-
Prospective association between handgrip strength in childhood and the metabolic syndrome score and insulin resistance indices in adolescence: an analysis based on the Ewha Birth and Growth Study
-
Seunghee Jun, Hyunjin Park, Hyelim Lee, Hye Ah Lee, Young Sun Hong, Hyesook Park
-
Epidemiol Health. 2025;47:e2025001. Published online January 2, 2025
-
DOI: https://doi.org/10.4178/epih.e2025001
-
-
 Abstract
Summary
 PDF Supplementary Material
-
Abstract
OBJECTIVES
Low handgrip strength (HGS) in children and adolescents might be associated with the risk of metabolic syndrome (MetS) and insulin resistance. This study prospectively evaluated the association between HGS in childhood and MetS in adolescence.
METHODS Based on data from the Ewha Birth and Growth Study, this study analyzed HGS at ages 7 to 9 and metabolic indices at ages 13 to 15. In total, 219 participants were analyzed. The risk of MetS was evaluated using the continuous metabolic syndrome score (cMetS), and insulin resistance was assessed using fasting blood insulin and homeostasis model assessment of insulin resistance (HOMA-IR). Relative HGS in childhood was determined by dividing HGS by body weight and categorized as sex-specific quartiles.
RESULTS This study found an inverse association between relative HGS levels in childhood and MetS and insulin resistance in adolescence. For each 1-group increase in relative HGS quartiles, cMetS (standarard [Std] β=-0.64, p<0.01), HOMA-IR (Std β=-0.21, p<0.01), and fasting blood insulin (Std β=-0.21, p<0.01) all decreased on average. These associations remained significant even after adjusting for confounding factors.
CONCLUSIONS Our study showed a prospective association between HGS in childhood and the risk of MetS and insulin resistance in adolescence. It provides significant epidemiological evidence, emphasizing the importance of efforts to increase muscle strength from a young age to mitigate the risk of MetS and insulin resistance in adolescence.
-
Summary
Korean summary
본 연구는 소아기 악력 수준이 청소년기의 대사증후군 및 인슐린 저항성과 연관이 있음을 발견했음. 이러한 결과는 소아기 근력 향상이 향후 대사 위험을 완화하는데 중요함을 강조함.
Key Message
This study found that higher childhood relative handgrip strength was inversely associated with metabolic syndrome and insulin resistance in adolescence. The findings emphasize the importance of enhancing muscle strength early in life to mitigate metabolic risks.
-
Identifying adverse reactions following COVID-19 vaccination from data collected through active surveillance: a text mining approach
-
Hye Ah Lee, Bomi Park, Chung Ho Kim, Yeonjae Kim, Hyunjin Park, Seunghee Jun, Hyelim Lee, Seunghyun Lewis Kwon, Yesul Heo, Hyungmin Lee, Hyesook Park
-
Epidemiol Health. 2025;e2025034. Published online June 30, 2025
-
DOI: https://doi.org/10.4178/epih.e2025034
[Accepted]
-
-
Abstract
PDF
-
Abstract
OBJECTIVES
Unstructured text data collected through vaccine safety surveillance systems can identify previously unreported adverse reactions and provide critical information to enhance these systems. This study explored adverse reactions using text data collected through an active surveillance system following COVID-19 vaccination.
METHODS We performed text mining on 2,608 and 2,054 records from 2 survey seasons (2023–2024 and 2024–2025), in which participants reported health conditions experienced within 7 days of vaccination using free-text responses. Frequency analysis was conducted to identify key terms, followed by subgroup analyses by sex, age, and concomitant influenza vaccination. In addition, semantic network analysis was used to examine terms reported together.
RESULTS The analysis identified several common (≥1%) adverse events, such as respiratory symptoms, sleep disturbances, lumbago, and indigestion, which had not been frequently noted in prior literature. Moreover, less frequent (≥0.1% to <1%) adverse reactions affecting the eyes, ears, and oral cavity were also detected. These adverse reactions did not differ significantly in frequency based on the presence or absence of simultaneous influenza vaccination. Co-occurrence analysis and estimation of correlation coefficients further revealed associations between frequently co-reported symptoms.
CONCLUSIONS This study utilized text mining to uncover previously unrecognized adverse reactions associated with COVID-19 vaccination, thereby broadening our understanding of the vaccine’s safety profile. The insights obtained may inform future investigations into vaccine-related adverse reactions and improve the processing of text data in surveillance systems.
