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Original Articles
- Recent trends in opioid prescriptions in Korea from 2002 to 2015 based on the Korean NHIS-NSC cohort
- Joungyoun Kim, Sang-Jun Shin, Jihyun Yoon, Hyeong-Seop Kim, Jae-woo Lee, Ye-seul Kim, Yonghwan Kim, Hyo-Sun You, Hee-Taik Kang
- Epidemiol Health. 2022;44:e2022029. Published online February 21, 2022
- DOI: https://doi.org/10.4178/epih.e2022029
- 9,872 View
- 519 Download
- 4 Web of Science
- 6 Crossref
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Abstract
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AbstractOBJECTIVES
Opioids are prescribed to treat moderate to severe pain. We investigated recent trends in opioid (morphine, oxycodone, fentanyl, and hydromorphone) prescriptions using data from the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2015.METHODSThe morphine milligram equivalent (MME) was calculated to standardize the relative potency of opioids. The number (cases) or amount (MME) of annual opioid prescriptions per 10,000 registrants was computed to analyze trends in opioid prescriptions after age standardization. Joinpoint regression analysis was conducted to calculate the annual percentage change and average annual percentage change (AAPC).RESULTSThe number (cases) of prescriptions per 10,000 registrants increased from 0.07 in 2002 to 41.23 in 2015 (AAPC, 76.0%; 95% confidence interval [CI], 61.6 to 91.7). The MME per 10,000 registrants increased from 15.06 in 2002 to 40,727.80 in 2015 (AAPC, 103.0%; 95% CI, 78.2 to 131.3). The highest AAPC of prescriptions and MME per 10,000 registrants were observed in the elderly (60-69 years) and in patients treated at general hospitals. Fentanyl prescriptions increased most rapidly among the 4 opioids.CONCLUSIONSConsumption of opioids greatly increased in Korea over the 14-year study period. -
SummaryKorean summary
- 중강도 이상의 통증을 치료하기위해 아편유사체가 처방되고 있다. - 본 연구는 아편유사체(모르핀, 옥시코돈, 펜타닐, 히드로모르폰)의 처방 추세를 조인포인트 회귀분석으로 분석하였다. - 아편유사체의 사용은 증가하고 있다. 특히 노인과 종합병원에서 아편유사체의 처방은 지속적으로 증가하고 있으며, 펜타닐 처방이 제일 많이 증가하였다.Key Message
- Opioid prescriptions (morphine, oxycodone, fentanyl, and hydromorphone) fentanyl to treat moderate to severe pain have increased. - Trends in opioid prescriptions were analyzed using Joinpoint regression analysis after age standardization, based on the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2015. - Trends in opioid prescriptions have increased. - In particular, the highest increment in opioid prescription was observed in the elderly population (60-69 years) and patients admitted in general hospitals. - Fentanyl prescriptions among four types of opioids increased most rapidly. -
Citations
Citations to this article as recorded by
- Current status of opioid prescription in South Korea using narcotics information management system
Soo-Hyuk Yoon, Jeongsoo Kim, Susie Yoon, Ho-Jin Lee
The Korean Journal of Pain.2024; 37(1): 41. CrossRef - Opioid Prescription and Long-Term Survival Outcomes in Adults: A Nationwide Cohort Study in Korea
Tak Kyu Oh, In-Ae Song
Journal of Korean Medical Science.2024;[Epub] CrossRef - Opioid Prescription and Long-term Survival Outcomes in Adults: A Nationwide Cohort Study in Korea
Tak Kyu Oh, In-Ae Song
Journal of Korean Medical Science.2024;[Epub] CrossRef - Expert Opinion Survey on Proposals for Safety Management of Prescription Opioids
Seunghyun Cheon, Seo-Yong Choi, Sang-Hyeon Oh, Myoungon Eun, Jungbo Kim, Songhee Park, Soyoung Park, Ryang Soon Im, Su Bin Lee, Hye Won Han, Jungwha Lee, Hyun-A Sohn, Younghee Lee, Sook Hee An, Jee-Eun Chung
Journal of Korean Society of Health-System Pharmacists.2023; 40(3): 326. CrossRef - Prevention, diagnosis, and treatment of opioid use disorder under the supervision of opioid stewardship programs: it’s time to act now
Eun-Ji Kim, Eun-Jung Hwang, Yeong-Min Yoo, Kyung-Hoon Kim
The Korean Journal of Pain.2022; 35(4): 361. CrossRef - Economic burden of opioid misuse focused on direct medical costs
Miryoung Kim, Siin Kim, Hae Sun Suh
Frontiers in Pharmacology.2022;[Epub] CrossRef
- Current status of opioid prescription in South Korea using narcotics information management system
- Clinical and laboratory findings of rhabdomyolysis in opioid overdose patients in the intensive care unit of a poisoning center in 2014 in Iran
- Khoshideh Babak, Arefi Mohammad, Ghorbani Mazaher, Akbarpour Samaneh, Taghizadeh Fatemeh
- Epidemiol Health. 2017;39:e2017050. Published online November 8, 2017
