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Original Article
- Effects of antibiotic consumption on children 2-8 years of age developing asthma
- Hamid Reza Khalkhali, Sima Oshnouei, Shaker Salarilak, Mohammadhossein Rahimi Rad, Mohammad Karamyar, Javad Khashabi
- Epidemiol Health. 2014;36:e2014006. Published online July 4, 2014
- DOI: https://doi.org/10.4178/epih/e2014006
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- 142 Download
- 13 Web of Science
- 12 Crossref
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Abstract
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AbstractOBJECTIVES
Antibiotic exposure in children is a possible contributor to the increasing asthma prevalence in several countries. The present study aimed to investigate the association between antibiotic exposure and the risk of developing childhood asthma at 2-8 years of age.METHODSA case-control study was undertaken among children aged 2-8 years old between March and September 2010 in the Urmia district in the northwest of Iran. The cases were doctor-diagnosed asthmatic children based on Global Initiative for Asthma criteria (n=207), and the controls were children without respiratory symptoms (n=400) selected by frequency matching by age and gender. Clinical data including antibiotic exposure was collected by a validated and reliable questionnaire, which was completed by interviewing parents/guardians.RESULTSAntibiotic consumption during the first year of life increased the odds ratio [OR] of asthma symptoms at 2-8 years of age (crude OR, 2.26; 95% confidence interval [CI], 1.53-3.35; p<0.01), and the strength of association was similar after adjusting for a family history of asthma or atopic disorder, preterm delivery, birth order, and delivery method (adjusted OR, 1.91; 95% CI, 1.27-2.88; p=0.03).CONCLUSIONSOur study suggests that antibiotic consumption in children was associated with an increased risk of childhood asthma, and an additional confirmative study is needed. -
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Citations
Citations to this article as recorded by
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