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Original Article
Aspergillus sensitization associated with current asthma in children in the United States: an analysis of data from the 2005-2006 NHANES
Hui-Ju Wen, Shu-Li Wang, Ming-Chieh Li, Yue Leon Guo
Epidemiol Health. 2022;44:e2022099.   Published online October 28, 2022
DOI: https://doi.org/10.4178/epih.e2022099
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  • 116 Download
  • 1 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
OBJECTIVES
This study investigated the association between allergen sensitization and current asthma in children in the United States using data from the 2005-2006 National Health and Nutrition Examination Survey (NHANES).
METHODS
Children who participated in the 2005–2006 NHANES, aged 6 years to 19 years, were included in this study. A structured questionnaire was used to assess asthma status (without asthma, asthma in remission, or current asthma). Nineteen specific immunoglobulin E (sIgE) levels were measured using the Pharmacia Diagnostics ImmunoCAP 1000 System (Kalamazoo, MI, USA). A machine-learning method was applied to select important sIgEs related to childhood asthma. Multivariate regression analysis was used to test this hypothesis.
RESULTS
In total, 2,875 children were recruited. The prevalence of ever having asthma and current asthma was 16.5% and 5.6%, respectively. Six sIgE levels were found to contribute to asthma using bootstrap forest selection. After adjusting for the child’s sex, age, and family income, children with double the sIgE levels of <i>Dermatophagoides farinae</i>, dogs, and <i>Aspergillus</i> were more likely to have current asthma than children without asthma (odds ratio [95% confident interval]: 1.11 [1.04 to 1.19], 1.30 [1.16 to 1.46], and 1.55 [1.39 to 1.72], respectively).
CONCLUSIONS
Our findings suggest that allergen sensitization, especially to <i>Aspergillus</i>, is associated with current asthma in children. Strategies to reduce sensitization may help prevent and manage asthma.
Summary
Key Message
This investigation studied 2,875 children from the National Health and Nutrition Examination Survey (NHANES) 2005-2006, aged less than 19 years, for the association between allergen sensitization and persistent asthma. Six specific IgE levels (i.e. Dermatophagoides farina, Dermatophagoides pteronyssinus, cat, dog, Alternaria, and Aspergillus) were found to contribute to asthma using bootstrap forest selection. Our findings suggested that allergen sensitization, especially to Aspergillus, is associated with asthma persistence in children after adjusting for potential confounders. Strategies to reduce sensitization may help prevent and manage asthma.

