Epidemiology and Health

Original Article

Androgen deprivation therapy is associated with decreased second primary lung cancer risk in the United States veterans with prostate cancer: Kyungsuk Jung, Jong Chul Park, Hyunseok Kang, Johann Christoph Brandes; Epidemiol Health. 2018;40:e2018040. Published online August 11, 2018; DOI: https://doi.org/10.4178/epih.e2018040

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Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
We investigated whether androgen deprivation therapy (ADT) in prostate cancer patients was associated with a decreased risk for second primary lung cancer in US veterans.

METHODS

Prostate cancer diagnoses in the US Veterans Affairs Cancer Registry between 1999 and 2008 were identified. Use of hormonal therapy and diagnoses of second primary lung cancer were determined from the registry. Synchronous prostate and lung cancers, defined as 2 diagnoses made within 1 year, were excluded from the analysis. Cancer-free survival was estimated using the Kaplan-Meier method and hazard ratios were estimated using Cox proportional hazard models.

RESULTS

Among the 63,141 identified patients with prostate cancer, 18,707 subjects were eligible for the study. Hormonal therapy was used in 38% of patients and the median follow-up period was 28 months. ADT use was associated with longer lung cancer-free survival in prostate cancer patients (log-rank p=0.01). After adjusting for age, race, smoking and prostate cancer stage, ADT use was associated with decreased lung cancer risk by 15, 21, and 24% after 1, 2, and 3 years, respectively.

CONCLUSIONS

ADT in prostate cancer patients may be associated with decreased second primary lung cancer risk among US veterans.

Summary

Korean summary
비소세포성 폐암이 호르몬 수용체에 의해 영향을 받을 수 있다는 기존의 연구 결과를 바탕으로, 이 연구는 미국 재향 군인 병원 암등록 자료를 분석하여 전립선암 환자 중, 안드로겐 박탈 요법으로 치료를 받은 경우와 그렇지 않은 경우의 비소세포성 폐암 발생율을 비교분석하였다. 분석 결과, 전립선암을 진단받은 미국 재향군인들 중 안드로겐 박탈 요법으로 치료를 받은 환자들이 그렇지 않은 환자들에 비해 비소세포성 폐암 발생율이 통계적으로 유의미하게 감소하는 것이 관찰되었다.

Citations

Citations to this article as recorded by

Correlation between second and first primary cancer: systematic review and meta-analysis of 9 million cancer patients
Xinyu Wang, Meiyuan Zeng, Xueming Ju, Anqi Lin, Chaozheng Zhou, Junyi Shen, Zaoqu Liu, Bufu Tang, Quan Cheng, Youyu Wang, Jian Zhang, Peng Luo
British Journal of Surgery.2024;[Epub] CrossRef
New Perspectives on Sex Steroid Hormones Signaling in Cancer-Associated Fibroblasts of Non-Small Cell Lung Cancer
Chihiro Inoue, Yasuhiro Miki, Takashi Suzuki
Cancers.2023; 15(14): 3620. CrossRef
Role of sex and sex hormones in PD-L1 expression in NSCLC: clinical and therapeutic implications
Vianey Rodriguez-Lara, Giovanny Soca-Chafre, Maria Rosa Avila-Costa, Juan Jose Juarez-Vignon Whaley, Jeronimo Rafael Rodriguez-Cid, José Luis Ordoñez-Librado, Emma Rodriguez-Maldonado, Nallely A. Heredia-Jara
Frontiers in Oncology.2023;[Epub] CrossRef
Endogenous sex hormones, aromatase activity and lung cancer risk in postmenopausal never‐smoking women
Yingya Zhao, Yu‐Tang Gao, Xianglan Zhang, Alan L. Rockwood, Mark M. Kushnir, Qiuyin Cai, Jie Wu, Jiajun Shi, Qing Lan, Nathaniel Rothman, Yu Shyr, Xiao‐Ou Shu, Wei Zheng, Gong Yang
International Journal of Cancer.2022; 151(5): 699. CrossRef
Racial and ethnic differences in risk of second primary cancers among prostate cancer survivors
Diana R. Withrow, Sara J. Schonfeld, Rochelle E. Curtis, Lindsay M. Morton, Michael B. Cook, Eboneé N. Butler, Amy Berrington de González
Cancer Causes & Control.2020; 31(11): 1011. CrossRef
Sex steroid metabolism and actions in non-small cell lung carcinoma
Teeranut Asavasupreechar, Monica S.M. Chan, Ryoko Saito, Yasuhiro Miki, Viroj Boonyaratanakornkit, Hironobu Sasano
The Journal of Steroid Biochemistry and Molecular Biology.2019; 193: 105440. CrossRef