-
Summary
-
Cancer risk based on alcohol consumption levels: a comprehensive systematic review and meta-analysis
-
Seunghee Jun, Hyunjin Park, Ui-Jeong Kim, Eun Jeong Choi, Hye Ah Lee, Bomi Park, Soon Young Lee, Sun Ha Jee, Hyesook Park
-
Epidemiol Health. 2023;45:e2023092. Published online October 16, 2023
-
DOI: https://doi.org/10.4178/epih.e2023092
-
-
31,986
View
-
780
Download
-
23
Web of Science
-
29
Crossref
-
Abstract
Summary
PDFSupplementary Material
-
Abstract
OBJECTIVES
Alcohol consumption is a well-established risk factor for cancer. Despite extensive research into the relationship between alcohol consumption and cancer risk, the effect of light alcohol consumption on cancer risk remains a topic of debate. To contribute to this discourse, we conducted a comprehensive systematic review and meta-analysis.
METHODS Our systematic review aimed to investigate the associations between different levels of alcohol consumption and the risk of several cancer types. We focused on analyzing prospective associations using data from 139 cohort studies. Among them, 106 studies were included in the meta-analysis after a quantitative synthesis.
RESULTS Our analysis did not find a significant association between light alcohol consumption and all-cause cancer risk (relative risk, 1.02; 95% confidence interval, 0.99 to 1.04), but we observed a dose-response relationship. Light alcohol consumption was significantly associated with higher risks of esophageal, colorectal, and breast cancers. Light to moderate drinking was associated with elevated risks of esophageal, colorectal, laryngeal, and breast cancers. Heavy drinking was also found to contribute to the risk of stomach, liver, pancreas, and prostate cancers, thereby increasing the risk of almost all types of cancer. Additionally, females generally had lower cancer risks compared to males.
CONCLUSIONS Our findings highlight that cancer risks extend beyond heavy alcohol consumption to include light alcohol consumption as well. These findings suggest that there is no safe level of alcohol consumption associated with cancer risk. Our results underscore the importance of public health interventions addressing alcohol consumption to mitigate cancer risks.
-
Summary
Korean summary
본 연구는 코호트 연구를 기반으로 하여 음주의 수준에 따른 암 위험 연관성에 대해 체계적 문헌고찰(139편)과 메타분석(106편)을 수행하였다. 연구 결과, 음주와 암 위험 사이에 용량-반응 관계가 나타났으며, 소량의 음주는 암 유형에 따라 차이가 있었으나, 식도암, 대장암, 전립선암(남성), 유방암(여성)에서 암 위험과의 연관성이 있음을 발견했다. 따라서, 암 위험 측면에서 음주에 안전한 수준이 없음을 시사하며, 음주와 관련된 잠재적 피해를 완화하기 위해서는 음주 지침 강화와 같은 공중보건개입이 필요하다.
Key Message
The aim of this study was to assess the relationship between different levels of alcohol consumption and the risk of various cancer types through a systematic review and meta-analysis, providing insights into the ongoing debate about alcohol consumption and cancer causality. The findings support a dose-response relationship between alcohol consumption levels and cancer risk and the light alcohol consumption was associated with risks of esophageal, colorectal, prostate (male), and breast (female) cancer. These results emphasize the absence of a safe threshold for alcohol consumption in terms of cancer risk.
