingsih, Stephen Diah Iskandar, Anastasia Michelle Pratanata, Ivana Yapiy, Mikhael Yosia, Fernando Tricta
    ISBT Science Series.2020; 15(3): 334.     CrossRef
Associations between a health-promoting lifestyle and quality of life among adults with beta-thalassemia major
Aghbabak Maheri, Roya Sadeghi, Davoud Shojaeizadeh, Azar Tol, Mehdi Yaseri, Mojtaba Ebrahimi
Epidemiol Health. 2016;38:e2016050.   Published online November 15, 2016
DOI: https://doi.org/10.4178/epih.e2016050
  • 15,998 View
  • 325 Download
  • 16 Web of Science
  • 18 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
A health-promoting lifestyle (HPL) is a factor that affects the quality of life (QoL) in patients with beta-thalassemia (β-thalassemia). Due to the lack of studies of this issue, this study aimed to determine the association between HPL and QoL among adults with β-thalassemia.
METHODS
This cross-sectional (descriptive-analytic) study was conducted among 389 adult patients with β-thalassemia in Tehran, Iran. The research instrument included a questionnaire consisting of three parts: demographic items, the Short-Form Health Survey and the Health-Promoting Lifestyle Profile. The data were analyzed using SPSS version 23.0. The results were considered significant at the conventional p<0.05 level.
RESULTS
The mean age of the participants was 30.2±8.3 years. The mean score of the HPL dimensions was 127.28±21.53, and the mean score of the QoL domains was 61.44±23.38. The highest and the lowest mean scores of the HPL dimensions were found for spiritual growth (23.96±5.74) and physical activity (11.32±3.95), respectively. The QoL scores in all three domains (total, physical component summary score, and mental component summary score) were moderate. Health responsibility, physical activity, spiritual growth, and interpersonal relations were significant predictive factors of QoL in adults with β-thalassemia; these four dimensions explained 37.9% of the variance in QoL.
CONCLUSIONS
QoL and HPL were not at acceptable levels among patients with thalassemia. Therefore, educational interventions emphasizing spiritual growth, physical activity, and interpersonal relations are necessary for patients with thalassemia.
Summary

Citations

Citations to this article as recorded by  
  • The Effect of Benson Relaxation Technique on Anxiety and Quality of Life in Patients with Thalassemia Major: A Clinical Trial
    Mahnaz Ghaljeh, Fatemeh Kord Salarzehi, Sajad Salehipour
    Indian Journal of Hematology and Blood Transfusion.2023; 39(4): 557.     CrossRef
  • Aftermath of the COVID-19 Pandemic on Mental Health and Well-Being of Patients With Thalassemia Major in Pakistan: A Qualitative Study
    Muhammad Hammad , Rasikh Arif, Sehar Bano, Usman Ghani, Hima Bindu Reddy Basani, Vivek Sanker
    Cureus.2023;[Epub]     CrossRef
  • Thalassaemia - part 1: a clinical update for the dental team
    Brasanyaa Raveendran, Mohammed Dungarwalla
    BDJ Team.2023; 10(8): 28.     CrossRef
  • Cardiopulmonary testing in adult patients with β-thalassemia major in comparison to healthy subjects
    G. Piatti, M. Giuditta, D. Consonni, E. Cassinerio, M. D. Cappellini
    Annals of Hematology.2022; 101(11): 2445.     CrossRef
  • Thalassaemia - part 1: a clinical update for the dental team
    Brasanyaa Raveendran, Mohammed Dungarwalla
    British Dental Journal.2022; 233(11): 931.     CrossRef
  • Assessment of Health-promoting Lifestyle among Medical Students of Mashhad University of Medical Sciences in 2018-2019