Brief Communication

Epidemiological evidences on overdiagnosis of prostate and kidney cancers in Korean: Jong-Myon Bae; Epidemiol Health. 2015;37:e2015015. Published online March 7, 2015; DOI: https://doi.org/10.4178/epih/e2015015

18,389 View
164 Download
7 Web of Science
9 Crossref

Abstract Summary PDF Supplementary Material

Abstract

OBJECTIVES
The prostate specific antigen test is widely used as the main method of screening prostate cancer in Korea. Additionally, the use of ultrasound sonography may lead to overdiagnosis of kidney cancer as well as thyroid cancer. This study aimed to highlight epidemiological evidences regarding overdiagnosis of prostate and kidney cancers in Korean.

METHODS

The annual trends of national incidence and mortality of prostate and kidney cancers provided by the Korean Statistical Information Service were evaluated.

RESULTS

The rate of increase in the incidence of prostate and kidney cancer was 6 and 5 times higher than that of mortality between 2000 and 2011, respectively. Additionally, the age group showing the highest incidence in prostate cancer shifted from 85 years and older to 75-79 years.

CONCLUSIONS

This evidence suggests that prostate and kidney cancers are overdiagnosed in Korea. Further research in this area, using national cancer registry databases, should be encouraged to prevent overdiagnosis.

Summary

Korean summary
갑상선암의 과진단은 목초음파검사의 시행에 따른 것이란 주장에 따라, 전립선암과 신장암은 각각 전립선특이항원검사와 복부초음파검사의 시행에 따라 과진단이 있을 것으로 예상된다. 과진단의 여부는 검사 시행 이후 발생률이 증가하는 반면, 사망률은 변동이 없는 것으로 판단할 수 있다. 통계청의 해당 암 발생률과 사망률 추이를 살펴볼 때, 국내에서도 전립선암과 신장암에서 과진단이 있음을 확인할 수 있었다.

Citations

Citations to this article as recorded by

Twenty-two-year incidence trend of urological cancers in the Republic of Korea: 1999–2020
Seunghyeon Cho, Won-Ju Park
Investigative and Clinical Urology.2024; 65(1): 23. CrossRef
A single-center long-term experience of active surveillance for prostate cancer: 15 years of follow-up
Sang Hun Song, Jung Kwon Kim, Hakmin Lee, Sangchul Lee, Sung Kyu Hong, Seok-Soo Byun
Investigative and Clinical Urology.2021; 62(1): 32. CrossRef
Risk of thyroid as a first or second primary cancer. A population‐based study in Italy, 1998–2012
Emanuele Crocetti, Veronica Mattioli, Carlotta Buzzoni, Silvia Franceschi, Diego Serraino, Salvatore Vaccarella, Stefano Ferretti, Susanna Busco, Ugo Fedeli, Massimo Varvarà, Fabio Falcini, Manuel Zorzi, Giuliano Carrozzi, Walter Mazzucco, Cinzia Gasparot
Cancer Medicine.2021; 10(19): 6855. CrossRef
Cancer Incidence by Occupation in Korea: Longitudinal Analysis of a Nationwide Cohort
Hye-Eun Lee, Masayoshi Zaitsu, Eun-A Kim, Ichiro Kawachi
Safety and Health at Work.2020; 11(1): 41. CrossRef
The Overdiagnosis of Kidney Cancer in Koreans and the Active Surveillance on Small Renal Mass
Byung Hoon Chi, In Ho Chang
The Korean Journal of Urological Oncology.2018; 16(1): 15. CrossRef
Potential Epigenetic Biomarkers for Prostate Cancer Screening
Jong-Myon Bae
International Neurourology Journal.2018; 22(2): 142. CrossRef
Strategies for Appropriate Patient-centered Care to Decrease the Nationwide Cost of Cancers in Korea
Jong-Myon Bae
Journal of Preventive Medicine and Public Health.2017; 50(4): 217. CrossRef
It needs adaptation to the 2015 Korean guideline for breast cancer screening
Jong-Myon Bae
Journal of the Korean Medical Association.2015; 58(9): 833. CrossRef
Two different views of interpreting the related evidences on the reply to reader's letter
Jong-Myon Bae
Journal of the Korean Medical Association.2015; 58(12): 1196. CrossRef

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