Citations

Citations to this article as recorded by  
  • Age-related differences in IgE between childhood and adulthood allergic asthma: Analysis of NHANES 2005–2006
    Heping Fang, Juan Li, Luo Ren, Enmei Liu
    World Allergy Organization Journal.2023; 16(12): 100842.     CrossRef
Data Profile
Data resource profile: the allergic disease database of the Korean National Health Insurance Service
Sunyong Yoo, Dong-Wook Kim, Young-Eun Kim, Jong Heon Park, Yeon-Yong Kim, Kyu-dong Cho, Mi-Ji Gwon, Jae-In Shin, Eun-Joo Lee
Epidemiol Health. 2021;43:e2021010.   Published online January 21, 2021
DOI: https://doi.org/10.4178/epih.e2021010
  • 12,347 View
  • 421 Download
  • 3 Web of Science
  • 3 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Abstract
Researchers have been interested in probing how the environmental factors associated with allergic diseases affect the use of medical services. Considering this demand, we have constructed a database, named the Allergic Disease Database, based on the National Health Insurance Database (NHID). The NHID contains information on demographic and medical service utilization for approximately 99% of the Korean population. This study targeted 3 major allergic diseases, including allergic rhinitis, atopic dermatitis, and asthma. For the target diseases, our database provides daily medical service information, including the number of daily visits from 2013 and 2017, categorized by patients’ characteristics such as address, sex, age, and duration of residence. We provide additional information, including yearly population, a number of patients, and averaged geocoding coordinates by <i>eup, myeon</i>, and <i>dong</i> district code (the smallest-scale administrative units in Korea). This information enables researchers to analyze how daily changes in the environmental factors of allergic diseases (e.g., particulate matter, sulfur dioxide, and ozone) in certain regions would influence patients’ behavioral patterns of medical service utilization. Moreover, researchers can analyze long-term trends in allergic diseases and the health effects caused by environmental factors such as daily climate and pollution data. The advantages of this database are easy access to data, additional levels of geographic detail, time-efficient data-refining and processing, and a de-identification process that minimizes the exposure of identifiable personal information. All datasets included in the Allergic Disease Database can be downloaded by accessing the National Health Insurance Service data sharing webpage (https://nhiss.nhis.or.kr).
Summary
Korean summary
알레르기질환DB는 환경적 변화와 의료이용 연관성 연구를 지원하기 위해 만들어진 누구나 다운로드 가능한 공개용DB이다. 알레르기질환DB는 한국 전국민의 사회인구학적 특성 및 의료이용 정보가 구축되어 있는 국민건강보험공단의 국민건강정보DB를 활용하여 구축되었다. 알레르기질환DB는 2013년~2017년 알레르기성 비염, 아토피, 천식 상병코드로 청구된 의료이용 정보를 제공하고 있으며, 이를 활용하여 특정 지역에 다양한 환경적 변화와 의료이용과의 연관성 연구 등에 활발히 활용될 것으로 기대된다.
Key Message
