While the main product of Jeju Island is citrus fruit and the prevalence of atopic dermatitis among the students who live there is relatively high, the incidence of pancreatic cancer is lowest in Korea. Systematic reviews reporting allergic history and intake of citrus fruit as protective factors against pancreatic cancer (PCC) were published in 2005 and 2008, respectively. Although there were discrepancies in the results of the subgroup analyses between case-control and cohort studies, it is necessary to evaluate an interaction effect between allergic history and intake of citrus fruits on PCC risk.
Summary
Korean summary
췌장암 발생과 관련한 요인들의 규명이 절실한 상황에서, 알레르기 질환과 감귤섭취 각각이 발생억제 효과가 있다는 체계적 고찰연구가 있다. 그러나 코호트 연구들만으로 메타분석을 하였을 때는 두 억제 요인 모두 통계적 유의성이 없는 것으로 나왔다. 한편 지역별 췌장암 발생률에서 낮은 수준을 보이는 제주도는 주요 감귤생산지이면서, 초중고등학생의 아토피 유병률이 상대적으로 높은 것으로 알려져 있다. 이런 사실들에 근거할 때 췌장암 발생에 있어 알레르기질환과 감귤섭취의 상호작용을 규명하는 코호트 연구를 제안한다.
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