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The association of pancreatic cancer incidence with smoking status and smoking amount in Korean men
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Do Jin Nam, Chang-Mo Oh, Eunhee Ha, Min-Ho Kim, Eun Hye Yang, Hyo Choon Lee, Soon Su Shin, Woo Yeon Hwang, Ann Hee You, Jae-Hong Ryoo
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Epidemiol Health. 2022;44:e2022040. Published online April 21, 2022
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DOI: https://doi.org/10.4178/epih.e2022040
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Abstract
OBJECTIVES
Our study examined the dose-response relationship between smoking amounts (pack-years) and the risk of developing pancreatic cancer in Korean men.
METHODS Of 125,743 participants who underwent medical health checkups in 2009, 121,408 were included in the final analysis and observed for the development of pancreatic cancer. We evaluated the associations between smoking amounts and incident pancreatic cancer in 4 groups classified by pack-year amounts. Cox proportional hazards models were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of incident pancreatic cancer by comparing groups 2 (<20 pack-year smokers), 3 (20-≤40 pack-year smokers), and 4 (>40 pack-year smokers) with group 1 (never smokers).
RESULTS During 527,974.5 person-years of follow-up, 245 incident cases of pancreatic cancer developed between 2009 and 2013. The multivariate-adjusted HRs (95% CIs) for incident pancreatic cancer in groups 2, 3, and 4 were 1.05 (0.76 to 1.45), 1.28 (0.91 to 1.80), and 1.57 (1.00 to 2.46), respectively (p for trend=0.025). The HR (95% CI) of former smokers showed a dose-response relationship in the unadjusted model, but did not show a statistically significant association in the multivariate-adjusted model. The HR (95% CI) of current smokers showed a dose-response relationship in both the unadjusted (p for trend=0.020) and multivariate-adjusted models (p for trend=0.050).
CONCLUSIONS The risk of developing pancreatic cancer was higher in current smokers status than in former smokers among Korean men, indicating that smoking cessation may have a protective effect.
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Summary
Korean summary
본 연구에서는 대한민국 남성을 대상으로 흡연양 및 흡연상태에 따른 췌장암 발병을 분석하였다. 흡연양이 많을수록, 현재 흡연상태일수록 췌장암 발병이 높았고, 금연한 경우 췌장암의 발병이 낮은 것을 확인할 수 있었다.
Key Message
As a result of analyzing the incidence of pancreatic cancer according to the amount of smoking and smoking status among Korean men, it was confirmed that the more smoked and the current smoking status, the higher the incidence of pancreatic cancer, and the lower the incidence of pancreatic cancer when quitting smoking.
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Citations
Citations to this article as recorded by  - Childhood and adulthood passive and active smoking, and the ABO group as risk factors for pancreatic cancer in women
Anne‐Laure Vedie, Nasser Laouali, Amandine Gelot, Gianluca Severi, Marie‐Christine Boutron‐Ruault, Vinciane Rebours
United European Gastroenterology Journal.2024; 12(4): 440. CrossRef - Progress in understanding of relationship between smoking and pancreatic injury
Xue Wei, Jian-Yu Hao
World Chinese Journal of Digestology.2024; 32(3): 203. CrossRef - Associations between smoking status and infertility: a cross-sectional analysis among USA women aged 18-45 years
Sijie He, Li Wan
Frontiers in Endocrinology.2023;[Epub] CrossRef - Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
Natalia Michalak, Ewa Małecka-Wojciesko
Journal of Clinical Medicine.2023; 12(13): 4318. CrossRef
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