-
Citations
Citations to this article as recorded by  - Unraveling the bidirectional link between cancer and dementia and the impact of cancer therapies on dementia risk: A systematic review and meta‐analysis
Liwei Ma, Edwin C. K. Tan, Benjamin Goudey, Liang Jin, Yijun Pan
Alzheimer's & Dementia.2025;[Epub] CrossRef - Associations of lifestyle factors with oral cancer risk: An umbrella review
Haobo Xu, Zhonglan Gao, Hairong Liu, Liya An, Ting Yang, Bojun Zhang, Guobin LIU, Dali Sun
Journal of Stomatology Oral and Maxillofacial Surgery.2025; 126(3): 102234. CrossRef - Estudio bibliométrico de las publicaciones sobre cirugía pancreática realizadas por cirujanos españoles
Juan Jesús Rubio-García, Celia Villodre Tudela, Cándido Alcázar López, Silvia Carbonell Morote, Mariano Franco Campello, Paola Melgar Requena, Adrián Paredes Segura, José Manuel Ramia Ángel
Cirugía Española.2025; 103(4): 201. CrossRef - Personalized Lifestyle Interventions for Prevention and Treatment of Obesity-Related Cancers: A Call to Action
Mohamad Motevalli, Fatima Cody Stanford
Cancers.2025; 17(8): 1255. CrossRef - Bibliometric study of publications on pancreatic surgery carried out by spanish surgeons
Juan Jesús Rubio-García, Celia Villodre Tudela, Cándido Alcázar López, Silvia Carbonell Morote, Mariano Franco Campello, Paola Melgar Requena, Adrián Paredes Segura, José Manuel Ramia Ángel
Cirugía Española (English Edition).2025; 103(4): 201. CrossRef - Alcohol consumption and breast lesions: targets for risk-based screening in high-risk Italian women
Sonia Cerrai, Alessio Lachi, Michela Franchini, Stefania Pieroni, Giada Anastasi, Marco Scalese, Anna Odone, Silvano Gallus, Luc Smits, Sabrina Molinaro
Breast Cancer.2025;[Epub] CrossRef - Design and Optimization of Surface Plasmon Resonance-Based Non-Invasive Refractive Index Biosensor Using Ag-SiO2 Materials for Alcoholic Beverages Compound Detection
Trupti Kamani, Shobhit K. Patel, Sana Ben Khalifa, Pankaj Pathak, Saleh Chebaane, Marouan Kouki
Plasmonics.2025;[Epub] CrossRef - Invisible foes: how air pollution and lifestyle conspire in the rise of colorectal cancer
Di Zhao, Meng Zhu
QJM: An International Journal of Medicine.2025;[Epub] CrossRef - Wine Consumption and Lung Cancer Risk: A Systematic Review and Meta-Analysis
Carlotta Bertola, Camilla Gobbetti, Gaia Baccarini, Roberto Fabiani
Nutrients.2025; 17(8): 1322. CrossRef - A narrative review on alcohol and alimentary tract cancer with special emphasis on acetaldehyde and oxidative stress
Helmut Karl Seitz
Zeitschrift für Gastroenterologie.2025;[Epub] CrossRef - Association of Cigarette Smoking and Alcohol Drinking With Risk of 12 Common Cancers Among Low-Income American Adults in the Southeastern United States
Jiajun Shi, Wanqing Wen, Qiuyin Cai, Martha J. Shrubsole, Xiao-Ou Shu, Wei Zheng
Cancer Control.2025;[Epub] CrossRef - Identification of MMP14 and MKLN1 as colorectal cancer susceptibility genes and drug-repositioning candidates from a genome-wide association study
Dabin Yun, Jung-Ho Yang, Jin-ah Sim, Minjung Kim, Ji Won Park, Seung Yong Jeong, Aesun Shin, Sun-Seog Kweon, Nan Song
Journal of Translational Medicine.2025;[Epub] CrossRef - Research Progress on Risk Factors and Endoscopic Diagnosis of Gastric Mucosal Intestinal Metaplasia
思妤 刘
Advances in Clinical Medicine.2025; 15(05): 1135. CrossRef - Global Cancer Burden Forecast for 204 Countries and Territories, 2022–2050: A Predictive Analysis from the Global Burden of Disease Study 2021
Jinghao Liang, Yijian Lin, Wenxi Wang, Jingchun Ni, Hongmiao Lin, Zishan Huang, Jihao Qi, Zhaofeng Tan, Hengrui Liang, Jianxing He
Cancer Letters.2025; 629: 217883. CrossRef - Global burden of breast cancer attributable to alcohol consumption: a multi-regional observational analysis (1990–2021)
Fangfang Cui, Yuntian Chu, Weiyi Wang, Meihao Ji, Sidong Zhang, Zhengyu Wu, Yadong Song
Addictive Behaviors.2025; 170: 108426. CrossRef - Patterns of cigarette, e-cigarette, heated tobacco, and alcohol use in solid organ transplant recipients, a pre- versus posttransplant comparison: Survey results from a transplantation center in Poland
Zuzanna Marczak, Bartosz Olkowski, Olga Maria Rostkowska, Dorota Miszewska-Szyszkowska, Olga Kozińska-Przybył, Tomasz Warężak, Magdalena Durlik