The Allergic Disease Database based on the National Health Insurance Data is constructed for analyzing how environmental factors affect the use of medical services. The database provides most Korean medical service information of allergic diseases, such as allergic rhinitis, atopic dermatitis, and asthma from 2013 and 2017. This information enables researchers to study how daily changes of environmental factors in certain regions would influence patients’ behavioral patterns of medical service utilization. Moreover, researchers can analyze the long-term trend of allergic diseases, and health effects caused by environmental factors such as daily climate and pollution data.

Citations

Citations to this article as recorded by  
  • Evaluation of the Regulatory Required Post-Authorization Safety Study for Propacetamol: Nested Case-Control and Case-Time-Control Studies
    Sungho Bea, Dongwon Yoon, Han Eol Jeong, Juhong Jung, Seung-Mok Park, Juhee Jeon, Young-Min Ye, Jae-Hyun Lee, Ju-Young Shin
    Yonsei Medical Journal.2024; 65(2): 120.     CrossRef
  • The relationship between exposure to environmental noise and risk of atopic dermatitis, asthma, and allergic rhinitis
    Yongho Lee, Seunghyun Lee, Seula Park, Seong-Kyu Kang, June-Hee Lee, Dong-Wook Lee, Won-Jun Choi, Wanhyung Lee
    Ecotoxicology and Environmental Safety.2023; 268: 115677.     CrossRef
  • Increased risk of cataract surgery in patients with allergic disease: a population based cohort study
    Ji-Sun Paik, Kyungdo Han, Gahee Nam, Sun-Kyoung Park, Ho Sik Hwang, Yoon Hong Chun, Kyung-Sun Na
    Scientific Reports.2022;[Epub]     CrossRef
Cohort Profile
The Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA), India
Padukudru Anand Mahesh, Komarla Sundararaja Lokesh, Purnima Madhivanan, Sindaghatta Krishnarao Chaya, Biligere Siddaiah Jayaraj, Koustav Ganguly, Murali Krishna
Epidemiol Health. 2018;40:e2018027.   Published online June 23, 2018
DOI: https://doi.org/10.4178/epih.e2018027
  • 13,416 View
  • 209 Download
  • 13 Web of Science
  • 13 Crossref
AbstractAbstract PDF
Abstract
Between 2006 and 2010, in 16 randomly selected villages in rural areas of Mysore district, in south India, 8,457 subjects aged 30 and above were screened for symptoms of chronic respiratory disease. Of the 8,457 subjects, 1,692 were randomly invited for further evaluation of lung function and chronic obstructive pulmonary disease (COPD) by spirometry, and 1,085 of these subjects underwent lung function assessments for prevalent COPD and its risk factors. These 1,085 subjects, who were then aged between 35 and 80 years, constituted the Mysuru stUdies of Determinants of Health in Rural Adults (MUDHRA) cohort. Among other findings, threshold of biomass fuel smoke exposure suitable for use as a dichotomous risk factor for the diagnosis of chronic bronchitis was established, with a minimum biomass smoke exposure index of 60 found to be significantly associated with an elevated risk of developing chronic bronchitis. Five years later (between 2014 and 2016), 869 of the 1,085 participants were followed up with repeat lung function assessments for incident COPD and all-cause mortality. A subset of these participants (n=200) underwent blood tests for vitamin D levels, antioxidant activity, an assessment for anxiety and depression, and another subset (n=98) underwent a bioplex assay for 40 serum cytokines.
Summary