    Nafiseh Mousavi Bazaz, Masoumeh Haghighi, Roya Boujaran, Vida Vakili, Mojtaba Mousavi Bazzaz, Gholamreza Haghighi
    Jorjani Biomedicine Journal.2022; 10(1): 4.     CrossRef
  • A multicenter cross-sectional study of the quality of life and iron chelation treatment satisfaction of patients with transfusion-dependent β-thalassemia, in routine care settings in Western Greece
    Vassilis Goulas, Alexandra Kouraklis-Symeonidis, Kyriaki Manousou, Vassileios Lazaris, George Pairas, Paraskevi Katsaouni, Eugenia Verigou, Vassiliki Labropoulou, Vassiliki Pesli, Panagiotis Kaiafas, Urania Papageorgiou, Argiris Symeonidis
    Quality of Life Research.2021; 30(2): 467.     CrossRef
  • Health literacy and health-promoting behaviors among adults at risk for diabetes in a remote Filipino community
    Christian Sandor B. Ydirin
    Belitung Nursing Journal.2021; 7(2): 88.     CrossRef
  • Effects of aquatic exercise on dimensions of quality of life and blood indicators in patients with beta-thalassemia major
    AliHasanpour Dehkordi, Toba Hasani, Kiavash Fekri, Fatemeh Deris, Shahram Etemadifar
    International Journal of Preventive Medicine.2020; 11(1): 128.     CrossRef
  • Examining the Relationship Between Spiritual Coping and Spiritual Wellbeing in Patients with Beta-Thalassemia Major
    Narjes Khatoon Sadeghi, Sakine Miri, Farnaz Jahantigh, Reza Nikbakht
    Medical - Surgical Nursing Journal.2019;[Epub]     CrossRef
  • Effect of different iron chelation regimens on bone mass in transfusion-dependent thalassemia patients
    Mohammadreza Bordbar, Sezaneh Haghpanah, Omid Reza Zekavat, Forough Saki, Asghar Bazrafshan, Haleh Bozorgi
    Expert Review of Hematology.2019; 12(11): 997.     CrossRef
  • Effect of A Mobile-Phone Mediated Based Education on Self-Care Behaviors of Patients With Thalassemia Major
    Fatemeh Gharaati, Teamur Aghamolaei, Zahra Hosseini, Sayed Hossein Davoodi, laleh Hassani, Razieh Mohamadi, Shokroallah Mohsseni, Moussa Soleimani-Ahmadi
    Journal of Caring Sciences.2019; 8(3): 149.     CrossRef
  • Comparative effectiveness of alendronate and zoledronic acid on bone mass improvement in transfusion-dependent thalassemia patients
    Omid Reza Zekavat, Mohamadreza Bordbar, Sezaneh Haghpanah, Forough Saki, Asghar Bazrafshan, Haleh Bozorgi
    Journal of Bone and Mineral Metabolism.2019; 37(6): 996.     CrossRef
  • Depression, Anxiety, and Perceived Social Support among Adults with Beta-Thalassemia Major: Cross-Sectional Study
    Aghbabak Maheri, Roya Sadeghi, Davoud Shojaeizadeh, Azar Tol, Mehdi Yaseri, Alireza Rohban
    Korean Journal of Family Medicine.2018; 39(2): 101.     CrossRef
  • The Relationship between Health-Promoting Lifestyle (HPL) and Academic Self-Efficacy among students
    S Saadat, M Kalantari, MB Kajbaf
    Research in Medical Education.2018; 9(4): 38.     CrossRef
  • Quality of Life: Transfusion Dependent Thalassemia vs Non-Transfusion Dependent Thalassemia
    Mehran Karimi, Nader Cohan
    Thalassemia Reports.2018; 8(1): 7489.     CrossRef
  • Poor quality of life as a predictor of survival among thalassemia patients in Iran
    Shahab Rezaeian
    Epidemiology and Health.2017; 39: e2017013.     CrossRef
  • Determinants of health-related quality of life in Iranian adults: evidence from a cross-sectional study
    Satar Rezaei, Mohammad Hajizadeh, Ali Kazemi, Masoud Khosravipour, Farid Khosravi, Shahab Rezaeian
    Epidemiology and Health.2017; 39: e2017038.     CrossRef
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