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Original Articles
Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population
Sang Yeun Kim, Sun Ju Lee, Hyoun Kyoung Park, Ji Eun Yun, Myoungsook Lee, Jidong Sung, Sun Ha Jee
Epidemiol Health. 2011;33:e2011007.   Published online August 20, 2011
DOI: https://doi.org/10.4178/epih/e2011007
  • 19,563 View
  • 112 Download
  • 7 Crossref
AbstractAbstract PDF
Abstract
<sec><title>OBJECTIVES</title><p>Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown.</p></sec><sec><title>METHODS</title><p>The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis.</p></sec><sec><title>RESULTS</title><p>WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women.</p></sec><sec><title>CONCLUSION</title><p>These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.</p></sec>
Summary

Citations

Citations to this article as recorded by  
  • Determination of risk factors associated with inflammation in hypertensive patients with type-2 diabetes mellitus in a Palestinian Diabetes Study
    Mohammed S. Ellulu, Ihab A. Naser, Sahar M. Abuhajar, Ahmed A. Najim
    Current Medical Research and Opinion.2021; 37(9): 1451.     CrossRef
  • Insulin and Proinsulin Dynamics Progressively Deteriorate From Within the Normal Range Toward Impaired Glucose Tolerance
    Norimitsu Murai, Naoko Saito, Eriko Kodama, Tatsuya Iida, Kentaro Mikura, Hideyuki Imai, Mariko Kaji, Mai Hashizume, Yasuyoshi Kigawa, Go Koizumi, Rie Tadokoro, Chiho Sugisawa, Kei Endo, Toru Iizaka, Ryo Saiki, Fumiko Otsuka, Shun Ishibashi, Shoichiro Nag
    Journal of the Endocrine Society.2020;[Epub]     CrossRef
  • Association between the level of circulating adiponectin and prediabetes: A meta‐analysis
    Huasheng Lai, Nie Lin, Zhenzhen Xing, Huanhuan Weng, Hua Zhang
    Journal of Diabetes Investigation.2015; 6(4): 416.     CrossRef
  • Comparison of salivary and plasma adiponectin and leptin in patients with metabolic syndrome
    Supanee Thanakun, Hisashi Watanabe, Sroisiri Thaweboon, Yuichi Izumi
    Diabetology & Metabolic Syndrome.2014;[Epub]     CrossRef
  • Adiponectin as predictor for diabetes among pre-diabetic groups
    Hyon-Suk Kim, Jaeseong Jo, Jung Eun Lim, Young Duk Yun, Soo Jin Baek, Tae-Yong Lee, Kap Bum Huh, Sun Ha Jee
    Endocrine.2013; 44(2): 411.     CrossRef
  • Attenuation of plasma annexin A1 in human obesity
    Anna Kosicka, Adam D. Cunliffe, Richard Mackenzie, M. Gulrez Zariwala, Mauro Perretti, Roderick J. Flower, Derek Renshaw
    The FASEB Journal.2013; 27(1): 368.     CrossRef
  • Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study
    S. Sandy An, Anthony J.G. Hanley, Julie T. Ziegler, W. Mark Brown, Steven M. Haffner, Jill M. Norris, Jerome I. Rotter, Xiuqing Guo, Y.-D. Ida Chen, Lynne E. Wagenknecht, Carl D. Langefeld, Donald W. Bowden, Nicholette D. Palmer
    Molecular Genetics and Metabolism.2012; 107(4): 721.     CrossRef
The Association Between Adiponectin and Diabetes in the Korean Population.
Sun Ha Jee, Hee Yeon Lee, Sun Ju Lee, Ji Eun Yun, Eun Jung Jee, Hye Yun Song, Sang Yeun Kim, Jungyong Park, Hyon Suk Kim
Korean J Epidemiol. 2007;29(2):176-186.
  • 65,535 View
  • 21 Download
AbstractAbstract PDF
Abstract
BACKGROUND
As indicators of obesity, waist circumference (WC), body mass index (BMI), and adiponectin are well known risk factor for diabetes mellitus. The objectives of this study were to measure the independent association between these obesity indicators and diabetes and to examine the combined effect of these indicators on diabetes in a Korean population.
METHODS
The WC, BMI, and serum adiponectin were measured in 6,505 healthy Koreans and were classified into tertile groups for men and women. The independent and combined associations of the obesity indicators with diabetes were measured using logistic regression analyses. Diabetes was defined as fasting serum glucose greater than 126 mg/dL or taking medication.
RESULTS
Levels of adiponectin were inversely associated with BMI and WC and directly associated with age and high density lipoprotein cholesterol (HDL) cholesterol (P <0.001). After adjusting for age, WC, and other lifestyle factors, low levels of adiponectin were associated with an increased prevalence of diabetes. Further adjustment for HDL cholesterol and triglyceride attenuated this association in both men and women. The best cut-off value of adiponectin in terms of identifying the presence of diabetes was 5.5 /ml with a sensitivity and specificity of 46.7% and 63.9% for men and 9.5 /ml with a sensitivity and specificity of 68.2% and 55.2 for women.
CONCLUSIONS
These results suggest that adiponectin was associated with diabetes. The association was independent of WC and was partly modified by HDL and triglyceride. There were no effect modifications of adiponectin with WC on diabetes.
Summary
Development of ELISA-kit of Quantitative Analysis for Adiponectin and Their Correlation with Cardiovascular Risk Factors.
Sun Ha Jee, Seungbok Lee, Sungsik Min, Jungyong Park, Hyon Suk Kim, Sang Yeun Kim, Ji Eun Yun, Sun Ju Lee, Eun Jung Jee, Hee Yeon Lee, Hye Yun Song
Korean J Epidemiol. 2007;29(2):165-175.
  • 41,492 View
  • 33 Download
AbstractAbstract PDF
Abstract
PURPOSE
S: To develop a rapid, sensitive, qualitative ELISA-kit for serum adiponectin and examine correlation with adiponectin and cardiovascular risk factors.
METHODS
On the base of monoclonal antibodies against adiponectin, apply indirect ELISA to study the performance parameter of the kit. The correlation was examined between adiponectin and cardiovascular risk factors including waist circumference, body mass index, triglyceride, and HDL cholesterol.
RESULTS
The limited concentration of detection of the ELISA-kit was 1ug/ml. Linearity with R&D system and AdipoGen with this ELISA-kit was acceptable: the linear equation with R&D system was y=1.0116x + 0.4629 (R2=0.97) and linear equation with AdipoGen was y=0.9562x + 1.1961 (R2=0.93), respectively. The average recovery rate of the ELISA-kit ranged 92 to 104%. The correlation coefficient of waist circumference with adiponectin was -0.2276 (p<0.0001) among men and -0.2328 (p<0.0001) among women.
CONCLUSION
This ELISA-kit was quick, sensitive, and stable and can be used to determine adiponectin in serum.
Summary
Epidemiol Health : Epidemiology and Health
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