- DOI: https://doi.org/10.4178/epih.e2017050
- 13,836 View
- 253 Download
- 13 Web of Science
- 11 Crossref
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Abstract
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AbstractOBJECTIVES
The aim of this study was to investigate the clinical and demographic characteristics and some laboratory findings of hospitalized patients with acute opioid toxicity and rhabdomyolysis.METHODSThis cross-sectional study investigated 354 patients hospitalized at Baharloo Hospital in Tehran in 2014 with acute illicit drug toxicity. Data were collected using an investigator-made checklist. The collected data (such as mortality rate, demographic data, and renal function tests, as well as serum biochemical findings) were analyzed by descriptive statistics and the chi-square test.RESULTSA total of 354 patients were admitted to the hospital in 2014 with acute illicit drug toxicity, including 291 males and 63 females. The total number of patients with rhabdomyolysis was 76 (21.5% of the total), of whom 69 (90.8%) were male and 7 (9.2%) were female. Most cases of rhabdomyolysis were associated with methadone abuse, followed by opium abuse. Rhabdomyolysis was most common in those 20-29 and 30-39 years old, with methadone and opium the most commonly abused illicit drugs. The mean blood urea level was 3.8±1.0 mg/dL, and the mean serum potassium and sodium levels were 3.8±0.3 mg/dL and 140.4±4.0 mg/dL, respectively. Five patients, all of whom were male, passed away due to severe renal failure (6.5%).CONCLUSIONSToxicity caused by opioids is associated with clinical complications and laboratory disorders, such as electrolyte disorders, which can lead to lethal or life-threatening results in some cases. Abnormal laboratory test findings should be identified in patients with opioid toxicity in order to initiate efficient treatment. -
Summary
Citations
Citations to this article as recorded by- Mental health status, health service utilization, drug use behaviors associated with non-fatal overdose among people who use illicit drugs: A meta-analysis
Bahram Armoon, Peter Higgs, Rasool Mohammadi
Journal of Substance Use.2023; 28(2): 154. CrossRef - Incidence of rhabdomyolysis occurrence in psychoactive substances intoxication: a systematic review and meta-analysis
Alireza Amanollahi, Tannaz Babeveynezhad, Mohsen Sedighi, Shahin Shadnia, Sadaf Akbari, Mahbobeh Taheri, Mahboobeh Besharatpour, Goljamal Jorjani, Elham Salehian, Koorosh Etemad, Yadollah Mehrabi
Scientific Reports.2023;[Epub] CrossRef - Public health risks associated with methadone in Iran: A systematic review and meta-analysis
Yasna Rostam-Abadi, Jaleh Gholami, Alireza Noroozi, Mina Ansari, Shahab Baheshmat, Marziyeh Hamzehzadeh, Mohammad Reza Ghadirzadeh, Bita Vahdani, Hamed Ekhtiari, Ramin Mojtabai, Afarin Rahimi-Movaghar
International Journal of Drug Policy.2022; 100: 103529. CrossRef - A Fatal Case of Opioid Intoxication After Raw Poppy Plant Ingestion
Gurkan Bozan, Hasan Bora Ulukapi, Ummuhan Oncul, Serkan Levent, Ener C Dinleyici
Cureus.2021;[Epub] CrossRef - Opioids and Acute Kidney Injury
Mary Mallappallil, Siddhartha Bajracharya, Moro Salifu, Ernie Yap
Seminars in Nephrology.2021; 41(1): 11. CrossRef - Epidemiology and the Impact of Acute Kidney Injury on Outcomes in Patients with Rhabdomyolysis
Chien-Wen Yang, Si Li, Yishan Dong, Nitpriya Paliwal, Yichen Wang
Journal of Clinical Medicine.2021; 10(9): 1950. CrossRef - Review of Neurologic Comorbidities in Hospitalized Patients With Opioid Abuse
Kevin R. Nelson, Katelyn Dolbec, William Watson, Hanwen Yuan, Mam Ibraheem
Neurology Clinical Practice.2021; 11(6): 527. CrossRef - Multiple limb compartment syndrome as a manifestation of capillary leak syndrome secondary to metformin and dipeptidyl peptidase IV inhibitor overdose
Daisuke Kasugai, Kosuke Tajima, Naruhiro Jingushi, Norimichi Uenishi, Akihiko Hirakawa
Medicine.2020; 99(29): e21202. CrossRef - Case report: Methadone caused rhabdomyolysis
Zoran Kovačević, Maja Derić-Jeremić, Danijela Derić, Neda Ognjanović, Maja Sazdanović
Engrami.2020; 42(1): 83. CrossRef - Non -fatal overdose among people who inject drugs in Tehran, Iran
Mehdi Noroozi, Peter Higgs, Azadeh Bayani, Bahram Armoon, Ali Nazeri Astaneh, Ladan Fattah Moghaddam, Mohammad Askari
Substance Abuse Treatment, Prevention, and Policy.2020;[Epub] CrossRef - Methadone overdose
Reactions Weekly.2017; 1679(1): 111. CrossRef
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