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Original Article
- Age at first childbirth and the risk of hypertriglyceridemia among Korean women
- Hye Rin Choi, Hyeon Chang Kim
- Epidemiol Health. 2023;45:e2023010. Published online December 29, 2022
- DOI: https://doi.org/10.4178/epih.e2023010
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- 1 Web of Science
- 1 Crossref
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Abstract
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AbstractOBJECTIVES
We aimed to investigate the association of age at first childbirth with the risk of hypertriglyceridemia among Korean women.METHODSThis study used data from the Korean Genome and Epidemiology Study–Cardiovascular Disease Association Study. In total, 16,747 women were included in the cross-sectional analysis, and 6,250 women were included in the longitudinal analysis. The participants were divided based on their age at first childbirth (<20, 20-24, 25-29, and ≥30 years). Hypertriglyceridemia was defined as triglyceride levels of ≥150 mg/dL.RESULTSThe multivariable-adjusted odds ratio for prevalent hypertriglyceridemia was 1.19 (95% confidence interval [CI], 1.01 to 1.40) in women whose first childbirth was before 20 years of age, compared to those whose first childbirth was at 25-29 years of age, after adjustment for age, study site, body mass index, blood pressure, diabetes, alcohol consumption, carbohydrate intake, income, marital status, education, parity, usage of oral contraceptives, and hormone replacement status. During a median follow-up of 5.2 years, 1,770 women developed hypertriglyceridemia. Compared with women who gave birth to their first child between 25 years and 29 years of age, those giving birth to their first child before 20 years of age had a higher risk for incident hypertriglyceridemia in later life (adjusted hazard ratio, 1.25; 95% CI, 0.99 to 1.57).CONCLUSIONSGiving birth to one’s first child before the age of 20 years was associated with an increased risk of hypertriglyceridemia among Korean women. -
SummaryKorean summary
한국인유전체역학조사사업의 농촌기반 코호트 자료를 분석한 결과, 20세 이전에 초산을 경험한 한국 여성에서 25-29세에 경험한 군에 비해 고중성지방혈증에 걸릴 위험이 증가하였음 폐경 후 여성을 한정하여 보았을 때도 20세 이전 초산과 고중성지방혈증 간의 유의한 관련성을 보였음 여성의 출산 등 여성력이 심혈관계 질환 발생의 위험요인으로 작용할 수 있으며, 출산력에 따른 혈중 중성지방수치 관리 전략 마련이 필요함Key Message
Among Korean women, having their first child before the age of 20 was associated with an increased risk of hypertriglyceridemia. Targeted preventive actions should be developed for those women who give birth at an early age in order to manage their blood triglyceride levels. -
Citations
Citations to this article as recorded by
- Adolescent childbirth and mobility disability among women ages 15–49: an analysis of population health surveys from 14 low-income and middle-income countries
Katherine E Peck, Diego G Bassani, Saionara MA Camara, Marlos R Domingues, Tetine Sentell, Maria P Velez, Catherine M Pirkle
BMJ Open.2023; 13(7): e072535. CrossRef
- Adolescent childbirth and mobility disability among women ages 15–49: an analysis of population health surveys from 14 low-income and middle-income countries
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