Epidemiology and Health

Hypothesises

Modifiable risk factors of lung cancer in “never-smoker” women: Jong-Myon Bae; Epidemiol Health. 2015;37:e2015047. Published online October 29, 2015; DOI: https://doi.org/10.4178/epih/e2015047

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Abstract

Korean women with a history of never smoking and with adenocarcinoma showed an increasing trend in lung cancer occurrence during 2002 to 2012. The two modifiable factors of never-smoker lung cancer in women are hormone and oncogenic virus infection. Based on previous studies, hormone replacement therapy (HRT) and human papillomavirus (HPV) infection might afford protection or be a risk factor, respectively. It is necessary to perform a pooled analysis of cohort studies to evaluate HRT and never-smoker lung cancer in women and a systematic review of case-control studies to determine the association between HPV infection and never-smoker lung cancer.

Summary

Korean summary
2002년에서 2012년간 폐암 통계를 살펴보면 비흡연 여성에서 선암종의 발생이 크게 증가하는 것으로 확인된다. 이렇게 여성에서 비흡연 폐암발생과 관련한 요인들로는 호르몬 대체요법 (HRT)과 인유두종바이러스 (HPV) 감염이 알려져 있다. 환자-대조군연구를 이용한 메타분석에 따르면 호르몬대체요법은 폐암발생을 억제하는 것으로 나왔다. HPV에 대한 메타분석은 아직 없는 가운데 위험요인으로 의심하고 있다. 따라서 HRT에 대하여는 코호트 연구 결과를 이용한 연합분석 (pooled analysis)이 필요하며, HPV에 대하여는 환자-대조군연구 결과를 이용한 메타분석이 수행될 필요가 있다.

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Journal of the American College of Radiology.2023; 20(2): 156. CrossRef
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International Journal of Cancer.2022; 151(5): 699. CrossRef
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Journal of Surgical Oncology.2022; 126(8): 1551. CrossRef
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International Journal of Environmental Research and Public Health.2022; 19(23): 15991. CrossRef
Associations between female lung cancer risk and sex steroid hormones: a systematic review and meta-analysis of the worldwide epidemiological evidence on endogenous and exogenous sex steroid hormones
Hui Zeng, Zhuoyu Yang, Jiang Li, Yan Wen, Zheng Wu, Yadi Zheng, Yiwen Yu, Yongjie Xu, Shugeng Gao, Fengwei Tan, Ni Li, Qi Xue, Jie He
BMC Cancer.2021;[Epub] CrossRef
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Di Liang, Jingxi Wang, Daojuan Li, Jin Shi, Jin Jing, Baoen Shan, Yutong He
Frontiers in Oncology.2019;[Epub] CrossRef
Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2018; 51(5): 263. CrossRef
Age at menopause and hormone replacement therapy as risk factors for head and neck and oesophageal cancer
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Oncology Reports.2017; 38(4): 1915. CrossRef
Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis
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Epidemiology and Health.2015; 37: e2015052. CrossRef

The necessity of an observational study on the interactions between allergic history and citrus fruit intake for the prevention of pancreatic cancer: Jong-Myon Bae; Epidemiol Health. 2015;37:e2015028. Published online June 16, 2015; DOI: https://doi.org/10.4178/epih/e2015028

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Abstract

While the main product of Jeju Island is citrus fruit and the prevalence of atopic dermatitis among the students who live there is relatively high, the incidence of pancreatic cancer is lowest in Korea. Systematic reviews reporting allergic history and intake of citrus fruit as protective factors against pancreatic cancer (PCC) were published in 2005 and 2008, respectively. Although there were discrepancies in the results of the subgroup analyses between case-control and cohort studies, it is necessary to evaluate an interaction effect between allergic history and intake of citrus fruits on PCC risk.

Summary

Korean summary
췌장암 발생과 관련한 요인들의 규명이 절실한 상황에서, 알레르기 질환과 감귤섭취 각각이 발생억제 효과가 있다는 체계적 고찰연구가 있다. 그러나 코호트 연구들만으로 메타분석을 하였을 때는 두 억제 요인 모두 통계적 유의성이 없는 것으로 나왔다. 한편 지역별 췌장암 발생률에서 낮은 수준을 보이는 제주도는 주요 감귤생산지이면서, 초중고등학생의 아토피 유병률이 상대적으로 높은 것으로 알려져 있다. 이런 사실들에 근거할 때 췌장암 발생에 있어 알레르기질환과 감귤섭취의 상호작용을 규명하는 코호트 연구를 제안한다.

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Citation Discovery Tools for Conducting Adaptive Meta-analyses to Update Systematic Reviews
Jong-Myon Bae, Eun Hee Kim
Journal of Preventive Medicine and Public Health.2016; 49(2): 129. CrossRef
Hormonal Replacement Therapy and the Risk of Lung Cancer in Women: An Adaptive Meta-analysis of Cohort Studies
Jong-Myon Bae, Eun Hee Kim
Journal of Preventive Medicine and Public Health.2015; 48(6): 280. CrossRef
Human papillomavirus infection and risk of lung cancer in never-smokers and women: an ‘adaptive’ meta-analysis
Jong-Myon Bae, Eun Hee Kim
Epidemiology and Health.2015; 37: e2015052. CrossRef
Hormone Replacement Therapy and Risk of Breast Cancer in Korean Women: A Quantitative Systematic Review
Jong-Myon Bae, Eun Hee Kim
Journal of Preventive Medicine and Public Health.2015; 48(5): 225. CrossRef

Two hypotheses of dense breasts and viral infection for explaining incidence of breast cancer by age group in Korean women: Jong-Myon Bae; Epidemiol Health. 2014;36:e2014020. Published online September 26, 2014; DOI: https://doi.org/10.4178/epih/e2014020

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135 Download
13 Citations

Abstract PDF Supplementary Material

Abstract

Breast cancer, the second leading type of cancer in Korean women, has shown increasing incidence over the past 10 years. However, the curves of incidence by age group cast doubt on the birth cohort effect hypothesis. To explain the curves, here I suggest two alternative hypotheses of breast density and viral infection based on pre-existing evidences. Evaluating these hypotheses would require important clues to find unknown risk factors of breast cancer and to plan more effective strategies for breast cancer control in Korean women.

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Korean summary

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Citations

Citations to this article as recorded by

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Modifiable risk factors of lung cancer in “never-smoker” women
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Epidemiology and Health.2015; 37: e2015047. CrossRef
Human papillomavirus 16 infection as a potential risk factor for prostate cancer: an adaptive meta-analysis
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