Citations

Citations to this article as recorded by  
  • Exploring the links between indoor air pollutants and health outcomes in South Asian countries: a systematic review
    Laiba Rafiq, Syeda Hamayal Zahra Naqvi, Laila Shahzad, Syed Mustafa Ali
    Reviews on Environmental Health.2023; 38(4): 741.     CrossRef
  • Unmasking the Silent Threat: Periodontal Health’s Impact on COPD Severity and Hospitalization
    Anitha Subbappa, Komarla Sundararaja Lokesh, Sindaghatta Krishnarao Chaya, Mohammed Kaleem Ullah, Jayaraj Biligere Siddaiah, Nandlal Bhojraj, Padukudru Anand Mahesh
    Journal of Personalized Medicine.2023; 13(12): 1714.     CrossRef
  • Associations of Vitamin D, chronic obstructive pulmonary disease and acute exacerbations of COPD with anxiety and depression: a nested case control study
    Komarla Sundararaja Lokesh, Ananya Ananth Rao, Sindaghatta Krishnarao Chaya, Biligere Siddaiah Jayaraj, Attahalli Shivanarayanprasad Praveena, Murali Krishna, Purnima Madhivanan, Mahesh Padukudru Anand
    Wellcome Open Research.2022; 7: 86.     CrossRef
  • Calcifediol for Use in Treatment of Respiratory Disease
    Marta Entrenas-Castillo, Lourdes Salinero-González, Luis M. Entrenas-Costa, Rubén Andújar-Espinosa
    Nutrients.2022; 14(12): 2447.     CrossRef
  • Occupational Impact on The Respiratory Health & Function of Women, Working in The Glass Bangle Industry
    Arshad Sattar Lakho , Akbar Gohar Abro , Abdul Hafeez Thebo, Khalil Kazi , Saba Bashir, Ghulam Shahar Bano
    Pakistan BioMedical Journal.2022; : 107.     CrossRef
  • Vitamin D deficiency is associated with chronic obstructive pulmonary disease and exacerbation of COPD
    Komarla Sundararaja Lokesh, Sindaghatta Krishnarao Chaya, Biligere Siddaiah Jayaraj, Attahalli Shivanarayanprasad Praveena, Murali Krishna, Purnima Madhivanan, Padukudru Anand Mahesh
    The Clinical Respiratory Journal.2021; 15(4): 389.     CrossRef
  • Use of Exposomic Methods Incorporating Sensors in Environmental Epidemiology
    Brett T. Doherty, Jeremy P. Koelmel, Elizabeth Z. Lin, Megan E. Romano, Krystal J. Godri Pollitt
    Current Environmental Health Reports.2021; 8(1): 34.     CrossRef
  • Inflammatory Biomarkers Interleukin 1 Beta (IL-1β) and Tumour Necrosis Factor Alpha (TNF-α) Are Differentially Elevated in Tobacco Smoke Associated COPD and Biomass Smoke Associated COPD
    Bellipady Shyam Prasad Shetty, Sindaghatta Krishnarao Chaya, Sravan Kumar V, Maheswarappa Mahendra, Biligere Siddaiah Jayaraj, Komarla Sundararaja Lokesh, Koustav Ganguly, Padukudru Anand Mahesh
    Toxics.2021; 9(4): 72.     CrossRef
  • Prevalence of COPD among population above 30 years in India: A systematic review and meta-analysis
    Ashwani Verma, Nachiket Gudi, Uday N Yadav, Manas Pratim Roy, Amreen Mahmood, Ravishankar Nagaraja, Pradeepa Nayak
    Journal of Global Health.2021;[Epub]     CrossRef
  • Household air pollution in India and respiratory diseases: current status and future directions
    Surinder K. Jindal, Ashutosh N. Aggarwal, Aditya Jindal
    Current Opinion in Pulmonary Medicine.2020; 26(2): 128.     CrossRef
  • Methodology of Seasonal Waves of Respiratory Disorders survey conducted at respiratory outpatient clinics across India
    BharatBhushan Sharma, Sheetu Singh, KrishnaKumar Sharma, KP Suraj, Tariq Mahmood, KumarUtsav Samaria, Surya Kant, Nishtha Singh, Tejraj Singh, Aradhna Singh, Rajeev Gupta, ParvaizA Koul, Sundeep Salvi, Virendra Singh, SWORD Study Group
    Lung India.2020; 37(2): 100.     CrossRef
  • Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020
    Mahesh Padukudru Anand, Kjell Larsson, Gunnar Johanson, Harish C. Phuleria, P. Veeranna Ravindra, Lena Ernstgård, Ulaganathan Mabalirajan, Murali Krishna, Lena Palmberg, Krystal J. Godri Pollitt, Swapna Upadhyay, Koustav Ganguly
    Toxics.2020; 8(3): 68.     CrossRef
  • Putative Systemic Biomarkers of Biomass Smoke-Induced Chronic Obstructive Pulmonary Disease among Women in a Rural South Indian Population
    Sangeetha Vishweswaraiah, Tania Ahalya Thimraj, Leema George, Chaya Sindaghatta Krishnarao, Komarla Sundararaja Lokesh, Jayaraj Biligere Siddaiah, Kjell Larsson, Swapna Upadhyay, Lena Palmberg, Mahesh Padukudru Anand, Koustav Ganguly
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Original Articles
Effects of antibiotic consumption on children 2-8 years of age developing asthma
Hamid Reza Khalkhali, Sima Oshnouei, Shaker Salarilak, Mohammadhossein Rahimi Rad, Mohammad Karamyar, Javad Khashabi
Epidemiol Health. 2014;36:e2014006.   Published online July 4, 2014
DOI: https://doi.org/10.4178/epih/e2014006
  • 16,314 View
  • 142 Download
  • 13 Web of Science
  • 12 Crossref
AbstractAbstract PDF
Abstract
OBJECTIVES
Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age.
METHODS
A case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic children based on Global Initiative for Asthma criteria (n=207), and the controls were children without respiratory symptoms (n=400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing parents/guardians.
RESULTS
Antibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symptoms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p<0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p=0.03).
CONCLUSIONS
Our study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed.
Summary