Tobacco Prevention & Cessation.2025; 11(June): 1. CrossRef - Analysis of Novel DNA Adducts Derived from Acetaldehyde
Yuuki Betsuyaku, Mina Motohashi, Akira Sassa, Takeji Takamura-Enya, Yukari Totsuka
Biomolecules.2025; 15(6): 878. CrossRef - Granulocyte function in response to acute alcohol consumption: temporal shifts from proinflammatory activation to antiinflammatory modulation in healthy volunteers
Ramona Sturm, Florian Haag, Helen Rinderknecht, Jasmin Maria Bülow, Nils Wagner, Julian Zabel, Christian B Bergmann, Ingo Marzi, Borna Relja
Journal of Leukocyte Biology.2025;[Epub] CrossRef - Exploring genetic associations of Crohn’s disease and ulcerative colitis with extraintestinal cancers in European and East Asian populations
Chengdong Yu, Jiawei Xu, Siyi Xu, Lei Tang, Qinyuan Han, Xiaoqiang Zeng, Yanxiao Huang, Tenghua Yu, Zhengkui Sun
Frontiers in Immunology.2024;[Epub] CrossRef - The Impact of Tobacco Smoking and Alcohol Consumption on the Development of Gastric Cancers
Waku Hatta, Tomoyuki Koike, Naoki Asano, Yutaka Hatayama, Yohei Ogata, Masahiro Saito, Xiaoyi Jin, Kaname Uno, Akira Imatani, Atsushi Masamune
International Journal of Molecular Sciences.2024; 25(14): 7854. CrossRef - Genetic Heterogeneity Across Dimensions of Alcohol Use Behaviors
Jeanne E. Savage, Peter B. Barr, Tanya Phung, Younga H. Lee, Yingzhe Zhang, Vivia V. McCutcheon, Tian Ge, Jordan W. Smoller, Lea K. Davis, Jacquelyn Meyers, Bernice Porjesz, Danielle Posthuma, Travis T. Mallard, Sandra Sanchez-Roige
American Journal of Psychiatry.2024; 181(11): 1006. CrossRef - To Drink or Not to Drink? Investigating Alcohol’s Impact on Prostate Cancer Risk
Aris Kaltsas, Michael Chrisofos, Evangelos N. Symeonidis, Athanasios Zachariou, Marios Stavropoulos, Zisis Kratiras, Ilias Giannakodimos, Asterios Symeonidis, Fotios Dimitriadis, Nikolaos Sofikitis
Cancers.2024; 16(20): 3453. CrossRef - Factors associated with acquiring exercise habits through health guidance for metabolic syndrome among middle-aged Japanese workers: A machine learning approach
Jiawei Wan, Kyohsuke Wakaba, Takeshi Onoue, Kazuyo Tsushita, Yoshio Nakata
Preventive Medicine Reports.2024; 48: 102915. CrossRef - Development of an algorithm for identifying paraneoplastic ischemic stroke in association with lung, pancreatic, and colorectal cancer
Rebecca Kassubek, Marc-Andre G. R. Winter, Jens Dreyhaupt, Mona Laible, Jan Kassubek, Albert C. Ludolph, Jan Lewerenz
Therapeutic Advances in Neurological Disorders.2024;[Epub] CrossRef - Alimentación y cáncer
Carlos A. González Svatetz
FMC - Formación Médica Continuada en Atención Primaria.2024; 31(8): 403. CrossRef - Alcohol consumption and its association with cancer, cardiovascular, liver and brain diseases: a systematic review of Mendelian randomization studies
Naouras Bouajila, Cloé Domenighetti, Henri-Jean Aubin, Mickael Naassila
Frontiers in Epidemiology.2024;[Epub] CrossRef - Prévention et dépistage des cancers dans les rhumatismes inflammatoires chroniques
Elodie Mamou, Laetitia Morardet, Djaha Mogni, Bruno Fautrel, Laure Gossec
Revue du Rhumatisme.2024;[Epub] CrossRef - Global, regional, and national trends in gastric cancer burden: 1990-2021 and projections to 2040
Tao Zhang, Yiqun Zhang, Xiaofei Leng
Frontiers in Oncology.2024;[Epub] CrossRef - Alcohol Consumption and Breast and Ovarian Cancer Development: Molecular Pathways and Mechanisms
Francesca Fanfarillo, Brunella Caronti, Marco Lucarelli, Silvia Francati, Luigi Tarani, Mauro Ceccanti, Maria Grazia Piccioni, Loredana Verdone, Micaela Caserta, Sabrina Venditti, Giampiero Ferraguti, Marco Fiore
Current Issues in Molecular Biology.2024; 46(12): 14438. CrossRef
-
Changes in eating behaviors according to household income in adolescents during the COVID-19 pandemic: findings from the Korea National Health and Nutrition Examination Survey
-
Hye Ah Lee, Ho Jung Lee, Bomi Park, Yoonhee Shin, Hyunjin Park, Hyesook Park
-
Epidemiol Health. 2022;44:e2022102. Published online November 9, 2022
-
DOI: https://doi.org/10.4178/epih.e2022102
-
-
10,185
View
-
157
Download
-
2
Web of Science
-
4
Crossref
-
Abstract
Summary
PDFSupplementary Material
-
Abstract
OBJECTIVES
To assess social inequalities in changes in dietary behaviors among adolescents during the coronavirus disease 2019 (COVID-19) pandemic, we compared changes in dietary behavior indicators by household income.
