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Epidemic characteristics of measles and efforts to control measles infections in Zhejiang Province, China
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Rui Yan, Mengya Yang, Hanqing He, Yan Feng, Yang Zhou, Xuewen Tang, Xuan Deng, Yao Zhu, Yuxia Du, Can Chen, Cao Kexin, Shigui Yang, RIDPHE Group
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Epidemiol Health. 2024;46:e2024075. Published online September 11, 2024
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DOI: https://doi.org/10.4178/epih.e2024075
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 Abstract
Summary
 PDF Supplementary Material
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Abstract
OBJECTIVES
Several countries have successfully eliminated measles, and China is making significant strides toward achieving this goal. This study focused on investigating the patterns of measles infections in Zhejiang Province, China, as well as control measures. The objective was to provide valuable insights that could contribute to the development of nationwide elimination strategies.
METHODS We analyzed measles surveillance data from 2005 to 2022 in Zhejiang Province. We utilized a joinpoint regression model to examine trends in measles. Additionally, we employed SaTScan version 9.5 to identify spatial-temporal clusters. Finally, we used an age-period-cohort model to assess the effects of age, period, and cohort.
RESULTS The age-standardized incidence rate (ASIR) of measles infection in Zhejiang Province from 2005 to 2022 was 5.24 per 100,000, showing a consistent and significant downward trend with an annual percentage change of -24.93% (p<0.05). After 2020, the ASIR for measles infection fell to below 0.1 per 100,000. The majority of measles cases occurred in individuals either without an immunization history or with an unknown immunization status, representing 41.06% and 41.40% of the cases from 2010 to 2022, respectively. According to data from the National Measles Surveillance System, the annual rate of discarded measles cases from 2009 to 2014, and the annual rate of discarded measles and rubella cases from 2015 to 2022, were both above 2 per 100,000, indicating the high sensitivity of the measles surveillance system.
CONCLUSIONS The significant reduction in measles incidence from 2005 to 2022 demonstrates substantial progress in Zhejiang Province towards the elimination of measles.
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Summary
Key Message
Measles incidence in Zhejiang Province has been declining since 2008, with a particularly notable decrease from 2020 to 2022. Adults remain the primary population susceptible to measles in Zhejiang Province. Therefore, it is essential to enhance prevention and control measures for measles, especially among individuals who have not received the MCV immunization. The reduced incidence of measles during the COVID-19 pandemic presents Zhejiang Province with a unique opportunity to leverage the lowest recorded measles incidence in its history and accelerate efforts in measles elimination.
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