Citations

Citations to this article as recorded by  
  • Antibiotic exposure and adverse long-term health outcomes in children: A systematic review and meta-analysis
    Quynh A Duong, Laure F Pittet, Nigel Curtis, Petra Zimmermann
    Journal of Infection.2022; 85(3): 213.     CrossRef
  • Analysis of medication patterns for pediatric asthma patients in emergency department: Does the sequence placement of glucocorticoids administration matter?
    Hoon Jang, Mustafa Ozkaynak, Claudia R. Amura, Turgay Ayer, Marion R. Sills
    Journal of Asthma.2021; 58(2): 180.     CrossRef
  • Factors Associated With First Medication Time for Children Treated in the Emergency Department for Asthma
    Hoon Jang, Mustafa Ozkaynak, Turgay Ayer, Marion R. Sills
    Pediatric Emergency Care.2021; 37(1): e42.     CrossRef
  • Predicting hospitalization of pediatric asthma patients in emergency departments using machine learning
    Marion R. Sills, Mustafa Ozkaynak, Hoon Jang
    International Journal of Medical Informatics.2021; 151: 104468.     CrossRef
  • Risk factors of asthma in the Asian population: a systematic review and meta-analysis
    Yang Yie Sio, Fook Tim Chew
    Journal of Physiological Anthropology.2021;[Epub]     CrossRef
  • Association of infant antibiotic exposure and risk of childhood asthma: A meta-analysis
    Zeyi Zhang, Jingjing Wang, Haixia Wang, Yizhang Li, Yuanmin Jia, Mo Yi, Ou Chen
    World Allergy Organization Journal.2021; 14(11): 100607.     CrossRef
  • Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood
    Karoliny dos Santos, Caroline J. Lodge, Michael J. Abramson, Bircan Erbas, Catherine M. Bennett, Jennie Hui, Shyamali C. Dharmage, Adrian J. Lowe
    Chest.2020; 157(2): 334.     CrossRef
  • The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review
    Ruth Baron, Meron Taye, Isolde Besseling-van der Vaart, Joanne Ujčič-Voortman, Hania Szajewska, Jacob C. Seidell, Arnoud Verhoeff
    BMC Pediatrics.2020;[Epub]     CrossRef
  • Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32–35 weeks
    Júlia Morata-Alba, Maria Teresa Romero-Rubio, Silvia Castillo-Corullón, Amparo Escribano-Montaner
    European Journal of Pediatrics.2019; 178(7): 973.     CrossRef
  • Evaluation of Allergic Symptoms Prevalence and Its Relationship with Acetaminophen/Antibiotic Use and Hospitalization Among School-Aged Children in Tehran, Iran
    Mohammad Reza Fazlollahi, Javid Morad Abbasi, Vahid Ghobadi Dana, Alireza Yousefzade, Nastaran Sabetkish, Shahpar Haghighat
    Iranian Red Crescent Medical Journal.2017;[Epub]     CrossRef
  • Airway Microbiota and the Implications of Dysbiosis in Asthma
    Juliana Durack, Homer A. Boushey, Susan V. Lynch
    Current Allergy and Asthma Reports.2016;[Epub]     CrossRef
  • Early-life antibiotic use is associated with wheezing among children with high atopic risk: a prospective European study
    Wenjie Sun, Erik R. Svendsen, Wilfried J. J. Karmaus, Joachim Kuehr, Johannes Forster
    Journal of Asthma.2015; 52(7): 647.     CrossRef
The Usefulness of the Secondary Database for Occupational Asthma Surveillance System in Korea.
Hyungjune Im, Sungwoo Choi, Jaiyong Kim, Sang Yun Lee, Kijung Yoon, Youngju Lee, Ho Jang Kwon, Daehee Kang, Soo Hun Cho
Korean J Epidemiol. 1999;21(2):266-275.
  • 5,212 View
  • 18 Download
AbstractAbstract PDF
Abstract
Occupational asthma is defined as a disease that is characterized by airway narrowing and bronchial hyperresponsiveness caused by specific working environment. It is estimated that occupational asthma cases in Korea have been underreported. This study, using Korean Medical Insurance Data(KMID), examined the distribution of asthma patients' occupations and the frequency of high risk occupations for occupational asthma in Seoul, Korea to evaluate the usefulness of the KMID data as a database for active occupational asthma surveillance system. Six hundreds and forty two(30.7%) of 2093 patients who were finally chosen as a study population by using 1995-year KMID, were contacted by telephone. 296 persons(47.4%) of 642 patients replied that they were diagnosed as asthma. The occupations of 296 asthma patients were classified by Korean standardized industrial classfication (KSIC). The most common occupations included Wholesale and Retail trade(19.5%), Real estate, Renting and Business activities(14.9%), Construction(14.9%), Manufacturing(12.3%). Forty(13.5%) of 296 patients who could be classified by KSIC were working at high risk jobs for occupational asthma. KMID could be used as a useful data for occupational asthma surveillance system if the limitations of KMID, which is the accuracy of diagnosis, data accessibility, difficulty of following up study subjects, would be solved. The prevalence of occupational asthma could be estimated if the follow-up study diagnosing occupational asthma for asthma patients working in high risk jobs would be held.
Summary

Epidemiol Health : Epidemiology and Health