METHODS Using cross-sectional data from the 2019 and 2020 Korea National Health and Nutrition Examination Survey, the prevalence of dietary behaviors in adolescents (12-18 years old) was estimated and changes in dietary behaviors during the COVID-19 pandemic were evaluated. We assessed changes in dietary behaviors with a household income (as a measure of socioeconomic status, SES) disparity.
RESULTS During the COVID-19 pandemic, the average consumption of vegetables decreased and food insecurity worsened. Adolescents were more likely to skip breakfast than before COVID-19 (33.1 and 37.4%). Soft drink consumption also increased in 2020 from 2019 (7.6 and 14.8%), especially among boys. Average sugar intake and sodium intake showed a tendency to decrease only in girls, but there was no significant difference according to SES level. Skipping breakfast was particularly evident in the low-SES group, and the difference according to household income level (high vs. low) was greater during COVID-19 than before. The prevalence of soft drink consumption increased significantly in the low-SES group, but the rate of increase did not differ by SES level.
CONCLUSIONS We found that the social disparity in skipping breakfast was further aggravated during the COVID-19 pandemic. To reach a better understanding of the dietary behaviors of adolescents, continuous monitoring is necessary.
-
Summary
Korean summary
국민건강영양조사 자료를 활용하여, COVID-19 팬데믹 전후 청소년의 식생활 변화 및 가구소득 수준에 따른 차이를 평가하였다. 대체로, 평균 채소 섭취량은 감소하고 탄산음료 소비는 증가한 것으로 나타났으며, 아침식사 결식율도 약간 증가한 것으로 나타났다. 게다가, 가구소득 수준에 따라 평가하였을 때, 아침식사 결식율 증가는 가구소득이 높은 군에 비해 가구소득 수준이 낮은 군에서 두드러진 것으로 나타났다. COVID-19 팬데믹이 장기화됨에 따라, 청소년의 식생활 변화에 대해서는 지속적인 모니터링이 필요하다.
Key Message
Using data from the 2019 and 2020 Korea National Health and Nutrition Examination Survey, changes in dietary behaviors of adolescents (12-18 years old) during the COVID-19 pandemic were evaluated. During the COVID-19 pandemic, average consumption of vegetables decreased and consumption of soft drinks increased in 2020 from 2019 (7.6% and 14.8%). In addition, the social disparity in skipping breakfast among adolescents was further aggravated. To reach a better understanding of the dietary behaviors of adolescents, continuous monitoring is necessary.
-
Citations
Citations to this article as recorded by - Dietary Changes of Youth during the COVID-19 Pandemic: A Systematic Review
Nicolas Woods, Jamie A Seabrook, Holly Schaafsma, Shauna Burke, Trish Tucker, Jason Gilliland
The Journal of Nutrition.2024; 154(4): 1376. CrossRef - Perceived Familial Financial Insecurity and Obesity Among Korean Adolescents During the COVID-19 Pandemic
Fumie Kaneko, Eunji Kim, Hokyou Lee, Kokoro Shirai, Ryo Kawasaki, Hyeon Chang Kim
Journal of Epidemiology.2024; 34(12): 587. CrossRef - Intake of energy and macronutrients according to household income among elementary, middle, and high school students before and during the COVID-19 pandemic: a cross-sectional study
Chae-Eun Jeong, Heejin Lee, Jung Eun Lee
Korean Journal of Community Nutrition.2024; 29(3): 234. CrossRef - Analysis of health behavior, mental health, and nutritional status among Korean adolescents before and after COVID-19 outbreak: based on the 2019–2020 Korea National Health and Nutrition Examination Survey
Misun Lee, Sarang Jeong, Chong-Su Kim, Yoon Jung Yang
Journal of Nutrition and Health.2023; 56(6): 667. CrossRef
|
KSE
